Bastiaan Driehuys | Scholars@Duke

Bastiaan Driehuys
Professor of Radiology

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Current Appointments & Affiliations

Professor of Radiology, Radiology, Clinical Science Departments 2018
Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2019

Contact Information

161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Box 3302 Med Ctr, Durham, NC 27710
bastiaan.driehuys@duke.edu (919) 684-7786
Google Scholar

Background
Education, Training, & Certifications
- Ph.D., Princeton University 1995
Previous Appointments & Affiliations
- Professor of Physics, Physics, Trinity College of Arts & Sciences 2016 - 2022
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2013 - 2019
- Professor of Radiology, Radiology, Clinical Science Departments 2015 - 2018
- Associate Research Professor in the Department of Physics, Physics, Trinity College of Arts & Sciences 2013 - 2016
- Associate Professor in the Department of Radiology, Radiology, Clinical Science Departments 2009 - 2015
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2009 - 2013
- Assistant Professor in Radiology, Radiology, Clinical Science Departments 2006 - 2009
- Assistant Research Professor in Radiology, Radiology, Clinical Science Departments 2005 - 2006
- Instructor, Temporary of Radiology, Radiology, Clinical Science Departments 2004 - 2005
Expertise
Subject Headings
Research
Selected Grants
- Pulmonary Structure and Function with Hyperpolarized 129Xe Magnetic Resonance Imaging in Patients with Pulmonary Hypertension awarded by American Heart Association 2023 - 2026
- Xenon MRI in Pulmonary Hypertension awarded by National Institutes of Health 2021 - 2025
- Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary Fibrosis awarded by National Institutes of Health 2015 - 2025
- Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma awarded by National Institutes of Health 2020 - 2024
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2024
- Core Lab for Genentech 129Xe MRI Study of COPD Patients Receiving Azithromycin awarded by Genentech, Inc. 2020 - 2023
- Assessing Response to Inhaled Prostacyclin with Hyperpolarized 129Xe MRI awarded by United Therapeutics Corporation 2017 - 2022
- Data-driven Approaches to Healthcare Provider Resilience & Burnout during COVID-19 awarded by Department of Defense 2021 - 2022
- Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI awarded by National Institutes of Health 2011 - 2022
- Pilot Study to Determine Health Effects of e-cigarette in Healthy Young Adults. awarded by University of Virginia - Charlottesville 2020 - 2022
- Hyperpolarized 129Xe MR Imaging of the Lung Function in Healthy Volunteers and Subjects with Pulmonary Disease awarded by Siemens Medical Solutions USA, Inc. 2016 - 2021
- Utilization of HP 129XE for Diagnosis in Pulmonary Fibrosis awarded by Radiological Society of North America 2018 - 2021
- Non-invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe MRI awarded by National Institutes of Health 2016 - 2020
- Training in Medical Imaging awarded by National Institutes of Health 2003 - 2020
- Detecting ventilation and gas exchange abnormalities by 129Xe MRI in alpha-1 antitrypsin carriers awarded by CSL Behring LLC 2016 - 2019
- Human Lung Regional Ventilation Defect Severity Measured by Fluorine-19 Gas MRI awarded by National Institutes of Health 2012 - 2018
- Quantitative 129Xe Gas Exchange MRI for Idiopathic Pulmonary Fibrosis awarded by Gilead Sciences, Inc. 2015 - 2017
- Sensitive and Specific Molecular Imaging of Pulmonary Nodules awarded by National Institutes of Health 2010 - 2016
- Time-Resolved 129Xe Ventilation-Perfusion MRI in Rat Models of Acute Lung Injury awarded by National Institutes of Health 2012 - 2014
- Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health 2012 - 2013
- Cross-disciplinary Training in Medical Physics awarded by National Institutes of Health 2007 - 2013
- Hyperpolarized 129Xe Imaging of Pulmonary Gas Exchange awarded by National Institutes of Health 2007 - 2010
External Relationships
- Polarean
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Bechtel, Aryil, Junlan Lu, David Mummy, Elianna Bier, Suphachart Leewiwatwong, John Mugler, Sakib Kabir, Alex Church, and Bastiaan Driehuys. “Establishing a hemoglobin adjustment for 129 Xe gas exchange MRI and MRS.” Magn Reson Med, May 29, 2023. https://doi.org/10.1002/mrm.29712.
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  - “Erratum: Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.” Annals of the American Thoracic Society 20, no. 4 (April 2023): 620–620. https://doi.org/10.1513/annalsats.v20erratum4.
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  - Hsia, Connie C. W., Jason H. T. Bates, Bastiaan Driehuys, Sean B. Fain, Jonathan G. Goldin, Eric A. Hoffman, James C. Hogg, et al. “Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.” Ann Am Thorac Soc 20, no. 2 (February 2023): 161–95. https://doi.org/10.1513/AnnalsATS.202211-915ST.
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  - Subashi, Ergys, Li Feng, Yilin Liu, Scott Robertson, Paul Segars, Bastiaan Driehuys, Christopher R. Kelsey, Fang-Fang Yin, Ricardo Otazo, and Jing Cai. “View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy.” Phys Imaging Radiat Oncol 25 (January 2023): 100409. https://doi.org/10.1016/j.phro.2022.12.006.
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  - Matheson, Alexander M., Marrissa J. McIntosh, Harkiran K. Kooner, Justin Lee, Vedanth Desaigoudar, Elianna Bier, Bastiaan Driehuys, et al. “Persistent 129Xe MRI Pulmonary and CT Vascular Abnormalities in Symptomatic Individuals with Post-acute COVID-19 Syndrome.” Radiology 305, no. 2 (November 2022): 466–76. https://doi.org/10.1148/radiol.220492.
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  - O’Sullivan-Murphy, Bryan, Bastiaan Driehuys, and Joseph Mammarappallil. “MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We?” Radiol Clin North Am 60, no. 6 (November 2022): 1021–32. https://doi.org/10.1016/j.rcl.2022.06.007.
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  - Willmering, Matthew M., Laura L. Walkup, Peter J. Niedbalski, Hui Wang, Ziyi Wang, Erik B. Hysinger, Kasiani C. Myers, et al. “Pediatric 129 Xe Gas-Transfer MRI-Feasibility and Applicability.” J Magn Reson Imaging 56, no. 4 (October 2022): 1207–19. https://doi.org/10.1002/jmri.28136.
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  - Lu, Junlan, Ziyi Wang, Elianna Bier, Suphachart Leewiwatwong, David Mummy, and Bastiaan Driehuys. “Bias field correction in hyperpolarized 129 Xe ventilation MRI using templates derived by RF-depolarization mapping.” Magn Reson Med 88, no. 2 (August 2022): 802–16. https://doi.org/10.1002/mrm.29254.
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  - Niedbalski, Peter J., Junlan Lu, Chase S. Hall, Mario Castro, John P. Mugler, Yun M. Shim, and Bastiaan Driehuys. “Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging.” Magn Reson Med 87, no. 3 (March 2022): 1490–99. https://doi.org/10.1002/mrm.29040.
