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Chemical and biological applications of digital-microfluidic devices

Publication ,  Journal Article
Fair, RB; Khlystov, A; Tailor, TD; Ivanov, V; Evans, RD; Srinivasan, V; Pamula, VK; Pollack, MG; Griffin, PB; Zhou, J
Published in: IEEE Design and Test of Computers
January 1, 2007

The advent of digital microfluidic lab-on-a-chip (LoC) technology offers a platform for developing diagnostic applications with the advantages of portability, reduction of the volumes of the sample and reagents, faster analysis times, increased automation, low power consumption, compatibility with mass manufacturing, and high throughput. Moreover, digital microfluidics is being applied in other areas such as airborne chemical detection, DNA sequencing by synthesis, and tissue engineering. In most diagnostic and chemical-detection applications, a key challenge is the preparation of the analyte for presentation to the on-chip detection system. Thus, in diagnostics, raw physiological samples must be introduced onto the chip and then further processed by lysing blood cells and extracting DNA. For massively parallel DNA sequencing, sample preparation can be performed off chip, but the synthesis steps must be performed in a sequential on-chip format by automated control of buffers and nucleotides to extend the read lengths of DNA fragments. In airborne particulate-sampling applications, the sample collection from an air stream must be integrated into the LoC analytical component, which requires a collection droplet to scan an exposed impacted surface after its introduction into a closed analytical section. Finally, in tissue-engineering applications, the challenge for LoC technology is to build high-resolution (less than 10 microns) 3D tissue constructs with embedded cells and growth factors by manipulating and maintaining live cells in the chip platform. This article discusses these applications and their implementation in digital-microfluidic LoC platforms. © 2007 IEEE.

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Published In

IEEE Design and Test of Computers

DOI

ISSN

0740-7475

Publication Date

January 1, 2007

Volume

24

Issue

1

Start / End Page

10 / 24

Related Subject Headings

  • Computer Hardware & Architecture
  • 4009 Electronics, sensors and digital hardware
  • 1006 Computer Hardware
  • 0906 Electrical and Electronic Engineering
 

Citation

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Fair, R. B., Khlystov, A., Tailor, T. D., Ivanov, V., Evans, R. D., Srinivasan, V., … Zhou, J. (2007). Chemical and biological applications of digital-microfluidic devices. IEEE Design and Test of Computers, 24(1), 10–24. https://doi.org/10.1109/MDT.2007.8
Fair, R. B., A. Khlystov, T. D. Tailor, V. Ivanov, R. D. Evans, V. Srinivasan, V. K. Pamula, M. G. Pollack, P. B. Griffin, and J. Zhou. “Chemical and biological applications of digital-microfluidic devices.” IEEE Design and Test of Computers 24, no. 1 (January 1, 2007): 10–24. https://doi.org/10.1109/MDT.2007.8.
Fair RB, Khlystov A, Tailor TD, Ivanov V, Evans RD, Srinivasan V, et al. Chemical and biological applications of digital-microfluidic devices. IEEE Design and Test of Computers. 2007 Jan 1;24(1):10–24.
Fair, R. B., et al. “Chemical and biological applications of digital-microfluidic devices.” IEEE Design and Test of Computers, vol. 24, no. 1, Jan. 2007, pp. 10–24. Scopus, doi:10.1109/MDT.2007.8.
Fair RB, Khlystov A, Tailor TD, Ivanov V, Evans RD, Srinivasan V, Pamula VK, Pollack MG, Griffin PB, Zhou J. Chemical and biological applications of digital-microfluidic devices. IEEE Design and Test of Computers. 2007 Jan 1;24(1):10–24.

Published In

IEEE Design and Test of Computers

DOI

ISSN

0740-7475

Publication Date

January 1, 2007

Volume

24

Issue

1

Start / End Page

10 / 24

Related Subject Headings

  • Computer Hardware & Architecture
  • 4009 Electronics, sensors and digital hardware
  • 1006 Computer Hardware
  • 0906 Electrical and Electronic Engineering