Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Nottingham (United Kingdom) 1981
  • B.S., Nottingham Trent University (United Kingdom) 1975
• 

  Duke Appointment History

  • Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2003 - 2004
  • Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1999 - 2000
  • Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1997 - 1999
  • Associate Professor with Tenure, Mechanical Engineering and Materials Science, Pratt School of Engineering 1993 - 1998
  • Associate Professor, Biomedical Engineering, Pratt School of Engineering 1992 - 1994
  • Associate Professor, Mechanical Engineering and Materials Science, Pratt School of Engineering 1991 - 1993
  • Assistant Professor, Mechanical Engineering and Materials Science, Pratt School of Engineering 1987 - 1990
• Recognition
• 

  In the News

  • JAN 12, 2017

    Developing New Strategies for Cancer Drug Delivery, in Denmark and at Duke

  • JUL 18, 2014

    David Needham Named Honorary Professor of Pharmacy at the University of Nottingham
• Expertise
• 

  Global Scholarship

  • Teaching

    • Denmark (Country) 
• Research
• 

  Selected Grants

  • TRP and AQP Channels: Modulation of Function, Raft Location by Membrane Lipids awarded by National Institutes of Health 1980 - 2015
  • PLGA Protein Microspheres: Single Particle Engineering awarded by National Institutes of Health 2006 - 2011
  • Faculty Development Workshop: "Course Enhancement Projects" Across the Pratt Curriculum 2009 - 2010
  • Integrating Nanoscale Systems and Design into the Undergraduate Engineering and Science Curricula awarded by  National Science Foundation 2007 - 2010
  • Training in Biomolecular and Tissue Engineering awarded by National Institutes of Health 2003 - 2009
  • Ultra High-speed Imaging System awarded by National Institutes of Health 2003 - 2008
  • Graduate training in Biologically Inspired Materials awarded by  National Science Foundation 2002 - 2007
  • Thermally Sensitive Drug Delivery System for Tumors awarded by National Institutes of Health 2000 - 2006
  • Molecular Exchange with Lipid Membranes awarded by National Institutes of Health 1995 - 2005
  • Engineering Biology at the Nanoscale awarded by National Institutes of Health 2004 - 2005
  • Upgrade of a Shared Instrumentation Resource in the PSOE: The Laser Scanning Confocal Microscope 2002 - 2005
  • Development and Construction of Single Molecule Spectrometers for Research and Student Training awarded by  National Science Foundation 2001 - 2003
  • Molecular Forces in Blood-vasular Cell Interaction awarded by National Institutes of Health 1995 - 2000
  • Molecular Forces in Blood/Vascular Cell Adhesion awarded by National Institutes of Health 1995 - 2000
  • Molecular Exchange and Defect Formation in Membranes awarded by National Institutes of Health 1988 - 1999
  • Particle Size Measurement: Instrumentation Grant 1998 - 1999
  • Molecular Exchange and Defect Formation in Membranes awarded by National Institutes of Health 1988 - 1999
  • Molecular Exchange and Defect Formation in Membranes awarded by National Institutes of Health 1988 - 1999
  • ME265.03 Biological Materials Sci; Curriculum Development & Textbook... 1997 - 1998
  • Viscoelasticity of Blood Cells awarded by National Institutes of Health 1979 - 1995
  • Viscoelasticity of Blood Cells awarded by National Institutes of Health 1979 - 1995
  • Biorheology of Hybridomas and Cell Damage awarded by  National Science Foundation 1991 - 1994
  • Electropermeabilitization/ Fusion of Lipid Vesicles and Cells awarded by National Institutes of Health 1988 - 1993
  • Electropermeabilization/Fusion of Lipid Vesicles & Cells awarded by National Institutes of Health 1988 - 1993
  • Electropermeabilization/Fusion of Lipid Vesicles and Cells awarded by National Institutes of Health 1988 - 1993
  • Electropermeabilization/Fusion of Lipid Vesicles and Cells awarded by National Institutes of Health 1988 - 1993
  • Electropermeabilization/Fusion of Liquid Vesicles and Cells awarded by National Institutes of Health 1988 - 1993
• 

