hSnm1B is a novel telomere-associated protein.
Publication
, Journal Article
Freibaum, BD; Counter, CM
Published in: J Biol Chem
June 2, 2006
Artemis, a member of the beta-CASP family, has been implicated in the regulation of both telomere stability and length. Prompted by this, we examined whether the other two putative DNA-binding members of this family, hSnm1A and hSnm1B, may associate with telomeres. hSnm1A was found to not interact with the telomere. Conversely, hSnm1B was found to associate with telomeres in vivo by both immunofluorescence and chromatin immunoprecipitation. Furthermore, the C terminus of hSnm1B was shown to interact with the TRF homology domain of TRF2 indicating that hSnm1B is likely recruited to the telomere via interaction with the double-stranded telomere-binding protein TRF2.
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Published In
J Biol Chem
DOI
ISSN
0021-9258
Publication Date
June 2, 2006
Volume
281
Issue
22
Start / End Page
15033 / 15036
Location
United States
Related Subject Headings
- Telomeric Repeat Binding Protein 2
- Telomere
- TATA Box Binding Protein-Like Proteins
- Sequence Deletion
- Recombinant Proteins
- Protein Structure, Tertiary
- Protein Binding
- Peptide Mapping
- Nuclear Proteins
- Humans
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Freibaum, B. D., & Counter, C. M. (2006). hSnm1B is a novel telomere-associated protein. J Biol Chem, 281(22), 15033–15036. https://doi.org/10.1074/jbc.C600038200
Freibaum, Brian D., and Christopher M. Counter. “hSnm1B is a novel telomere-associated protein.” J Biol Chem 281, no. 22 (June 2, 2006): 15033–36. https://doi.org/10.1074/jbc.C600038200.
Freibaum BD, Counter CM. hSnm1B is a novel telomere-associated protein. J Biol Chem. 2006 Jun 2;281(22):15033–6.
Freibaum, Brian D., and Christopher M. Counter. “hSnm1B is a novel telomere-associated protein.” J Biol Chem, vol. 281, no. 22, June 2006, pp. 15033–36. Pubmed, doi:10.1074/jbc.C600038200.
Freibaum BD, Counter CM. hSnm1B is a novel telomere-associated protein. J Biol Chem. 2006 Jun 2;281(22):15033–15036.
Published In
J Biol Chem
DOI
ISSN
0021-9258
Publication Date
June 2, 2006
Volume
281
Issue
22
Start / End Page
15033 / 15036
Location
United States
Related Subject Headings
- Telomeric Repeat Binding Protein 2
- Telomere
- TATA Box Binding Protein-Like Proteins
- Sequence Deletion
- Recombinant Proteins
- Protein Structure, Tertiary
- Protein Binding
- Peptide Mapping
- Nuclear Proteins
- Humans