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Enzymatic fabrication of DNA nanostructures: extension of a self-assembled oligonucleotide monolayer on gold arrays.

Publication ,  Journal Article
Chow, DC; Lee, W-K; Zauscher, S; Chilkoti, A
Published in: Journal of the American Chemical Society
October 2005

Nucleic acid nanostructures are useful as templates for bionanofabrication of composite molecular nanostructures in materials science, molecular electronics, and biosensing. Here, we demonstrate that terminal deoxynucleotidyl transferase, which repetitively adds mononucleotides to the 3' end of a short DNA initiator, can be used to rapidly fabricate DNA nanostructures up to 121 nm high with lateral dimensions from 0.1 to 4 mum in 2 h. These programmable scaffolds can potentially be employed to build more complex nanostructures consisting of natural or unnatural nucleotides with selective docking sites along the single-stranded DNA.

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Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

October 2005

Volume

127

Issue

41

Start / End Page

14122 / 14123

Related Subject Headings

  • Time Factors
  • Surface Properties
  • Surface Plasmon Resonance
  • Oligonucleotides
  • Nanotechnology
  • Nanostructures
  • Gold
  • General Chemistry
  • Enzymes, Immobilized
  • DNA Nucleotidylexotransferase
 

Citation

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Chow, D. C., Lee, W.-K., Zauscher, S., & Chilkoti, A. (2005). Enzymatic fabrication of DNA nanostructures: extension of a self-assembled oligonucleotide monolayer on gold arrays. Journal of the American Chemical Society, 127(41), 14122–14123. https://doi.org/10.1021/ja052491z
Chow, Dominic C., Woo-Kyung Lee, Stefan Zauscher, and Ashutosh Chilkoti. “Enzymatic fabrication of DNA nanostructures: extension of a self-assembled oligonucleotide monolayer on gold arrays.Journal of the American Chemical Society 127, no. 41 (October 2005): 14122–23. https://doi.org/10.1021/ja052491z.
Chow DC, Lee W-K, Zauscher S, Chilkoti A. Enzymatic fabrication of DNA nanostructures: extension of a self-assembled oligonucleotide monolayer on gold arrays. Journal of the American Chemical Society. 2005 Oct;127(41):14122–3.
Chow, Dominic C., et al. “Enzymatic fabrication of DNA nanostructures: extension of a self-assembled oligonucleotide monolayer on gold arrays.Journal of the American Chemical Society, vol. 127, no. 41, Oct. 2005, pp. 14122–23. Epmc, doi:10.1021/ja052491z.
Chow DC, Lee W-K, Zauscher S, Chilkoti A. Enzymatic fabrication of DNA nanostructures: extension of a self-assembled oligonucleotide monolayer on gold arrays. Journal of the American Chemical Society. 2005 Oct;127(41):14122–14123.
Journal cover image

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

October 2005

Volume

127

Issue

41

Start / End Page

14122 / 14123

Related Subject Headings

  • Time Factors
  • Surface Properties
  • Surface Plasmon Resonance
  • Oligonucleotides
  • Nanotechnology
  • Nanostructures
  • Gold
  • General Chemistry
  • Enzymes, Immobilized
  • DNA Nucleotidylexotransferase