  External Relationships

  • Stabican, The Netherlands
  • University of Nottingham, Nottingham, UK
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Munk, M. B., A. Utoft, F. H. Larsen, D. Needham, and J. Risbo. “Oleogelating properties of ethylcellulose in oil-in-water emulsions: The impact of emulsification methods studied by ¹³C MAS NMR, surface tension and micropipette manipulation studies.” Food Hydrocolloids 89 (April 1, 2019): 700–706. https://doi.org/10.1016/j.foodhyd.2018.11.019.
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    • Pipó-Ollé, Emma, Prasad Walke, Martine K. Notabi, Rime B. El-Houri, Morten Østergaard Andersen, David Needham, and Eva C. Arnspang. “Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells.” Journal of Visualized Experiments : Jove, no. 144 (February 9, 2019). https://doi.org/10.3791/59094.
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    • Needham, David, Koji Kinoshita, and Anders Utoft. “Micro-Surface and -Interfacial Tensions Measured Using the Micropipette Technique: Applications in Ultrasound-Microbubbles, Oil-Recovery, Lung-Surfactants, Nanoprecipitation, and Microfluidics.” Micromachines 10, no. 2 (February 2019). https://doi.org/10.3390/mi10020105.
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    • Hervella, Pablo, Johan Hygum Dam, Helge Thisgaard, Christina Baun, Birgitte Brinkmann Olsen, Poul Flemming Høilund-Carlsen, and David Needham. “Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with 57Co-porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors.” Journal of Controlled Release : Official Journal of the Controlled Release Society 291 (December 2018): 11–25. https://doi.org/10.1016/j.jconrel.2018.09.027.
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    • Utoft, Anders, Koji Kinoshita, Deborah L. Bitterfield, and David Needham. “Manipulating Single Microdroplets of NaCl Solutions: Solvent Dissolution, Microcrystallization, and Crystal Morphology.” Langmuir : The Acs Journal of Surfaces and Colloids 34, no. 12 (March 13, 2018): 3626–41. https://doi.org/10.1021/acs.langmuir.7b03977.
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    • Kinoshita, Koji, Elisa Parra, and David Needham. “Adsorption of ionic surfactants at microscopic air-water interfaces using the micropipette interfacial area-expansion method: Measurement of the diffusion coefficient and renormalization of the mean ionic activity for SDS.” Journal of Colloid and Interface Science 504 (October 2017): 765–79. https://doi.org/10.1016/j.jcis.2017.05.077.
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    • Parra, Elisa, Pablo Hervella, and David Needham. “Real-Time Visualization of the Precipitation and Phase Behavior of Octaethylporphyrin in Lipid Microparticles.” Journal of Pharmaceutical Sciences 106, no. 4 (April 2017): 1025–41. https://doi.org/10.1016/j.xphs.2016.11.019.
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    • Kinoshita, Koji, Elisa Parra, and David Needham. “New sensitive micro-measurements of dynamic surface tension and diffusion coefficients: Validated and tested for the adsorption of 1-Octanol at a microscopic air-water interface and its dissolution into water.” Journal of Colloid and Interface Science 488 (February 2017): 166–79. https://doi.org/10.1016/j.jcis.2016.10.052.
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    • Yi, J., T. A. Knudsen, A. L. Nielsen, L. Duelund, M. Christensen, P. Hervella, D. Needham, and O. G. Mouritsen. “Data for the size of cholesterol-fat micelles as a function of bile salt concentration and the physico-chemical properties of six liquid experimental pine-derived phytosterol formulations in a cholesterol-containing artificial intestine fluid.” Data in Brief 10 (February 1, 2017): 478–81. https://doi.org/10.1016/j.dib.2016.12.027.
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    • Bitterfield, Deborah L., Anders Utoft, and David Needham. “An Activity-Based Dissolution Model for Solute-Containing Microdroplets.” Langmuir : The Acs Journal of Surfaces and Colloids 32, no. 48 (December 2016): 12749–59. https://doi.org/10.1021/acs.langmuir.6b03126.
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    • Kinoshita, K., E. Parra, A. Hussein, A. Utoft, P. Walke, R. de Bruijn, and D. Needham. “From single microparticles to microfluidic emulsification: Fundamental properties (solubility, density, phase separation) from micropipette manipulation of solvent, drug and polymer microspheres.” Processes 4, no. 4 (December 1, 2016). https://doi.org/10.3390/pr4040049.
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    • Needham, David, Amina Arslanagic, Kasper Glud, Pablo Hervella, Leena Karimi, Poul-Flemming Høeilund-Carlsen, Koji Kinoshita, et al. “Bottom up design of nanoparticles for anti-cancer diapeutics: "put the drug in the cancer's food".” Journal of Drug Targeting 24, no. 9 (November 2016): 836–56. https://doi.org/10.1080/1061186x.2016.1238092.
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    • Parra, Elisa, Koji Kinoshita, and David Needham. “Micropipette Technique Study of Natural and Synthetic Lung Surfactants at the Air-Water Interface: Presence of a SP-B Analog Peptide Promotes Membrane Aggregation, Formation of Tightly Stacked Lamellae, and Growth of Myelin Figures.” Langmuir : The Acs Journal of Surfaces and Colloids 32, no. 41 (October 3, 2016): 10570–81. https://doi.org/10.1021/acs.langmuir.6b01420.
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    • Yi, Jinsoo, Tine A. Knudsen, Anne-Louise Nielsen, Lars Duelund, Morten Christensen, Pablo Hervella, David Needham, and Ole G. Mouritsen. “Inhibition of cholesterol transport in an intestine cell model by pine-derived phytosterols.” Chemistry and Physics of Lipids 200 (October 2016): 62–73. https://doi.org/10.1016/j.chemphyslip.2016.06.008.
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    • Hervella, Pablo, Elisa Parra, and David Needham. “Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation.” European Journal of Pharmaceutics and Biopharmaceutics 102 (May 2016): 64–76. https://doi.org/10.1016/j.ejpb.2016.02.015.
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    • Aniket, Julie Ann, David A. Gaul, Deborah L. Bitterfield, Jonathan T. Su, Victoria M. Li, Ishita Singh, Jackson Morton, and David Needham. “Enzyme dehydration using Microglassification™ preserves the protein's structure and function.” Journal of Pharmaceutical Sciences 104, no. 2 (February 2015): 640–51. https://doi.org/10.1002/jps.24279.
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    • Zagar, Timothy M., Zeljko Vujaskovic, Silvia Formenti, Hope Rugo, Franco Muggia, Brigid O’Connor, Robert Myerson, et al. “Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer.” Int J Hyperthermia 30, no. 5 (August 2014): 285–94. https://doi.org/10.3109/02656736.2014.936049.
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    • Bagatolli, Luis A., and David Needham. “Quantitative optical microscopy and micromanipulation studies on the lipid bilayer membranes of giant unilamellar vesicles.” Chemistry and Physics of Lipids 181 (July 2014): 99–120. https://doi.org/10.1016/j.chemphyslip.2014.02.009.
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    • Aniket, Tong H., David A. Gaul, Deborah L. Rickard, and David Needham. “Microglassification™: a novel technique for protein dehydration.” Journal of Pharmaceutical Sciences 103, no. 3 (March 2014): 810–20. https://doi.org/10.1002/jps.23847.
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    • Olsen, B. B., H. Thisgaard, S. Vogel, M. Thomassen, T. A. Kruse, D. Needham, J. Mollenhauer, and P. Flemming Høilund-Carlsen. “Novel radioisotope-based nanomedical approaches.” European Journal of Nanomedicine 5, no. 4 (December 1, 2013): 181–93. https://doi.org/10.1515/ejnm-2013-0025.
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    • Needham, D., and M. W. Dewhirst. “Materials science and engineering of the low temperature sensitive liposome (LTSL): Composition-structure-property relationships that underlie its design and performance.” Rsc Smart Materials 1, no. 1 (November 25, 2013): 33–79.
    • Su, Jonathan T., and David Needham. “Mass transfer in the dissolution of a multicomponent liquid droplet in an immiscible liquid environment.” Langmuir : The Acs Journal of Surfaces and Colloids 29, no. 44 (November 2013): 13339–45. https://doi.org/10.1021/la402533j.
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    • Davis, Ryan M., Benjamin L. Viglianti, Pavel Yarmolenko, Ji-Young Park, Paul Stauffer, David Needham, and Mark W. Dewhirst. “A method to convert MRI images of temperature change into images of absolute temperature in solid tumours.” Int J Hyperthermia 29, no. 6 (September 2013): 569–81. https://doi.org/10.3109/02656736.2013.790091.
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    • Needham, David, Ji-Young Park, Alexander M. Wright, and Jihong Tong. “Materials characterization of the low temperature sensitive liposome (LTSL): effects of the lipid composition (lysolipid and DSPE-PEG2000) on the thermal transition and release of doxorubicin.” Faraday Discussions 161 (January 2013): 515–34. https://doi.org/10.1039/c2fd20111a.
