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Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates.

Publication ,  Journal Article
Zalutsky, MR; Bigner, DD
Published in: Acta Oncol
1996

Radionuclides which decay by the emission of alpha-particles are attractive for certain radioimmunotherapeutic applications. These include the treatment of lymphomas, compartmentally spread malignancies such as ovarian cancer and neoplastic meningitis, and micrometastatic disease. Two alpha-emitting radionuclides of interest for this purpose are 212Bi (60.6 min half life) and 211At (7.2 hr half life). Compared with the beta-emitters commonly used for radiotherapy, the alpha-particles of 212Bi and 211At are of higher energy, much shorter range (less than 100 microm), and considerably higher linear energy transfer. Preliminary results obtained in a variety of in vitro systems and in vivo models have documented the exquisite toxicity of alpha-particles and have established a basis for initiating radiotherapy trials in humans with monoclonal antibodies labeled with alpha-emitting radionuclides.

Duke Scholars

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Published In

Acta Oncol

DOI

ISSN

0284-186X

Publication Date

1996

Volume

35

Issue

3

Start / End Page

373 / 379

Location

England

Related Subject Headings

  • Radioisotopes
  • Radioimmunotherapy
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Meningitis
  • Lymphoma
  • Linear Energy Transfer
  • Immunoconjugates
  • Humans
 

Citation

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Zalutsky, M. R., & Bigner, D. D. (1996). Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates. Acta Oncol, 35(3), 373–379. https://doi.org/10.3109/02841869609101654
Zalutsky, M. R., and D. D. Bigner. “Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates.Acta Oncol 35, no. 3 (1996): 373–79. https://doi.org/10.3109/02841869609101654.
Zalutsky MR, Bigner DD. Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates. Acta Oncol. 1996;35(3):373–9.
Zalutsky, M. R., and D. D. Bigner. “Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates.Acta Oncol, vol. 35, no. 3, 1996, pp. 373–79. Pubmed, doi:10.3109/02841869609101654.
Zalutsky MR, Bigner DD. Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates. Acta Oncol. 1996;35(3):373–379.
Journal cover image

Published In

Acta Oncol

DOI

ISSN

0284-186X

Publication Date

1996

Volume

35

Issue

3

Start / End Page

373 / 379

Location

England

Related Subject Headings

  • Radioisotopes
  • Radioimmunotherapy
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Meningitis
  • Lymphoma
  • Linear Energy Transfer
  • Immunoconjugates
  • Humans