Blood vessels engineered from human cells.
Publication
, Journal Article
Poh, M; Boyer, M; Solan, A; Dahl, SLM; Pedrotty, D; Banik, SSR; McKee, JA; Klinger, RY; Counter, CM; Niklason, LE
Published in: Lancet
June 18, 2005
Tissue engineering has made considerable progress in the past decade, but advances have stopped short of clinical application for most tissues. We postulated that an obstacle in engineering human tissues is the limited replicative capacity of adult somatic cells. To test this hypothesis, the effectiveness of telomerase expression to extend cellular lifespan was assessed in a model of human vascular tissue engineering. Telomerase expression in vascular cells isolated from elderly patients enabled the successful culture of engineered autologous blood vessels. Engineered vessels may one day provide a source of bypass conduit for patients with atherosclerotic disease.
Duke Scholars
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Published In
Lancet
DOI
EISSN
1474-547X
Publication Date
June 18, 2005
Volume
365
Issue
9477
Start / End Page
2122 / 2124
Location
England
Related Subject Headings
- Transfection
- Tissue Engineering
- Telomerase
- Saphenous Vein
- Muscle, Smooth, Vascular
- Middle Aged
- Male
- Humans
- General & Internal Medicine
- Endothelium, Vascular
Citation
APA
Chicago
ICMJE
MLA
NLM
Poh, M., Boyer, M., Solan, A., Dahl, S. L. M., Pedrotty, D., Banik, S. S. R., … Niklason, L. E. (2005). Blood vessels engineered from human cells. Lancet, 365(9477), 2122–2124. https://doi.org/10.1016/S0140-6736(05)66735-9
Poh, Melissa, Matthew Boyer, Amy Solan, Shannon L. M. Dahl, Dawn Pedrotty, Soma S. R. Banik, J Andrew McKee, Rebecca Y. Klinger, Christopher M. Counter, and Laura E. Niklason. “Blood vessels engineered from human cells.” Lancet 365, no. 9477 (June 18, 2005): 2122–24. https://doi.org/10.1016/S0140-6736(05)66735-9.
Poh M, Boyer M, Solan A, Dahl SLM, Pedrotty D, Banik SSR, et al. Blood vessels engineered from human cells. Lancet. 2005 Jun 18;365(9477):2122–4.
Poh, Melissa, et al. “Blood vessels engineered from human cells.” Lancet, vol. 365, no. 9477, June 2005, pp. 2122–24. Pubmed, doi:10.1016/S0140-6736(05)66735-9.
Poh M, Boyer M, Solan A, Dahl SLM, Pedrotty D, Banik SSR, McKee JA, Klinger RY, Counter CM, Niklason LE. Blood vessels engineered from human cells. Lancet. 2005 Jun 18;365(9477):2122–2124.
Published In
Lancet
DOI
EISSN
1474-547X
Publication Date
June 18, 2005
Volume
365
Issue
9477
Start / End Page
2122 / 2124
Location
England
Related Subject Headings
- Transfection
- Tissue Engineering
- Telomerase
- Saphenous Vein
- Muscle, Smooth, Vascular
- Middle Aged
- Male
- Humans
- General & Internal Medicine
- Endothelium, Vascular