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Frequency and predictors of de novo hepatocellular carcinoma in patients awaiting orthotopic liver transplantation during the model for end-stage liver disease era.

Publication ,  Journal Article
Brady, CW; Smith, AD; Stechuchak, KM; Coffman, CJ; Tuttle-Newhall, JE; Provenzale, D; Muir, AJ
Published in: Liver Transpl
February 2008

In the current system of allocation, patients awaiting orthotopic liver transplantation (OLT) remain at risk of developing de novo hepatocellular carcinoma (HCC) and removal from the waiting list. Using the United Network for Organ Sharing database, we calculated the rate and identified predictors of de novo HCC in patients listed for OLT between February 2002 and December 2004. Among 8566 patients, 1167 (13.6%) developed de novo HCC. Predictors of increased odds of de novo HCC were older age, male gender, Asian race, other race, hepatitis C, and hepatitis B. A sensitivity analysis of 2067 patients waiting at least 6 months found that 16.2% developed de novo HCC. Older age [odds ratio (OR) 1.05; 95% confidence interval (CI) 1.03, 1.07], male gender (OR 2.01; 95% CI 1.49, 2.71), Asian race (OR 2.39; 95% CI 1.20, 4.76), other race (OR 1.94; 95% CI 1.40, 2.68), hepatitis C (OR 2.36; 95% CI 1.76, 3.16), and hepatitis B (OR 1.96; 95% CI 1.19, 3.23) remained predictors of increased odds of de novo HCC, and alcoholic liver disease (OR 1.40; 95% CI 1.06, 1.86) emerged as a predictor of increased odds of de novo HCC. A significant proportion of patients listed for OLT develop de novo HCC. Identifying predictors of HCC in these patients may facilitate timely HCC screening and diagnosis.

Duke Scholars

Published In

Liver Transpl

DOI

ISSN

1527-6465

Publication Date

February 2008

Volume

14

Issue

2

Start / End Page

228 / 234

Location

United States

Related Subject Headings

  • Waiting Lists
  • United States
  • Tissue and Organ Procurement
  • Time Factors
  • Surgery
  • Sex Factors
  • Risk Factors
  • Risk Assessment
  • Odds Ratio
  • Models, Biological
 

Citation

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ICMJE
MLA
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Brady, C. W., Smith, A. D., Stechuchak, K. M., Coffman, C. J., Tuttle-Newhall, J. E., Provenzale, D., & Muir, A. J. (2008). Frequency and predictors of de novo hepatocellular carcinoma in patients awaiting orthotopic liver transplantation during the model for end-stage liver disease era. Liver Transpl, 14(2), 228–234. https://doi.org/10.1002/lt.21346
Brady, Carla W., Alastair D. Smith, Karen M. Stechuchak, Cynthia J. Coffman, Janet E. Tuttle-Newhall, Dawn Provenzale, and Andrew J. Muir. “Frequency and predictors of de novo hepatocellular carcinoma in patients awaiting orthotopic liver transplantation during the model for end-stage liver disease era.Liver Transpl 14, no. 2 (February 2008): 228–34. https://doi.org/10.1002/lt.21346.
Brady CW, Smith AD, Stechuchak KM, Coffman CJ, Tuttle-Newhall JE, Provenzale D, et al. Frequency and predictors of de novo hepatocellular carcinoma in patients awaiting orthotopic liver transplantation during the model for end-stage liver disease era. Liver Transpl. 2008 Feb;14(2):228–34.
Brady, Carla W., et al. “Frequency and predictors of de novo hepatocellular carcinoma in patients awaiting orthotopic liver transplantation during the model for end-stage liver disease era.Liver Transpl, vol. 14, no. 2, Feb. 2008, pp. 228–34. Pubmed, doi:10.1002/lt.21346.
Brady CW, Smith AD, Stechuchak KM, Coffman CJ, Tuttle-Newhall JE, Provenzale D, Muir AJ. Frequency and predictors of de novo hepatocellular carcinoma in patients awaiting orthotopic liver transplantation during the model for end-stage liver disease era. Liver Transpl. 2008 Feb;14(2):228–234.
Journal cover image

Published In

Liver Transpl

DOI

ISSN

1527-6465

Publication Date

February 2008

Volume

14

Issue

2

Start / End Page

228 / 234

Location

United States

Related Subject Headings

  • Waiting Lists
  • United States
  • Tissue and Organ Procurement
  • Time Factors
  • Surgery
  • Sex Factors
  • Risk Factors
  • Risk Assessment
  • Odds Ratio
  • Models, Biological