David Needham | Scholars@Duke

David Needham
Professor in the Department of Mechanical Engineering and Materials Science

Professor Needham also holds appointments as Associate Professor of Biomedical Engineering; Associate Professor, Center for Bioinspired materials and material Systems, and the Center for Biomolecular and Tissue Engineering; and Associate Professor, Duke Comprehensive Cancer Center.

Needham's Lab uses a platform technology of micropipette manipulation to manipulate single and pairs of micro particles in order to assess their behavior in well defined fluids and excipient concentrations. He brings a wealth of expertise in micromanipulation, colloid stability, and drug delivery formulation.

Current Appointments & Affiliations

Professor in the Department of Mechanical Engineering and Materials Science, Mechanical Engineering and Materials Science, Pratt School of Engineering 1999
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2010

Contact Information

3391 CIEMAS, Durham, NC 27708
Box 90300, Durham, NC 27708-0300
d.needham@duke.edu (919) 660-5355

Background
Education, Training, & Certifications
- Ph.D., University of Nottingham 1981
- B.S., Nottingham Trent University 1975
Duke Appointment History
- Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1999 - 2004
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1992 - 1999
- Associate Professor with Tenure, Mechanical Engineering and Materials Science, Pratt School of Engineering 1993 - 1998
- Associate Professor, Mechanical Engineering and Materials Science, Pratt School of Engineering 1991 - 1993
- Assistant Professor, Mechanical Engineering and Materials Science, Pratt School of Engineering 1987 - 1990
Recognition
In the News
- JAN 12, 2017
  
  Developing New Strategies for Cancer Drug Delivery, in Denmark and at Duke
- JUL 18, 2014
  
  David Needham Named Honorary Professor of Pharmacy at the University of Nottingham
Expertise
Global Scholarship
- Teaching
  - Denmark (Country)
Research
Selected Grants
- TRP and AQP Channels: Modulation of Function, Raft Location by Membrane Lipids awarded by National Institutes of Health 1980 - 2015
- PLGA Protein Microspheres: Single Particle Engineering awarded by National Institutes of Health 2006 - 2011
- Faculty Development Workshop: "Course Enhancement Projects" Across the Pratt Curriculum awarded by Lord Foundation of North Carolina 2009 - 2010
- Integrating Nanoscale Systems and Design into the Undergraduate Engineering and Science Curricula awarded by National Science Foundation 2007 - 2010
- Training in Biomolecular and Tissue Engineering awarded by National Institutes of Health 2003 - 2009
- Ultra High-speed Imaging System awarded by National Institutes of Health 2003 - 2008
- Graduate training in Biologically Inspired Materials awarded by National Science Foundation 2002 - 2007
- Thermally Sensitive Drug Delivery System for Tumors awarded by National Institutes of Health 2000 - 2006
- Molecular Exchange with Lipid Membranes awarded by National Institutes of Health 1995 - 2005
- Engineering Biology at the Nanoscale awarded by National Institutes of Health 2004 - 2005
- Upgrade of a Shared Instrumentation Resource in the PSOE: The Laser Scanning Confocal Microscope awarded by Lord Foundation of North Carolina 2002 - 2005
- Development and Construction of Single Molecule Spectrometers for Research and Student Training awarded by National Science Foundation 2001 - 2003
- (95-0189) Molecular Forces in Blood-vasular Cell Interaction awarded by National Institutes of Health 1995 - 2000
- (96-0807) Molecular Forces in Blood/Vascular Cell Adhesion awarded by National Institutes of Health 1995 - 2000
- (97-0846) Molecular Forces in Blood/Vascular Cell Adhesion awarded by National Institutes of Health 1995 - 2000
- (98-0573) Molecular Exchange and Defect Formation in Membranes awarded by National Institutes of Health 1988 - 1999
- Particle Size Measurement: Instrumentation Grant awarded by Lord Foundation of North Carolina 1998 - 1999
- (94-1004) Molecular Exchange and Defect Formation in Membranes awarded by National Institutes of Health 1988 - 1999
- (96-0604) Molecular Exchange and Defect Formation in Membranes awarded by National Institutes of Health 1988 - 1999
- (97-0628) Molecular Exchange and Defect Formation in Membranes awarded by National Institutes of Health 1988 - 1999
- (97-0933) ME265.03 Biological Materials Sci; Curriculum Development & Textbook... awarded by Lord Foundation of North Carolina 1997 - 1998
- (93-0137) Viscoelasticity of Blood Cells awarded by National Institutes of Health 1979 - 1995
- (95-0153) Viscoelasticity of Blood Cells awarded by National Institutes of Health 1979 - 1995
- (93-0073) Biorheology of Hybridomas and Cell Damage awarded by National Science Foundation 1991 - 1994
- (87-0337) Electropermeabilization/Fusion of Liquid Vesicles and Cells awarded by National Institutes of Health 1988 - 1993
- (90-0151) Electropermeabilitization/ Fusion of Lipid Vesicles and Cells awarded by National Institutes of Health 1988 - 1993
- (91-0232) Electropermeabilization/Fusion of Lipid Vesicles and Cells awarded by National Institutes of Health 1988 - 1993
- (92-0207) Electropermeabilization/Fusion of Lipid Vesicles & Cells awarded by National Institutes of Health 1988 - 1993
- (93-0180) Electropermeabilization/Fusion of Lipid Vesicles and Cells awarded by National Institutes of Health 1988 - 1993
- (91-0174) Biorheology of Hybridomas and Cell Damage awarded by National Science Foundation 1991 - 1992
Publications & Artistic Works
Selected Publications
- Book Sections
  - Needham, D. "Reverse engineering of the low temperature-sensitive liposome (LTSL) for treating cancer." In Biomaterials for Cancer Therapeutics: Diagnosis, Prevention and Therapy, 270-348. January 1, 2013. Full Text
  - Needham, D, and Zhelev, D. "Use of Micropipet Manipulation Techniques to Measure the Properties of Giant Lipid Vesicles." In Giant Vesicles: Perspectives in Supramolecular Chemistry, 102-147. March 12, 2007. Full Text
- Conference Papers