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    • Manzoor, Ashley A., Lars H. Lindner, Chelsea D. Landon, Ji-Young Park, Andrew J. Simnick, Matthew R. Dreher, Shiva Das, et al. “Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.” Cancer Res 72, no. 21 (November 1, 2012): 5566–75. https://doi.org/10.1158/0008-5472.CAN-12-1683.
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    • Gilchrist, Samuel E., Deborah L. Rickard, Kevin Letchford, David Needham, and Helen M. Burt. “Phase separation behavior of fusidic acid and rifampicin in PLGA microspheres.” Molecular Pharmaceutics 9, no. 5 (May 2012): 1489–1501. https://doi.org/10.1021/mp300099f.
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    • Needham, David. “Lipid structures: a brief history of multisomes.” Nature Nanotechnology 6, no. 12 (December 6, 2011): 761–62. https://doi.org/10.1038/nnano.2011.218.
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    • Grant, Gerald A., Christy Wilson, Sara Salami, Paolo Macaroni, Shuqin Li, Ji-Young Park, David Needham, Darell Bigner, and Mark Dewhirst. “PRECLINICAL USE OF MILD HYPERTHERMIA TO ENHANCE DRUG DELIVERY TO BRAIN TUMORS.” Neuro Oncology 13 (November 1, 2011): 111–111.
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    • Landon, Chelsea D., Ji-Young Park, David Needham, and Mark W. Dewhirst. “Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.” Open Nanomed J 3 (January 1, 2011): 38–64. https://doi.org/10.2174/1875933501103010038.
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    • Rickard, Deborah L., P Brent Duncan, and David Needham. “Hydration potential of lysozyme: protein dehydration using a single microparticle technique.” Biophysical Journal 98, no. 6 (March 2010): 1075–84. https://doi.org/10.1016/j.bpj.2009.11.043.
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    • Su, Jonathan T., P Brent Duncan, Amit Momaya, Arimatti Jutila, and David Needham. “The effect of hydrogen bonding on the diffusion of water in n-alkanes and n-alcohols measured with a novel single microdroplet method.” The Journal of Chemical Physics 132, no. 4 (January 2010): 044506. https://doi.org/10.1063/1.3298857.
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    • Yarmolenko, Pavel S., Yulin Zhao, Chelsea Landon, Ivan Spasojevic, Fan Yuan, David Needham, Benjamin L. Viglianti, and Mark W. Dewhirst. “Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours.” Int J Hyperthermia 26, no. 5 (2010): 485–98. https://doi.org/10.3109/02656731003789284.
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    • Yang, Chiming, David Plackett, David Needham, and Helen M. Burt. “PLGA and PHBV microsphere formulations and solid-state characterization: possible implications for local delivery of fusidic acid for the treatment and prevention of orthopaedic infections.” Pharmaceutical Research 26, no. 7 (July 2009): 1644–56. https://doi.org/10.1007/s11095-009-9875-5.
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    • Chen, Qing, Ava Krol, Alex Wright, David Needham, Mark W. Dewhirst, and Fan Yuan. “Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome.” Int J Hyperthermia 24, no. 6 (September 2008): 475–82. https://doi.org/10.1080/02656730701854767.
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    • Tashjian, Jessica A., Mark W. Dewhirst, David Needham, and Benjamin L. Viglianti. “Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.” Int J Hyperthermia 24, no. 1 (February 2008): 79–90. https://doi.org/10.1080/02656730701840147.
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    • Montalvo-Ortiz, Brenda Liz, Brian Sosa, Denisse Velez, David Needham, and Kai Griebenow. “Novel encapsulation of partially dehydrated protein microparticles in PLGA microspheres.” Journal of Biotechnology 131, no. 2 (September 2007): S51–52. https://doi.org/10.1016/j.jbiotec.2007.07.084.
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    • Holden, Matthew A., David Needham, and Hagan Bayley. “Functional bionetworks from nanoliter water droplets.” Journal of the American Chemical Society 129, no. 27 (July 2007): 8650–55. https://doi.org/10.1021/ja072292a.
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    • Simon, Scott I., Tun Nyunt, Kathryn Florine-Casteel, Ken Ritchie, H. P. Ting-Beall, Evan Evans, and David Needham. “Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer.” Annals of Biomedical Engineering 35, no. 4 (April 2007): 595–604. https://doi.org/10.1007/s10439-007-9260-7.
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    • Mills, J. K., and D. Needham. “Temperature-triggered nanotechnology for chemotherapy: Rapid release from lysolipid temperature-sensitive liposomes.” 2006 Nsti Nanotechnology Conference and Trade Show  Nsti Nanotech 2006 Technical Proceedings 2 (December 8, 2006): 5–8.
    • Wei, Chiming, Yuri L. Lyubchenko, Hamid Ghandehari, Justin Hanes, Kathleen J. Stebe, Hai-Quan Mao, Donald T. Haynie, et al. “New technology and clinical applications of nanomedicine: highlights of the second annual meeting of the American Academy of Nanomedicine (Part I).” Nanomedicine : Nanotechnology, Biology, and Medicine 2, no. 4 (December 2006): 253–63. https://doi.org/10.1016/j.nano.2006.11.001.
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    • Hauck, Marlene L., Susan M. LaRue, William P. Petros, Jean M. Poulson, Daohai Yu, Ivan Spasojevic, Amy F. Pruitt, et al. “Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors.” Clin Cancer Res 12, no. 13 (July 1, 2006): 4004–10. https://doi.org/10.1158/1078-0432.CCR-06-0226.
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    • Ponce, Ana M., Zeljko Vujaskovic, Fan Yuan, David Needham, and Mark W. Dewhirst. “Hyperthermia mediated liposomal drug delivery.” Int J Hyperthermia 22, no. 3 (May 2006): 205–13. https://doi.org/10.1080/02656730600582956.
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    • Duncan, P Brent, and David Needham. “Microdroplet dissolution into a second-phase solvent using a micropipet technique: test of the Epstein-Plesset model for an aniline-water system.” Langmuir : The Acs Journal of Surfaces and Colloids 22, no. 9 (April 2006): 4190–97. https://doi.org/10.1021/la053314e.
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    • Ponce, Ana M., Alex Wright, Mark W. Dewhirst, and David Needham. “Targeted bioavailability of drugs by triggered release from liposomes.” Future Lipidology 1, no. 1 (February 2006): 25–34. https://doi.org/10.2217/17460875.1.1.25.
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    • Eichenbaum, K. D., A. A. Thomas, G. M. Eichenbaum, B. R. Gibney, D. Needham, and P. F. Kiser. “Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks.” Macromolecules 38, no. 26 (December 27, 2005): 10757–62. https://doi.org/10.1021/ma0518306.
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    • Merkin, J. H., D. J. Needham, and B. D. Sleeman. “A mathematical model for the spread of morphogens with density dependent chemosensitivity.” Nonlinearity 18, no. 6 (November 1, 2005): 2745–73. https://doi.org/10.1088/0951-7715/18/6/018.
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    • Mills, Jeffrey K., and David Needham. “Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition.” Biochimica Et Biophysica Acta 1716, no. 2 (October 2005): 77–96. https://doi.org/10.1016/j.bbamem.2005.08.007.
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    • Dhawan, M., D. Price, D. Trump, P. Kanter, N. Shore, D. Needham, and M. Dewhirst. “New drug delivery approach for the treatment of prostate cancer (preclinical results and phase I study results).” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 22, no. 14_suppl (July 2004): 4661.
    • Duncan, P Brent, and David Needham. “Test of the Epstein-Plesset model for gas microparticle dissolution in aqueous media: effect of surface tension and gas undersaturation in solution.” Langmuir : The Acs Journal of Surfaces and Colloids 20, no. 7 (March 2004): 2567–78. https://doi.org/10.1021/la034930i.
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    • Mills, Jeffrey K., and David Needham. “The materials engineering of temperature-sensitive liposomes.” Methods in Enzymology 387 (January 2004): 82–113. https://doi.org/10.1016/s0076-6879(04)87006-x.
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    • Needham, D. “Lipid Membranes: Biological Inspiration for Micro and Nano Encapsulation Technologies, Especially Drug Delivery.” Materials Research Society Symposium  Proceedings 774 (December 8, 2003): 173–202.
    • Kim, D. H., M. J. Costello, P. B. Duncan, and D. Needham. “Mechanical properties and microstructure of polycrystalline phospholipid monolayer shells: Novel solid microparticles.” Langmuir 19, no. 20 (September 30, 2003): 8455–66. https://doi.org/10.1021/la034779c.
