Scholars@Duke
Bastiaan Driehuys

Bastiaan Driehuys

Professor of Radiology
Radiology
bastiaan.driehuys@duke.edu
Box 3302 Med Ctr, Durham, NC
161-B Bryan Research, 311 Research Drive, Durham, NC 27710

Selected Publications

Hyperpolarized 129Xe MRI and spectroscopy of gas exchange abnormalities in chronic hypersensitivity pneumonitis.

Journal Article Respir Med · October 5, 2024 PURPOSE: To evaluate 3D gas-exchange functional imaging characteristics using 129Xe MRI in a group of study participants with chronic hypersensitivity pneumonitis (CHP) as compared with healthy control participants. METHODS: In this prospective study, 11 p ... Full text Link to item Cite

Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized 129Xe Gas Exchange Magnetic Resonance Imaging.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2024 PURPOSE: Radiation-induced lung injury has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured. METHODS AND MATERIALS: Ten patients receiving conventional ... Full text Link to item Cite

Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarized 129 Xe gas exchange MRI: Digital phantoms and clinical evaluation in CTEPH.

Journal Article Magn Reson Med · April 2024 PURPOSE: The interaction between 129 Xe atoms and pulmonary capillary red blood cells provides cardiogenic signal oscillations that display sensitivity to precapillary and postcapillary pulmonary hypertension. Recently, such oscillations have been spatiall ... Full text Link to item Cite

Cluster Analysis to Identify Long COVID Phenotypes Using 129Xe Magnetic Resonance Imaging: A Multi-centre Evaluation.

Journal Article Eur Respir J · February 8, 2024 BACKGROUND: Long COVID impacts ∼10% of people diagnosed with COVID-19, yet the pathophysiology driving ongoing symptoms is poorly understood. We hypothesised that 129Xe magnetic resonance imaging (MRI) could identify unique pulmonary phenotypic subgroups o ... Full text Link to item Cite

Functional gas exchange measures on 129Xe MRI and spectroscopy are associated with age, sex, and BMI in healthy subjects.

Journal Article Front Med (Lausanne) · 2024 INTRODUCTION: Hyperpolarized 129Xe MRI and spectroscopy is a rapidly growing technique for assessing lung function, with applications in a wide range of obstructive, restrictive, and pulmonary vascular disease. However, normal variations in 129Xe measures ... Full text Link to item Cite

Combining neural networks and image synthesis to enable automatic thoracic cavity segmentation of hyperpolarized 129Xe MRI without proton scans.

Journal Article Magn Reson Imaging · November 2023 RATIONALE AND OBJECTIVES: Quantification of 129Xe MRI relies on accurate segmentation of the thoracic cavity, typically performed manually using a combination of 1H and 129Xe scans. This can be accelerated by using Convolutional Neural Networks (CNNs) that ... Full text Link to item Cite

Establishing a hemoglobin adjustment for 129 Xe gas exchange MRI and MRS.

Journal Article Magn Reson Med · October 2023 PURPOSE: 129 Xe MRI and MRS signals from airspaces, membrane tissues (M), and red blood cells (RBCs) provide measurements of pulmonary gas exchange. However, 129 Xe MRI/MRS studies have yet to account for hemoglobin concentration (Hb), which is expected to ... Full text Link to item Cite

Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.

Journal Article Ann Am Thorac Soc · February 2023 Multiple thoracic imaging modalities have been developed to link structure to function in the diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders three-dimensional maps of lung structures and may be combined with positron ... Full text Link to item Cite

View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy.

Journal Article Phys Imaging Radiat Oncol · January 2023 BACKGROUND AND PURPOSE: The accuracy and precision of radiation therapy are dependent on the characterization of organ-at-risk and target motion. This work aims to demonstrate a 4D magnetic resonance imaging (MRI) method for improving spatial and temporal ... Full text Link to item Cite

Monitoring and Management of Respiratory Function in Pompe Disease: Current Perspectives.

Journal Article Ther Clin Risk Manag · 2023 Pompe disease (PD) is a neuromuscular disorder caused by a deficiency of acid alpha-glucosidase (GAA) - a lysosomal enzyme responsible for hydrolyzing glycogen. GAA deficiency leads to accumulation of glycogen in lysosomes, causing cellular disruption. The ... Full text Link to item Cite

129Xe Magnetic Resonance Imaging-based Phenotypes of Long COVID: A Multi-center Evaluation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2023 Cite

Persistent 129Xe MRI Pulmonary and CT Vascular Abnormalities in Symptomatic Individuals with Post-acute COVID-19 Syndrome.

Journal Article Radiology · November 2022 BACKGROUND: In patients with post-acute COVID-19 syndrome (PACS), abnormal gas-transfer and pulmonary vascular density have been reported, but such findings have not been related to each other or to symptoms and exercise limitation. The pathophysiologic dr ... Full text Link to item Cite

MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We?