  - Brousell, SC, Longo, TA, Fantony, JJ, Etienne, W, Needham, D, Dewhirst, MW, Maccarini, PF, Spasojevic, I, and Inman, BA. "MP65-08 HEAT-TARGETED DRUG DELIVERY USING THE COMBAT BRS DEVICE FOR TREATING BLADDER CANCER." April 2017. Full Text
  - Kinoshita, K, Glud, K, and Needham, D. "New Measurements of Lung Surfactant Interfacial Tension with Micropipette Manipulation Technique." January 2014. Full Text
  - Rickard, DL, Duncan, PB, and Needham, D. "Hydration Potential of Lysozyme: Protein Dehydration Using a Single Microparticle Technique." January 2010. Full Text Link to Item
  - Needham, D, Wright, A, Tong, J, Dewhirst, M, Ponce, A, and Yuan, F. "Mapping engineering onto biology at the nanoscale: nature's encapsulation technologies as bioinspiration for nano-scale anti-tumor drug delivery." December 2006. Full Text
  - Lee, SH, Needham, D, Duncan, PB, and Jutila, A. "Water micro-droplets in simple hydrocarbons: Dissolution, free energies of adhesion and bilayer permeability." March 13, 2005. Link to Item
  - Dhawan, M, Price, D, Trump, D, Kanter, P, Shore, N, Needham, D, and Dewhirst, M. "New drug delivery approach for the treatment of prostate cancer (preclinical results and phase I study results)." July 15, 2004. Link to Item
  - Needham, D. "From properties to performance: The mechanochemistry of lipid vesicles with implications for drug carrier design." 2003. Link to Item
  - Needham, D, and Lee, S. "From soft materials to rational design of active carrier delivery systems." August 18, 2002. Link to Item
  - Zhelev, DV, Stoicheva, NG, and Needham, D. "Interaction of the amphipatic peptide AcE4K with SOPC membranes." January 2001. Link to Item
  - Kiser, PF, Thomas, AA, Eichenbaum, GM, Needham, D, and Kim, I. "Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable cross-linkers composed of oligo-lactate and oligo-glycolate esters." March 26, 2000. Link to Item
  - Dewhirst, MW, Kong, G, and Needham, D. "Use of hyperthermia to augment liposomal drug delivery to tumours." 2000. Link to Item
  - Stoicheva, NG, Zhelev, DV, and Needham, D. "Exchange of monooleoylphophatidylcholine with membranes containing cholesterol." January 2000. Link to Item
  - Needham, D, and Wong, I. "An expert panel review to evaluate the effectiveness of community pharmacist's interventions in the palliative care setting." September 18, 1999.
  - Florine-Casteel, K, Ritchie, K, Ting-Beall, HP, Evans, E, and Needham, D. "Nanomechanics of the neutrophil interface: Cell surface compliance." January 1999. Link to Item
  - Eichenbaum, GM, Kiser, PF, Simon, SA, and Needham, D. "Environmental response of anionic microgels." August 23, 1998. Link to Item
  - Eichenbaum, GM, Kiser, PF, Simon, SA, and Needham, D. "pH and NaCl triggered response of anionic microgels." August 23, 1998. Link to Item
  - Florine-Casteel, K, Ritchie, K, Evans, E, and Needham, D. "Nanomechanics of the neutrophil interface: Cell surface compliance." August 23, 1998. Link to Item
  - Kim, DH, Klibanov, AL, Evans, EA, and Needham, D. "Viscoelastic properties of phospholipid monolayer shells on air microbubbles." February 1998. Link to Item
  - Needham, D, Stoicheva, N, and Zhelev, DV. "Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid." February 1998. Link to Item
  - Olbrich, KC, Hutter, OF, and Needham, D. "Arachidonic acid increases water permeability of sarcolemmal vesicles from rabbit skeletal muscle." February 1998. Link to Item
  - Zhelev, DV, Stoicheva, N, and Needham, D. "Uptake of fuson peptide by bilayer membranes and mechanical properties of membranes containing fuson peptide." February 1998. Link to Item
  - Evans, E, Bowman, H, Leung, A, Needham, D, and Tirrell, D. "Biomembrane templating of nanometer-scale polymer patterns." September 7, 1997. Link to Item
  - Kiser, PF, Needham, D, and Wilson, G. "Mimicking the smart polymer matrix of the secretory granule: A new concept in controlled release drug delivery." April 13, 1997. Link to Item
  - Needham, D, and NopplSimson, D. "Barrier properties of surface-grafted PEG for macromolecule-surface interactions." April 13, 1997. Link to Item
  - TingBeall, HP, Kao, W, Valentine, WM, and Needham, D. "Toxin-induced changes in cell mechanochemical properties." February 28, 1997. Link to Item
  - Bowman, H, Evans, E, Needham, D, and Tirrell, D. "Nanometer-scale polymeric patterns and networks." March 24, 1996. Link to Item
  - Noppl, DA, and Needham, D. "Avidin-biotin interactions at vesicle surfaces: Adsorption and binding, cross bridge formation, and lateral interactions." February 1996. Link to Item
  - Olbrich, KC, Rawicz, W, Evans, EA, and Needham, D. "Water permeability and mechanical properties of polyunsaturated lipid membranes." February 1996. Link to Item
  - MCINTOSH, TJ, NEEDHAM, D, ZHELEV, DV, and SIMON, SA. "EXPERIMENTAL TESTS FOR MOLECULAR PROTRUSIONS AND UNDULATIONS IN LIPID BILAYERS." August 20, 1995. Link to Item
  - HRISTOVA, K, and NEEDHAM, D. "INCORPORATION OF POLYMER-LIPIDS INTO BILAYERS LEADS TO PHASE-TRANSITION." February 1994. Link to Item
  - KENWORTHY, AK, MCINTOSH, TJ, HRISTOVA, K, and NEEDHAM, D. "STERIC INTERACTIONS BETWEEN GEL AND LIQUID-CRYSTALLINE PHOSPHATIDYLCHOLINE BILAYERS CONTAINING LIPIDS WITH COVALENTLY ATTACHED POLYETHYLENE-GLYCOL." February 1994. Link to Item
  - HOCHMUTH, RM, TINGBEALL, HP, NEEDHAM, D, and TRANSONTAY, R. "RECOVERY OF PASSIVE HUMAN NEUTROPHILS AFTER SMALL DEFORMATIONS." February 1993. Link to Item
  - HRISTOVA, K, and NEEDHAM, D. "THEORETICAL-STUDIES OF MODEL BIOSURFACE PROPERTIES." February 1993. Link to Item
  - KENWORTHY, AK, MCINTOSH, TJ, NEEDHAM, D, and HRISTOVA, K. "STERIC INTERACTIONS BETWEEN BILAYERS CONTAINING LIPIDS WITH COVALENTLY ATTACHED POLYETHYLENE-GLYCOL." February 1993. Link to Item
  - ZHELEV, DV, NEEDHAM, D, and HOCHMUTH, RM. "A NOVEL MICROPIPET TECHNIQUE FOR STUDYING NEUTROPHIL LOCOMOTION, SPREADING AND CONTRACTILITY DURING PHAGOCYTOSIS AND MECHANICALLY STIMULATED POLYMERIZATION OF ACTIN NETWORK." February 1993. Link to Item