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    • Ickenstein, Ludger M., Maria C. Arfvidsson, David Needham, Lawrence D. Mayer, and Katarina Edwards. “Disc formation in cholesterol-free liposomes during phase transition.” Biochimica Et Biophysica Acta 1614, no. 2 (August 2003): 135–38. https://doi.org/10.1016/s0005-2736(03)00196-2.
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    • Zhelev, D. V., and D. Needham. “Interactions of pH-sensitive peptides and polymers with lipid bilayers: Binding and membrane stability.” Current Topics in Membranes 52 (December 1, 2002): 437–64.
    • Hasik, Matthew J., Dennis H. Kim, Laurens E. Howle, David Needham, and Donald P. Prush. “Evaluation of synthetic phospholipid ultrasound contrast agents.” Ultrasonics 40, no. 9 (November 2002): 973–82. https://doi.org/10.1016/s0041-624x(02)00384-0.
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    • Needham, D. S., I. C. K. Wong, P. D. Campion, and P. D. Hull and East Riding Pharmacy Developmnet Group. “Evaluation of the effectiveness of UK community pharmacists' interventions in community palliative care.” Palliative Medicine 16, no. 3 (May 2002): 219–25. https://doi.org/10.1191/0269216302pm533oa.
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    • Needham, D., and M. W. Dewhirst. “The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors.” Adv Drug Deliv Rev 53, no. 3 (December 31, 2001): 285–305. https://doi.org/10.1016/s0169-409x(01)00233-2.
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    • Lee, S., D. H. Kim, and D. Needham. “Equilibrium and dynamic interfacial tension measurements at microscopic interfaces using a micropipet technique - 2. Dynamics of phospholipid monolayer formation and equilibrium tensions at the water-air interface.” Langmuir 17, no. 18 (September 4, 2001): 5544–50. https://doi.org/10.1021/la0103261.
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    • Lee, S., D. H. Kim, and D. Needham. “Equilibrium and Dynamic Interfacial Tension Measurements at Microscopic Interfaces Using a Micropipet Technique. 1. A New Method for Determination of Interfacial Tension.” Langmuir 17, no. 18 (September 4, 2001): 5537–43. https://doi.org/10.1021/la0103259.
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    • Eichenbaum, Gary M., Patrick F. Kiser, Andrey V. Dobrynin, Sidney A. Simon, and David Needham. “Investigation of the Swelling Response and Loading of Ionic Microgels with Drugs and Proteins:  The Dependence on Cross-Link Density. Volume 32, Number 15, July 27, 1999, 4867−4878.” Macromolecules 34, no. 18 (August 2001): 6526–6526. https://doi.org/10.1021/ma0124892.
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    • Zhelev, D. V., N. Stoicheva, P. Scherrer, and D. Needham. “Interaction of synthetic HA2 influenza fusion peptide analog with model membranes.” Biophysical Journal 81, no. 1 (July 2001): 285–304. https://doi.org/10.1016/s0006-3495(01)75699-8.
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    • Eichenbaum, GM, Kiser, PF, Simon, SA, and Needham, D. "Erratum: pH and ion-triggered volume responses of anionic hydrogel microspheres (Macromolecules (July 28, 1998) 31:15 (5084-5093))." Macromolecules 34, no. 20 (2001): 7230-. (Academic Article)  Full Text  Link to Item
    • Kong, G., G. Anyarambhatla, W. P. Petros, R. D. Braun, O. M. Colvin, D. Needham, and M. W. Dewhirst. “Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.” Cancer Res 60, no. 24 (December 15, 2000): 6950–57.
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    • Kim, D. H., A. L. Klibanov, and D. Needham. “The influence of tiered layers of surface-grafted poly(ethylene glycol) on receptor-ligand-mediated adhesion between phospholipid monolayer-stabilized microbubbles and coated glass beads.” Langmuir 16, no. 6 (December 1, 2000): 2808–17.
    • Needham, D., and D. H. Kim. “PEG-covered lipid surfaces: bilayers and monolayers.” Colloids and Surfaces. B, Biointerfaces 18, no. 3–4 (October 2000): 183–95. https://doi.org/10.1016/s0927-7765(99)00147-2.
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    • Matteucci, M. L., G. Anyarambhatla, G. Rosner, C. Azuma, P. E. Fisher, M. W. Dewhirst, D. Needham, and D. E. Thrall. “Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas.” Clin Cancer Res 6, no. 9 (September 2000): 3748–55.
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    • Howell, M. L., E. Alsabbagh, J. F. Ma, U. A. Ochsner, M. G. Klotz, T. J. Beveridge, K. M. Blumenthal, et al. “AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide.” Journal of Bacteriology 182, no. 16 (August 2000): 4545–56. https://doi.org/10.1128/jb.182.16.4545-4556.2000.
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    • Kiser, P. F., G. Wilson, and D. Needham. “Lipid-coated microgels for the triggered release of doxorubicin.” Journal of Controlled Release : Official Journal of the Controlled Release Society 68, no. 1 (July 2000): 9–22. https://doi.org/10.1016/s0168-3659(00)00236-4.
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    • Olbrich, K., W. Rawicz, D. Needham, and E. Evans. “Water permeability and mechanical strength of polyunsaturated lipid bilayers.” Biophysical Journal 79, no. 1 (July 2000): 321–27. https://doi.org/10.1016/s0006-3495(00)76294-1.
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    • Rawicz, W., K. C. Olbrich, T. McIntosh, D. Needham, and E. Evans. “Effect of chain length and unsaturation on elasticity of lipid bilayers.” Biophys J 79, no. 1 (July 2000): 328–39. https://doi.org/10.1016/S0006-3495(00)76295-3.
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    • Eichenbaum, G. M., P. F. Kiser, D. Shah, W. P. Meuer, D. Needham, and S. A. Simon. “Alkali earth metal binding properties of ionic microgels.” Macromolecules 33, no. 11 (May 30, 2000): 4087–93. https://doi.org/10.1021/ma9917139.
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    • Kiser, P. F., A. A. Thomas, G. M. Eichenbaum, D. Needham, and I. Kim. “Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 41, no. 1 (March 1, 2000): 712–13.
    • Needham, D., G. Anyarambhatla, G. Kong, and M. W. Dewhirst. “A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.” Cancer Res 60, no. 5 (March 1, 2000): 1197–1201.
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    • Needham, D., S. Demurjian, and T. Peters. “An IDL to Ada95 mapping to support propagation modeling.” Ada Lett. (Usa) 20, no. 1 (2000): 58–66.
    • Eichenbaum, G. M., P. F. Kiser, D. Shah, S. A. Simon, and D. Needham. “Investigation of the swelling response and drug loading of ionic microgels: The dependence on functional group composition.” Macromolecules 32, no. 26 (December 28, 1999): 8996–9006. https://doi.org/10.1021/ma9908393.
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    • Mills, J. K., and D. Needham. “Targeted drug delivery.” Expert Opinion on Therapeutic Patents 9, no. 11 (November 17, 1999): 1499–1513. https://doi.org/10.1517/13543776.9.11.1499.
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    • Needham, D. “Materials engineering of lipid bilayers for drug carrier performance.” Mrs Bulletin 24, no. 10 (October 1, 1999): 32–40.
    • Eichenbaum, G. M., P. F. Kiser, A. V. Dobrynin, S. A. Simon, and D. Needham. “Investigation of the swelling response and loading of ionic microgels with drugs and proteins: the dependence on cross-link density.” Macromolecules 32, no. 15 (July 27, 1999): 4867–78. https://doi.org/10.1021/ma981945s.
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    • Anyarambhatla, G. R., and D. Needham. “Enhancement of the phase transition permeability of DPPC liposomes by incorporation of MPPC: A new temperature-sensitive liposome for use with mild hyperthermia.” Journal of Liposome Research 9, no. 4 (January 1, 1999): 491–506. https://doi.org/10.3109/08982109909035549.
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    • Klibanov, A. L., H. Gu, J. K. Wojdyla, J. Wible, D. H. Kim, D. Needham, F. S. Villanueva, and G. H. Brandenburger. “Attachment of ligands to gas-filled microbubbles via PEG spacer and lipid residues anchored at the interface.” Proceedings of the Controlled Release Society, no. 26 (January 1, 1999): 124–25.
    • Mills, J. K., G. Eichenbaum, and D. Needham. “Effect of bilayer cholesterol and surface grafted poly(ethylene glycol) on pH-induced release of contents from liposomes by poly(2-ethylacrylic acid).” Journal of Liposome Research 9, no. 2 (January 1, 1999): 275–90. https://doi.org/10.3109/08982109909024790.
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    • Needham, D. J., and S. McAllister. “Centre families in two–dimensional complex holomorphic dynamical systems.” Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences 454, no. 1976 (August 8, 1998): 2267–78. https://doi.org/10.1098/rspa.1998.0258.
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    • Eichenbaum, G. M., P. F. Kiser, S. A. Simon, and D. Needham. “pH and Ion-Triggered Volume Response of Anionic Hydrogel Microspheres.” Macromolecules 31, no. 15 (July 28, 1998): 5084–93. https://doi.org/10.1021/ma970897t.
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    • Kiser, P. F., G. Wilson, and D. Needham. “A synthetic mimic of the secretory granule for drug delivery.” Nature 394, no. 6692 (July 1998): 459–62. https://doi.org/10.1038/28822.