Journal Article Radiol Clin North Am · November 2022 Patients with diffuse lung diseases require thorough medical and social history and physical examinations, coupled with a multitude of laboratory tests, pulmonary function tests, and radiologic imaging to discern and manage the specific disease. This revie ... Full text Link to item Cite

Pediatric 129 Xe Gas-Transfer MRI-Feasibility and Applicability.

Journal Article J Magn Reson Imaging · October 2022 BACKGROUND: 129 Xe gas-transfer MRI provides regional measures of pulmonary gas exchange in adults and separates xenon in interstitial lung tissue/plasma (barrier) from xenon in red blood cells (RBCs). The technique has yet to be demonstrated in pediatric ... Full text Link to item Cite

Bias field correction in hyperpolarized 129 Xe ventilation MRI using templates derived by RF-depolarization mapping.

Journal Article Magn Reson Med · August 2022 PURPOSE: To correct for RF inhomogeneity for in vivo 129 Xe ventilation MRI using flip-angle mapping enabled by randomized 3D radial acquisitions. To extend this RF-depolarization mapping approach to create a flip-angle map template applicable to arbitrary ... Full text Link to item Cite

Noninvasive diagnosis of pulmonary hypertension with hyperpolarised 129Xe magnetic resonance imaging and spectroscopy.

Conference ERJ Open Res · April 2022 BACKGROUND: The diagnosis of pulmonary hypertension (PH) remains challenging. Pre- and post-capillary PH have different signatures on noninvasive 129Xe gas-exchange magnetic resonance imaging (MRI) and dynamic MR spectroscopy (MRS). We tested the accuracy ... Full text Link to item Cite

Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging.

Journal Article Magn Reson Med · March 2022 PURPOSE: To reduce scan duration in hyperpolarized 129 Xe 1-point Dixon gas exchange imaging by utilizing flip angle (FA)/TR equivalence. METHODS: Images were acquired in 12 subjects (n = 3 radiation therapy, n = 1 unexplained dyspnea, n = 8 healthy) using ... Full text Link to item Cite

Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life.

Journal Article Respirology · February 2022 Pulmonary functional MRI (PfMRI) using inhaled hyperpolarized, radiation-free gases (such as 3 He and 129 Xe) provides a way to directly visualize inhaled gas distribution and ventilation defects (or ventilation heterogeneity) in real time with high spatia ... Full text Link to item Cite

Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium.

Journal Article Magn Reson Med · December 2021 Hyperpolarized (HP) 129 Xe MRI uniquely images pulmonary ventilation, gas exchange, and terminal airway morphology rapidly and safely, providing novel information not possible using conventional imaging modalities or pulmonary function tests. As such, ther ... Full text Link to item Cite

Hyperpolarized 129Xe Magnetic Resonance Imaging for Functional Avoidance Treatment Planning in Thoracic Radiation Therapy: A Comparison of Ventilation- and Gas Exchange-Guided Treatment Plans.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2021 PURPOSE: To present a methodology to use pulmonary gas exchange maps to guide functional avoidance treatment planning in radiation therapy (RT) and evaluate its efficacy compared with ventilation-guided treatment planning. METHODS AND MATERIALS: Before rec ... Full text Link to item Cite

Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia.

Journal Article Radiology · October 2021 Background Recent studies demonstrate that antifibrotic drugs previously reserved for idiopathic pulmonary fibrosis (IPF) may slow progression in other interstitial lung diseases (ILDs), creating an urgent need for tools that can sensitively assess disease ... Full text Link to item Cite

Regional Gas Exchange Measured by 129 Xe Magnetic Resonance Imaging Before and After Combination Bronchodilators Treatment in Chronic Obstructive Pulmonary Disease.

Journal Article J Magn Reson Imaging · September 2021 BACKGROUND: Hyperpolarized 129 Xe magnetic resonance imaging (MRI) provides a non-invasive assessment of regional pulmonary gas exchange function. This technique has demonstrated that chronic obstructive pulmonary disease (COPD) patients exhibit ventilatio ... Full text Open Access Link to item Cite

Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity.

Journal Article J Appl Physiol (1985) · May 1, 2021 Hyperpolarized 129Xe MRI has emerged as a novel means to evaluate pulmonary function via 3D mapping of ventilation, interstitial barrier uptake, and RBC transfer. However, the physiological interpretation of these measurements has yet to be firmly establis ... Full text Link to item Cite

Imaging in alpha-1 antitrypsin deficiency: a window into the disease.

Journal Article Ther Adv Chronic Dis · 2021 Imaging modalities such as plain chest radiograph and computed tomography (CT) are important tools in the assessment of patients with chronic obstructive pulmonary disease (COPD) of any etiology. These methods facilitate differential diagnoses and the asse ... Full text Link to item Cite

Hyperpolarized 129Xe Magnetic Resonance Oscillation Imaging in Pulmonary Hypertension

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Within-Session Repeatability of Pulmonary 129Xe Static and Dynamic Spectroscopy

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Hyperpolarized 129Xe MRI in the Imaging of Chronic Lung Allograft Dysfunction

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI.

