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Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate.

Publication ,  Journal Article
Zalutsky, MR; Narula, AS
Published in: Int J Rad Appl Instrum A
1988
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A method is described for labeling proteins with 7.2 h half-life 211 At. The alpha particle-emitting nuclide was coupled to goat IgG using an N-succinimidyl 3-(tri-n-butylstannyl) benzoate intermediate. The reaction and purification sequence requires about 2 h to produce 211 At-labeled IgG in 25-40% radiochemical yield. Comparative blood clearance measurements in mice suggest that the 211 At-labeled IgG conjugate is stable in vivo.

Duke Scholars

Michael Rod Zalutsky
Author Michael Rod Zalutsky Radiology
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Published In

Int J Rad Appl Instrum A

DOI

10.1016/0883-2889(88)90176-1

ISSN

0883-2889

Publication Date

1988

Volume

39

Issue

3

Start / End Page

227 / 232

Location

England

Related Subject Headings

  • Trialkyltin Compounds
  • Proteins
  • Mice
  • Isotope Labeling
  • Indicators and Reagents
  • Immunoglobulin G
  • Female
  • Drug Stability
  • Benzoates
  • Astatine
 

Citation

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Zalutsky, M. R., & Narula, A. S. (1988). Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate. Int J Rad Appl Instrum A, 39(3), 227–232. https://doi.org/10.1016/0883-2889(88)90176-1
Zalutsky, M. R., and A. S. Narula. “Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate.” Int J Rad Appl Instrum A 39, no. 3 (1988): 227–32. https://doi.org/10.1016/0883-2889(88)90176-1.
Zalutsky MR, Narula AS. Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate. Int J Rad Appl Instrum A. 1988;39(3):227–32.
Zalutsky, M. R., and A. S. Narula. “Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate.” Int J Rad Appl Instrum A, vol. 39, no. 3, 1988, pp. 227–32. Pubmed, doi:10.1016/0883-2889(88)90176-1.
Zalutsky MR, Narula AS. Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate. Int J Rad Appl Instrum A. 1988;39(3):227–232.

Published In

Int J Rad Appl Instrum A

DOI

10.1016/0883-2889(88)90176-1

ISSN

0883-2889

Publication Date

1988

Volume

39

Issue

3

Start / End Page

227 / 232

Location

England

Related Subject Headings

  • Trialkyltin Compounds
  • Proteins
  • Mice
  • Isotope Labeling
  • Indicators and Reagents
  • Immunoglobulin G
  • Female
  • Drug Stability
  • Benzoates
  • Astatine