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Phase Behavior of a Lipid/Polymer-Lipid Mixture in Aqueous Medium

Publication ,  Journal Article
Hristova, K; Needham, D
Published in: Macromolecules
July 1, 1995

The phase behavior of a mixture of bilayer forming lipids and polymer-lipids (lipids with covalently attached polymer to their hydrophilic moieties) in excess water is studied theoretically. The mixture is predicted to exhibit complex phase behavior for polymer molecular weights 2000 and 5000, depending on the concentration (fraction) of polymer-lipids in the lipid mixture. The bilayer is characterized by a maximal concentration nMt (saturation limit) of polymer-lipids that it can incorporate, as determined by its material properties (elastic modulus of area expansion and critical area expansion). At a different concentration ntr, which we call the thermodynamics crossover, micelle formation becomes energetically favorable over bilayer formation. We show that for DSPC and SOPC bilayers ntr < nsat. Increase of the polymer-lipid concentration above ntr leads to a gradual transition from a bilayer to a micellar phase; bilayers and micelles can coexist. In the transition region the polymer-lipid concentration is higher in the micellar phase than in the coexisting bilayer. © 1995, American Chemical Society. All rights reserved.

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Published In

Macromolecules

DOI

EISSN

1520-5835

ISSN

0024-9297

Publication Date

July 1, 1995

Volume

28

Issue

4

Start / End Page

991 / 1002

Related Subject Headings

  • Polymers
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
 

Citation

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Hristova, K., & Needham, D. (1995). Phase Behavior of a Lipid/Polymer-Lipid Mixture in Aqueous Medium. Macromolecules, 28(4), 991–1002. https://doi.org/10.1021/ma00108a029
Hristova, K., and D. Needham. “Phase Behavior of a Lipid/Polymer-Lipid Mixture in Aqueous Medium.” Macromolecules 28, no. 4 (July 1, 1995): 991–1002. https://doi.org/10.1021/ma00108a029.
Hristova K, Needham D. Phase Behavior of a Lipid/Polymer-Lipid Mixture in Aqueous Medium. Macromolecules. 1995 Jul 1;28(4):991–1002.
Hristova, K., and D. Needham. “Phase Behavior of a Lipid/Polymer-Lipid Mixture in Aqueous Medium.” Macromolecules, vol. 28, no. 4, July 1995, pp. 991–1002. Scopus, doi:10.1021/ma00108a029.
Hristova K, Needham D. Phase Behavior of a Lipid/Polymer-Lipid Mixture in Aqueous Medium. Macromolecules. 1995 Jul 1;28(4):991–1002.
Journal cover image

Published In

Macromolecules

DOI

EISSN

1520-5835

ISSN

0024-9297

Publication Date

July 1, 1995

Volume

28

Issue

4

Start / End Page

991 / 1002

Related Subject Headings

  • Polymers
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences