Overview
Our research focuses on magnetic resonance imaging (MRI) research with hyperpolarized 129Xe gas. We are at at the forefront of developing this novel technology for imaging the lungs of patients with pulmonary disease. We currently have multiple, ongoing NIH and industry-sponsored studies invovling this technique. Hyperpolarization is a laser-based process that enhances the MRI signal of xenon gas by a factor of 100,000 to allow for high-resolution, non-invasive MRI of pulmonary function. In addition to our research program, this technology was recently FDA approved and efforts are underway to implement it clinically.
Current studies are applying 129Xe MRI for early diagnosis and monitoring of interstitial and pulmonary vascular diseases. Our group, which is comprised of MRI scientists and radiologists, works closely with colleagues in pulmonary medicine. Our laboratory provides research opportunities to Ph.D., Masters, and medical students as well as select undergraduate students.
Current Appointments & Affiliations
Recent Publications
Design and Implementation of a Multi-Center Trial of 129Xe Gas Exchange MRI and MRS to Evaluate Longitudinal Progression of COPD.
Journal Article J Magn Reson Imaging · December 2025 MR imaging holds the potential to enhance drug development efficiency by de-risking early phase studies and increasing confidence in results. It can improve patient selection, increase repeatability, and provide greater sensitivity to change, thereby enabl ... Full text Link to item CiteThe emerging role of hyperpolarized 129Xe MRI in pulmonary hypertension.
Journal Article Expert Rev Respir Med · December 2025 Full text Link to item CiteEstablishing standardized healthy reference distributions and values for multisite 129Xe gas exchange MRI/MR spectroscopy at 3 T across major scanner platforms.
Journal Article Magn Reson Med · October 2025 PURPOSE: To establish standardized reference distributions and values for 1-point Dixon 129Xe gas exchange MRI/MR spectroscopy (MRS) in a multicenter healthy cohort of 18-30-year-olds scanned on three major 3T platforms. These distributions and values enab ... Full text Link to item CiteRecent Grants
Dissolved Phased Hyperpolarized Xenon-129 MRI: a novel biomarker to quantify pulmonary pathology in young healthy e-cigarette users
ResearchPrincipal Investigator · Awarded by University of Virginia - Charlottesville · 2024 - 2029Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI
ResearchPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2011 - 2027Xenon MRI in Pulmonary Hypertension
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2026View All Grants