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Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction.

Publication ,  Journal Article
Kraitchman, DL; Tatsumi, M; Gilson, WD; Ishimori, T; Kedziorek, D; Walczak, P; Segars, WP; Chen, HH; Fritzges, D; Izbudak, I; Young, RG ...
Published in: Circulation
September 6, 2005

BACKGROUND: Recent results from animal studies suggest that stem cells may be able to home to sites of myocardial injury to assist in tissue regeneration. However, the histological interpretation of postmortem tissue, on which many of these studies are based, has recently been widely debated. METHODS AND RESULTS: With the use of the high sensitivity of a combined single-photon emission CT (SPECT)/CT scanner, the in vivo trafficking of allogeneic mesenchymal stem cells (MSCs) colabeled with a radiotracer and MR contrast agent to acute myocardial infarction was dynamically determined. Redistribution of the labeled MSCs after intravenous injection from initial localization in the lungs to nontarget organs such as the liver, kidney, and spleen was observed within 24 to 48 hours after injection. Focal and diffuse uptake of MSCs in the infarcted myocardium was already visible in SPECT/CT images in the first 24 hours after injection and persisted until 7 days after injection and was validated by tissue counts of radioactivity. In contrast, MRI was unable to demonstrate targeted cardiac localization of MSCs in part because of the lower sensitivity of MRI. CONCLUSIONS: Noninvasive radionuclide imaging is well suited to dynamically track the biodistribution and trafficking of mesenchymal stem cells to both target and nontarget organs.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

September 6, 2005

Volume

112

Issue

10

Start / End Page

1451 / 1461

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Stem Cells
  • Reproducibility of Results
  • Oxyquinoline
  • Organometallic Compounds
  • Myocardial Infarction
  • Mesenchymal Stem Cell Transplantation
  • Magnetic Resonance Imaging
 

Citation

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Kraitchman, D. L., Tatsumi, M., Gilson, W. D., Ishimori, T., Kedziorek, D., Walczak, P., … Bulte, J. W. M. (2005). Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation, 112(10), 1451–1461. https://doi.org/10.1161/CIRCULATIONAHA.105.537480
Kraitchman, Dara L., Mitsuaki Tatsumi, Wesley D. Gilson, Takayoshi Ishimori, Dorota Kedziorek, Piotr Walczak, W Paul Segars, et al. “Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction.Circulation 112, no. 10 (September 6, 2005): 1451–61. https://doi.org/10.1161/CIRCULATIONAHA.105.537480.
Kraitchman DL, Tatsumi M, Gilson WD, Ishimori T, Kedziorek D, Walczak P, et al. Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation. 2005 Sep 6;112(10):1451–61.
Kraitchman, Dara L., et al. “Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction.Circulation, vol. 112, no. 10, Sept. 2005, pp. 1451–61. Pubmed, doi:10.1161/CIRCULATIONAHA.105.537480.
Kraitchman DL, Tatsumi M, Gilson WD, Ishimori T, Kedziorek D, Walczak P, Segars WP, Chen HH, Fritzges D, Izbudak I, Young RG, Marcelino M, Pittenger MF, Solaiyappan M, Boston RC, Tsui BMW, Wahl RL, Bulte JWM. Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation. 2005 Sep 6;112(10):1451–1461.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

September 6, 2005

Volume

112

Issue

10

Start / End Page

1451 / 1461

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Stem Cells
  • Reproducibility of Results
  • Oxyquinoline
  • Organometallic Compounds
  • Myocardial Infarction
  • Mesenchymal Stem Cell Transplantation
  • Magnetic Resonance Imaging