Journal Article Acad Radiol · August 2020 RATIONALE: Hyperpolarized 129Xe ventilation MRI is typically acquired using multislice fast gradient recalled echo (GRE), but interleaved 3D radial 129Xe gas transfer MRI now provides dissolved-phase and ventilation images from a single breath. To investig ... Full text Open Access Link to item Cite

Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved 129Xe MRI.

Journal Article J Appl Physiol (1985) · August 1, 2020 Magnetic resonance (MR) imaging and spectroscopy using dissolved hyperpolarized (HP) 129Xe have expanded the ability to probe lung function regionally and noninvasively. In particular, HP 129Xe imaging has been used to quantify impaired gas uptake by the p ... Full text Link to item Cite

Quantitative 129Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension.

Journal Article Sci Rep · April 30, 2020 Hyperpolarized 129Xe magnetic resonance imaging (MRI) is capable of regional mapping of pulmonary gas-exchange and has found application in a wide range of pulmonary disorders in humans and animal model analogs. This study is the first application of 129Xe ... Full text Link to item Cite

Hyperpolarized 129Xe Magnetic Resonance Imaging Is Sensitive to Therapy Response in Idiopathic Pulmonary Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Using 129Xenon MR Gas Exchange MRI to Measure the Membrane and Capillary Components of DLCO and KCO

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Hyperpolarized 129Xe Magnetic Resonance Imaging Measures of Gas Exchange in Non-Specific Interstitial Pneumonia

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Hyperpolarized 129Xe MRI of Regional Capillary-Level Cardio-Pulmonary Dynamics Predict Outcomes in IPF Patients

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Spatial Correlation of 129Xenon Gas Exchange MRI with 99mTc Perfusion Scintigraphy

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures.

Journal Article Eur Respir J · December 2019 BACKGROUND: As an increasing number of patients exhibit concomitant cardiac and pulmonary disease, limitations of standard diagnostic criteria are more frequently encountered. Here, we apply noninvasive 129Xe magnetic resonance imaging (MRI) and spectrosco ... Full text Open Access Link to item Cite

A thermally polarized 129 Xe phantom for quality assurance in multi-center hyperpolarized gas MRI studies.

Journal Article Magn Reson Med · November 2019 PURPOSE: Hyperpolarized 129 Xe MR is increasingly being adopted worldwide, but no standards exist for assessing or comparing performance at different 129 Xe imaging centers. Therefore, we sought to develop a thermally polarized xenon phantom assembly, appr ... Full text Link to item Cite

A Comparison of Two Hyperpolarized 129Xe MRI Ventilation Quantification Pipelines: The Effect of Signal to Noise Ratio.

Journal Article Acad Radiol · July 2019 RATIONALE: Hyperpolarized 129Xe MRI enables quantitative evaluation of regional ventilation. To this end, multiple classifiers have been proposed to determine ventilation defect percentage (VDP) as well as other cluster populations. However, consensus has ... Full text Link to item Cite

Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI.

Journal Article AJR Am J Roentgenol · April 2019 OBJECTIVE: The objective of our study was to identify the magnitude and distribution of ventilation defect scores (VDSs) derived from hyperpolarized (HP) 129Xe-MRI associated with clinically relevant airway obstruction. MATERIALS AND METHODS: From 2012 to ... Full text Link to item Cite

Applications of 3D printing in small animal magnetic resonance imaging.

Journal Article J Med Imaging (Bellingham) · April 2019 Three-dimensional (3D) printing has significantly impacted the quality, efficiency, and reproducibility of preclinical magnetic resonance imaging. It has vastly expanded the ability to produce MR-compatible parts that readily permit customization of animal ... Full text Link to item Cite

New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging.

Journal Article J Thorac Imaging · March 2019 Idiopathic pulmonary fibrosis (IPF) is a progressive pulmonary disease that is ultimately fatal. Although the diagnosis of IPF has been revolutionized by high-resolution computed tomography, this imaging modality still exhibits significant limitations, par ... Full text Link to item Cite

A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis.

Journal Article NMR Biomed · January 2019 The spectral parameters of hyperpolarized 129 Xe exchanging between airspaces, interstitial barrier, and red blood cells (RBCs) are sensitive to pulmonary pathophysiology. This study sought to evaluate whether the dynamics of 129 Xe spectroscopy provide ad ... Full text Link to item Cite

Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T.

Journal Article Magn Reson Med · December 2018 PURPOSE: Hyperpolarized 129 Xe MRI depicting 3D ventilation, interstitial barrier uptake, and transfer to red blood cells (RBCs) has emerged as a powerful new means of detecting pulmonary disease. However, given the challenging susceptibility environment o ... Full text Link to item Cite

A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents.

Journal Article J Magn Reson · October 2018 Hyperpolarized (HP) 129Xe MRI is emerging as a powerful, non-invasive method to image lung function and is beginning to find clinical application across a range of conditions. As clinical implementation progresses, it becomes important to translate back to ... Full text Link to item Cite

Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2018 PURPOSE: To investigate the degree to which lung ventilation and gas exchange are regionally correlated, using the emerging technology of hyperpolarized (HP)-129Xe magnetic resonance imaging (MRI). METHODS AND MATERIALS: Hyperpolarized-129Xe MRI studies we ... Full text Link to item Cite

Functional airway obstruction observed with hyperpolarized 129 Xenon-MRI.

