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Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.

Publication ,  Journal Article
Månsson, S; Wolber, J; Driehuys, B; Wollmer, P; Golman, K
Published in: Magn Reson Med
December 2003

The ability to quantify pulmonary diffusing capacity and perfusion using dynamic hyperpolarized (129)Xe NMR spectroscopy is demonstrated. A model of alveolar gas exchange was developed, which, in conjunction with (129)Xe NMR, enables quantification of average alveolar wall thickness, pulmonary perfusion, capillary diffusion length, and mean transit time. The technique was employed to compare a group of naïve rats (n = 10) with a group of rats with acute inflammatory lung injury (n = 10), caused by instillation of lipopolysaccaride (LPS). The measured structural and perfusion-related parameters were in agreement with reported values from studies using non-NMR methods. Significant differences between the groups were found in total diffusion length (control 8.5 +/- 0.5 microm, LPS 9.9 +/- 0.6 microm, P < 0.001), in capillary diffusion length (control 2.9 +/- 0.4 microm, LPS 3.9 +/- 1.0 microm, P < 0.05), and in pulmonary hematocrit (control 0.55 +/- 0.06, LPS 0.43 +/- 0.08, P < 0.01), whereas no differences were observed in alveolar wall thickness, pulmonary perfusion, and mean transit time. These results demonstrate the ability of the method to distinguish two main aspects of lung function, namely, diffusing capacity and pulmonary perfusion.

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Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

December 2003

Volume

50

Issue

6

Start / End Page

1170 / 1179

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Respiratory Distress Syndrome
  • Rats, Wistar
  • Rats
  • Pulmonary Diffusing Capacity
  • Pulmonary Circulation
  • Pulmonary Alveoli
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Spectroscopy
 

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Månsson, S., Wolber, J., Driehuys, B., Wollmer, P., & Golman, K. (2003). Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. Magn Reson Med, 50(6), 1170–1179. https://doi.org/10.1002/mrm.10649
Månsson, Sven, Jan Wolber, Bastiaan Driehuys, Per Wollmer, and Klaes Golman. “Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.Magn Reson Med 50, no. 6 (December 2003): 1170–79. https://doi.org/10.1002/mrm.10649.
Månsson S, Wolber J, Driehuys B, Wollmer P, Golman K. Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. Magn Reson Med. 2003 Dec;50(6):1170–9.
Månsson, Sven, et al. “Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.Magn Reson Med, vol. 50, no. 6, Dec. 2003, pp. 1170–79. Pubmed, doi:10.1002/mrm.10649.
Månsson S, Wolber J, Driehuys B, Wollmer P, Golman K. Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. Magn Reson Med. 2003 Dec;50(6):1170–1179.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

December 2003

Volume

50

Issue

6

Start / End Page

1170 / 1179

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Respiratory Distress Syndrome
  • Rats, Wistar
  • Rats
  • Pulmonary Diffusing Capacity
  • Pulmonary Circulation
  • Pulmonary Alveoli
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Spectroscopy