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A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT.

Publication ,  Journal Article
He, B; Du, Y; Song, X; Segars, WP; Frey, EC
Published in: Phys Med Biol
September 7, 2005

Accurate estimation of the 3D in vivo activity distribution is important for dose estimation in targeted radionuclide therapy (TRT). Although SPECT can potentially provide such estimates, SPECT without compensation for image degrading factors is not quantitatively accurate. In this work, we evaluated quantitative SPECT (QSPECT) reconstruction methods that include compensation for various physical effects. Experimental projection data were obtained using a GE VH/Hawkeye system and an RSD torso phantom. Known activities of In-111 chloride were placed in the lungs, liver, heart, background and two spherical compartments with inner diameters of 22 mm and 34 mm. The 3D NCAT phantom with organ activities based on clinically derived In-111 ibritumomab tiuxetan data was used for the Monte Carlo (MC) simulation studies. Low-noise projection data were simulated using previously validated MC simulation methods. Fifty sets of noisy projections with realistic count levels were generated. Reconstructions were performed using the OS-EM algorithm with various combinations of attenuation (A), scatter (S), geometric response (G), collimator-detector response (D) and partial volume compensation (PVC). The QSPECT images from the various combinations of compensations were evaluated in terms of the accuracy and precision of the estimates of the total activity in each organ. For experimental data, the errors in organ activities for ADS and PVC compensation were less than 6.5% except the smaller sphere (-11.9%). For the noisy simulated data, the errors in organ activity for ADS compensation were less than 5.5% except the lungs (20.9%) and blood vessels (15.2%). Errors for other combinations of compensations were significantly (A, AS) or somewhat (AGS) larger. With added PVC, the error in the organ activities improved slightly except for the lungs (11.5%) and blood vessels (3.6%) where the improvement was more substantial. The standard deviation/mean ratios were all less than 1.5%. We conclude that QSPECT methods with appropriate compensations provided accurate In-111 organ activity estimates. For the collimator used, AGS was almost as good as ADS and may be preferable due to the reduced reconstruction time. PVC was important for small structures such as tumours or for organs in close proximity to regions with high activity. The improved quantitative accuracy from QSPECT methods has the potential for improving organ dose estimations in TRT.

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Published In

Phys Med Biol

DOI

ISSN

0031-9155

Publication Date

September 7, 2005

Volume

50

Issue

17

Start / End Page

4169 / 4185

Location

England

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Tissue Distribution
  • Thorax
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiopharmaceuticals
  • Phantoms, Imaging
  • Organ Specificity
  • Nuclear Medicine & Medical Imaging
  • Monte Carlo Method
 

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He, B., Du, Y., Song, X., Segars, W. P., & Frey, E. C. (2005). A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT. Phys Med Biol, 50(17), 4169–4185. https://doi.org/10.1088/0031-9155/50/17/018
He, Bin, Yong Du, Xiyun Song, W Paul Segars, and Eric C. Frey. “A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT.Phys Med Biol 50, no. 17 (September 7, 2005): 4169–85. https://doi.org/10.1088/0031-9155/50/17/018.
He B, Du Y, Song X, Segars WP, Frey EC. A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT. Phys Med Biol. 2005 Sep 7;50(17):4169–85.
He, Bin, et al. “A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT.Phys Med Biol, vol. 50, no. 17, Sept. 2005, pp. 4169–85. Pubmed, doi:10.1088/0031-9155/50/17/018.
He B, Du Y, Song X, Segars WP, Frey EC. A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT. Phys Med Biol. 2005 Sep 7;50(17):4169–4185.
Journal cover image

Published In

Phys Med Biol

DOI

ISSN

0031-9155

Publication Date

September 7, 2005

Volume

50

Issue

17

Start / End Page

4169 / 4185

Location

England

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Tissue Distribution
  • Thorax
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiopharmaceuticals
  • Phantoms, Imaging
  • Organ Specificity
  • Nuclear Medicine & Medical Imaging
  • Monte Carlo Method