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  - Kooner, Harkiran K., Marrissa J. McIntosh, Vedanth Desaigoudar, Jonathan H. Rayment, Rachel L. Eddy, Bastiaan Driehuys, and Grace Parraga. “Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life.” Respirology 27, no. 2 (February 2022): 114–33. https://doi.org/10.1111/resp.14197.
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  - Barton, A. S., N. R. Newbury, G. D. Cates, B. Driehuys, H. Middleton, and B. Saam. “Erratum: Self-calibrating measurement of polarization-dependent frequency shifts from Rb- He3 collisions [Phys. Rev. A 49 , 2766 (1994)].” Physical Review A 104, no. 6 (December 17, 2021). https://doi.org/10.1103/physreva.104.069904.
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  - Niedbalski, Peter J., Chase S. Hall, Mario Castro, Rachel L. Eddy, Jonathan H. Rayment, Sarah Svenningsen, Grace Parraga, et al. “Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium.” Magn Reson Med 86, no. 6 (December 2021): 2966–86. https://doi.org/10.1002/mrm.28985.
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  - Rankine, Leith J., Ziyi Wang, Chris R. Kelsey, Elianna Bier, Bastiaan Driehuys, Lawrence B. Marks, and Shiva K. Das. “Hyperpolarized 129Xe Magnetic Resonance Imaging for Functional Avoidance Treatment Planning in Thoracic Radiation Therapy: A Comparison of Ventilation- and Gas Exchange-Guided Treatment Plans.” Int J Radiat Oncol Biol Phys 111, no. 4 (November 15, 2021): 1044–57. https://doi.org/10.1016/j.ijrobp.2021.07.002.
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  - Mummy, David G., Elianna A. Bier, Ziyi Wang, Jennifer Korzekwinski, Lake Morrison, Christina Barkauskas, H Page McAdams, Robert M. Tighe, Bastiaan Driehuys, and Joseph G. Mammarappallil. “Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia.” Radiology 301, no. 1 (October 2021): 211–20. https://doi.org/10.1148/radiol.2021204149.
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  - Mummy, David G., Erika M. Coleman, Ziyi Wang, Elianna A. Bier, Junlan Lu, Bastiaan Driehuys, and Yuh-Chin Huang. “Regional Gas Exchange Measured by ¹²⁹ Xe Magnetic Resonance Imaging Before and After Combination Bronchodilators Treatment in Chronic Obstructive Pulmonary Disease.” Journal of Magnetic Resonance Imaging : Jmri 54, no. 3 (September 2021): 964–74. https://doi.org/10.1002/jmri.27662.
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  - Wang, Ziyi, Leith Rankine, Elianna A. Bier, David Mummy, Junlan Lu, Alex Church, Robert M. Tighe, et al. “Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity.” J Appl Physiol (1985) 130, no. 5 (May 1, 2021): 1398–1409. https://doi.org/10.1152/japplphysiol.00702.2020.
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  - Huang, Yuh-Chin Tony, Marion Wencker, and Bastiaan Driehuys. “Imaging in alpha-1 antitrypsin deficiency: a window into the disease.” Ther Adv Chronic Dis 12_suppl (2021): 20406223211024524. https://doi.org/10.1177/20406223211024523.
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  - He, Mu, Ziyi Wang, Leith Rankine, Sheng Luo, John Nouls, Rohan Virgincar, Joseph Mammarappallil, and Bastiaan Driehuys. “Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI.” Acad Radiol 27, no. 8 (August 2020): e193–203. https://doi.org/10.1016/j.acra.2019.10.016.
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  - Niedbalski, Peter J., Elianna A. Bier, Ziyi Wang, Matthew M. Willmering, Bastiaan Driehuys, and Zackary I. Cleveland. “Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved 129Xe MRI.” J Appl Physiol (1985) 129, no. 2 (August 1, 2020): 218–29. https://doi.org/10.1152/japplphysiol.00186.2020.
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  - Mummy, David, and Bastiaan Driehuys. “Illuminating Lung Inflammation at the Alveolar Capillary Interface.” J Magn Reson Imaging 51, no. 6 (June 2020): 1677–78. https://doi.org/10.1002/jmri.27086.
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  - Virgincar, Rohan S., John C. Nouls, Ziyi Wang, Simone Degan, Yi Qi, Xinyu Xiong, Sudarshan Rajagopal, and Bastiaan Driehuys. “Quantitative 129Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension.” Sci Rep 10, no. 1 (April 30, 2020): 7385. https://doi.org/10.1038/s41598-020-64361-1.
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  - Rankine, Leith J., Ziyi Wang, Jennifer M. Wang, Mu He, H Page McAdams, Joseph Mammarappallil, Craig R. Rackley, Bastiaan Driehuys, and Robert M. Tighe. “129Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis.” Ann Am Thorac Soc 17, no. 1 (January 2020): 121–25. https://doi.org/10.1513/AnnalsATS.201905-413RL.
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  - Wang, Ziyi, Elianna A. Bier, Aparna Swaminathan, Kishan Parikh, John Nouls, Mu He, Joseph G. Mammarappallil, Sheng Luo, Bastiaan Driehuys, and Sudarshan Rajagopal. “Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures.” Eur Respir J 54, no. 6 (December 2019). https://doi.org/10.1183/13993003.00831-2019.
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  - Bier, Elianna A., John C. Nouls, Ziyi Wang, Mu He, Geoff Schrank, Naomi Morales-Medina, Ralph Hashoian, Harvey Svetlik, John P. Mugler, and Bastiaan Driehuys. “A thermally polarized 129 Xe phantom for quality assurance in multi-center hyperpolarized gas MRI studies.” Magn Reson Med 82, no. 5 (November 2019): 1961–68. https://doi.org/10.1002/mrm.27836.
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  - He, Mu, Wei Zha, Fei Tan, Leith Rankine, Sean Fain, and Bastiaan Driehuys. “A Comparison of Two Hyperpolarized 129Xe MRI Ventilation Quantification Pipelines: The Effect of Signal to Noise Ratio.” Acad Radiol 26, no. 7 (July 2019): 949–59. https://doi.org/10.1016/j.acra.2018.08.015.
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  - Ebner, Lukas, Rohan S. Virgincar, Mu He, Kingshuk R. Choudhury, Scott H. Robertson, Andreas Christe, Achille Mileto, et al. “Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI.” Ajr Am J Roentgenol 212, no. 4 (April 2019): 758–65. https://doi.org/10.2214/AJR.18.20036.
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  - Nouls, John C., Rohan S. Virgincar, Alexander G. Culbert, Nathann Morand, Dana W. Bobbert, Anne D. Yoder, Robert S. Schopler, et al. “Applications of 3D printing in small animal magnetic resonance imaging.” J Med Imaging (Bellingham) 6, no. 2 (April 2019): 021605. https://doi.org/10.1117/1.JMI.6.2.021605.