Journal Article J Med Imaging Radiat Oncol · February 2018 Hyperpolarized 129 Xenon-MRI (HP 129 Xe MRI) is an emerging imaging modality that allows assessment of both ventilation and gas transfer. Most research to date has focused on non-malignant pulmonary diseases. However, the capability of evaluating the two p ... Full text Link to item Cite

Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis.

Journal Article Thorax · January 2018 BACKGROUND: Assessing functional impairment, therapeutic response and disease progression in patients with idiopathic pulmonary fibrosis (IPF) continues to be challenging. Hyperpolarized 129Xe MRI can address this gap through its unique capability to image ... Full text Link to item Cite

Ventilation and Gas Transfer Distribution in Alpha-1 Antitrypsin Deficiency After Replacement Therapy

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Ventilation and Gas Transfer Measured by 129Xe MRI in Alpha-1 Antitrypsin Heterozygotes: A Pilot Study

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Longitudinal Follow Up After Xe-129 MRI Scan; Potential to Stratify Idiopathic Pulmonary Fibrosis Disease Progression

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis.

Journal Article Magn Reson Med · October 2017 PURPOSE: The purpose of this work was to accurately characterize the spectral properties of hyperpolarized 129 Xe in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers. METHODS: Subjects underwent hyperpolarized 129 Xe breath- ... Full text Link to item Cite

Electron microscopic observations of Rb particles and pitting in 129Xe spin-exchange optical pumping cells.

Journal Article J Appl Phys · July 14, 2017 High-volume production of hyperpolarized 129Xe by spin-exchange optical pumping (SEOP) has historically fallen short of theoretical predictions. Recently, this shortfall was proposed to be caused by the formation of alkali metal clusters during optical pum ... Full text Link to item Cite

Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients.

Journal Article Am J Transplant · July 2017 Bronchial stenosis in lung transplant recipients is a common disorder that adversely affects clinical outcomes. It is evaluated by spirometry, CT scanning, and bronchoscopy with significant limitations. We hypothesize that MRI using both ultrashort echo ti ... Full text Link to item Cite

Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI.

Journal Article Med Phys · June 2017 PURPOSE: Hyperpolarized 129 Xe magnetic resonance imaging (MRI) using Dixon-based decomposition enables single-breath imaging of 129 Xe in the airspaces, interstitial barrier tissues, and red blood cells (RBCs). However, methods to quantitatively visualize ... Full text Link to item Cite

Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo.

Journal Article Magn Reson Med · April 2017 PURPOSE: 129 Xe interacts with biological media to exhibit chemical shifts exceeding 200 ppm that report on physiology and pathology. Extracting this functional information requires shifts to be measured precisely. Historically, shifts have been reported r ... Full text Link to item Cite

Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice.

Journal Article Am J Physiol Lung Cell Mol Physiol · April 1, 2017 Human genome-wide association studies have identified over 50 loci associated with pulmonary function and related phenotypes, yet follow-up studies to determine causal genes or variants are rare. Single nucleotide polymorphisms in serotonin receptor 4 (HTR ... Full text Link to item Cite

Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests.

Journal Article Invest Radiol · February 2017 OBJECTIVES: The aim of this study was to investigate ventilation in mild to moderate asthmatic patients and age-matched controls using hyperpolarized (HP) Xenon magnetic resonance imaging (MRI) and correlate findings with pulmonary function tests (PFTs). M ... Full text Link to item Cite

The role of hyperpolarized 129xenon in MR imaging of pulmonary function.

Journal Article Eur J Radiol · January 2017 In the last two decades, functional imaging of the lungs using hyperpolarized noble gases has entered the clinical stage. Both helium (3He) and xenon (129Xe) gas have been thoroughly investigated for their ability to assess both the global and regional pat ... Full text Link to item Cite

Htr4 Regulates Pulmonary Function Through Neural Innervation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Comparing Quantitative 129xe Ventilation Analysis Pipelines Between Mri Centers

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution.

Journal Article Acad Radiol · December 2016 RATIONALE AND OBJECTIVES: Ventilation heterogeneity is impossible to detect with spirometry. Alternatively, pulmonary ventilation can be imaged three-dimensionally using inhaled 129Xe magnetic resonance imaging (MRI). To date, such images have been quantif ... Full text Link to item Cite

TH-EF-BRA-10: High Spatiotemporal Resolution Self-Sorted 4D MRI.

Journal Article Med Phys · June 2016 PURPOSE: To describe a novel method for self-sorted 4D-MRI and to characterize the output image quality as measured by signal-to-noise ratio (SNR), spatiotemporal resolution, and level of artifact. METHODS: A three-dimensional radial sampling function with ... Full text Link to item Cite

Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition.

