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E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.

Publication ,  Journal Article
Goulet, JL; Pace, AJ; Key, ML; Byrum, RS; Nguyen, M; Tilley, SL; Morham, SG; Langenbach, R; Stock, JL; McNeish, JD; Smithies, O; Coffman, TM ...
Published in: J Immunol
July 15, 2004

PGs are derived from arachidonic acid by PG-endoperoxide synthase (PTGS)-1 and PTGS2. Although enhanced levels of PGs are present during acute and chronic inflammation, a functional role for prostanoids in inflammation has not been clearly defined. Using a series of genetically engineered mice, we find that PTGS1 has the capacity to induce acute inflammation, but PTGS2 has negligible effects on the initiation of this response. Furthermore, we show that the contribution of PTGS1 is mediated by PGE(2) acting through the E-prostanoid (EP)3 receptor. Moreover, in the absence of EP3 receptors, inflammation is markedly attenuated, and the addition of nonsteroidal anti-inflammatory agents does not further impair the response. These studies demonstrate that PGE(2) promotes acute inflammation by activating EP3 receptors and suggest that EP3 receptors may be useful targets for anti-inflammatory therapy.

Duke Scholars

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

July 15, 2004

Volume

173

Issue

2

Start / End Page

1321 / 1326

Location

United States

Related Subject Headings

  • Skin
  • Receptors, Prostaglandin E
  • Prostaglandin-Endoperoxide Synthases
  • Mice
  • Isoenzymes
  • Inflammation
  • Indomethacin
  • Immunology
  • Dinoprostone
  • Cyclooxygenase Inhibitors
 

Citation

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MLA
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Goulet, J. L., Pace, A. J., Key, M. L., Byrum, R. S., Nguyen, M., Tilley, S. L., … Koller, B. H. (2004). E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. J Immunol, 173(2), 1321–1326. https://doi.org/10.4049/jimmunol.173.2.1321
Goulet, Jennifer L., Amy J. Pace, Mikelle L. Key, Robert S. Byrum, MyTrang Nguyen, Stephen L. Tilley, Scott G. Morham, et al. “E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.J Immunol 173, no. 2 (July 15, 2004): 1321–26. https://doi.org/10.4049/jimmunol.173.2.1321.
Goulet JL, Pace AJ, Key ML, Byrum RS, Nguyen M, Tilley SL, et al. E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. J Immunol. 2004 Jul 15;173(2):1321–6.
Goulet, Jennifer L., et al. “E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.J Immunol, vol. 173, no. 2, July 2004, pp. 1321–26. Pubmed, doi:10.4049/jimmunol.173.2.1321.
Goulet JL, Pace AJ, Key ML, Byrum RS, Nguyen M, Tilley SL, Morham SG, Langenbach R, Stock JL, McNeish JD, Smithies O, Coffman TM, Koller BH. E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. J Immunol. 2004 Jul 15;173(2):1321–1326.

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

July 15, 2004

Volume

173

Issue

2

Start / End Page

1321 / 1326

Location

United States

Related Subject Headings

  • Skin
  • Receptors, Prostaglandin E
  • Prostaglandin-Endoperoxide Synthases
  • Mice
  • Isoenzymes
  • Inflammation
  • Indomethacin
  • Immunology
  • Dinoprostone
  • Cyclooxygenase Inhibitors