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  - Mammarappallil, Joseph G., Leith Rankine, Jim M. Wild, and Bastiaan Driehuys. “New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging.” J Thorac Imaging 34, no. 2 (March 2019): 136–50. https://doi.org/10.1097/RTI.0000000000000392.
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  - Bier, Elianna A., Scott H. Robertson, Geoffry M. Schrank, Craig Rackley, Joseph G. Mammarappallil, Sudarshan Rajagopal, H Page McAdams, and Bastiaan Driehuys. “A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis.” Nmr Biomed 32, no. 1 (January 2019): e4029. https://doi.org/10.1002/nbm.4029.
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  - Wang, Ziyi, Mu He, Elianna Bier, Leith Rankine, Geoffry Schrank, Sudarshan Rajagopal, Yuh-Chin Huang, et al. “Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T.” Magn Reson Med 80, no. 6 (December 2018): 2374–83. https://doi.org/10.1002/mrm.27377.
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  - Virgincar, Rohan S., Jerry Dahlke, Scott H. Robertson, Nathann Morand, Yi Qi, Simone Degan, Bastiaan Driehuys, and John C. Nouls. “A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents.” J Magn Reson 295 (October 2018): 63–71. https://doi.org/10.1016/j.jmr.2018.07.017.
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  - Rankine, Leith J., Ziyi Wang, Bastiaan Driehuys, Lawrence B. Marks, Chris R. Kelsey, and Shiva K. Das. “Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning.” Int J Radiat Oncol Biol Phys 101, no. 5 (August 1, 2018): 1113–22. https://doi.org/10.1016/j.ijrobp.2018.04.017.
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  - Song, Erin J., Chris R. Kelsey, Bastiaan Driehuys, and Leith Rankine. “Functional airway obstruction observed with hyperpolarized 129 Xenon-MRI.” J Med Imaging Radiat Oncol 62, no. 1 (February 2018): 91–93. https://doi.org/10.1111/1754-9485.12660.
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  - Wang, Jennifer M., Scott H. Robertson, Ziyi Wang, Mu He, Rohan S. Virgincar, Geoffry M. Schrank, Rose Marie Smigla, et al. “Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis.” Thorax 73, no. 1 (January 2018): 21–28. https://doi.org/10.1136/thoraxjnl-2017-210070.
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  - Robertson, Scott H., Rohan S. Virgincar, Elianna A. Bier, Mu He, Geoffrey M. Schrank, Rose Marie Smigla, Craig Rackley, H Page McAdams, and Bastiaan Driehuys. “Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis.” Magn Reson Med 78, no. 4 (October 2017): 1306–15. https://doi.org/10.1002/mrm.26533.
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  - Flower, C., M. S. Freeman, M. Plue, and B. Driehuys. “Electron microscopic observations of Rb particles and pitting in 129Xe spin-exchange optical pumping cells.” J Appl Phys 122, no. 2 (July 14, 2017): 024902. https://doi.org/10.1063/1.4991642.
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  - Mahmood, K., L. Ebner, M. He, S. H. Robertson, Z. Wang, H. P. McAdams, M. M. Wahidi, S. L. Shofer, Y. T. Huang, and B. Driehuys. “Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients.” Am J Transplant 17, no. 7 (July 2017): 1895–1904. https://doi.org/10.1111/ajt.14287.
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  - Wang, Ziyi, Scott Haile Robertson, Jennifer Wang, Mu He, Rohan S. Virgincar, Geoffry M. Schrank, Elianna A. Bier, et al. “Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI.” Med Phys 44, no. 6 (June 2017): 2415–28. https://doi.org/10.1002/mp.12264.
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  - House, John S., Cody E. Nichols, Huiling Li, Christina Brandenberger, Rohan S. Virgincar, Laura M. DeGraff, Bastiaan Driehuys, Darryl C. Zeldin, and Stephanie J. London. “Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice.” Am J Physiol Lung Cell Mol Physiol 312, no. 4 (April 1, 2017): L520–30. https://doi.org/10.1152/ajplung.00495.2016.
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  - Virgincar, Rohan S., Scott H. Robertson, John Nouls, Simone Degan, Geoffry M. Schrank, Mu He, and Bastiaan Driehuys. “Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo.” Magn Reson Med 77, no. 4 (April 2017): 1438–45. https://doi.org/10.1002/mrm.26229.
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  - Ebner, Lukas, Mu He, Rohan S. Virgincar, Timothy Heacock, Suryanarayanan S. Kaushik, Matthew S. Freemann, H Page McAdams, Monica Kraft, and Bastiaan Driehuys. “Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests.” Invest Radiol 52, no. 2 (February 2017): 120–27. https://doi.org/10.1097/RLI.0000000000000322.
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  - Driehuys, Bastiaan. “Crossing the Chasm(s): Demonstrating the Clinical Value of Hyperpolarized Gas MRI.” Acad Radiol 24, no. 1 (January 2017): 1–3. https://doi.org/10.1016/j.acra.2016.11.002.
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  - Ebner, Lukas, Jeff Kammerman, Bastiaan Driehuys, Mark L. Schiebler, Robert V. Cadman, and Sean B. Fain. “The role of hyperpolarized 129xenon in MR imaging of pulmonary function.” Eur J Radiol 86 (January 2017): 343–52. https://doi.org/10.1016/j.ejrad.2016.09.015.
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  - He, Mu, Bastiaan Driehuys, Loretta G. Que, and Yuh-Chin T. Huang. “Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution.” Acad Radiol 23, no. 12 (December 2016): 1521–31. https://doi.org/10.1016/j.acra.2016.07.014.
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  - Subashi, E., Y. Liu, S. Robertson, P. Segars, B. Driehuys, F. Yin, and J. Cai. “TH-EF-BRA-10: High Spatiotemporal Resolution Self-Sorted 4D MRI.” Med Phys 43, no. 6 (June 2016): 3899. https://doi.org/10.1118/1.4958267.
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  - Kaushik, S Sivaram, Scott H. Robertson, Matthew S. Freeman, Mu He, Kevin T. Kelly, Justus E. Roos, Craig R. Rackley, W Michael Foster, H Page McAdams, and Bastiaan Driehuys. “Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition.” Magn Reson Med 75, no. 4 (April 2016): 1434–43. https://doi.org/10.1002/mrm.25675.
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  - Dahhan, Talal, Shiv S. Kaushik, Mu He, Joseph G. Mammarappallil, Victor F. Tapson, Holman P. McAdams, Thomas A. Sporn, Bastiaan Driehuys, and Sudarshan Rajagopal. “Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease.” Pulm Circ 6, no. 1 (March 2016): 126–31. https://doi.org/10.1086/685110.
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  - He, Mu, Scott H. Robertson, S Sivaram Kaushik, Matthew S. Freeman, Rohan S. Virgincar, John Davies, Jane Stiles, William M. Foster, H Page McAdams, and Bastiaan Driehuys. “Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.” Magn Reson Imaging 33, no. 7 (September 2015): 877–85. https://doi.org/10.1016/j.mri.2015.04.005.
