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In vitro temperature map of cardiac ablation demonstrates the effect of flow on lesion development.

Publication ,  Journal Article
Jain, MK; Wolf, PD
Published in: Annals of biomedical engineering
September 2000

This paper presents an in vitro temperature mapping study of bovine cardiac tissue during radiofrequency ablation. The objectives were to: (i) develop a technique for measuring the spatial and temporal temperature distribution in the tissue and in the blood during ablation, and (ii) use the temperature measurements to characterize the effects of fluid flow on lesion dimensions, ablation efficiency, and temperature distributions. In vitro ablation (20 W, 60 s) of bovine cardiac tissue was performed. The tissue was placed in a saline-dextrose solution maintained at 37+/- 0.5 degrees C. The solution also irrigated the tissue surface and simulated blood flow velocities of (i) 30, (ii) 55, and (iii) 85 mm/s. Thermocouple measurements were recorded from 25 and 2 locations in the tissue and in the fluid, respectively. The lowest flow resulted in the largest lesion, the maximum tissue, fluid, and electrode temperature increases, and the highest ablation efficiency. The lesions were 5.8 +/- 0.81, 4.8 +/- 0.84, and 4.4 +/- 1.25 mm deep, and 9.3 +/- 1.07, 7.9 +/- 1.48, and 7.8 +/- 1.27 mm wide for flows (i)-(iii), respectively. The blood and tissue temperature distributions were asymmetric around the ablating electrode axis with higher temperatures on the outflow than on the inflow side. The experimental measurements were used to validate a numeric model of ablation in an accompanying paper.

Duke Scholars

Published In

Annals of biomedical engineering

DOI

EISSN

1573-9686

ISSN

0090-6964

Publication Date

September 2000

Volume

28

Issue

9

Start / End Page

1066 / 1074

Related Subject Headings

  • Temperature
  • Rheology
  • Radiofrequency Therapy
  • In Vitro Techniques
  • Humans
  • Cattle
  • Catheter Ablation
  • Blood Flow Velocity
  • Biomedical Engineering
  • Biomedical Engineering
 

Citation

APA
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ICMJE
MLA
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Jain, M. K., & Wolf, P. D. (2000). In vitro temperature map of cardiac ablation demonstrates the effect of flow on lesion development. Annals of Biomedical Engineering, 28(9), 1066–1074. https://doi.org/10.1114/1.1310218
Jain, M. K., and P. D. Wolf. “In vitro temperature map of cardiac ablation demonstrates the effect of flow on lesion development.Annals of Biomedical Engineering 28, no. 9 (September 2000): 1066–74. https://doi.org/10.1114/1.1310218.
Jain MK, Wolf PD. In vitro temperature map of cardiac ablation demonstrates the effect of flow on lesion development. Annals of biomedical engineering. 2000 Sep;28(9):1066–74.
Jain, M. K., and P. D. Wolf. “In vitro temperature map of cardiac ablation demonstrates the effect of flow on lesion development.Annals of Biomedical Engineering, vol. 28, no. 9, Sept. 2000, pp. 1066–74. Epmc, doi:10.1114/1.1310218.
Jain MK, Wolf PD. In vitro temperature map of cardiac ablation demonstrates the effect of flow on lesion development. Annals of biomedical engineering. 2000 Sep;28(9):1066–1074.
Journal cover image

Published In

Annals of biomedical engineering

DOI

EISSN

1573-9686

ISSN

0090-6964

Publication Date

September 2000

Volume

28

Issue

9

Start / End Page

1066 / 1074

Related Subject Headings

  • Temperature
  • Rheology
  • Radiofrequency Therapy
  • In Vitro Techniques
  • Humans
  • Cattle
  • Catheter Ablation
  • Blood Flow Velocity
  • Biomedical Engineering
  • Biomedical Engineering