  - ZHELEV, DV, and NEEDHAM, D. "LONG LIVED REVERSIBLE PORES IN GIANT LIPOSOMES - A NOVEL METHOD FOR DETERMINATION OF PORE-SIZE AND PORE LINE TENSION." February 1993. Link to Item
  - LASIC, DD, MACLEOD, K, HUANG, A, ABRA, RM, NEWMAN, MS, MARTIN, FJ, NEEDHAM, D, and MAYHEW, E. "GRAFTED POLYMER (STEALTH) LIPOSOMES." April 5, 1992. Link to Item
  - NEEDHAM, D, MCINTOSH, TJ, and SIMON, SA. "CONFORMATION AND INTERACTIVE PROPERTIES OF SURFACE-BOUND POLYETHYLENE-GLYCOL (PEG) IN LIPID-MEMBRANES AND MONOLAYERS." January 1, 1992. Link to Item
  - SONKIN, PL, NEEDHAM, D, RAO, KMK, FREEDMAN, SF, and HATCHELL, DL. "PENTOXIFYLLINE IMPROVES DEFORMABILITY AND DECREASES F-ACTIN CONTENT OF PASSIVE POLYMORPHONUCLEAR LEUKOCYTES IN A CAT MODEL OF DIABETES." March 15, 1991. Link to Item
  - NEEDHAM, D, and NUNN, RS. "COHESIVE PROPERTIES (ELASTIC-DEFORMATION AND FAILURE) OF LIPID BILAYERS CONTAINING CHOLESTEROL." February 1990. Link to Item
  - NEEDHAM, D, and EVANS, E. "STRONG ATTRACTION INDUCED BETWEEN LIPID BILAYER-MEMBRANES BY NON-ADSORBING POLYMERS." February 1988. Link to Item
- Journal Articles
  - Utoft, A, Kinoshita, K, Bitterfield, DL, and Needham, D. "Manipulating Single Microdroplets of NaCl Solutions: Solvent Dissolution, Microcrystallization, and Crystal Morphology." Langmuir : the Acs Journal of Surfaces and Colloids 34, no. 12 (March 13, 2018): 3626-3641. Full Text
  - Kinoshita, K, Parra, E, and Needham, D. "Adsorption of ionic surfactants at microscopic air-water interfaces using the micropipette interfacial area-expansion method: Measurement of the diffusion coefficient and renormalization of the mean ionic activity for SDS." Journal of colloid and interface science 504 (October 2017): 765-779. Full Text
  - Parra, E, Hervella, P, and Needham, D. "Real-Time Visualization of the Precipitation and Phase Behavior of Octaethylporphyrin in Lipid Microparticles." Journal of pharmaceutical sciences 106, no. 4 (April 2017): 1025-1041. Full Text
  - Kinoshita, K, Parra, E, and Needham, D. "New sensitive micro-measurements of dynamic surface tension and diffusion coefficients: Validated and tested for the adsorption of 1-Octanol at a microscopic air-water interface and its dissolution into water." Journal of colloid and interface science 488 (February 2017): 166-179. Full Text
  - Yi, J, Knudsen, TA, Nielsen, A-L, Duelund, L, Christensen, M, Hervella, P, Needham, D, and Mouritsen, OG. "Data for the size of cholesterol-fat micelles as a function of bile salt concentration and the physico-chemical properties of six liquid experimental pine-derived phytosterol formulations in a cholesterol-containing artificial intestine fluid." Data in Brief 10 (February 2017): 478-481. Full Text
  - Bitterfield, DL, Utoft, A, and Needham, D. "An Activity-Based Dissolution Model for Solute-Containing Microdroplets." Langmuir : the ACS journal of surfaces and colloids 32, no. 48 (December 2016): 12749-12759. Full Text
  - Needham, D, Arslanagic, A, Glud, K, Hervella, P, Karimi, L, Høeilund-Carlsen, P-F, Kinoshita, K, Mollenhauer, J, Parra, E, Utoft, A, and Walke, P. "Bottom up design of nanoparticles for anti-cancer diapeutics: "put the drug in the cancer's food"." Journal of drug targeting 24, no. 9 (November 2016): 836-856. Full Text
  - Yi, J, Knudsen, TA, Nielsen, A-L, Duelund, L, Christensen, M, Hervella, P, Needham, D, and Mouritsen, OG. "Inhibition of cholesterol transport in an intestine cell model by pine-derived phytosterols." Chemistry and physics of lipids 200 (October 2016): 62-73. Full Text
  - Parra, E, Kinoshita, K, and Needham, D. "A micropipette technique study of natural and synthetic lung surfactants at the air-water interface: The presence of a SP-B analog peptide promotes membrane aggregation, formation of tightly stacked lamellae and growth of myelin figures." Langmuir : the ACS journal of surfaces and colloids (September 21, 2016). Full Text
  - Hervella, P, Parra, E, and Needham, D. "Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation." European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 102 (May 2016): 64-76. Full Text
  - Aniket, , Gaul, DA, Bitterfield, DL, Su, JT, Li, VM, Singh, I, Morton, J, and Needham, D. "Enzyme dehydration using Microglassification™ preserves the protein's structure and function." Journal of pharmaceutical sciences 104, no. 2 (February 2015): 640-651. Full Text
  - Zagar, TM, Vujaskovic, Z, Formenti, S, Rugo, H, Muggia, F, O'Connor, B, Myerson, R, Stauffer, P, Hsu, I-C, Diederich, C, Straube, W, Boss, M-K, Boico, A, Craciunescu, O, Maccarini, P, Needham, D, Borys, N, Blackwell, KL, and Dewhirst, MW. "Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer." International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 30, no. 5 (August 2014): 285-294. Full Text
  - Bagatolli, LA, and Needham, D. "Quantitative optical microscopy and micromanipulation studies on the lipid bilayer membranes of giant unilamellar vesicles." Chemistry and physics of lipids 181 (July 2014): 99-120. (Review) Full Text
  - Aniket, , Gaul, DA, Rickard, DL, and Needham, D. "Microglassification™: a novel technique for protein dehydration." J Pharm Sci 103, no. 3 (March 2014): 810-820. Full Text Link to Item
  - Aniket, , Gaul, DA, Rickard, DL, and Needham, D. "Microglassification^TM: A novel technique for protein dehydration." Journal of Pharmaceutical Sciences 103, no. 3 (March 1, 2014): 810-819. Full Text
  - Bagatolli, LA, and Needham, D. "Quantitative optical microscopy and micromanipulation studies on the lipid bilayer membranes of giant unilamellar vesicles." Chemistry and Physics of Lipids 181 (January 1, 2014): 99-120. Full Text
  - Olsen, BB, Thisgaard, H, Vogel, S, Thomassen, M, Kruse, TA, Needham, D, Mollenhauer, J, and Flemming Høilund-Carlsen, P. "Novel radioisotope-based nanomedical approaches." European Journal of Nanomedicine 5, no. 4 (December 1, 2013): 181-193. (Review) Full Text
  - Needham, D, and Dewhirst, MW. "Materials science and engineering of the low temperature sensitive liposome (LTSL): Composition-structure-property relationships that underlie its design and performance." RSC Smart Materials 1, no. 1 (November 25, 2013): 33-79.