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  - Robertson, S. H., R. S. Virgincar, M. He, M. S. Freeman, S. S. Kaushik, and B. Driehuys. “Optimizing 3D noncartesian gridding reconstruction for hyperpolarized ¹²⁹Xe MRI-focus on preclinical applications.” Concepts in Magnetic Resonance Part A: Bridging Education and Research 44, no. 4 (July 1, 2015): 190–202. https://doi.org/10.1002/cmr.a.21352.
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  - Roos, Justus E., Holman P. McAdams, S Sivaram Kaushik, and Bastiaan Driehuys. “Hyperpolarized Gas MR Imaging: Technique and Applications.” Magn Reson Imaging Clin N Am 23, no. 2 (May 2015): 217–29. https://doi.org/10.1016/j.mric.2015.01.003.
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  - Cleveland, Zackary I., Rohan S. Virgincar, Yi Qi, Scott H. Robertson, Simone Degan, and Bastiaan Driehuys. “3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis.” Nmr Biomed 27, no. 12 (December 2014): 1502–14. https://doi.org/10.1002/nbm.3127.
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  - He, Mu, S Sivaram Kaushik, Scott H. Robertson, Matthew S. Freeman, Rohan S. Virgincar, H Page McAdams, and Bastiaan Driehuys. “Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI.” Acad Radiol 21, no. 12 (December 2014): 1530–41. https://doi.org/10.1016/j.acra.2014.07.017.
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  - Kaushik, S Sivaram, Matthew S. Freeman, Suk W. Yoon, Maria G. Liljeroth, Jane V. Stiles, Justus E. Roos, W Michael Foster, Craig R. Rackley, H. P. McAdams, and Bastiaan Driehuys. “Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis.” J Appl Physiol (1985) 117, no. 6 (September 15, 2014): 577–85. https://doi.org/10.1152/japplphysiol.00326.2014.
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  - Freeman, M. S., K. Emami, and B. Driehuys. “Characterizing and modeling the efficiency limits in large-scale production of hyperpolarized 129Xe.” Phys Rev A 90, no. 2 (August 6, 2014): 023406. https://doi.org/10.1103/physreva.90.023406.
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  - He, M., T. Heacock, S. S. Kaushik, S. H. Robertson, M. S. Freeman, H. P. McAdams, D. Beaver, M. Kraft, and B. Driehuys. “Hyperpolarized 129xe Mri To Quantify Regional Ventilation Differences In Older Versus Younger Asthmatics.” American Journal of Respiratory and Critical Care Medicine 189 (January 1, 2014).
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  - Kaushik, S. S., T. Heacock, M. Freeman, K. T. Kelly, C. R. Rackley, J. Stiles, W. M. Foster, H. P. McAdams, and B. Driehuys. “Hyperpolarized 129xe Spectroscopy As A Biomarker For Gas-Transfer Impairment In Idiopathic Pulmonary Fibrosis.” American Journal of Respiratory and Critical Care Medicine 189 (January 1, 2014).
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  - Freeman, Matthew S., Zackary I. Cleveland, Yi Qi, and Bastiaan Driehuys. “Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin.” Magn Reson Med 70, no. 5 (November 2013): 1192–99. https://doi.org/10.1002/mrm.24915.
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  - Kaushik, S Sivaram, Matthew S. Freeman, Zackary I. Cleveland, John Davies, Jane Stiles, Rohan S. Virgincar, Scott H. Robertson, et al. “Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.” J Appl Physiol (1985) 115, no. 6 (September 2013): 850–60. https://doi.org/10.1152/japplphysiol.00092.2013.
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  - Virgincar, Rohan S., Zackary I. Cleveland, S Sivaram Kaushik, Matthew S. Freeman, John Nouls, Gary P. Cofer, Santiago Martinez-Jimenez, et al. “Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease.” Nmr Biomed 26, no. 4 (April 2013): 424–35. https://doi.org/10.1002/nbm.2880.
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  - Cleveland, Z. I., Y. Qi, and B. Driehuys. “Detecting Impaired Gas Uptake In A Rat Model Of Pulmonary Fibrosis With 3d Hyperpolarized 129xe Mri.” American Journal of Respiratory and Critical Care Medicine 187 (January 1, 2013).
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  - Driehuys, B., J. Nouls, A. Badea, E. Bucholz, K. Ghaghada, A. Petiet, and L. W. Hedlund. “Small animal imaging with magnetic resonance microscopy.” Ilar Journal 53, no. 1 (September 11, 2012): 35–53.
  - Cleveland, Zackary I., Harald E. Möller, Laurence W. Hedlund, John C. Nouls, Matthew S. Freeman, Yi Qi, and Bastiaan Driehuys. “In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe.” Plos One 7, no. 2 (2012): e31306. https://doi.org/10.1371/journal.pone.0031306.
    Full Text Link to Item
  - Driehuys, Bastiaan, Santiago Martinez-Jimenez, Zackary I. Cleveland, Gregory M. Metz, Denise M. Beaver, John C. Nouls, S Sivaram Kaushik, et al. “Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients.” Radiology 262, no. 1 (January 2012): 279–89. https://doi.org/10.1148/radiol.11102172.
    Full Text Link to Item
  - Möller, Harald E., Zackary I. Cleveland, and Bastiaan Driehuys. “Relaxation of hyperpolarized 129Xe in a deflating polymer bag.” J Magn Reson 212, no. 1 (September 2011): 109–15. https://doi.org/10.1016/j.jmr.2011.06.017.
    Full Text Link to Item
  - Thomas, Abe C., John C. Nouls, Bastiaan Driehuys, James W. Voltz, Boma Fubara, Julie Foley, J Alyce Bradbury, and Darryl C. Zeldin. “Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury.” Am J Respir Cell Mol Biol 44, no. 5 (May 2011): 648–54. https://doi.org/10.1165/rcmb.2009-0287OC.
    Full Text Link to Item
  - Kaushik, S Sivaram, Zackary I. Cleveland, Gary P. Cofer, Gregory Metz, Denise Beaver, John Nouls, Monica Kraft, et al. “Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.” Magn Reson Med 65, no. 4 (April 2011): 1154–65. https://doi.org/10.1002/mrm.22697.
    Full Text Link to Item
  - Nouls, John, Manuel Fanarjian, Laurence Hedlund, and Bastiaan Driehuys. “A Constant-Volume Ventilator and Gas Recapture System for Hyperpolarized Gas MRI of Mouse and Rat Lungs.” Concepts Magn Reson Part B Magn Reson Eng 39B, no. 2 (April 2011): 78–88. https://doi.org/10.1002/cmr.b.20192.
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  - Zheng, Wangzhi, Zackary I. Cleveland, Harald E. Möller, and Bastiaan Driehuys. “Gradient-induced longitudinal relaxation of hyperpolarized noble gases in the fringe fields of superconducting magnets used for magnetic resonance.” J Magn Reson 208, no. 2 (February 2011): 284–90. https://doi.org/10.1016/j.jmr.2010.11.006.