Journal Article Magn Reson Med · April 2016 PURPOSE: We sought to develop and test a clinically feasible 1-point Dixon, three-dimensional (3D) radial acquisition strategy to create isotropic 3D MR images of (129)Xe in the airspaces, barrier, and red blood cells (RBCs) in a single breath. The approac ... Full text Link to item Cite

Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease.

Journal Article Pulm Circ · March 2016 The diagnosis of pulmonary vascular disease (PVD) is usually based on hemodynamic and/or clinical criteria. Noninvasive imaging of the heart and proximal vasculature can also provide useful information. An alternate approach to such criteria in the diagnos ... Full text Link to item Cite

Differentiating Early Stage And Later Stage Ipf Using Hyperpolarized 129xe Ventilation Mri

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.

Journal Article Magn Reson Imaging · September 2015 PURPOSE: The aim of this study was to evaluate the effect of hyperpolarized (129)Xe dose on image signal-to-noise ratio (SNR) and ventilation defect conspicuity on both multi-slice gradient echo and isotropic 3D-radially acquired ventilation MRI. MATERIALS ... Full text Link to item Cite

Optimizing 3D noncartesian gridding reconstruction for hyperpolarized 129Xe MRI-focus on preclinical applications

Journal Article Concepts in Magnetic Resonance Part A: Bridging Education and Research · July 1, 2015 The goal of this work is to characterize and optimize gridding reconstruction of 3D radial hyperpolarized (HP) 129Xe MRI. In support of this objective, we developed a flexible, open source reconstruction software package in MATLAB to optimally reconstruct ... Full text Cite

Hyperpolarized Gas MR Imaging: Technique and Applications.

Journal Article Magn Reson Imaging Clin N Am · May 2015 Functional imaging offers information more sensitive to changes in lung structure and function. Hyperpolarized helium ((3)He) and xenon ((129)Xe) MR imaging of the lungs provides sensitive contrast mechanisms to probe changes in pulmonary ventilation, micr ... Full text Link to item Cite

3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis.

Journal Article NMR Biomed · December 2014 A variety of pulmonary pathologies, in particular interstitial lung diseases, are characterized by thickening of the pulmonary blood-gas barrier, and this thickening results in reduced gas exchange. Such diffusive impairment is challenging to quantify spat ... Full text Link to item Cite

Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI.

Journal Article Acad Radiol · December 2014 RATIONALE AND OBJECTIVES: Clinical deployment of hyperpolarized (129)Xe magnetic resonance imaging requires accurate quantification and visualization of the ventilation defect percentage (VDP). Here, we improve the robustness of our previous semiautomated ... Full text Link to item Cite

Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis.

Journal Article J Appl Physiol (1985) · September 15, 2014 Although xenon is classically taught to be a "perfusion-limited" gas, (129)Xe in its hyperpolarized (HP) form, when detected by magnetic resonance (MR), can probe diffusion limitation. Inhaled HP (129)Xe diffuses across the pulmonary blood-gas barrier, and ... Full text Link to item Cite

Characterizing and modeling the efficiency limits in large-scale production of hyperpolarized 129Xe.

Journal Article Phys Rev A · August 6, 2014 The ability to produce liter volumes of highly spin-polarized 129Xe enables a wide range of investigations, most notably in the fields of materials science and biomedical MRI. However, for nearly all polarizers built to date, both peak 129Xe polarization a ... Full text Link to item Cite

Hyperpolarized 129xe Mri To Quantify Regional Ventilation Differences In Older Versus Younger Asthmatics

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2014 Link to item Cite

Hyperpolarized 129xe Spectroscopy As A Biomarker For Gas-Transfer Impairment In Idiopathic Pulmonary Fibrosis

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2014 Link to item Cite

Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin.

Journal Article Magn Reson Med · November 2013 PURPOSE: Hyperpolarized (HP) (129) Xe gas in the alveoli can be detected separately from (129) Xe dissolved in pulmonary barrier tissues (blood plasma and parenchyma) and red blood cells (RBCs) of humans, allowing this isotope to probe impaired gas uptake. ... Full text Link to item Cite

Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.

Journal Article J Appl Physiol (1985) · September 2013 Featured Publication Although some central aspects of pulmonary function (ventilation and perfusion) are known to be heterogeneous, the distribution of diffusive gas exchange remains poorly characterized. A solution is offered by hyperpolarized 129Xe magnetic resonance (MR) im ... Full text Link to item Cite

Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease.

