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Prostate cancer laterality does not predict prostate-specific antigen recurrence after radical prostatectomy.

Publication ,  Journal Article
Mouraviev, V; Sun, L; Madden, JF; Mayes, JM; Moul, JW; Polascik, TJ
Published in: Urology
December 2007

OBJECTIVES: To evaluate biologic behaviors of unilateral cancers compared with bilateral cancers on prostate-specific antigen (PSA) recurrence after radical prostatectomy. METHODS: Analysis included demographic, clinical, and pathologic parameters of 1184 men who underwent RP for clinically localized prostate cancer at our institution between 2002 and 2006. Final pathologic assessment was performed with particular attention to laterality and percentage of tumor involvement, along with other routine parameters. On the basis of percentage of tumor involvement, all cancer foci were ranked as 5% or less, 5.01% to 10%, 10.01% to 15%, or greater than 15%. Statistical analysis was performed with univariate and multivariate methods. RESULTS: Overall, 19.2% of 1184 patients had completely unilateral cancers. Prostate-specific antigen recurrence was revealed in 164 of 1184 patients (13.9%) at a mean (+/- standard deviation) follow-up of 2.7 +/- 2.4 years. Among men who had recurrence, 26 of 227 (11.5%) had unilateral tumors and 138 of 957 (14.4%) had bilateral disease (P = 0.25). The most common characteristics associated with PSA recurrence of unilateral tumors in the Cox model were diagnostic PSA level, prostate weight, and pathologic Gleason score (P <0.05). CONCLUSIONS: Unilateral or bilateral prostate cancer did not predict PSA recurrence in men receiving radical prostatectomy. In contrast, baseline PSA level and pathologic Gleason score strongly predicted PSA recurrence.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

December 2007

Volume

70

Issue

6

Start / End Page

1141 / 1145

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prostatectomy
  • Prostate-Specific Antigen
  • Middle Aged
  • Male
  • Humans
  • Aged
  • Adult
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Mouraviev, V., Sun, L., Madden, J. F., Mayes, J. M., Moul, J. W., & Polascik, T. J. (2007). Prostate cancer laterality does not predict prostate-specific antigen recurrence after radical prostatectomy. Urology, 70(6), 1141–1145. https://doi.org/10.1016/j.urology.2007.07.066
Mouraviev, Vladimir, Leon Sun, John F. Madden, Janice M. Mayes, Judd W. Moul, and Thomas J. Polascik. “Prostate cancer laterality does not predict prostate-specific antigen recurrence after radical prostatectomy.Urology 70, no. 6 (December 2007): 1141–45. https://doi.org/10.1016/j.urology.2007.07.066.
Mouraviev V, Sun L, Madden JF, Mayes JM, Moul JW, Polascik TJ. Prostate cancer laterality does not predict prostate-specific antigen recurrence after radical prostatectomy. Urology. 2007 Dec;70(6):1141–5.
Mouraviev, Vladimir, et al. “Prostate cancer laterality does not predict prostate-specific antigen recurrence after radical prostatectomy.Urology, vol. 70, no. 6, Dec. 2007, pp. 1141–45. Pubmed, doi:10.1016/j.urology.2007.07.066.
Mouraviev V, Sun L, Madden JF, Mayes JM, Moul JW, Polascik TJ. Prostate cancer laterality does not predict prostate-specific antigen recurrence after radical prostatectomy. Urology. 2007 Dec;70(6):1141–1145.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

December 2007

Volume

70

Issue

6

Start / End Page

1141 / 1145

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prostatectomy
  • Prostate-Specific Antigen
  • Middle Aged
  • Male
  • Humans
  • Aged
  • Adult
  • 3202 Clinical sciences