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  - Cleveland, Zackary I., Gary P. Cofer, Gregory Metz, Denise Beaver, John Nouls, S Sivaram Kaushik, Monica Kraft, et al. “Hyperpolarized Xe MR imaging of alveolar gas uptake in humans.” Plos One 5, no. 8 (August 16, 2010): e12192. https://doi.org/10.1371/journal.pone.0012192.
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  - Mistry, Nilesh N., Abraham Thomas, S Sivaram Kaushik, G Allan Johnson, and Bastiaan Driehuys. “Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine.” Magn Reson Med 63, no. 3 (March 2010): 658–66. https://doi.org/10.1002/mrm.22311.
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  - Branca, Rosa T., Zackary I. Cleveland, Boma Fubara, Challa S. S. R. Kumar, Robert R. Maronpot, Carola Leuschner, Warren S. Warren, and Bastiaan Driehuys. “Molecular MRI for sensitive and specific detection of lung metastases.” Proc Natl Acad Sci U S A 107, no. 8 (February 23, 2010): 3693–97. https://doi.org/10.1073/pnas.1000386107.
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  - Cleveland, Zackary I., Harald E. Möller, Laurence W. Hedlund, and Bastiaan Driehuys. “Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes.” J Phys Chem B 113, no. 37 (September 17, 2009): 12489–99. https://doi.org/10.1021/jp9049582.
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  - Driehuys, Bastiaan, Harald E. Möller, Zackary I. Cleveland, James Pollaro, and Laurence W. Hedlund. “Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe.” Radiology 252, no. 2 (August 2009): 386–93. https://doi.org/10.1148/radiol.2513081550.
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  - Thomas, Abraham C., Erin N. Potts, Ben T. Chen, Deborah M. Slipetz, W Michael Foster, and Bastiaan Driehuys. “A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI.” Nmr Biomed 22, no. 5 (June 2009): 502–15. https://doi.org/10.1002/nbm.1362.
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  - Couture, A. H., T. B. Clegg, and B. Driehuys. “Pressure shifts and broadening of the Cs D1 and D2 lines by He, N2, and Xe at densities used for optical pumping and spin exchange polarization.” Journal of Applied Physics 104, no. 9 (November 24, 2008). https://doi.org/10.1063/1.3018181.
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  - Brown, Robert H., Charles G. Irvin, Gilman B. Allen, Steven D. Shapiro, William J. Martin, Martin R. J. Kolb, Dallas M. Hyde, et al. “An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology.” Proc Am Thorac Soc 5, no. 5 (July 15, 2008): 591–600. https://doi.org/10.1513/pats.200708-116ST.
    Full Text Link to Item
  - Driehuys, Bastiaan, Jim Pollaro, and Gary P. Cofer. “In vivo MRI using real-time production of hyperpolarized 129Xe.” Magn Reson Med 60, no. 1 (July 2008): 14–20. https://doi.org/10.1002/mrm.21651.
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  - Driehuys, Bastiaan, John Nouls, Alexandra Badea, Elizabeth Bucholz, Ketan Ghaghada, Alexandra Petiet, and Laurence W. Hedlund. “Small animal imaging with magnetic resonance microscopy.” Ilar J 49, no. 1 (2008): 35–53. https://doi.org/10.1093/ilar.49.1.35.
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  - Driehuys, Bastiaan, Julia Walker, Jim Pollaro, Gary P. Cofer, Nilesh Mistry, David Schwartz, and G Allan Johnson. “3He MRI in mouse models of asthma.” Magn Reson Med 58, no. 5 (November 2007): 893–900. https://doi.org/10.1002/mrm.21306.
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  - Driehuys, Bastiaan, and Laurence W. Hedlund. “Imaging techniques for small animal models of pulmonary disease: MR microscopy.” Toxicol Pathol 35, no. 1 (January 2007): 49–58. https://doi.org/10.1080/01926230601132048.
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  - Macfall, J. R., and B. Driehuys. “Hyperpolarized Gas Imaging.” Emagres 2007 (January 1, 2007). https://doi.org/10.1002/9780470034590.emrstm0220.
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  - Driehuys, Bastiaan, Gary P. Cofer, Jim Pollaro, Julie Boslego Mackel, Laurence W. Hedlund, and G Allan Johnson. “Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.” Proc Natl Acad Sci U S A 103, no. 48 (November 28, 2006): 18278–83. https://doi.org/10.1073/pnas.0608458103.
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  - Spector, Z. Z., K. Emami, M. C. Fischer, J. Zhu, M. Ishii, V. Vahdat, J. Yu, et al. “Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.” Magn Reson Med 53, no. 6 (June 2005): 1341–46. https://doi.org/10.1002/mrm.20514.
    Full Text Link to Item
  - Spector, Z. Z., K. Emami, M. C. Fischer, J. Zhu, M. Ishii, J. Yu, S. Kadlecek, et al. “A small animal model of regional alveolar ventilation using HP 3He MRI1.” Acad Radiol 11, no. 10 (October 2004): 1171–79. https://doi.org/10.1016/j.acra.2004.08.001.
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  - Månsson, Sven, Jan Wolber, Bastiaan Driehuys, Per Wollmer, and Klaes Golman. “Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.” Magn Reson Med 50, no. 6 (December 2003): 1170–79. https://doi.org/10.1002/mrm.10649.
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  - Babcock, Earl, Ian Nelson, Steve Kadlecek, Bastiaan Driehuys, L. W. Anderson, F. W. Hersman, and Thad G. Walker. “Hybrid spin-exchange optical pumping of 3He.” Phys Rev Lett 91, no. 12 (September 19, 2003): 123003. https://doi.org/10.1103/PhysRevLett.91.123003.
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  - Jacob, R. E., B. Driehuys, and B. Saam. “Fundamental mechanisms of ³ He relaxation on glass.” Chemical Physics Letters 370, no. 1–2 (March 7, 2003): 261–67. https://doi.org/10.1016/S0009-2614(03)00110-6.
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  - Ruppert, K., J. R. Brookeman, K. D. Hagspiel, B. Driehuys, and J. P. Mugler. “NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold.” Nmr Biomed 13, no. 4 (June 2000): 220–28. https://doi.org/10.1002/1099-1492(200006)13:4<220::aid-nbm638>3.0.co;2-f.
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  - Chen, X. J., H. E. Möller, M. S. Chawla, G. P. Cofer, B. Driehuys, L. W. Hedlund, J. R. MacFall, and G. A. Johnson. “Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2).” Magn Reson Med 42, no. 4 (October 1999): 729–37. https://doi.org/10.1002/(sici)1522-2594(199910)42:4<729::aid-mrm15>3.0.co;2-2.
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  - Chen, X. J., H. E. Möller, M. S. Chawla, G. P. Cofer, B. Driehuys, L. W. Hedlund, and G. A. Johnson. “Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient.” Magn Reson Med 42, no. 4 (October 1999): 721–28. https://doi.org/10.1002/(sici)1522-2594(199910)42:4<721::aid-mrm14>3.0.co;2-d.
