Skip to main content
Journal cover image

Diarrhea in patients with AIDS.

Publication ,  Journal Article
Morpeth, SC; Thielman, NM
Published in: Curr Treat Options Gastroenterol
February 2006

Diarrhea in patients with AIDS is a worldwide problem that can have a devastating impact on quality of life for the patient. Chronic diarrhea, usually defined as at least 4 weeks' duration, is more common in patients with low CD4-positive T-lymphocyte counts, signaling advanced immunosuppression. Some organisms, such as Microsporidia, usually cause diarrhea only in the immunosuppressed; others, such as Cryptosporidium, Salmonella, Shigella, and Campylobacter, which are capable of causing diarrhea in the immunocompetent population, produce more severe or prolonged infections in people living with AIDS. Familiarity with the most common pathogens in the clinician's region will help with diagnosis and treatment. Because treatment options vary widely depending upon the infectious agent, thorough microbiologic evaluation is warranted. A stepped diagnostic approach of stool cultures and specialized microscopy and stains for protozoa, followed by sigmoidoscopy or colonoscopy and duodenoscopy with biopsies for histopathological examination is recommended in all patients with persistent, disabling diarrhea who have a CD4 count of less than 200/mm3, and should be considered for those with higher counts on an individual basis. Treatment, tailored to the specific pathogen, may need to be prolonged in the most severely immunocompromised patients to prevent relapse or recrudescence. For patients taking antiretroviral therapy (especially protease inhibitors) in whom no infectious agent can be found, diarrhea may be due to the medications. Nonspecific antidiarrheal agents should be tried until one that suits the patient is found. The most essential component of any therapeutic strategy for a patient with AIDS-associated diarrhea is restoration of the underlying immunologic defect using highly active antiretroviral therapy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Curr Treat Options Gastroenterol

DOI

ISSN

1092-8472

Publication Date

February 2006

Volume

9

Issue

1

Start / End Page

23 / 37

Location

United States

Related Subject Headings

  • Gastroenterology & Hepatology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Morpeth, S. C., & Thielman, N. M. (2006). Diarrhea in patients with AIDS. Curr Treat Options Gastroenterol, 9(1), 23–37. https://doi.org/10.1007/s11938-006-0021-8
Morpeth, Susan C., and Nathan M. Thielman. “Diarrhea in patients with AIDS.Curr Treat Options Gastroenterol 9, no. 1 (February 2006): 23–37. https://doi.org/10.1007/s11938-006-0021-8.
Morpeth SC, Thielman NM. Diarrhea in patients with AIDS. Curr Treat Options Gastroenterol. 2006 Feb;9(1):23–37.
Morpeth, Susan C., and Nathan M. Thielman. “Diarrhea in patients with AIDS.Curr Treat Options Gastroenterol, vol. 9, no. 1, Feb. 2006, pp. 23–37. Pubmed, doi:10.1007/s11938-006-0021-8.
Morpeth SC, Thielman NM. Diarrhea in patients with AIDS. Curr Treat Options Gastroenterol. 2006 Feb;9(1):23–37.
Journal cover image

Published In

Curr Treat Options Gastroenterol

DOI

ISSN

1092-8472

Publication Date

February 2006

Volume

9

Issue

1

Start / End Page

23 / 37

Location

United States

Related Subject Headings

  • Gastroenterology & Hepatology