  - Su, JT, and Needham, D. "Mass transfer in the dissolution of a multicomponent liquid droplet in an immiscible liquid environment." Langmuir : the Acs Journal of Surfaces and Colloids 29, no. 44 (November 2013): 13339-13345. Full Text
  - Davis, RM, Viglianti, BL, Yarmolenko, P, Park, J-Y, Stauffer, P, Needham, D, and Dewhirst, MW. "A method to convert MRI images of temperature change into images of absolute temperature in solid tumours." International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 29, no. 6 (September 2013): 569-581. Full Text
  - Needham, D, Park, J-Y, Wright, AM, and Tong, J. "Materials characterization of the low temperature sensitive liposome (LTSL): effects of the lipid composition (lysolipid and DSPE-PEG2000) on the thermal transition and release of doxorubicin." FARADAY DISCUSSIONS 161 (2013): 515-534. Full Text Link to Item
  - Manzoor, AA, Lindner, LH, Landon, CD, Park, J-Y, Simnick, AJ, Dreher, MR, Das, S, Hanna, G, Park, W, Chilkoti, A, Koning, GA, ten Hagen, TLM, Needham, D, and Dewhirst, MW. "Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors." Cancer Research 72, no. 21 (November 2012): 5566-5575. Full Text
  - Gilchrist, SE, Rickard, DL, Letchford, K, Needham, D, and Burt, HM. "Phase separation behavior of fusidic acid and rifampicin in PLGA microspheres." Molecular Pharmaceutics 9, no. 5 (2012): 1489-1501. Full Text
  - Needham, D. "Lipid structures: a brief history of multisomes." Nature Nanotechnology 6, no. 12 (December 6, 2011): 761-762. Full Text
  - Grant, GA, Wilson, C, Salami, S, Macaroni, P, Li, S, Park, J-Y, Needham, D, Bigner, D, and Dewhirst, M. "PRECLINICAL USE OF MILD HYPERTHERMIA TO ENHANCE DRUG DELIVERY TO BRAIN TUMORS." NEURO-ONCOLOGY 13 (November 2011): 111-111. Link to Item
  - Landon, CD, Park, J-Y, Needham, D, and Dewhirst, MW. "Nanoscale drug delivery and hyperthermia: The materials design and preclinical and clinical testing of low temperature-sensitive liposomes used in combination with mild hyperthermia in the treatment of local cancer." Open Nanomedicine Journal 3, no. SPEC. ISSUE (2011): 38-64.
  - Rickard, DL, Duncan, PB, and Needham, D. "Hydration potential of lysozyme: protein dehydration using a single microparticle technique." Biophysical Journal 98, no. 6 (March 2010): 1075-1084. Full Text
  - Su, JT, Duncan, PB, Momaya, A, Jutila, A, and Needham, D. "The effect of hydrogen bonding on the diffusion of water in n-alkanes and n-alcohols measured with a novel single microdroplet method." J Chem Phys 132, no. 4 (January 28, 2010): 044506-. Full Text Open Access Copy Link to Item
  - Yarmolenko, PS, Zhao, Y, Landon, C, Spasojevic, I, Yuan, F, Needham, D, Viglianti, BL, and Dewhirst, MW. "Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours." Int J Hyperthermia 26, no. 5 (2010): 485-498. Full Text Link to Item
  - Yang, C, Plackett, D, Needham, D, and Burt, HM. "PLGA and PHBV microsphere formulations and solid-state characterization: Possible implications for local delivery of fusidic acid for the treatment and prevention of orthopaedic infections." Pharmaceutical Research 26, no. 7 (2009): 1644-1656. Full Text
  - Chen, Q, Krol, A, Wright, A, Needham, D, Dewhirst, MW, and Yuan, F. "Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome." Int J Hyperthermia 24, no. 6 (September 2008): 475-482. Full Text Link to Item
  - Tashjian, JA, Dewhirst, MW, Needham, D, and Viglianti, BL. "Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques." Int J Hyperthermia 24, no. 1 (February 2008): 79-90. (Review) Full Text Link to Item
  - Montalvo-Ortiz, BL, Sosa, B, Velez, D, Needham, D, and Griebenow, K. "Novel encapsulation of partially dehydrated protein microparticles in PLGA microspheres." JOURNAL OF BIOTECHNOLOGY 131, no. 2 (September 2007): S51-S52. Full Text Link to Item
  - Ponce, AM, Wright, A, Dewhirts, MW, and Needham, D. "Targeted bioavailability of drugs by triggered release from liposomes." FUTURE LIPIDOLOGY 1, no. 1 (February 2007): 25-34. Full Text Link to Item
  - Holden, MA, Needham, D, and Bayley, H. "Functional bionetworks from nanoliter water droplets." Journal of the American Chemical Society 129, no. 27 (2007): 8650-8655. Full Text
  - Simon, SI, Nyunt, T, Florine-Casteel, K, Ritchie, K, Ting-Beall, HP, Evans, E, and Needham, D. "Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer." Annals of Biomedical Engineering 35, no. 4 (2007): 595-604. Full Text
  - Hauck, ML, LaRue, SM, Petros, WP, Poulson, JM, Yu, D, Spasojevic, I, Pruitt, AF, Klein, A, Case, B, Thrall, DE, Needham, D, and Dewhirst, MW. "Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 12, no. 13 (July 2006): 4004-4010. Full Text
  - Ponce, AM, Vujaskovic, Z, Yuan, F, Needham, D, and Dewhirst, MW. "Hyperthermia mediated liposomal drug delivery." Int J Hyperthermia 22, no. 3 (May 2006): 205-213. Full Text Link to Item
  - Duncan, PB, and Needham, D. "Microdroplet dissolution into a second-phase solvent using a micropipet technique: test of the Epstein-Plesset model for an aniline-water system." Langmuir 22, no. 9 (April 25, 2006): 4190-4197. Full Text Link to Item
  - Mills, JK, and Needham, D. "Temperature-triggered nanotechnology for chemotherapy: Rapid release from lysolipid temperature-sensitive liposomes." 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings 2 (2006): 5-8.