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  - Stith, A., T. K. Hitchens, D. P. Hinton, S. S. Berr, B. Driehuys, J. R. Brookeman, and R. G. Bryant. “Consequences of (129)Xe-(1)H cross relaxation in aqueous solutions.” J Magn Reson 139, no. 2 (August 1999): 225–31. https://doi.org/10.1006/jmre.1999.1781.
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  - Möller, H. E., M. S. Chawla, X. J. Chen, B. Driehuys, L. W. Hedlund, C. T. Wheeler, and G. A. Johnson. “Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.” Magn Reson Med 41, no. 5 (May 1999): 1058–64. https://doi.org/10.1002/(sici)1522-2594(199905)41:5<1058::aid-mrm26>3.0.co;2-c.
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  - Möller, H. E., X. J. Chen, M. S. Chawla, G. P. Cofer, B. Driehuys, L. W. Hedlund, S. A. Suddarth, and G. A. Johnson. “Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases.” Magn Reson Med 41, no. 4 (April 1999): 800–808. https://doi.org/10.1002/(sici)1522-2594(199904)41:4<800::aid-mrm20>3.0.co;2-k.
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  - Möller, H. E., X. J. Chen, M. S. Chawla, B. Driehuys, L. W. Hedlund, and G. A. Johnson. “Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases.” J Magn Reson 135, no. 1 (November 1998): 133–43. https://doi.org/10.1006/jmre.1998.1563.
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  - Johnson, G. A., G. Cates, X. J. Chen, G. P. Cofer, B. Driehuys, W. Happer, L. W. Hedlund, B. Saam, M. D. Shattuck, and J. Swartz. “Dynamics of magnetization in hyperpolarized gas MRI of the lung.” Magn Reson Med 38, no. 1 (July 1997): 66–71. https://doi.org/10.1002/mrm.1910380111.
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  - Mugler, J. P., B. Driehuys, J. R. Brookeman, G. D. Cates, S. S. Berr, R. G. Bryant, T. M. Daniel, et al. “MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results.” Magn Reson Med 37, no. 6 (June 1997): 809–15. https://doi.org/10.1002/mrm.1910370602.
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  - Driehuys, B., G. D. Cates, E. Miron, K. Sauer, D. K. Walter, and W. Happer. “High-volume production of laser-polarized ¹²⁹Xe.” Applied Physics Letters 69, no. 12 (September 16, 1996): 1668–70. https://doi.org/10.1063/1.117022.
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  - MacFall, J. R., H. C. Charles, R. D. Black, H. Middleton, J. C. Swartz, B. Saam, B. Driehuys, et al. “Human lung air spaces: potential for MR imaging with hyperpolarized He-3.” Radiology 200, no. 2 (August 1996): 553–58. https://doi.org/10.1148/radiology.200.2.8685356.
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  - Black, R. D., H. L. Middleton, G. D. Cates, G. P. Cofer, B. Driehuys, W. Happer, L. W. Hedlund, G. A. Johnson, M. D. Shattuck, and J. C. Swartz. “In vivo He-3 MR images of guinea pig lungs.” Radiology 199, no. 3 (June 1996): 867–70. https://doi.org/10.1148/radiology.199.3.8638019.
    Full Text Link to Item
  - Driehuys, B., G. D. Cates, and W. Happer. “Surface relaxation mechanisms of laser-polarized 129Xe.” Phys Rev Lett 74, no. 24 (June 12, 1995): 4943–46. https://doi.org/10.1103/PhysRevLett.74.4943.
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  - Johnson, J. R., A. K. Thompson, T. E. Chupp, T. B. Smith, G. D. Cates, B. Driehuys, H. Middleton, N. R. Newbury, E. W. Hughes, and W. Meyer. “The SLAC high-density gaseous polarized ³He target.” Nuclear Inst. and Methods in Physics Research, A 356, no. 1 (March 1, 1995): 148–52. https://doi.org/10.1016/0168-9002(94)01465-5.
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  - Albert, M. S., G. D. Cates, B. Driehuys, W. Happer, B. Saam, C. S. Springer, and A. Wishnia. “Biological magnetic resonance imaging using laser-polarized 129Xe.” Nature 370, no. 6486 (July 21, 1994): 199–201. https://doi.org/10.1038/370199a0.
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  - Barton, A. S., N. R. Newbury, G. D. Cates, B. Driehuys, H. Middleton, and B. Saam. “Self-calibrating measurement of polarization-dependent frequency shifts from Rb-3He collisions.” Phys Rev A 49, no. 4 (April 1994): 2766–70. https://doi.org/10.1103/physreva.49.2766.
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  - Driehuys, B., G. D. Cates, W. Happer, H. Mabuchi, B. Saam, M. S. Albert, and A. Wishnia. “Spin transfer between laser-polarized ¹²⁹Xe nuclei and surface protons.” Physics Letters A 184, no. 1 (December 27, 1993): 88–92. https://doi.org/10.1016/0375-9601(93)90352-Z.
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  - Gatzke, M., G. D. Cates, B. Driehuys, D. Fox, W. Happer, and B. Saam. “Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe.” Phys Rev Lett 70, no. 5 (February 1, 1993): 690–93. https://doi.org/10.1103/PhysRevLett.70.690.
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- Conference Papers
  - Bier, Elianna A., Fawaz Alenezi, Junlan Lu, Ziyi Wang, Joseph G. Mammarappallil, Bryan O’Sullivan-Murphy, Alaattin Erkanli, Bastiaan Driehuys, and Sudarshan Rajagopal. “Noninvasive diagnosis of pulmonary hypertension with hyperpolarised 129Xe magnetic resonance imaging and spectroscopy.” In Erj Open Res, Vol. 8, 2022. https://doi.org/10.1183/23120541.00035-2022.
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  - Mummy, D., A. Swaminathan, K. Yarnall, E. Bier, J. Lu, S. Leewiwatwong, J. Korzekwinski, and B. Driehuys. “Hyperpolarized 129Xe MRI in Healthy Control Subjects Reveals Age-Related Changes in Measurements of Ventilation and Red Blood Cell Transfer but Not Interstitial Tissue Barrier.” In American Journal of Respiratory and Critical Care Medicine, Vol. 205, 2022.
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  - Mummy, D., E. Bier, J. Lu, S. Leewiwatwong, A. Bechtel, I. Dummer, S. Kabir, et al. “Hyperpolarized 129Xe MRI Is Sensitive to Variations in Gas Exchange Impairment in Patients with Long Haul COVID-19 and Normal Cardiac Structure and Function.” In American Journal of Respiratory and Critical Care Medicine, Vol. 205, 2022.
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  - Rankine, L. J., J. Lu, Z. Wang, C. R. Kelsey, L. B. Marks, S. K. Das, and B. Driehuys. “Radiation-Induced Lung Injury Quantified by Hyperpolarized 129Xe MRI: Dose-Dependence and Association with Changes in Global Lung Function.” In International Journal of Radiation Oncology Biology Physics, 114:E556–E556, 2022.
