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Improved spatial localization based on flow-moment-nulled and intra-voxel incoherent motion-weighted fMRI.

Publication ,  Journal Article
Song, AW; Li, T
Published in: NMR Biomed
May 2003

Functional MRI signal based on the blood oxygenation level-dependent contrast can reveal brain vascular activities secondary to neuronal activation. It could, however, arise from vascular compartments of all sizes, and in particular, be largely influenced by contributions of large vein origins that are distant from the neuronal activities. Alternative contrasts can be generated based on the cerebral blood flow or volume changes that would provide complementary information to help achieve more accurate localization to the small vessel origins. Recent reports also indicated that apparent diffusion coefficient-based contrast using intravoxel incoherent motion (IVIM) weighting could be used to efficiently detect synchronized signal changes with the functional activities. It was found that this contrast has significant arterial contribution where flow changes are more dominant. In this study, a refined approach was proposed that incorporated the flow-moment-nulling (FMN) strategy to study signal changes from the brain activation. The results were then compared with those from conventional IVIM- and BOLD-weighted acquisitions. It was shown that the activated region using the new acquisition strategy had smaller spatial extent, which was contained within the activated areas from the other two methods. Based on the known characteristics of the conventional IVIM and BOLD contrasts, it was inferred that the FMN-IVIM acquisition had improved selective sensitivity towards smaller vessels where volume changes were prevalent. Therefore, such an acquisition method may provide more specific spatial localization closely coupled to the true neuronal activities.

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Published In

NMR Biomed

DOI

ISSN

0952-3480

Publication Date

May 2003

Volume

16

Issue

3

Start / End Page

137 / 143

Location

England

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Neurons
  • Motion
  • Magnetic Resonance Imaging
  • Image Enhancement
  • Humans
  • Cerebrovascular Circulation
  • Brain Mapping
 

Citation

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Song, A. W., & Li, T. (2003). Improved spatial localization based on flow-moment-nulled and intra-voxel incoherent motion-weighted fMRI. NMR Biomed, 16(3), 137–143. https://doi.org/10.1002/nbm.819
Song, Allen W., and Tianlu Li. “Improved spatial localization based on flow-moment-nulled and intra-voxel incoherent motion-weighted fMRI.NMR Biomed 16, no. 3 (May 2003): 137–43. https://doi.org/10.1002/nbm.819.
Song, Allen W., and Tianlu Li. “Improved spatial localization based on flow-moment-nulled and intra-voxel incoherent motion-weighted fMRI.NMR Biomed, vol. 16, no. 3, May 2003, pp. 137–43. Pubmed, doi:10.1002/nbm.819.
Journal cover image

Published In

NMR Biomed

DOI

ISSN

0952-3480

Publication Date

May 2003

Volume

16

Issue

3

Start / End Page

137 / 143

Location

England

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Neurons
  • Motion
  • Magnetic Resonance Imaging
  • Image Enhancement
  • Humans
  • Cerebrovascular Circulation
  • Brain Mapping