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Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide.

Publication ,  Journal Article
Ahmed, A; Fujisawa, T; Niu, X-L; Ahmad, S; Al-Ani, B; Chudasama, K; Abbas, A; Potluri, R; Bhandari, V; Findley, CM; Lam, GKW; Huang, J ...
Published in: Circ Res
June 19, 2009

Atherosclerosis is promoted by a combination of hypercholesterolemia and vascular inflammation. The function of Angiopoietin (Ang)-2, a key regulator of angiogenesis, in the maintenance of large vessels is unknown. A single systemic administration of Ang-2 adenovirus (AdAng-2) to apoE(-/-) mice fed a Western diet significantly reduced atherosclerotic lesion size ( approximately 40%) and oxidized LDL and macrophage content of the plaques. These beneficial effects were abolished by the inhibition of nitric oxide synthase (NOS). In endothelial cells, endothelial NOS activation per se inhibited LDL oxidation and Ang-2 stimulated NO release in a Tie2-dependent manner to decrease LDL oxidation. These findings demonstrate a novel atheroprotective role for Ang-2 when endothelial cell function is compromised and suggest that growth factors, which stimulate NO release without inducing inflammation, could offer atheroprotection.

Duke Scholars

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

June 19, 2009

Volume

104

Issue

12

Start / End Page

1333 / 1336

Location

United States

Related Subject Headings

  • Vasculitis
  • Transduction, Genetic
  • Receptor, TIE-2
  • Oxidation-Reduction
  • Nitric Oxide Synthase Type III
  • Nitric Oxide
  • Neovascularization, Physiologic
  • Mice, Knockout
  • Mice
  • Male
 

Citation

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Chicago
ICMJE
MLA
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Ahmed, A., Fujisawa, T., Niu, X.-L., Ahmad, S., Al-Ani, B., Chudasama, K., … Kontos, C. D. (2009). Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. Circ Res, 104(12), 1333–1336. https://doi.org/10.1161/CIRCRESAHA.109.196154
Ahmed, Asif, Takeshi Fujisawa, Xi-Lin Niu, Shakil Ahmad, Bahjat Al-Ani, Kunal Chudasama, Allyah Abbas, et al. “Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide.Circ Res 104, no. 12 (June 19, 2009): 1333–36. https://doi.org/10.1161/CIRCRESAHA.109.196154.
Ahmed A, Fujisawa T, Niu X-L, Ahmad S, Al-Ani B, Chudasama K, et al. Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. Circ Res. 2009 Jun 19;104(12):1333–6.
Ahmed, Asif, et al. “Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide.Circ Res, vol. 104, no. 12, June 2009, pp. 1333–36. Pubmed, doi:10.1161/CIRCRESAHA.109.196154.
Ahmed A, Fujisawa T, Niu X-L, Ahmad S, Al-Ani B, Chudasama K, Abbas A, Potluri R, Bhandari V, Findley CM, Lam GKW, Huang J, Hewett PW, Cudmore M, Kontos CD. Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. Circ Res. 2009 Jun 19;104(12):1333–1336.

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

June 19, 2009

Volume

104

Issue

12

Start / End Page

1333 / 1336

Location

United States

Related Subject Headings

  • Vasculitis
  • Transduction, Genetic
  • Receptor, TIE-2
  • Oxidation-Reduction
  • Nitric Oxide Synthase Type III
  • Nitric Oxide
  • Neovascularization, Physiologic
  • Mice, Knockout
  • Mice
  • Male