Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices.
Publication
, Journal Article
Aitken, PG; Jaffe, DB; Nadler, JV
Published in: Peptides
1991
We investigated the relationship between the effects of cholecystokinin (CCK) and kainic acid (KA) in the CA3 region of hippocampal slices from rats. As has been reported previously, KA in nanomolar concentrations caused spontaneous epileptiform discharges (bursts) and an excitatory shift of the input/output (I/O) curve. CCK octapeptide (100-200 nM) applied alone had no effect on spontaneous activity or I/O curves. Pretreatment of slices with sulfated CCK blocked the effect of KA on synaptic transmission, but had no effect on KA-induced bursting. Pretreatment with nonsulfated CCK had no effect.
Duke Scholars
Published In
Peptides
DOI
ISSN
0196-9781
Publication Date
1991
Volume
12
Issue
1
Start / End Page
127 / 129
Location
United States
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Kainic Acid
- In Vitro Techniques
- Hippocampus
- Cholecystokinin
- Animals
- Action Potentials
Citation
APA
Chicago
ICMJE
MLA
NLM
Aitken, P. G., Jaffe, D. B., & Nadler, J. V. (1991). Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices. Peptides, 12(1), 127–129. https://doi.org/10.1016/0196-9781(91)90178-r
Aitken, P. G., D. B. Jaffe, and J. V. Nadler. “Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices.” Peptides 12, no. 1 (1991): 127–29. https://doi.org/10.1016/0196-9781(91)90178-r.
Aitken PG, Jaffe DB, Nadler JV. Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices. Peptides. 1991;12(1):127–9.
Aitken, P. G., et al. “Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices.” Peptides, vol. 12, no. 1, 1991, pp. 127–29. Pubmed, doi:10.1016/0196-9781(91)90178-r.
Aitken PG, Jaffe DB, Nadler JV. Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices. Peptides. 1991;12(1):127–129.
Published In
Peptides
DOI
ISSN
0196-9781
Publication Date
1991
Volume
12
Issue
1
Start / End Page
127 / 129
Location
United States
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Kainic Acid
- In Vitro Techniques
- Hippocampus
- Cholecystokinin
- Animals
- Action Potentials