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Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo.

Publication ,  Journal Article
Schwartz, RD; Kellar, KJ
Published in: Science
April 8, 1983

Tritiated acetylcholine was used to measure binding sites with characteristics of nicotinic cholinergic receptors in rat brain. Regulation of the binding sites in vivo was examined by administering two drugs that stimulate nicotinic receptors directly or indirectly. After 10 days of exposure to the cholinesterase inhibitor diisopropyl fluorophosphate, binding of tritiated acetylcholine in the cerebral cortex was decreased. However, after repeated administration of nicotine for 10 days, binding of tritiated acetylcholine in the cortex was increased. Saturation analysis of tritiated acetylcholine binding in the cortices of rats treated with diisopropyl fluorophosphate or nicotine indicated that the number of binding sites decreased and increased, respectively, while the affinity of the sites was unaltered.

Duke Scholars

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

April 8, 1983

Volume

220

Issue

4593

Start / End Page

214 / 216

Location

United States

Related Subject Headings

  • Receptors, Nicotinic
  • Receptors, Cholinergic
  • Rats, Inbred Strains
  • Rats
  • Nicotine
  • Male
  • Isoflurophate
  • General Science & Technology
  • Cerebral Cortex
  • Brain Chemistry
 

Citation

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Schwartz, R. D., & Kellar, K. J. (1983). Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Science, 220(4593), 214–216. https://doi.org/10.1126/science.6828889
Schwartz, R. D., and K. J. Kellar. “Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo.Science 220, no. 4593 (April 8, 1983): 214–16. https://doi.org/10.1126/science.6828889.
Schwartz RD, Kellar KJ. Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Science. 1983 Apr 8;220(4593):214–6.
Schwartz, R. D., and K. J. Kellar. “Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo.Science, vol. 220, no. 4593, Apr. 1983, pp. 214–16. Pubmed, doi:10.1126/science.6828889.
Schwartz RD, Kellar KJ. Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Science. 1983 Apr 8;220(4593):214–216.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

April 8, 1983

Volume

220

Issue

4593

Start / End Page

214 / 216

Location

United States

Related Subject Headings

  • Receptors, Nicotinic
  • Receptors, Cholinergic
  • Rats, Inbred Strains
  • Rats
  • Nicotine
  • Male
  • Isoflurophate
  • General Science & Technology
  • Cerebral Cortex
  • Brain Chemistry