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The study of cell dynamics with a novel phase referenced low coherence interferometer with sub-wavelength and sub-hertz sensitivity

Publication ,  Journal Article
Yang, C; Wax, A; Badizadegan, K; Dasari, RR; Feld, MS
Published in: Proceedings of SPIE - The International Society for Optical Engineering
January 1, 2002

We report the use of a highly sensitive phase based motion measurement technique to study the correlation of cellular metabolic rate with cellular motions. The technique is based on a modified Michelson interferometer with a composite laser beam of 1550 nm low coherence light and 775 nm CW light. In this system, motional artifacts from vibrations in the interferometer are completely eliminated. We demonstrate that the system is sensitive to motions as small as 3.6 nm and velocities as small as 1 nm/s. Using the system, we show that the cellular motions are strongly dependent on the ambient temperature. We observe that the dependency does not conform to Brownian motion predictions but instead appears to correlate with the optical ambient temperature that the cells have evolved to operate in.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

January 1, 2002

Volume

4619

Start / End Page

202 / 209
 

Citation

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Yang, C., Wax, A., Badizadegan, K., Dasari, R. R., & Feld, M. S. (2002). The study of cell dynamics with a novel phase referenced low coherence interferometer with sub-wavelength and sub-hertz sensitivity. Proceedings of SPIE - The International Society for Optical Engineering, 4619, 202–209. https://doi.org/10.1117/12.470484
Yang, C., A. Wax, K. Badizadegan, R. R. Dasari, and M. S. Feld. “The study of cell dynamics with a novel phase referenced low coherence interferometer with sub-wavelength and sub-hertz sensitivity.” Proceedings of SPIE - The International Society for Optical Engineering 4619 (January 1, 2002): 202–9. https://doi.org/10.1117/12.470484.
Yang C, Wax A, Badizadegan K, Dasari RR, Feld MS. The study of cell dynamics with a novel phase referenced low coherence interferometer with sub-wavelength and sub-hertz sensitivity. Proceedings of SPIE - The International Society for Optical Engineering. 2002 Jan 1;4619:202–9.
Yang, C., et al. “The study of cell dynamics with a novel phase referenced low coherence interferometer with sub-wavelength and sub-hertz sensitivity.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 4619, Jan. 2002, pp. 202–09. Scopus, doi:10.1117/12.470484.
Yang C, Wax A, Badizadegan K, Dasari RR, Feld MS. The study of cell dynamics with a novel phase referenced low coherence interferometer with sub-wavelength and sub-hertz sensitivity. Proceedings of SPIE - The International Society for Optical Engineering. 2002 Jan 1;4619:202–209.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

January 1, 2002

Volume

4619

Start / End Page

202 / 209