Journal Article NMR Biomed · April 2013 In this study, hyperpolarized (129) Xe MR ventilation and (1) H anatomical images were obtained from three subject groups: young healthy volunteers (HVs), subjects with chronic obstructive pulmonary disease (COPD) and age-matched controls (AMCs). Ventilati ... Full text Link to item Cite

Detecting Impaired Gas Uptake In A Rat Model Of Pulmonary Fibrosis With 3d Hyperpolarized 129xe Mri

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Probing Diffusive Gas Uptake In Mice Using Hyperpolarized 129xe Magnetic Resonance Spectroscopy And Imaging

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Quantitative Analysis Of 3he And 1h Mr Images Of Regional Pulmonary Injury In House-Dust-Mite Allergic Mice

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Reproducibility Of Hyperpolarized 129xe Mri: Alveolar Capillary Gas-Transfer Spectroscopy And Imaging

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Small animal imaging with magnetic resonance microscopy

Journal Article ILAR Journal · September 11, 2012 Featured Publication Small animal magnetic resonance microscopy (MRM) has evolved significantly from testing the boundaries of imaging physics to its expanding use today as a tool in noninvasive biomedical investigations. MRM now increasingly provides functional information ab ... Cite

Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients.

Journal Article Radiology · January 2012 Featured Publication PURPOSE: To evaluate the safety and tolerability of inhaling multiple 1-L volumes of undiluted hyperpolarized xenon 129 ((129)Xe) followed by up to a 16-second breath hold and magnetic resonance (MR) imaging. MATERIALS AND METHODS: This study was approved ... Full text Link to item Cite

In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe.

Journal Article PLoS One · 2012 Featured Publication BACKGROUND: Hyperpolarized (HP) (129)Xe magnetic resonance imaging (MRI) permits high resolution, regional visualization of pulmonary ventilation. Additionally, its reasonably high solubility (>10%) and large chemical shift range (>200 ppm) in tissues allo ... Full text Link to item Cite

Relaxation of hyperpolarized 129Xe in a deflating polymer bag.

Journal Article J Magn Reson · September 2011 In magnetic resonance imaging with hyperpolarized (HP) noble gases, data is often acquired during prolonged gas delivery from a storage reservoir. However, little is known about the extent to which relaxation within the reservoir will limit the useful acqu ... Full text Link to item Cite

Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury.

Journal Article Am J Respir Cell Mol Biol · May 2011 Featured Publication Regions of diminished ventilation are often evident during functional pulmonary imaging studies, including hyperpolarized gas magnetic resonance imaging (MRI), positron emission tomography, and computed tomography (CT). The objective of this study was to c ... Full text Link to item Cite

Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.

Journal Article Magn Reson Med · April 2011 Featured Publication Given its greater availability and lower cost, (129) Xe apparent diffusion coefficient (ADC) MRI offers an alternative to (3) He ADC MRI. To demonstrate the feasibility of hyperpolarized (129) Xe ADC MRI, we present results from healthy volunteers (HV), ch ... Full text Link to item Cite

Gradient-induced longitudinal relaxation of hyperpolarized noble gases in the fringe fields of superconducting magnets used for magnetic resonance.

Journal Article J Magn Reson · February 2011 When hyperpolarized noble gases are brought into the bore of a superconducting magnet for magnetic resonance imaging (MRI) or spectroscopy studies, the gases must pass through substantial field gradients, which can cause rapid longitudinal relaxation. In t ... Full text Link to item Cite

Hyperpolarized Xe MR imaging of alveolar gas uptake in humans.

Journal Article PLoS One · August 16, 2010 Featured Publication BACKGROUND: One of the central physiological functions of the lungs is to transfer inhaled gases from the alveoli to pulmonary capillary blood. However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity a ... Full text Open Access Link to item Cite

Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine.

Journal Article Magn Reson Med · March 2010 The capability to use high-resolution (3)He MRI to depict regional ventilation changes and airway narrowing in mice challenged with methacholine (MCh) offers the opportunity to gain new insights into the study of asthma. However, to fully exploit the value ... Full text Link to item Cite

Molecular MRI for sensitive and specific detection of lung metastases.

Journal Article Proc Natl Acad Sci U S A · February 23, 2010 Featured Publication Early and specific detection of metastatic cancer cells in the lung (the most common organ targeted by metastases) could significantly improve cancer treatment outcomes. However, the most widespread lung imaging methods use ionizing radiation and have low ... Full text Link to item Cite

Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes.

Journal Article J Phys Chem B · September 17, 2009 Featured Publication Hyperpolarized (HP) (129)Xe yields high signal intensities in nuclear magnetic resonance (NMR) and, through its large chemical shift range of approximately 300 ppm, provides detailed information about the local chemical environment. To exploit these proper ... Full text Link to item Cite

Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe.

Journal Article Radiology · August 2009 Featured Publication PURPOSE: To develop and demonstrate a method for regional evaluation of pulmonary perfusion and gas exchange based on intravenous injection of hyperpolarized xenon 129 ((129)Xe) and subsequent magnetic resonance (MR) imaging of the gas-phase (129)Xe emergi ... Full text Link to item Cite

A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI.

