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Micropatterns of a cell-adhesive peptide on an amphiphilic comb polymer film

Publication ,  Journal Article
Hyun, J; Ma, H; Banerjee, P; Cole, J; Gonsalves, K; Chilkoti, A
Published in: Langmuir
April 16, 2002

We report in this paper a generic method to modify the surfaces of common polymeric biomaterials that enables spatially resolved attachment and growth of mammalian cells in a biologically relevant milieu. We demonstrate that an amphiphilic comb polymer presenting short oligoethylene glycol side chains can be coated onto a number of different polymeric biomaterials, namely polystyrene, poly(methyl methacrylate), and poly(ethylene terephthalate) from a methanol/water mixture. The comb polymer film is stable in water and presents reactive COOH groups at the oligoethylene glycol chain ends, thereby permitting the surface of the comb polymer to be patterned with a cell adhesive, arg-gly-asp peptide. The micropatterned surfaces spatially confine the attachment and growth of fibroblasts for ∼24 h in 10% serum to the patterned regions.

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Published In

Langmuir

DOI

ISSN

0743-7463

Publication Date

April 16, 2002

Volume

18

Issue

8

Start / End Page

2975 / 2979

Related Subject Headings

  • Chemical Physics
 

Citation

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Hyun, J., Ma, H., Banerjee, P., Cole, J., Gonsalves, K., & Chilkoti, A. (2002). Micropatterns of a cell-adhesive peptide on an amphiphilic comb polymer film. Langmuir, 18(8), 2975–2979. https://doi.org/10.1021/la015712x
Hyun, J., H. Ma, P. Banerjee, J. Cole, K. Gonsalves, and A. Chilkoti. “Micropatterns of a cell-adhesive peptide on an amphiphilic comb polymer film.” Langmuir 18, no. 8 (April 16, 2002): 2975–79. https://doi.org/10.1021/la015712x.
Hyun J, Ma H, Banerjee P, Cole J, Gonsalves K, Chilkoti A. Micropatterns of a cell-adhesive peptide on an amphiphilic comb polymer film. Langmuir. 2002 Apr 16;18(8):2975–9.
Hyun, J., et al. “Micropatterns of a cell-adhesive peptide on an amphiphilic comb polymer film.” Langmuir, vol. 18, no. 8, Apr. 2002, pp. 2975–79. Scopus, doi:10.1021/la015712x.
Hyun J, Ma H, Banerjee P, Cole J, Gonsalves K, Chilkoti A. Micropatterns of a cell-adhesive peptide on an amphiphilic comb polymer film. Langmuir. 2002 Apr 16;18(8):2975–2979.
Journal cover image

Published In

Langmuir

DOI

ISSN

0743-7463

Publication Date

April 16, 2002

Volume

18

Issue

8

Start / End Page

2975 / 2979

Related Subject Headings

  • Chemical Physics