  - Wei, C, Lyubchenko, YL, Ghandehari, H, Hanes, J, Stebe, KJ, Mao, H-Q, Haynie, DT, Tomalia, DA, Foldvari, M, Monteiro-Riviere, N, and al, E. "New technology and clinical applications of nanomedicine: Highlights of the second annual meeting of the American Academy of Nanomedicine (Part I)." Nanomedicine: Nanotechnology, Biology, and Medicine 2, no. 4 (2006): 253-263. Full Text
  - Mills, JK, and Needham, D. "Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition." Biochim Biophys Acta 1716, no. 2 (October 15, 2005): 77-96. Full Text Link to Item
  - Eichenbaum, KD, Thomas, AA, Eichenbaum, GM, Gibney, BR, Needham, D, and Kiser, PF. "Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks." Macromolecules 38, no. 26 (2005): 10757-10762. Full Text
  - Merkin, JH, Needham, DJ, and Sleeman, BD. "A mathematical model for the spread of morphogens with density dependent chemosensitivity." Nonlinearity (UK) 18, no. 6 (2005): 2745-2773. (Academic Article) Full Text Link to Item
  - Needham, DJ, Leach, JA, and Merkin, JH. "The effects of a complexation reaction on travelling wave-fronts in a quadratic autocatalytic system." Q. J. Mech. Appl. Math. (UK) 58 (2005): 577-599. (Academic Article) Full Text Link to Item
  - Dhawan, M, Price, D, Trump, D, Kanter, P, Shore, N, Needham, D, and Dewhirst, M. "New drug delivery approach for the treatment of prostate cancer (preclinical results and phase I study results)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, no. 14_suppl (July 2004): 4661-.
  - Duncan, PB, and Needham, D. "Test of the Epstein-Plesset model for gas microparticle dissolution in aqueous media: effect of surface tension and gas undersaturation in solution." Langmuir 20, no. 7 (March 30, 2004): 2567-2578. Link to Item
  - Mills, JK, and Needham, D. "The materials engineering of temperature-sensitive liposomes." Methods Enzymol 387 (2004): 82-113. Full Text Link to Item
  - Kim, DH, Costello, MJ, Duncan, PB, and Needham, D. "Mechanical Properties and Microstructure of Polycrystalline Phospholipid Monolayer Shells: Novel Solid Microparticles." Langmuir 19, no. 20 (September 2003): 8455-8466. Full Text
  - Ickenstein, LM, Arfvidsson, MC, Needham, D, Mayer, LD, and Edwards, K. "Disc formation in cholesterol-free liposomes during phase transition." Biochimica et Biophysica Acta - Biomembranes 1614, no. 2 (2003): 135-138. Full Text
  - Needham, D. "Lipid Membranes: Biological Inspiration for Micro and Nano Encapsulation Technologies, Especially Drug Delivery." Materials Research Society Symposium - Proceedings 774 (2003): 173-202.
  - Hasik, MJ, Kim, DH, Howle, LE, Needham, D, and Prush, DP. "Evaluation of synthetic phospholipid ultrasound contrast agents." Ultrasonics 40, no. 9 (November 2002): 973-982. Link to Item
  - Needham, DS, Wong, ICK, Campion, PD, and Hull and East Riding Pharmacy Developmnet Group, . "Evaluation of the effectiveness of UK community pharmacists' interventions in community palliative care." Palliative medicine 16, no. 3 (May 2002): 219-225. Full Text
  - Zhelev, DV, and Needham, D. "Interactions of pH-sensitive peptides and polymers with lipid bilayers: Binding and membrane stability." Current Topics in Membranes 52 (2002): 437-464.
  - Needham, D, and Dewhirst, MW. "The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors." Advanced Drug Delivery Reviews 53, no. 3 (December 2001): 285-305. (Review) Full Text
  - Zhelev, DV, Stoicheva, N, Scherrer, P, and Needham, D. "Interaction of synthetic HA2 influenza fusion peptide analog with model membranes." Biophys J 81, no. 1 (July 2001): 285-304. Full Text Link to Item
  - Eichenbaum, GM, Kiser, PF, Dobrynin, AV, Simon, SA, and Needham, D. "Erratum: Investigation of the swelling response and loading of ionic microgels with drugs and proteins; The dependence on cross-link density (Macromolecules (July 27, 1999) 32:15 (4867-4878))." Macromolecules 34, no. 18 (2001): 6526-. (Academic Article) Full Text Link to Item
  - Eichenbaum, GM, Kiser, PF, Simon, SA, and Needham, D. "Erratum: pH and ion-triggered volume responses of anionic hydrogel microspheres (Macromolecules (July 28, 1998) 31:15 (5084-5093))." Macromolecules 34, no. 20 (2001): 7230-. (Academic Article) Full Text Link to Item
  - Lee, S, Kim, DH, and Needham, D. "Equilibrium and dynamic interfacial tension measurements at microscopic interfaces using a micropipet technique - 2. Dynamics of phospholipid monolayer formation and equilibrium tensions at the water-air interface." Langmuir 17, no. 18 (2001): 5544-5550. Full Text
  - Lee, S, Kim, DH, and Needham, D. "Equilibrium and Dynamic Interfacial Tension Measurements at Microscopic Interfaces Using a Micropipet Technique. 1. A New Method for Determination of Interfacial Tension." Langmuir 17, no. 18 (2001): 5537-5543. Full Text
  - Kong, G, Anyarambhatla, G, Petros, WP, Braun, RD, Colvin, OM, Needham, D, and Dewhirst, MW. "Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release." Cancer Research 60, no. 24 (December 2000): 6950-6957.