Journal Article NMR Biomed · June 2009 Featured Publication Hyperpolarized (HP) (3)He magnetic resonance imaging has been recently used to produce high-resolution images of pulmonary ventilation after methacholine (MCh) challenge in mouse models of allergic inflammation. This capability presents an opportunity to g ... Full text Link to item Cite

Pressure shifts and broadening of the Cs D1 and D2 lines by He, N2, and Xe at densities used for optical pumping and spin exchange polarization

Journal Article Journal of Applied Physics · November 24, 2008 The production of hyperpolarized gases by spin-exchange optical pumping (SEOP) requires exact knowledge of the alkali metal's D1 absorption profile and the degree to which it is broadened and shifted by varying buffer gas composition and pressure. We have ... Full text Cite

In vivo MRI using real-time production of hyperpolarized 129Xe.

Journal Article Magn Reson Med · July 2008 Featured Publication MR imaging of hyperpolarized (HP) nuclei is challenging because they are typically delivered in a single dose of nonrenewable magnetization, from which the entire image must be derived. This problem can be overcome with HP (129)Xe, which can be produced su ... Full text Link to item Cite

Small animal imaging with magnetic resonance microscopy.

Journal Article ILAR J · 2008 Featured Publication Small animal magnetic resonance microscopy (MRM) has evolved significantly from testing the boundaries of imaging physics to its expanding use today as a tool in noninvasive biomedical investigations. MRM now increasingly provides functional information ab ... Full text Link to item Cite

3He MRI in mouse models of asthma.

Journal Article Magn Reson Med · November 2007 Featured Publication In the study of asthma, a vital role is played by mouse models, because knockout or transgenic methods can be used to alter disease pathways and identify therapeutic targets that affect lung function. Assessment of lung function in rodents by available met ... Full text Link to item Cite

Hyperpolarized Gas Imaging

Journal Article eMagRes · January 1, 2007 Full text Cite

Imaging techniques for small animal models of pulmonary disease: MR microscopy.

Journal Article Toxicol Pathol · January 2007 In vivo magnetic resonance microscopy (MRM) of the small animal lung has become a valuable research tool, especially for preclinical studies. MRM offers a noninvasive and nondestructive tool for imaging small animals longitudinally and at high spatial reso ... Full text Link to item Cite

Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.

Journal Article Proc Natl Acad Sci U S A · November 28, 2006 Featured Publication Effective pulmonary gas exchange relies on the free diffusion of gases across the thin tissue barrier separating airspace from the capillary red blood cells (RBCs). Pulmonary pathologies, such as inflammation, fibrosis, and edema, which cause an increased ... Full text Link to item Cite

Hyperpolarized 129Xe MRI for Functional Assessment of Radiation-Induced Lung Injury

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.

Journal Article Magn Reson Med · June 2005 In this experiment, Sprague-Dawley rats with elastase-induced emphysema were imaged using hyperpolarized (3)He MRI. Regional fractional ventilation r, the fraction of gas replaced with a single tidal breath, was calculated from a series of images in a wash ... Full text Link to item Cite

A small animal model of regional alveolar ventilation using HP 3He MRI1.

Journal Article Acad Radiol · October 2004 RATIONALE AND OBJECTIVES: The aim of this study was to establish a standardized procedure for the measurement of regional fractional ventilation in a healthy rat model as a baseline for further studies of pulmonary disorder models. MATERIALS AND METHODS: T ... Full text Link to item Cite

Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.

Journal Article Magn Reson Med · December 2003 Featured Publication The ability to quantify pulmonary diffusing capacity and perfusion using dynamic hyperpolarized (129)Xe NMR spectroscopy is demonstrated. A model of alveolar gas exchange was developed, which, in conjunction with (129)Xe NMR, enables quantification of aver ... Full text Link to item Cite

Hybrid spin-exchange optical pumping of 3He.

Journal Article Phys Rev Lett · September 19, 2003 Featured Publication We demonstrate spin-exchange optical pumping of 3He using a "hybrid" K-Rb vapor mixture. The Rb atoms absorb light from a standard laser at 795 nm, then collisionally polarize the potassium atoms. Spin-exchange collisions of K and 3He atoms then transfer t ... Full text Link to item Cite

Fundamental mechanisms of 3 He relaxation on glass

Journal Article Chemical Physics Letters · March 7, 2003 We present a model of 3 He relaxation on the surface of borosilicate glass which accurately predicts observed relaxation rates and their temperature dependence. Above room temperature 3 He dissolves into Pyrex, where interactions with Fe 3+ ions result in ... Full text Cite

NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold.

Journal Article NMR Biomed · June 2000 Featured Publication One of the major goals of hyperpolarized-gas MR imaging has been to obtain (129)Xe dissolved-phase images in humans. Since the dissolved-phase signal is much weaker than the gas-phase signal, highly optimized MR pulse sequences are required to obtain adequ ... Full text Link to item Cite

Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2).

Journal Article Magn Reson Med · October 1999 Featured Publication The transverse relaxation time, T *(2), of hyperpolarized (HP) gas in the lung in vivo is an important parameter for pulse sequence optimization and image contrast. We obtained T *(2) maps of HP (3)He and (129)Xe in guinea pig lungs (n = 17) and in human l ... Full text Link to item Cite

Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient.

