Transplantation of a child with sickle cell anemia with an unrelated cord blood unit after reduced intensity conditioning.
Publication
, Journal Article
Mazur, M; Kurtzberg, J; Halperin, E; Ciocci, G; Szabolcs, P
Published in: J Pediatr Hematol Oncol
December 2006
Sickle cell disease can be corrected by hematopoietic cell transplantation but success is limited by low availability of matched related/unrelated donors and comorbidities leading to the increased transplant-related morbidity/mortality. There is a need for expanded donor pools and reduced intensity regimens. We describe a case of a second unrelated cord blood transplant after a novel preparative regimen in a child with sickle cell disease related stroke and liver fibrosis. Hydroxyurea, rituximab, and alemtuzumab were followed by thiotepa and low dose total body irradiation before unrelated cord blood transplant. Rapid full donor chimerism and improved performance status was achieved and sustained over 2 years after transplant.
Duke Scholars
Published In
J Pediatr Hematol Oncol
DOI
ISSN
1077-4114
Publication Date
December 2006
Volume
28
Issue
12
Start / End Page
840 / 844
Location
United States
Related Subject Headings
- Transplantation, Homologous
- Transplantation Conditioning
- Transplantation Chimera
- Oncology & Carcinogenesis
- Myeloablative Agonists
- Male
- Humans
- Follow-Up Studies
- Cord Blood Stem Cell Transplantation
- Child
Citation
APA
Chicago
ICMJE
MLA
NLM
Mazur, M., Kurtzberg, J., Halperin, E., Ciocci, G., & Szabolcs, P. (2006). Transplantation of a child with sickle cell anemia with an unrelated cord blood unit after reduced intensity conditioning. J Pediatr Hematol Oncol, 28(12), 840–844. https://doi.org/10.1097/MPH.0b013e31802d3e53
Mazur, Melissa, Joanne Kurtzberg, Edward Halperin, Gilbert Ciocci, and Paul Szabolcs. “Transplantation of a child with sickle cell anemia with an unrelated cord blood unit after reduced intensity conditioning.” J Pediatr Hematol Oncol 28, no. 12 (December 2006): 840–44. https://doi.org/10.1097/MPH.0b013e31802d3e53.
Mazur M, Kurtzberg J, Halperin E, Ciocci G, Szabolcs P. Transplantation of a child with sickle cell anemia with an unrelated cord blood unit after reduced intensity conditioning. J Pediatr Hematol Oncol. 2006 Dec;28(12):840–4.
Mazur, Melissa, et al. “Transplantation of a child with sickle cell anemia with an unrelated cord blood unit after reduced intensity conditioning.” J Pediatr Hematol Oncol, vol. 28, no. 12, Dec. 2006, pp. 840–44. Pubmed, doi:10.1097/MPH.0b013e31802d3e53.
Mazur M, Kurtzberg J, Halperin E, Ciocci G, Szabolcs P. Transplantation of a child with sickle cell anemia with an unrelated cord blood unit after reduced intensity conditioning. J Pediatr Hematol Oncol. 2006 Dec;28(12):840–844.
Published In
J Pediatr Hematol Oncol
DOI
ISSN
1077-4114
Publication Date
December 2006
Volume
28
Issue
12
Start / End Page
840 / 844
Location
United States
Related Subject Headings
- Transplantation, Homologous
- Transplantation Conditioning
- Transplantation Chimera
- Oncology & Carcinogenesis
- Myeloablative Agonists
- Male
- Humans
- Follow-Up Studies
- Cord Blood Stem Cell Transplantation
- Child