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    • Needham, D., J. Mills, and G. Eichenbaum. “Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol).” Faraday Discussions, no. 111 (January 1998): 103–10. https://doi.org/10.1039/a808717b.
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    • Needham, D., T. J. McIntosh, S. A. Simon, and D. Zhelev. “Adsorption, molecular exchange and defect formation in membranes.” Current Opinion in Colloid and Interface Science 3, no. 5 (January 1, 1998): 511–17. https://doi.org/10.1016/S1359-0294(98)80026-5.
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    • Needham, D., and R. S. Sarpal. “Binding of paclitaxel to lipid interfaces: Correlations with interface compliance.” Journal of Liposome Research 8, no. 2 (January 1, 1998): 147–63. https://doi.org/10.3109/08982109809035523.
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    • Needham, D., N. Stoicheva, and D. V. Zhelev. “Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid.” Biophysical Journal 73, no. 5 (November 1997): 2615–29. https://doi.org/10.1016/s0006-3495(97)78291-2.
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    • Needham, D., and D. Noppl-Simson. “Barrier properties of surface-grafted PEG for macromolecule-surface interactions.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 38, no. 1 (April 1, 1997): 549–50.
    • Kiser, P. F., D. Needham, and G. Wilson. “Mimicking the smart polymer matrix of the secretory granule: a new concept in controlled release drug delivery.” Polymeric Materials Science and Engineering, Proceedings of the Acs Division of Polymeric Materials Science and Engineering 76 (January 1, 1997).
    • Zhelev, D. V., and D. Needham. “Pore formation and pore dynamics in bilayer membranes.” American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed 34 (December 1, 1996): 47–49.
    • Evans, E., H. Bowman, A. Leung, D. Needham, and D. Tirrell. “Biomembrane templates for nanoscale conduits and networks.” Science (New York, N.Y.) 273, no. 5277 (August 1996): 933–35. https://doi.org/10.1126/science.273.5277.933.
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    • Noppl-Simson, D. A., and D. Needham. “Avidin-biotin interactions at vesicle surfaces: adsorption and binding, cross-bridge formation, and lateral interactions.” Biophysical Journal 70, no. 3 (March 1996): 1391–1401. https://doi.org/10.1016/s0006-3495(96)79697-2.
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    • Bowman, H., E. Evans, D. Needham, and D. A. Tirrell. “Nanometer-scale polymeric patterns and networks.” Polymeric Materials Science and Engineering, Proceedings of the Acs Division of Polymeric Materials Science and Engineering 74 (1996).
    • Needham, D. J., A. C. King, and J. H. Merkin. “Reaction-diffusion model for autocatalytic polymerization: II. The initial value problem.” Ima Journal of Applied Mathematics (Institute of Mathematics & Its Applications) 56, no. 1 (1996): 65–86.
    • McIntosh, T. J., S. Advani, R. E. Burton, D. V. Zhelev, D. Needham, and S. A. Simon. “Experimental tests for protrusion and undulation pressures in phospholipid bilayers.” Biochemistry 34, no. 27 (July 11, 1995): 8520–32. https://doi.org/10.1021/bi00027a002.
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    • Hristova, K., and D. Needham. “Phase Behavior of a Lipid/Polymer-Lipid Mixture in Aqueous Medium.” Macromolecules 28, no. 4 (July 1, 1995): 991–1002. https://doi.org/10.1021/ma00108a029.
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    • Kenworthy, A. K., K. Hristova, D. Needham, and T. J. McIntosh. “Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol).” Biophys J 68, no. 5 (May 1995): 1921–36. https://doi.org/10.1016/S0006-3495(95)80369-3.
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    • Needham, D., and D. V. Zhelev. “Lysolipid exchange with lipid vesicle membranes.” Annals of Biomedical Engineering 23, no. 3 (May 1995): 287–98. https://doi.org/10.1007/bf02584429.
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    • Hristova, K., and D. Needham. “Influence of bilayer fluctuations on the steric interactions between polymer-grafted bilayers.” Liquid Crystals 18, no. 3 (January 1, 1995): 423–30. https://doi.org/10.1080/02678299508036641.
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    • Lasic, D. D., and D. Needham. “The “Stealth” Liposome: A Prototypical Biomaterial.” Chemical Reviews 95, no. 8 (January 1, 1995): 2601–28. https://doi.org/10.1021/cr00040a001.
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    • Needham, D. J. “Centre theorem for two-dimensional complex holomorphic systems and its generalization.” Proceedings of the Royal Society of London, Series A: Mathematical and Physical Sciences 450, no. 1939 (1995): 225–32.
    • Needham, D., and D. Noppl. “Adsorption and adhesion at vesicle surfaces: the influence of grafted polymer on avidin-biotin binding and tests of receptor-mediated adhesion.” American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed 29 (January 1, 1995): 331–32.
    • Needham, D., and D. V. Zhelev. “Lysolipid exchange with vesicle membranes and the formation and evolution of porous defects.” Annals of Biomedical Engineering 23, no. 3 (1995).
    • Zhelev, D. V., D. Needham, and R. M. Hochmuth. “A novel micropipet method for measuring the bending modulus of vesicle membranes.” Biophysical Journal 67, no. 2 (August 1994): 720–27. https://doi.org/10.1016/s0006-3495(94)80530-2.
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    • Zhelev, D. V., D. Needham, and R. M. Hochmuth. “Role of the membrane cortex in neutrophil deformation in small pipets.” Biophysical Journal 67, no. 2 (August 1994): 696–705. https://doi.org/10.1016/s0006-3495(94)80529-6.
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    • Simon, S. A., E. A. Disalvo, K. Gawrisch, V. Borovyagin, E. Toone, S. S. Schiffman, D. Needham, and T. J. McIntosh. “Increased adhesion between neutral lipid bilayers: interbilayer bridges formed by tannic acid.” Biophys J 66, no. 6 (June 1994): 1943–58. https://doi.org/10.1016/S0006-3495(94)80988-9.
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    • Hristova, K., and D. Needham. “The Influence of polymer-grafted lipids on the physical properties of lipid bilayers: A theoretical study.” Journal of Colloid and Interface Science 168, no. 2 (January 1, 1994): 302–14. https://doi.org/10.1006/jcis.1994.1424.
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    • Wu, N. Z., B. Klitzman, G. Rosner, D. Needham, and M. W. Dewhirst. “Measurement of material extravasation in microvascular networks using fluorescence video-microscopy.” Microvasc Res 46, no. 2 (September 1993): 231–53. https://doi.org/10.1006/mvre.1993.1049.
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    • Wu, N. Z., D. Da, T. L. Rudoll, D. Needham, A. R. Whorton, and M. W. Dewhirst. “Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue.” Cancer Res 53, no. 16 (August 15, 1993): 3765–70.
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    • Hochmuth, R. M., H. P. Ting-Beall, B. B. Beaty, D. Needham, and R. Tran-Son-Tay. “Viscosity of passive human neutrophils undergoing small deformations.” Biophysical Journal 64, no. 5 (May 1993): 1596–1601. https://doi.org/10.1016/s0006-3495(93)81530-3.
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    • Ting-Beall, H. P., D. Needham, and R. M. Hochmuth. “Volume and osmotic properties of human neutrophils.” Blood 81, no. 10 (May 1993): 2774–80.
    • Kavanagh, B. D., B. E. Coffey, D. Needham, R. M. Hochmuth, and M. W. Dewhirst. “The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment.” Br J Cancer 67, no. 4 (April 1993): 734–41. https://doi.org/10.1038/bjc.1993.134.
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    • Zhelev, D. V., and D. Needham. “Tension-stabilized pores in giant vesicles: determination of pore size and pore line tension.” Biochimica Et Biophysica Acta 1147, no. 1 (April 1993): 89–104. https://doi.org/10.1016/0005-2736(93)90319-u.
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    • NEEDHAM, D., D. DA, T. L. RUDOLL, H. P. TINGBEALL, N. WU, and M. W. DEWHIRST. “PERMEABILITY OF IMPLANTED-TUMOR VASCULATURE TO POLYMER-GRAFTED LIPOSOMES.” Biophysical Journal 64, no. 2 (February 1, 1993): A338–A338.
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    • Needham, D. “Measurement of interbilayer adhesion energies.” Methods in Enzymology 220 (January 1993): 111–29. https://doi.org/10.1016/0076-6879(93)20078-h.
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    • Sonkin, P. L., S. F. Freedman, D. Needham, K. M. Rao, and D. L. Hatchell. “Pentoxifylline modulates deformability, F-actin content, and superoxide anion production of polymorphonuclear leukocytes from diabetic cats.” Exp Eye Res 55, no. 6 (December 1992): 831–38. https://doi.org/10.1016/0014-4835(92)90009-h.