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  - Bier, E., D. Mummy, J. Lu, and B. Driehuys. “Within-Session Repeatability of Pulmonary Xe-129 Static and Dynamic Spectroscopy.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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  - Bier, E., F. Alenezi, J. Lu, J. Mammarappallil, B. Driehuys, and S. Rajagopal. “Hyperpolarized Xe-129 Magnetic Resonance Oscillation Imaging in Pulmonary Hypertension.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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  - Bier, E., J. Lu, D. Mummy, J. Mammarappallil, S. Palmer, B. Driehuys, and H. A. Ali. “Hyperpolarized Xe-129 MRI in the Imaging of Chronic Lung Allograft Dysfunction.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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  - Mummy, D., A. Swaminathan, K. Yarnall, J. Mammarappallil, B. Driehuys, and R. M. Tighe. “Hyperpolarized Xe-129 MRI Features Identify Functional Differences That Do Not Correlate with Chest CT in Patients with Idiopathic Pulmonary Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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  - Mummy, D., E. M. Coleman, Z. Wang, E. Bier, J. Lu, B. Driehuys, and Y. T. Huang. “Regional Changes in Ventilation Following Bronchodilation in COPD Are Not Associated with Improved Gas Exchange on Xenon-129 MRI.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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  - Rankine, L., Z. Wang, E. Bier, C. Kelsey, S. Das, L. Marks, and B. Driehuys. “Quantifying Radiation-Induced Lung Injury as a Function of Regional Radiation Therapy Dose Using Hyperpolarized-129Xe MRI.” In Medical Physics, Vol. 48, 2021.
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  - Driehuys, Bastiaan, Jaime Mata, Matthew Hartwig, Alejandro Aragaki-Nakahodo, Ken West, Kiarash Emami, Neil Wadehra, et al. “Randomized Phase III Trial Assessing Regional Lung Function for Lung Transplant by Hyperpolarized 129Xenon Gas MRI.” In Imaging. European Respiratory Society, 2020. https://doi.org/10.1183/13993003.congress-2020.2084.
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  - Shim, Yun, Jaime Mata, Matthew Hartwig, Alejandro Aragaki-Nakahodo, Ken West, Kiarash Emami, Neil Wadehra, et al. “Randomized Phase III Trial Assessing Regional Lung Function for Thoracic Resection by Hyperpolarized 129Xenon Gas MRI.” In Imaging. European Respiratory Society, 2020. https://doi.org/10.1183/13993003.congress-2020.2080.
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  - Coleman, E. M., D. Mummy, Z. Wang, E. Bier, S. Womack, J. Korzekwinski, J. Mammarappallil, B. Driehuys, and Y. T. Huang. “Hyperpolarized Xe-129 MRI Identifies Ventilation Responders to Glycopyrrolate/Formoterol Fumarate in Chronic Obstructive Pulmonary Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Mummy, D., L. Rankine, Z. Wang, E. Bier, C. Rackley, L. D. Morrison, J. Mammarappallil, B. Driehuys, and R. M. Tighe. “Hyperpolarized 129Xe Magnetic Resonance Imaging Is Sensitive to Therapy Response in Idiopathic Pulmonary Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Mummy, D., Z. Wang, E. Bier, R. M. Tighe, B. Driehuys, and J. Mammarappallil. “Hyperpolarized 129Xe Magnetic Resonance Imaging Measures of Gas Exchange in Non-Specific Interstitial Pneumonia.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Niedbalski, P. J., L. J. Rankine, E. A. Bier, Z. Wang, B. Driehuys, R. M. Tighe, and Z. I. Cleveland. “Hyperpolarized Xe-129 MRI of Regional Capillary-Level Cardio-Pulmonary Dynamics Predict Outcomes in IPF Patients.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Rajagopal, S., E. Bier, Z. Wang, K. Parikh, S. Almeida-Peters, S. Womack, J. Nouls, J. Mammarappallil, and B. Driehuys. “Monitoring Response to Inhaled Prostacyclin Therapy with (129)Xenon MR Imaging and Spectroscopy in Patients with Pulmonary Hypertension.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Rankine, L. J., Z. Wang, E. Bier, C. R. Kelsey, L. B. Marks, B. Driehuys, and S. K. Das. “Pulmonary Gas Exchange-guided Functional Avoidance Treatment Planning for Thoracic Radiation Therapy Using Hyperpolarized Xe-129 Magnetic Resonance Imaging.” In International Journal of Radiation Oncology Biology Physics, 108:S102–3, 2020.
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  - Rankine, L., Z. Wang, E. Bier, C. Kelsey, L. Marks, B. Driehuys, and S. Das. “Using Hyperpolarized Xe-129 Gas-Exchange MRI to Guide Functional Avoidance Planning in Thoracic Radiation Therapy.” In Medical Physics, 47:E370–E370, 2020.
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  - Shim, Y. M., J. Mata, M. Hartwig, A Aragaki Nakahodo, K. West, K. Emami, N. Wadehra, et al. “Positive Results from Two Randomized Phase III Trials Assessing Hyperpolarized (129)Xenon Gas MRI as a Measure of Regional Lung Function as Compared to Imaging with (133)Xenon Scintigraphy.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Wang, Z., A. Swaminathan, E. Bier, R. M. Tighe, Y. T. Huang, S. Rajagopal, and B. Driehuys. “Using (129)Xenon MR Gas Exchange MRI to Measure the Membrane and Capillary Components of DLCO and KCO.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Wang, Z., L. Rankine, M. Thorpe, J. Mammarappallil, S. Rajagopal, and B. Driehuys. “Spatial Correlation of 129Xenon Gas Exchange MRI with 99mTc Perfusion Scintigraphy.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Fenoli, J., L. Rankine, B. Driehuys, and S. Das. “Comparison of 129Xe-MR Ventilation and 4DCT Ventilation Computed From the Deformation Vector Field.” In Medical Physics, 46:E246–E246. WILEY, 2019.
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  - Rankine, L., Z. Wang, J. Wang, M. He, H. McAdams, J. Mammarappallil, C. Rackley, B. Driehuys, and R. Tighe. “Disease Progression in Idiopathic Pulmonary Fibrosis: The Potential for Stratifying Patients Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging.” In Medical Physics, 46:E300–E300. WILEY, 2019.