  - Needham, D, and Kim, DH. "PEG-covered lipid surfaces: bilayers and monolayers." Colloids and Surfaces. B, Biointerfaces 18, no. 3-4 (October 2000): 183-195. Full Text
  - Matteucci, ML, Anyarambhatla, G, Rosner, G, Azuma, C, Fisher, PE, Dewhirst, MW, Needham, D, and Thrall, DE. "Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas." Clin Cancer Res 6, no. 9 (September 2000): 3748-3755. Link to Item
  - Kiser, PF, Wilson, G, and Needham, D. "Lipid-coated microgels for the triggered release of doxorubicin." Journal of Controlled Release : Official Journal of the Controlled Release Society 68, no. 1 (July 2000): 9-22. Full Text
  - Olbrich, K, Rawicz, W, Needham, D, and Evans, E. "Water permeability and mechanical strength of polyunsaturated lipid bilayers." Biophysical Journal 79, no. 1 (July 2000): 321-327. Full Text
  - Rawicz, W, Olbrich, KC, McIntosh, T, Needham, D, and Evans, E. "Effect of chain length and unsaturation on elasticity of lipid bilayers." Biophysical Journal 79, no. 1 (July 2000): 328-339. Full Text
  - Needham, D, Anyarambhatla, G, Kong, G, and Dewhirst, MW. "A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model." Cancer Research 60, no. 5 (March 2000): 1197-1201.
  - Eichenbaum, GM, Kiser, PF, Shah, D, Meuer, WP, Needham, D, and Simon, SA. "Alkali earth metal binding properties of ionic microgels." Macromolecules 33, no. 11 (2000): 4087-4093. Full Text
  - Howell, ML, Alsabbagh, E, Ma, J-F, Ochsner, UA, Klotz, MG, Beveridge, TJ, Blumenthal, KM, Niederhoffer, EC, Morris, RE, Needham, D, and al, E. "AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide." Journal of Bacteriology 182, no. 16 (2000): 4545-4556. Full Text
  - Kim, DH, Klibanov, AL, and Needham, D. "The influence of tiered layers of surface-grafted poly(ethylene glycol) on receptor-ligand-mediated adhesion between phospholipid monolayer-stabilized microbubbles and coated glass beads." Langmuir 16, no. 6 (2000): 2808-2817.
  - Kiser, PF, Thomas, AA, Eichenbaum, GM, Needham, D, and Kim, I. "Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters." American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 41, no. 1 (2000): 712-713.
  - Needham, D, Demurjian, S, and Peters, T. "An IDL to Ada95 mapping to support propagation modeling." Ada Lett. (USA) 20, no. 1 (2000): 58-66. (Academic Article)
  - Anyarambhatla, GR, and Needham, D. "Enhancement of the phase transition permeability of DPPC liposomes by incorporation of MPPC: A new temperature-sensitive liposome for use with mild hyperthermia." Journal of Liposome Research 9, no. 4 (1999): 491-506.
  - Eichenbaum, GM, Kiser, PF, Dobrynin, AV, Simon, SA, and Needham, D. "Investigation of the swelling response and loading of ionic microgels with drugs and proteins: the dependence on cross-link density." Macromolecules 32, no. 15 (1999): 4867-4878. Full Text
  - Eichenbaum, GM, Kiser, PF, Shah, D, Simon, SA, and Needham, D. "Investigation of the swelling response and drug loading of ionic microgels: The dependence on functional group composition." Macromolecules 32, no. 26 (1999): 8996-9006. Full Text
  - Klibanov, AL, Gu, H, Wojdyla, JK, Jr, WJH, Kim, DH, Needham, D, Villanueva, FS, and Brandenburger, GH. "Attachment of ligands to gas-filled microbubbles via PEG spacer and lipid residues anchored at the interface." Proceedings of the Controlled Release Society , no. 26 (1999): 124-125.
  - Mills, JK, Eichenbaum, G, and Needham, D. "Effect of bilayer cholesterol and surface grafted poly(ethylene glycol) on pH-induced release of contents from liposomes by poly(2-ethylacrylic acid)." Journal of Liposome Research 9, no. 2 (1999): 275-290.
  - Mills, JK, and Needham, D. "Targeted drug delivery." Expert Opinion on Therapeutic Patents 9, no. 11 (1999): 1499-1513. Full Text
  - Needham, D. "Materials engineering of lipid bilayers for drug carrier performance." MRS Bulletin 24, no. 10 (1999): 32-40.
  - Eichenbaum, GM, Kiser, PF, Simon, SA, and Needham, D. "pH and Ion-Triggered Volume Response of Anionic Hydrogel Microspheres." Macromolecules 31, no. 15 (July 28, 1998): 5084-5093. Full Text Link to Item
  - Kiser, PF, Wilson, G, and Needham, D. "A synthetic mimic of the secretory granule for drug delivery." Nature 394, no. 6692 (July 1998): 459-462. Full Text
  - Needham, D, McIntosh, TJ, Simon, SA, and Zhelev, D. "Adsorption, molecular exchange and defect formation in membranes." Current Opinion in Colloid and Interface Science 3, no. 5 (1998): 511-517.
  - Needham, D, Mills, J, and Eichenbaum, G. "Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol)." Faraday Discuss , no. 111 (1998): 103-110. Link to Item
  - Needham, D, and Sarpal, RS. "Binding of paclitaxel to lipid interfaces: Correlations with interface compliance." Journal of Liposome Research 8, no. 2 (1998): 147-163.
  - Needham, DJ, and McAllister, S. "Centre families in two-dimensional complex holomorphic dynamical systems." Proc. R. Soc. Lond. A, Math. Phys. Eng. Sci. (UK) 454, no. 1976 (1998): 2267-2278. (Academic Article) Full Text Link to Item
  - Needham, D, Stoicheva, N, and Zhelev, DV. "Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid." Biophys J 73, no. 5 (November 1997): 2615-2629. Full Text Link to Item
  - Kiser, PF, Needham, D, and Wilson, G. "Mimicking the smart polymer matrix of the secretory granule: a new concept in controlled release drug delivery." Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering 76 (1997): 226--.
  - Needham, D, and Noppl-Simson, D. "Barrier properties of surface-grafted PEG for macromolecule-surface interactions." American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 38, no. 1 (1997): 549-550.
  - Noppl-Simson, DA, and Needham, D. "Avidin-biotin interactions at vesicle surfaces: adsorption and binding, cross-bridge formation, and lateral interactions." Biophys J 70, no. 3 (March 1996): 1391-1401. Full Text Link to Item
  - Bowman, H, Evans, E, Needham, D, and Tirrell, DA. "Nanometer-scale polymeric patterns and networks." Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering 74 (1996): 437-. (Academic Article)
  - Evans, E, Bowman, H, Leung, A, Needham, D, and Tirrell, D. "Biomembrane templates for nanoscale conduits and networks." Science 273, no. 5277 (1996): 933-935.
