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Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death.

Publication ,  Journal Article
Murtha, AP; Feng, L; Yonish, B; Leppert, PC; Schomberg, DW
Published in: Am J Obstet Gynecol
March 2007

OBJECTIVE: The purpose of this study was to determine whether progesterone exerts a protective effect in chorion and decidua cells when exposed to calcimycin. STUDY DESIGN: Fetal membrane samples were collected from term elective repeat cesarean deliveries and chorion and decidua cells that are separated and cultured. Cells were pretreated with progesterone and exposed to calcimycin. Cell viability was determined, and percent cell viability was calculated. RESULTS: Exposure to calcimycin resulted in a reduction of cell viability in both chorion and decidua cells in a dose-dependent fashion. In chorion and decidua cells, progesterone pretreatment followed by calcimycin increased cell viability compared with calcimycin treatment alone (chorion, 67%, vs controls, 24%; P < .001; decidua, 58%, vs controls, 35%; P < .001). The progesterone receptor antagonist, RTI 6413-49a, blocked the protective effect of progesterone in both chorion and decidua cells. CONCLUSION: These preliminary results suggest that progesterone may provide a protective effect in fetal membrane cells and that this effect may be mediated through the progesterone receptor.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

March 2007

Volume

196

Issue

3

Start / End Page

257.e1 / 257.e5

Location

United States

Related Subject Headings

  • Progesterone
  • Obstetrics & Reproductive Medicine
  • Humans
  • Female
  • Decidua
  • Chorion
  • Cells, Cultured
  • Cell Death
  • Calcimycin
  • 3215 Reproductive medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Murtha, A. P., Feng, L., Yonish, B., Leppert, P. C., & Schomberg, D. W. (2007). Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death. Am J Obstet Gynecol, 196(3), 257.e1-257.e5. https://doi.org/10.1016/j.ajog.2007.01.007
Murtha, Amy P., Liping Feng, Bryan Yonish, Phyllis C. Leppert, and David W. Schomberg. “Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death.Am J Obstet Gynecol 196, no. 3 (March 2007): 257.e1-257.e5. https://doi.org/10.1016/j.ajog.2007.01.007.
Murtha AP, Feng L, Yonish B, Leppert PC, Schomberg DW. Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death. Am J Obstet Gynecol. 2007 Mar;196(3):257.e1-257.e5.
Murtha, Amy P., et al. “Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death.Am J Obstet Gynecol, vol. 196, no. 3, Mar. 2007, pp. 257.e1-257.e5. Pubmed, doi:10.1016/j.ajog.2007.01.007.
Murtha AP, Feng L, Yonish B, Leppert PC, Schomberg DW. Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death. Am J Obstet Gynecol. 2007 Mar;196(3):257.e1-257.e5.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

March 2007

Volume

196

Issue

3

Start / End Page

257.e1 / 257.e5

Location

United States

Related Subject Headings

  • Progesterone
  • Obstetrics & Reproductive Medicine
  • Humans
  • Female
  • Decidua
  • Chorion
  • Cells, Cultured
  • Cell Death
  • Calcimycin
  • 3215 Reproductive medicine