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    • Needham, D., T. J. McIntosh, and D. D. Lasic. “Repulsive interactions and mechanical stability of polymer-grafted lipid membranes.” Biochim Biophys Acta 1108, no. 1 (July 8, 1992): 40–48. https://doi.org/10.1016/0005-2736(92)90112-y.
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    • Needham, D., and R. M. Hochmuth. “A sensitive measure of surface stress in the resting neutrophil.” Biophysical Journal 61, no. 6 (June 1992): 1664–70. https://doi.org/10.1016/s0006-3495(92)81970-7.
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    • Simon, S. A., T. J. McIntosh, A. D. Magid, and D. Needham. “Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface.” Biophys J 61, no. 3 (March 1992): 786–99. https://doi.org/10.1016/S0006-3495(92)81883-0.
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    • McIntosh, T. J., S. A. Simon, D. Needham, and C. H. Huang. “Structure and cohesive properties of sphingomyelin/cholesterol bilayers.” Biochemistry 31, no. 7 (February 25, 1992): 2012–20. https://doi.org/10.1021/bi00122a017.
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    • McIntosh, T. J., S. A. Simon, D. Needham, and C. H. Huang. “Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers.” Biochemistry 31, no. 7 (February 25, 1992): 2020–24. https://doi.org/10.1021/bi00122a018.
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    • Needham, D. J. “Formal theory concerning the generation and propagation of travelling wave-fronts in reaction-diffusion equations.” Quarterly Journal of Mechanics and Applied Mathematics 45, no. pt 3 (1992): 469–98.
    • Needham, D., K. Hristova, T. J. Mcintosh, M. Dewhirst, N. Wu, and D. D. Lasic. “Polymer-grafted liposomes: Physical basis for the "stealth" property.” Journal of Liposome Research 2, no. 3 (January 1, 1992): 411–30. https://doi.org/10.3109/08982109209010218.
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    • Hochmuth, R. M., D. Needham, H. P. Ting-Beall, and D. Zhelev. “Deformation and flow of neutrophils in micropipets.” Annals of Biomedical Engineering 19, no. 5 (December 1, 1991).
    • Hochmuth, R. M., D. Needham, and H. P. Ting-Beall. “Deformation and flow of neutrophils and monocytes.” American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed 20 (December 1, 1991): 417–19.
    • Needham, D. “Morphology, geometry and mechanical properties of GAP A3 hybridoma cells as a function of the cell cycle.” Annals of Biomedical Engineering 19, no. 5 (December 1, 1991): 592–93.
    • Needham, D., and T. J. McIntosh. “Mechanical and interactive properties of lipid membranes containing surface-bound polymer.” Annals of Biomedical Engineering 19, no. 5 (December 1, 1991).
    • Tran-Son-Tay, R., D. Needham, and R. M. Hochmuth. “Recovery of passive neutrophils after large deformation. Liquid drop model.” American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed 20 (December 1, 1991): 421–24.
    • Needham, D., H. P. Ting-Beall, and R. Tran-Son-Tay. “A physical characterization of GAP A3 hybridoma cells: morphology, geometry, and mechanical properties.” Biotechnology and Bioengineering 38, no. 8 (October 1991): 838–52. https://doi.org/10.1002/bit.260380806.
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    • Tran-Son-Tay, R., D. Needham, A. Yeung, and R. M. Hochmuth. “Time-dependent recovery of passive neutrophils after large deformation.” Biophysical Journal 60, no. 4 (October 1991): 856–66. https://doi.org/10.1016/s0006-3495(91)82119-1.
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    • Needham, D. “Possible role of cell cycle-dependent morphology, geometry, and mechanical properties in tumor cell metastasis.” Cell Biophysics 18, no. 2 (April 1991): 99–121. https://doi.org/10.1007/bf02989809.
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    • Needham, D., H. P. Ting-Beall, and R. Tran-Son-Tay. “Morphology and mechanical properties of gap A3 hybridoma cells as related to cell cycle.” American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed 16 (December 1, 1990): 5–10.
    • Needham, D., and R. S. Nunn. “Elastic deformation and failure of lipid bilayer membranes containing cholesterol.” Biophysical Journal 58, no. 4 (October 1990): 997–1009. https://doi.org/10.1016/s0006-3495(90)82444-9.
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    • Needham, D., and R. M. Hochmuth. “Rapid flow of passive neutrophils into a 4 microns pipet and measurement of cytoplasmic viscosity.” Journal of Biomechanical Engineering 112, no. 3 (August 1990): 269–76. https://doi.org/10.1115/1.2891184.
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    • Armstrong, M., D. Needham, D. L. Hatchell, and R. S. Nunn. “Effect of pentoxifylline on the flow of polymorphonuclear leukocytes through a model capillary.” Angiology 41, no. 4 (April 1990): 253–62. https://doi.org/10.1177/000331979004100401.
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    • Hochmuth, R. M., and D. Needham. “The viscosity of neutrophils and their transit times through small pores.” Biorheology 27, no. 6 (January 1990): 817–28. https://doi.org/10.3233/bir-1990-27603.
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    • Needham, D., M. Armstrong, D. L. Hatchell, and R. S. Nunn. “Rapid deformation of "passive" polymorphonuclear leukocytes: the effects of pentoxifylline.” J Cell Physiol 140, no. 3 (September 1989): 549–57. https://doi.org/10.1002/jcp.1041400321.
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    • Needham, D., and R. M. Hochmuth. “Electro-mechanical permeabilization of lipid vesicles. Role of membrane tension and compressibility.” Biophysical Journal 55, no. 5 (May 1989): 1001–9. https://doi.org/10.1016/s0006-3495(89)82898-x.
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    • Needham, D., and E. Evans. “Structure and mechanical properties of giant lipid (DMPC) vesicle bilayers from 20 degrees C below to 10 degrees C above the liquid crystal-crystalline phase transition at 24 degrees C.” Biochemistry 27, no. 21 (October 1988): 8261–69. https://doi.org/10.1021/bi00421a041.
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    • Needham, D., T. J. McIntosh, and E. Evans. “Thermomechanical and transition properties of dimyristoylphosphatidylcholine/cholesterol bilayers.” Biochemistry 27, no. 13 (June 28, 1988): 4668–73. https://doi.org/10.1021/bi00413a013.
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    • Evans, E., and D. Needham. “Attraction between Lipid Bilayer Membranes in Concentrated Solutions of Nonadsorbing Polymers: Comparison of Mean-Field Theory with Measurements of Adhesion Energy.” Macromolecules 21, no. 6 (January 1, 1988): 1822–31. https://doi.org/10.1021/ma00184a049.
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    • Evans, E., and D. Needham. “Physical properties of surfactant bilayer membranes: Thermal transitions, elasticity, rigidity, cohesion, and colloidal interactions.” Journal of Physical Chemistry 91, no. 16 (January 1, 1987): 4219–28. https://doi.org/10.1021/j100300a003.
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    • Evans, E., and D. Needham. “Giant vesicle bilayers composed of mixtures of lipids, cholesterol and polypeptides. Thermomechanical and (mutual) adherence properties.” Faraday Discussions of the Chemical Society, no. 81 (January 1986): 267–80. https://doi.org/10.1039/dc9868100267.
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    • Elliott, J. R., D. A. Haydon, B. M. Hendry, and D. Needham. “Inactivation of the sodium current in squid giant axons by hydrocarbons.” Biophysical Journal 48, no. 4 (October 1985): 617–22. https://doi.org/10.1016/s0006-3495(85)83817-0.
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    • Elliott, J. R., D. Needham, J. P. Dilger, O. Brandt, and D. A. Haydon. “A quantitative explanation of the effects of some alcohols on gramicidin single-channel lifetime.” Biochimica Et Biophysica Acta 814, no. 2 (April 1985): 401–4. https://doi.org/10.1016/0005-2736(85)90462-6.
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    • Eley, D. D., and D. Needham. “HYDRIDIZATION AND CATALYSIS BY LANTHANIDE FILMS.” Proceedings of the Royal Society of London, Series A: Mathematical and Physical Sciences 393, no. 1805 (1984): 257–76.
    • Elliott, J. R., D. Needham, J. P. Dilger, and D. A. Haydon. “The effects of bilayer thickness and tension on gramicidin single-channel lifetime.” Biochimica Et Biophysica Acta 735, no. 1 (October 1983): 95–103. https://doi.org/10.1016/0005-2736(83)90264-x.
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    • Needham, D., and D. A. Haydon. “Tensions and free energies of formation of "solventless" lipid bilayers. Measurement of high contact angles.” Biophysical Journal 41, no. 3 (March 1983): 251–57. https://doi.org/10.1016/s0006-3495(83)84435-x.
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    • Needham, D. J. “The effects of a complexation reaction on travelling wave-fronts in a quadratic autocatalytic system.” The Quarterly Journal of Mechanics and Applied Mathematics 58, no. 4 (n.d.): 577–99. https://doi.org/10.1093/qjmam/hbi022.
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  • Book Sections