Journal Article Magn Reson Med · October 1999 Featured Publication In imaging of hyperpolarized noble gases, a knowledge of the diffusion coefficient (D) is important both as a contrast mechanism and in the design of pulse sequences. We have made diffusion coefficient maps of both hyperpolarized (3)He and (129)Xe in guine ... Full text Link to item Cite

Consequences of (129)Xe-(1)H cross relaxation in aqueous solutions.

Journal Article J Magn Reson · August 1999 We have investigated the transfer of polarization from (129)Xe to solute protons in aqueous solutions to determine the feasibility of using hyperpolarized xenon to enhance (1)H sensitivity in aqueous systems at or near room temperatures. Several solutes, e ... Full text Link to item Cite

Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.

Journal Article Magn Reson Med · May 1999 Hyperpolarized (HP) 129Xe can be dissolved in biologically compatible lipid emulsions while maintaining sufficient polarization for in vivo vascular imaging. For xenon in Intralipid 30%, in vitro spectroscopy at 2 T yielded a chemical shift of 197 +/- 1 pp ... Full text Link to item Cite

Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases.

Journal Article Magn Reson Med · April 1999 Featured Publication Three-dimensional magnetic resonance images of the guinea pig lung were acquired in vivo using hyperpolarized (HP) noble gases and radial projection encoding (PE). Results obtained with 3He (voxel size 17 microl) demonstrated high image quality showing air ... Full text Link to item Cite

Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases.

Journal Article J Magn Reson · November 1998 Featured Publication The nonequilibrium bulk magnetic moment of hyperpolarized (HP) noble gases generated by optical pumping has unique characteristics. Based on the Bloch equations, a model was developed describing the signal dynamics of HP gases used in magnetic resonance im ... Full text Link to item Cite

Dynamics of magnetization in hyperpolarized gas MRI of the lung.

Journal Article Magn Reson Med · July 1997 Featured Publication The magnetization in hyperpolarized gas (HP) MRI is generated by laser polarization that is independent of the magnet and imaging process. As a consequence, there is no equilibrium magnetization during the image acquisition. The competing processes of gas ... Full text Link to item Cite

MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results.

Journal Article Magn Reson Med · June 1997 Featured Publication Using a new method of xenon laser-polarization that permits the generation of liter quantities of hyperpolarized 129Xe gas, the first 129Xe imaging results from the human chest and the first 129Xe spectroscopy results from the human chest and head have bee ... Full text Link to item Cite

High-volume production of laser-polarized 129Xe

Journal Article Applied Physics Letters · September 16, 1996 Featured Publication A method is described for producing several liters of nuclear spin polarized 129Xe gas via spin exchange with an optically pumped Rb vapor. We use a 140 W AlGaAs laser diode array whose broad spectral output is efficiently absorbed by employing ∼ 10 atm of ... Full text Cite

Human lung air spaces: potential for MR imaging with hyperpolarized He-3.

Journal Article Radiology · August 1996 Featured Publication Two healthy volunteers who had inhaled approximately 0.75 L of laser-polarized helium-3 gas underwent magnetic resonance imaging at 1.5 T with fast gradient-echo pulse sequences and small flip angles ( < 10 degrees). Thick-section (20 mm) coronal images, t ... Full text Link to item Cite

In vivo He-3 MR images of guinea pig lungs.

Journal Article Radiology · June 1996 Featured Publication The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange with rubidium metal vapor was delivered through an MR-compatible, small-animal ventila ... Full text Link to item Cite

Surface relaxation mechanisms of laser-polarized 129Xe.

Journal Article Phys Rev Lett · June 12, 1995 Featured Publication Full text Link to item Cite

The SLAC high-density gaseous polarized 3He target

Journal Article Nuclear Inst. and Methods in Physics Research, A · March 1, 1995 A large-scale high-pressure gaseous 3He polarized target has been developed for use with a high-intensity polarized electron beam at the Stanford Linear Accelerator Center. This target was used successfully in an experiment to study the spin structure of t ... Full text Cite

Biological magnetic resonance imaging using laser-polarized 129Xe.

Journal Article Nature · July 21, 1994 Featured Publication As currently implemented, magnetic resonance imaging (MRI) relies on the protons of water molecules in tissue to provide the NMR signal. Protons are, however, notoriously difficult to image in some biological environments of interest, notably the lungs and ... Full text Link to item Cite

Spin transfer between laser-polarized 129Xe nuclei and surface protons

Journal Article Physics Letters A · December 27, 1993 We have demonstrated a large polarization transfer from highly polarized gaseous 129Xe to protons in a silicone surface coating. The proton polarization enhancement of ∼ 104-105 over the thermal equilibrium polarization at 0.2 T makes possible the detectio ... Full text Cite

Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe.

Journal Article Phys Rev Lett · February 1, 1993 Featured Publication Full text Link to item Cite

INSITU GROWTH OF SUPERCONDUCTING FILMS OF BI SR CA CU O USING MAGNETRON SPUTTERING

Conference SCIENCE AND TECHNOLOGY OF THIN FILM SUPERCONDUCTORS 2 · January 1, 1990 Link to item Cite