  - Needham, DJ, King, AC, and Merkin, JH. "Reaction-diffusion model for autocatalytic polymerization: II. The initial value problem." IMA Journal of Applied Mathematics (Institute of Mathematics & Its Applications) 56, no. 1 (1996): 65-86. (Academic Article)
  - Zhelev, DV, and Needham, D. "Pore formation and pore dynamics in bilayer membranes." American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 34 (1996): 47-49.
  - McIntosh, TJ, Advani, S, Burton, RE, Zhelev, DV, Needham, D, and Simon, SA. "Experimental tests for protrusion and undulation pressures in phospholipid bilayers." Biochemistry 34, no. 27 (July 1995): 8520-8532. Full Text
  - Kenworthy, AK, Hristova, K, Needham, D, and McIntosh, TJ. "Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol)." Biophysical Journal 68, no. 5 (May 1995): 1921-1936. Full Text
  - Needham, D, and Zhelev, DV. "Lysolipid exchange with lipid vesicle membranes." Ann Biomed Eng 23, no. 3 (May 1995): 287-298. Link to Item
  - HRISTOVA, K, and NEEDHAM, D. "INFLUENCE OF BILAYER FLUCTUATIONS ON THE STERIC INTERACTIONS BETWEEN POLYMER-GRAFTED BILAYERS." LIQUID CRYSTALS 18, no. 3 (March 1995): 423-430. Full Text Link to Item
  - Hristova, K, and Needham, D. "Phase behavior of a lipid/polymer-lipid mixture in aqueous medium." Macromolecules 28, no. 4 (1995): 991-1002.
  - Lasic, DD, and Needham, D. "The "Stealth" liposome: A prototypical biomaterial." Chemical Reviews 95, no. 8 (1995): 2601-2628.
  - Needham, D, and Noppl, D. "Adsorption and adhesion at vesicle surfaces: the influence of grafted polymer on avidin-biotin binding and tests of receptor-mediated adhesion." American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 29 (1995): 331-332.
  - Needham, D, and Zhelev, DV. "Lysolipid exchange with vesicle membranes and the formation and evolution of porous defects." Annals of Biomedical Engineering 23, no. 3 (1995): 287-. (Academic Article)
  - Needham, DJ. "Centre theorem for two-dimensional complex holomorphic systems and its generalization." Proceedings of The Royal Society of London, Series A: Mathematical and Physical Sciences 450, no. 1939 (1995): 225-232. (Academic Article)
  - Zhelev, DV, Needham, D, and Hochmuth, RM. "A novel micropipet method for measuring the bending modulus of vesicle membranes." Biophys J 67, no. 2 (August 1994): 720-727. Full Text Link to Item
  - Zhelev, DV, Needham, D, and Hochmuth, RM. "Role of the membrane cortex in neutrophil deformation in small pipets." Biophys J 67, no. 2 (August 1994): 696-705. Full Text Link to Item
  - Simon, SA, Disalvo, EA, Gawrisch, K, Borovyagin, V, Toone, E, Schiffman, SS, Needham, D, and McIntosh, TJ. "Increased adhesion between neutral lipid bilayers: interbilayer bridges formed by tannic acid." Biophys J 66, no. 6 (June 1994): 1943-1958. Full Text Link to Item
  - Hristova, K, and Needham, D. "The Influence of Polymer-Grafted Lipids on the Physical Properties of Lipid Bilayers: A Theoretical Study." Journal of Colloid And Interface Science 168, no. 2 (1994): 302-314. Full Text
  - Wu, NZ, Klitzman, B, Rosner, G, Needham, D, and Dewhirst, MW. "Measurement of material extravasation in microvascular networks using fluorescence video-microscopy." Microvasc Res 46, no. 2 (September 1993): 231-253. Full Text Link to Item
  - Wu, NZ, Da, D, Rudoll, TL, Needham, D, Whorton, AR, and Dewhirst, MW. "Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue." Cancer Res 53, no. 16 (August 15, 1993): 3765-3770. Link to Item
  - Ting-Beall, HP, Needham, D, and Hochmuth, RM. "Volume and osmotic properties of human neutrophils." Blood 81, no. 10 (May 15, 1993): 2774-2780. Link to Item
  - Hochmuth, RM, Ting-Beall, HP, Beaty, BB, Needham, D, and Tran-Son-Tay, R. "Viscosity of passive human neutrophils undergoing small deformations." Biophys J 64, no. 5 (May 1993): 1596-1601. Full Text Link to Item
  - Zhelev, DV, and Needham, D. "Tension-stabilized pores in giant vesicles: determination of pore size and pore line tension." Biochim Biophys Acta 1147, no. 1 (April 8, 1993): 89-104. Link to Item
  - Kavanagh, BD, Coffey, BE, Needham, D, Hochmuth, RM, and Dewhirst, MW. "The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment." Br J Cancer 67, no. 4 (April 1993): 734-741. Link to Item
  - NEEDHAM, D, DA, D, RUDOLL, TL, TINGBEALL, HP, WU, N, and DEWHIRST, MW. "PERMEABILITY OF IMPLANTED-TUMOR VASCULATURE TO POLYMER-GRAFTED LIPOSOMES." BIOPHYSICAL JOURNAL 64, no. 2 (February 1993): A338-A338. Link to Item
  - Needham, D. "Measurement of interbilayer adhesion energies." Methods Enzymol 220 (1993): 111-129. Link to Item
  - Sonkin, PL, Freedman, SF, Needham, D, Rao, KM, and Hatchell, DL. "Pentoxifylline modulates deformability, F-actin content, and superoxide anion production of polymorphonuclear leukocytes from diabetic cats." Exp Eye Res 55, no. 6 (December 1992): 831-838. Link to Item
  - Needham, D, McIntosh, TJ, and Lasic, DD. "Repulsive interactions and mechanical stability of polymer-grafted lipid membranes." Biochim Biophys Acta 1108, no. 1 (July 8, 1992): 40-48. Link to Item
  - Needham, D, and Hochmuth, RM. "A sensitive measure of surface stress in the resting neutrophil." Biophys J 61, no. 6 (June 1992): 1664-1670. Full Text Link to Item
  - Simon, SA, McIntosh, TJ, Magid, AD, and Needham, D. "Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface." Biophys J 61, no. 3 (March 1992): 786-799. Full Text Link to Item
  - McIntosh, TJ, Simon, SA, Needham, D, and Huang, CH. "Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers." Biochemistry 31, no. 7 (February 25, 1992): 2020-2024. Link to Item
  - McIntosh, TJ, Simon, SA, Needham, D, and Huang, CH. "Structure and cohesive properties of sphingomyelin/cholesterol bilayers." Biochemistry 31, no. 7 (February 1992): 2012-2020. Full Text
  - Needham, D, Hristova, K, McIntosh, TJ, Dewhirst, M, Wu, N, Lasic, DD, Alving, CR, Wassef, NM, Senior, JH, Ghosh, PC, Bachhawat, BK, and Allen, TM. "Polymer-grafted liposomes: Physical basis for the 'Stealth' property." Journal of Liposome Research 2, no. 3 (1992): 411-430.