    • Anibal Disalvo, E., and S. Simon. “Preface.” In Permeability and Stability of Lipid Bilayers, 2017. https://doi.org/10.1201/9780203743805.
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    • Needham, D. “Bringing research to clinical application lessons from thermodox(r): A thermal-sensitive liposome for treatment of cancer.” In Drug Delivery: Fundamentals and Applications: Second Edition, 523–85, 2016. https://doi.org/10.1201/9781315382579.
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    • Needham, D. “Reverse engineering of the low temperature-sensitive liposome (LTSL) for treating cancer.” In Biomaterials for Cancer Therapeutics: Diagnosis, Prevention and Therapy, 270–348, 2013. https://doi.org/10.1533/9780857096760.3.270.
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    • Needham, D., and D. Zhelev. “Use of Micropipet Manipulation Techniques to Measure the Properties of Giant Lipid Vesicles.” In Giant Vesicles: Perspectives in Supramolecular Chemistry, 6:102–47, 2007. https://doi.org/10.1002/9780470511534.ch9.
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  • Conference Papers

    • Brousell, Steven C., Thomas A. Longo, Joseph J. Fantony, Wiguins Etienne, David Needham, Mark W. Dewhirst, Paolo F. Maccarini, Ivan Spasojevic, and Brant A. Inman. “MP65-08 HEAT-TARGETED DRUG DELIVERY USING THE COMBAT BRS DEVICE FOR TREATING BLADDER CANCER.” In Journal of Urology, Vol. 197. Ovid Technologies (Wolters Kluwer Health), 2017. https://doi.org/10.1016/j.juro.2017.02.2002.
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    • Kinoshita, Koji, Kasper Glud, and David Needham. “New Measurements of Lung Surfactant Interfacial Tension with Micropipette Manipulation Technique.” In Biophysical Journal, 106:518a-518a. Elsevier BV, 2014. https://doi.org/10.1016/j.bpj.2013.11.2891.
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    • Rickard, Deborah L., P Brent Duncan, and David Needham. “Hydration Potential of Lysozyme: Protein Dehydration Using a Single Microparticle Technique.” In Biophysical Journal, 98:45a-45a. Elsevier BV, 2010. https://doi.org/10.1016/j.bpj.2009.12.259.
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    • Needham, D., A. Wright, J. Tong, M. W. Dewhirst, A. Ponce, and F. Yuan. “Mapping engineering onto biology at the nanoscale: nature's encapsulation technologies as bioinspiration for nano-scale anti-tumor drug delivery.” In Nanomedicine: Nanotechnology, Biology and Medicine, 2:292–93. Elsevier BV, 2006. https://doi.org/10.1016/j.nano.2006.10.077.
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    • Lee, S. H., D. Needham, P. B. Duncan, and A. Jutila. “Water micro-droplets in simple hydrocarbons: Dissolution, free energies of adhesion and bilayer permeability.” In Abstracts of Papers of the American Chemical Society, 229:U667–U667. AMER CHEMICAL SOC, 2005.
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    • Dhawan, M., D. Price, D. Trump, P. Kanter, N. Shore, D. Needham, and M. Dewhirst. “New drug delivery approach for the treatment of prostate cancer (preclinical results and phase I study results).” In Journal of Clinical Oncology, 22:421S-421S. AMER SOC CLINICAL ONCOLOGY, 2004.
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    • Needham, D. “From properties to performance: The mechanochemistry of lipid vesicles with implications for drug carrier design.” In Journal of Liposome Research, 13:103–4. MARCEL DEKKER INC, 2003.
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    • Needham, D., and S. Lee. “From soft materials to rational design of active carrier delivery systems.” In Abstracts of Papers of the American Chemical Society, 224:U446–47. AMER CHEMICAL SOC, 2002.
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    • Zhelev, D. V., N. G. Stoicheva, and D. Needham. “Interaction of the amphipatic peptide AcE4K with SOPC membranes.” In Biophysical Journal, 80:531A-531A. BIOPHYSICAL SOCIETY, 2001.
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    • Kiser, P. F., A. A. Thomas, G. M. Eichenbaum, D. Needham, and I. Kim. “Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable cross-linkers composed of oligo-lactate and oligo-glycolate esters.” In Abstracts of Papers of the American Chemical Society, 219:U410–U410. AMER CHEMICAL SOC, 2000.
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    • Dewhirst, M. W., G. Kong, and D. Needham. “Use of hyperthermia to augment liposomal drug delivery to tumours.” In Radiation Research, Vol 2, Congress Proceedings, edited by M. Moriaty, M. Edington, C. Mothersill, J. F. Ward, C. Seymour, and R. J. M. Fry, 853–56. ALLEN PRESS INC, 2000.
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    • Stoicheva, N. G., D. V. Zhelev, and D. Needham. “Exchange of monooleoylphophatidylcholine with membranes containing cholesterol.” In Biophysical Journal, 78:184A-184A. BIOPHYSICAL SOCIETY, 2000.
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    • Needham, D., and I. Wong. “An expert panel review to evaluate the effectiveness of community pharmacist's interventions in the palliative care setting.” In Pharmaceutical Journal, Vol. 263, 1999.
    • Florine-Casteel, K., K. Ritchie, H. P. Ting-Beall, E. Evans, and D. Needham. “Nanomechanics of the neutrophil interface: Cell surface compliance.” In Biophysical Journal, 76:A96–A96. BIOPHYSICAL SOCIETY, 1999.
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    • Eichenbaum, G. M., P. F. Kiser, S. A. Simon, and D. Needham. “Environmental response of anionic microgels.” In Abstracts of Papers of the American Chemical Society, 216:U871–U871. AMER CHEMICAL SOC, 1998.
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    • Eichenbaum, G. M., P. F. Kiser, S. A. Simon, and D. Needham. “pH and NaCl triggered response of anionic microgels.” In Abstracts of Papers of the American Chemical Society, 216:U909–U909. AMER CHEMICAL SOC, 1998.
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    • Florine-Casteel, K., K. Ritchie, E. Evans, and D. Needham. “Nanomechanics of the neutrophil interface: Cell surface compliance.” In Abstracts of Papers of the American Chemical Society, 216:U674–75. AMER CHEMICAL SOC, 1998.
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    • Kim, D. H., A. L. Klibanov, E. A. Evans, and D. Needham. “Viscoelastic properties of phospholipid monolayer shells on air microbubbles.” In Biophysical Journal, 74:A313–A313. BIOPHYSICAL SOCIETY, 1998.