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  - Bier, E., Z. Wang, A. Swaminathan, J. Nouls, M. He, J. Mammarappallil, S. Luo, B. Driehuys, and S. Rajagopal. “129Xenon MR Imaging and Spectroscopic Signatures to Differentiate Pulmonary Arterial Hypertension from Other Heart and Lung Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
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  - Coleman, E., Z. Wang, M. He, E. Bier, J. Nouls, S. Womack, J. Mammarappallil, B. Driehuys, and Y. T. Huang. “Regional Gas Exchange Function Before and After Glycopyrrolate/Formoterol Fumarate Measured by Hyperpolarized Xe-129 MRI in Chronic Obstructive Lung Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
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  - Mammarappallil, J., E. Coleman, M. He, Z. Wang, E. Bier, J. Nouls, S. Womack, et al. “Identification of Gas Exchange Phenotypes Using Hyperpolarized Xe-129 MRI in Patients with Chronic Obstructive Pulmonary Disease (COPD).” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
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  - Rankine, L., Z. Wang, C. Kelsey, S. Das, L. Marks, and B. Driehuys. “Dose-Dependent Changes in Regional Lung Function Detected 6-12 Weeks After Radiation Therapy: A Novel Application of Hyperpolarized-129Xe MRI.” In Medical Physics, 45:E416–17. WILEY, 2018.
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  - Huang, Y. T., M. He, Z. Wang, L. Rankine, S. Womack, J. Mammarappallil, P. McAdams, and B. Driehuys. “Ventilation and Gas Transfer Measured by 129Xe MRI in Alpha-1 Antitrypsin Heterozygotes: A Pilot Study.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Huang, Y. T., Z. Wang, M. He, L. Rankine, S. Womack, P. McAdams, J. Mammarappalil, and B. Driehuys. “Ventilation and Gas Transfer Distribution in Alpha-1 Antitrypsin Deficiency After Replacement Therapy.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Tighe, R. M., L. Rankine, Z. Wang, J. Wang, M. He, C. Rackley, H. McAdams, J. Mammarappallil, and B. Driehuys. “Longitudinal Follow Up After Xe-129 MRI Scan; Potential to Stratify Idiopathic Pulmonary Fibrosis Disease Progression.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Swaminathan, Aparna, Elianna Bier, John Nouls, Karla Kennedy, Samantha Womack, Susana Almeida-Peters, Bastiaan Driehuys, and Sudarshan Rajagopal. “Non-Invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129-XenonMRI.” In Circulation, Vol. 138, 2018.
    Link to Item
  - Rankine, L. J., Z. Wang, B. Driehuys, C. R. Kelsey, L. B. Marks, and S. K. Das. “Is Lung Ventilation Imaging a Reasonable Surrogate for Gas Exchange? Implications for Functionally Guided Radiation Therapy Planning.” In International Journal of Radiation Oncology*Biology*Physics, 99:S109–S109. Elsevier BV, 2017. https://doi.org/10.1016/j.ijrobp.2017.06.258.
    Full Text
  - Rankine, L., Z. Wang, B. Driehuys, L. B. Marks, C. Kelsey, and S. Das. “BEST IN PHYSICS (JOINT IMAGING-THERAPY): Functional-Guidance for Lung Radiation Therapy Planning: Does Ventilation Imaging Correlate with Gas Exchange?” In Medical Physics, 44:3281–82. WILEY, 2017.
    Link to Item
  - He, M., W. Zha, S. B. Fain, and B. Driehuys. “Comparing Quantitative 129xe Ventilation Analysis Pipelines Between Mri Centers.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
    Link to Item
  - Nichols, C., J. House, H. Li, C. Brandenberger, R. Virgincar, L. Miller, B. Driehuys, D. Zeldin, and S. London. “Htr4 Regulates Pulmonary Function Through Neural Innervation.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
    Link to Item
  - He, M., S. H. Robertson, J. M. Wang, C. R. Rackley, H. P. McAdams, and B. Driehuys. “Differentiating Early Stage And Later Stage Ipf Using Hyperpolarized 129xe Ventilation Mri.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
    Link to Item
  - He, M., S. H. Robertson, J. M. Wang, L. G. Que, K. Mahmood, B. Driehuys, and Y. -. C. Huang. “Characterizing The Ventilation Distribution In Healthy Normal Subjects To Establish Robust Quantitative Analysis Of 129xe Mri.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
    Link to Item
  - Wang, J. M., S. H. Robertson, M. He, R. S. Virgincar, G. M. Schrank, R. Smigla, T. O’Riordan, et al. “Using Hyperpolarized 129xe Imaging To Quantify Apical Vs. Basal And Central Vs. Peripheral Gas Exchange Impairment In Idiopathic Pulmonary Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
    Link to Item
  - Cleveland, Z. I., M. Freeman, Y. Qi, and B. Driehuys. “Probing Diffusive Gas Uptake In Mice Using Hyperpolarized 129xe Magnetic Resonance Spectroscopy And Imaging.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.
    Link to Item
  - Kaushik, S. S., M. Liljeroth, R. S. Virgincar, S. H. Robertson, J. Davies, J. Stiles, K. T. Kelly, et al. “Reproducibility Of Hyperpolarized 129xe Mri: Alveolar Capillary Gas-Transfer Spectroscopy And Imaging.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.
    Link to Item
  - Virgincar, R. S., J. Nouls, M. He, S. S. Kaushik, E. Potts, W. M. Foster, D. M. Slipetz, L. Hedlund, and B. Driehuys. “Quantitative Analysis Of 3he And 1h Mr Images Of Regional Pulmonary Injury In House-Dust-Mite Allergic Mice.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.
    Link to Item
  - Driehuys, B., T. Raidy, J. Pollaro, A. Johnson, M. Dewhirst, L. Marks, and Z. Vujaskovic. “Hyperpolarized 129Xe MRI for Functional Assessment of Radiation-Induced Lung Injury.” In International Journal of Radiation Oncology*Biology*Physics, 63:S460–61. Elsevier BV, 2005. https://doi.org/10.1016/j.ijrobp.2005.07.784.
    Full Text
  - KAMPWIRTH, R. T., J. M. GRACE, D. J. MILLER, D. B. MCDONALD, K. E. GRAY, P. H. ANDERSEN, B. DRIEHUYS, M. REITEN, and M. ASCOLESE. “INSITU GROWTH OF SUPERCONDUCTING FILMS OF BI SR CA CU O USING MAGNETRON SPUTTERING.” In Science and Technology of Thin Film Superconductors 2, edited by R. D. MCCONNELL and R. NOUFI, 39–46. PLENUM PRESS DIV PLENUM PUBLISHING CORP, 1990.
    Link to Item
  - MILLER, D. J., J. M. GRACE, D. B. MCDONALD, K. E. GRAY, R. T. KAMPWIRTH, and B. DRIEHUYS. “MICROSTRUCTURE OF SPUTTERED SUPERCONDUCTING FILMS OF BI2SR2CACU2OX MADE BY LOW-TEMPERATURE, INSITU GROWTH.” In High Temperature Superconducting Compounds Ii, edited by S. H. WHANG, A. DASGUPTA, and R. LAIBOWITZ, 329–39. MINERALS, METALS & MATERIALS SOC, 1990.
    Link to Item
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- Our research group generally consists of 3-4 Ph.D. students from biomedical engineering, medical physics, and electrical and computer engineering. In addition, we are always happy to find projects for exceptional undergraduate students, master's degree students, and rotation students.

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