  - Needham, DJ. "Formal theory concerning the generation and propagation of travelling wave-fronts in reaction-diffusion equations." Quarterly Journal of Mechanics and Applied Mathematics 45, no. pt 3 (1992): 469-498. (Academic Article)
  - Needham, D, Ting-Beall, HP, and Tran-Son-Tay, R. "A physical characterization of GAP A3 hybridoma cells: morphology, geometry, and mechanical properties." Biotechnol Bioeng 38, no. 8 (October 20, 1991): 838-852. Full Text Link to Item
  - Tran-Son-Tay, R, Needham, D, Yeung, A, and Hochmuth, RM. "Time-dependent recovery of passive neutrophils after large deformation." Biophys J 60, no. 4 (October 1991): 856-866. Full Text Link to Item
  - Needham, D. "Possible role of cell cycle-dependent morphology, geometry, and mechanical properties in tumor cell metastasis." Cell Biophysics 18, no. 2 (April 1991): 99-121. (Review) Full Text
  - Hochmuth, RM, Needham, D, Ting-Beall, HP, and Zhelev, D. "Deformation and flow of neutrophils in micropipets." Annals of Biomedical Engineering 19, no. 5 (1991): 568--.
  - Hochmuth, RM, Needham, D, and Ting-Beall, HP. "Deformation and flow of neutrophils and monocytes." American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 20 (1991): 417-419.
  - Needham, D, and McIntosh, TJ. "Mechanical and interactive properties of lipid membranes containing surface-bound polymer." Annals of Biomedical Engineering 19, no. 5 (1991): 593--.
  - Needham, D. "Morphology, geometry and mechanical properties of GAP A3 hybridoma cells as a function of the cell cycle." Annals of Biomedical Engineering 19, no. 5 (1991): 592-593.
  - Tran-Son-Tay, R, Needham, D, and Hochmuth, RM. "Recovery of passive neutrophils after large deformation. Liquid drop model." American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 20 (1991): 421-424.
  - Needham, D, and Nunn, RS. "Elastic deformation and failure of lipid bilayer membranes containing cholesterol." Biophys J 58, no. 4 (October 1990): 997-1009. Full Text Link to Item
  - Needham, D, and Hochmuth, RM. "Rapid flow of passive neutrophils into a 4 microns pipet and measurement of cytoplasmic viscosity." J Biomech Eng 112, no. 3 (August 1990): 269-276. Link to Item
  - Armstrong, M, Needham, D, Hatchell, DL, and Nunn, RS. "Effect of pentoxifylline on the flow of polymorphonuclear leukocytes through a model capillary." Angiology 41, no. 4 (April 1990): 253-262. Full Text Link to Item
  - Hochmuth, RM, and Needham, D. "The viscosity of neutrophils and their transit times through small pores." Biorheology 27, no. 6 (1990): 817-828. Link to Item
  - Needham, D, Ting-Beall, HP, and Tran-Son-Tay, R. "Morphology and mechanical properties of gap A3 hybridoma cells as related to cell cycle." American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 16 (1990): 5-10.
  - Needham, D, Armstrong, M, Hatchell, DL, and Nunn, RS. "Rapid deformation of "passive" polymorphonuclear leukocytes: the effects of pentoxifylline." J Cell Physiol 140, no. 3 (September 1989): 549-557. Full Text Link to Item
  - Needham, D, and Hochmuth, RM. "Electro-mechanical permeabilization of lipid vesicles. Role of membrane tension and compressibility." Biophys J 55, no. 5 (May 1989): 1001-1009. Full Text Link to Item
  - Needham, D, McIntosh, TJ, and Evans, E. "Thermomechanical and transition properties of dimyristoylphosphatidylcholine/cholesterol bilayers." Biochemistry 27, no. 13 (June 28, 1988): 4668-4673. Link to Item
  - Evans, E, and Needham, D. "ATTRACTION BETWEEN LIPID BILAYER MEMBRANES IN CONCENTRATED SOLUTIONS OF NONADSORBING POLYMERS: COMPARISON OF MEAN-FIELD THEORY WITH MEASUREMENTS OF ADHESION ENERGY." Macromolecules 21, no. 6 (1988): 1822-1831.
  - Needham, D, and Evans, E. "Structure and mechanical properties of giant lipid (DMPC) vesicle bilayers from 20 °C below to 10 °C above the liquid crystal-crystalline phase transition at 24 °C." Biochemistry 27, no. 21 (1988): 8261-8269.
  - Evans, E, and Needham, D. "Physical properties of surfactant bilayer membranes: thermal transitions, elasticity, rigidity, cohesion and colloidal interactions." The Journal of Physical Chemistry 91, no. 16 (July 1987): 4219-4228. Full Text
  - Evans, E, and Needham, D. "Giant vesicle bilayers composed of mixtures of lipids, cholesterol and polypeptides: Thermomechanical and (mutual) adherence properties." Faraday Discussions of the Chemical Society 81 (1986): 267-280. Full Text
  - Elliott, JR, Haydon, DA, Hendry, BM, and Needham, D. "Inactivation of the sodium current in squid giant axons by hydrocarbons." Biophysical Journal 48, no. 4 (1985): 617-622.
  - Elliott, JR, Needham, D, Dilger, JP, Brandt, O, and Haydon, DA. "A quantitative explanation of the effects of some alcohols on gramicidin single-channel lifetime." BBA - Biomembranes 814, no. 2 (1985): 401-404.
  - Eley, DD, and Needham, D. "HYDRIDIZATION AND CATALYSIS BY LANTHANIDE FILMS." Proceedings of The Royal Society of London, Series A: Mathematical and Physical Sciences 393, no. 1805 (1984): 257-276. (Academic Article)
  - Elliott, JR, Needham, D, Dilger, JP, and Haydon, DA. "The effects of bilayer thickness and tension on gramicidin single-channel lifetime." BBA - Biomembranes 735, no. 1 (1983): 95-103.
  - Needham, D, and Haydon, DA. "Tensions and free energies of formation of 'solventless' lipid bilayers. Measurement of high contact angles." Biophysical Journal 41, no. 3 (1983): 251-257.

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