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    • Needham, D., N. Stoicheva, and D. V. Zhelev. “Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid.” In Biophysical Journal, 74:A393–A393. BIOPHYSICAL SOCIETY, 1998.
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    • Olbrich, K. C., O. F. Hutter, and D. Needham. “Arachidonic acid increases water permeability of sarcolemmal vesicles from rabbit skeletal muscle.” In Biophysical Journal, 74:A393–A393. BIOPHYSICAL SOCIETY, 1998.
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    • Zhelev, D. V., N. Stoicheva, and D. Needham. “Uptake of fuson peptide by bilayer membranes and mechanical properties of membranes containing fuson peptide.” In Biophysical Journal, 74:A221–A221. BIOPHYSICAL SOCIETY, 1998.
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    • Evans, E., H. Bowman, A. Leung, D. Needham, and D. Tirrell. “Biomembrane templating of nanometer-scale polymer patterns.” In Abstracts of Papers of the American Chemical Society, 214:84-PMSE. AMER CHEMICAL SOC, 1997.
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    • Kiser, P. F., D. Needham, and G. Wilson. “Mimicking the smart polymer matrix of the secretory granule: A new concept in controlled release drug delivery.” In Abstracts of Papers of the American Chemical Society, 213:134-PMSE. AMER CHEMICAL SOC, 1997.
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    • Needham, D., and D. NopplSimson. “Barrier properties of surface-grafted PEG for macromolecule-surface interactions.” In Abstracts of Papers of the American Chemical Society, 213:61-POLY. AMER CHEMICAL SOC, 1997.
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    • TingBeall, H. P., W. Kao, W. M. Valentine, and D. Needham. “Toxin-induced changes in cell mechanochemical properties.” In Faseb Journal, 11:3160–3160. FEDERATION AMER SOC EXP BIOL, 1997.
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    • Bowman, H., E. Evans, D. Needham, and D. Tirrell. “Nanometer-scale polymeric patterns and networks.” In Abstracts of Papers of the American Chemical Society, 211:93-PMSE. AMER CHEMICAL SOC, 1996.
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    • Noppl, D. A., and D. Needham. “Avidin-biotin interactions at vesicle surfaces: Adsorption and binding, cross bridge formation, and lateral interactions.” In Biophysical Journal, 70:SU359–SU359. CELL PRESS, 1996.
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    • Olbrich, K. C., W. Rawicz, E. A. Evans, and D. Needham. “Water permeability and mechanical properties of polyunsaturated lipid membranes.” In Biophysical Journal, 70:SU340–SU340. CELL PRESS, 1996.
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    • MCINTOSH, T. J., D. NEEDHAM, D. V. ZHELEV, and S. A. SIMON. “EXPERIMENTAL TESTS FOR MOLECULAR PROTRUSIONS AND UNDULATIONS IN LIPID BILAYERS.” In Abstracts of Papers of the American Chemical Society, 210:17-COLL. AMER CHEMICAL SOC, 1995.
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    • HRISTOVA, K., and D. NEEDHAM. “INCORPORATION OF POLYMER-LIPIDS INTO BILAYERS LEADS TO PHASE-TRANSITION.” In Biophysical Journal, 66:A177–A177. BIOPHYSICAL SOCIETY, 1994.
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    • KENWORTHY, A. K., T. J. MCINTOSH, K. HRISTOVA, and D. NEEDHAM. “STERIC INTERACTIONS BETWEEN GEL AND LIQUID-CRYSTALLINE PHOSPHATIDYLCHOLINE BILAYERS CONTAINING LIPIDS WITH COVALENTLY ATTACHED POLYETHYLENE-GLYCOL.” In Biophysical Journal, 66:A287–A287. BIOPHYSICAL SOCIETY, 1994.
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    • HOCHMUTH, R. M., H. P. TINGBEALL, D. NEEDHAM, and R. TRANSONTAY. “RECOVERY OF PASSIVE HUMAN NEUTROPHILS AFTER SMALL DEFORMATIONS.” In Biophysical Journal, 64:A292–A292. BIOPHYSICAL SOCIETY, 1993.
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    • HRISTOVA, K., and D. NEEDHAM. “THEORETICAL-STUDIES OF MODEL BIOSURFACE PROPERTIES.” In Biophysical Journal, 64:A298–A298. BIOPHYSICAL SOCIETY, 1993.
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    • KENWORTHY, A. K., T. J. MCINTOSH, D. NEEDHAM, and K. HRISTOVA. “STERIC INTERACTIONS BETWEEN BILAYERS CONTAINING LIPIDS WITH COVALENTLY ATTACHED POLYETHYLENE-GLYCOL.” In Biophysical Journal, 64:A348–A348. BIOPHYSICAL SOCIETY, 1993.
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    • ZHELEV, D. V., D. NEEDHAM, and R. M. HOCHMUTH. “A NOVEL MICROPIPET TECHNIQUE FOR STUDYING NEUTROPHIL LOCOMOTION, SPREADING AND CONTRACTILITY DURING PHAGOCYTOSIS AND MECHANICALLY STIMULATED POLYMERIZATION OF ACTIN NETWORK.” In Biophysical Journal, 64:A367–A367. BIOPHYSICAL SOCIETY, 1993.
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    • ZHELEV, D. V., and D. NEEDHAM. “LONG LIVED REVERSIBLE PORES IN GIANT LIPOSOMES - A NOVEL METHOD FOR DETERMINATION OF PORE-SIZE AND PORE LINE TENSION.” In Biophysical Journal, 64:A297–A297. BIOPHYSICAL SOCIETY, 1993.
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    • LASIC, D. D., K. MACLEOD, A. HUANG, R. M. ABRA, M. S. NEWMAN, F. J. MARTIN, D. NEEDHAM, and E. MAYHEW. “GRAFTED POLYMER (STEALTH) LIPOSOMES.” In Abstracts of Papers of the American Chemical Society, 203:51-BIOT. AMER CHEMICAL SOC, 1992.
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    • NEEDHAM, D., T. J. MCINTOSH, and S. A. SIMON. “CONFORMATION AND INTERACTIVE PROPERTIES OF SURFACE-BOUND POLYETHYLENE-GLYCOL (PEG) IN LIPID-MEMBRANES AND MONOLAYERS.” In Faseb Journal, 6:A237–A237. FEDERATION AMER SOC EXP BIOL, 1992.
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    • SONKIN, P. L., D. NEEDHAM, K. M. K. RAO, S. F. FREEDMAN, and D. L. HATCHELL. “PENTOXIFYLLINE IMPROVES DEFORMABILITY AND DECREASES F-ACTIN CONTENT OF PASSIVE POLYMORPHONUCLEAR LEUKOCYTES IN A CAT MODEL OF DIABETES.” In Investigative Ophthalmology & Visual Science, 32:1288–1288. LIPPINCOTT-RAVEN PUBL, 1991.
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    • NEEDHAM, D., and R. S. NUNN. “COHESIVE PROPERTIES (ELASTIC-DEFORMATION AND FAILURE) OF LIPID BILAYERS CONTAINING CHOLESTEROL.” In Biophysical Journal, 57:A219–A219. BIOPHYSICAL SOCIETY, 1990.
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    • NEEDHAM, D., and E. EVANS. “STRONG ATTRACTION INDUCED BETWEEN LIPID BILAYER-MEMBRANES BY NON-ADSORBING POLYMERS.” In Biophysical Journal, 53:A119–A119. BIOPHYSICAL SOCIETY, 1988.
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• Teaching & Mentoring
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  Recent Courses

  • EGR 393: Research Projects in Engineering 2020
  • ME 555: Advanced Topics in Mechanical Engineering 2019

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