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Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium.

Publication ,  Journal Article
Niedbalski, PJ; Hall, CS; Castro, M; Eddy, RL; Rayment, JH; Svenningsen, S; Parraga, G; Zanette, B; Santyr, GE; Thomen, RP; Stewart, NJ ...
Published in: Magn Reson Med
December 2021

Hyperpolarized (HP) 129 Xe MRI uniquely images pulmonary ventilation, gas exchange, and terminal airway morphology rapidly and safely, providing novel information not possible using conventional imaging modalities or pulmonary function tests. As such, there is mounting interest in expanding the use of biomarkers derived from HP 129 Xe MRI as outcome measures in multi-site clinical trials across a range of pulmonary disorders. Until recently, HP 129 Xe MRI techniques have been developed largely independently at a limited number of academic centers, without harmonizing acquisition strategies. To promote uniformity and adoption of HP 129 Xe MRI more widely in translational research, multi-site trials, and ultimately clinical practice, this position paper from the 129 Xe MRI Clinical Trials Consortium (https://cpir.cchmc.org/XeMRICTC) recommends standard protocols to harmonize methods for image acquisition in HP 129 Xe MRI. Recommendations are described for the most common HP gas MRI techniques-calibration, ventilation, alveolar-airspace size, and gas exchange-across MRI scanner manufacturers most used for this application. Moreover, recommendations are described for 129 Xe dose volumes and breath-hold standardization to further foster consistency of imaging studies. The intention is that sites with HP 129 Xe MRI capabilities can readily implement these methods to obtain consistent high-quality images that provide regional insight into lung structure and function. While this document represents consensus at a snapshot in time, a roadmap for technical developments is provided that will further increase image quality and efficiency. These standardized dosing and imaging protocols will facilitate the wider adoption of HP 129 Xe MRI for multi-site pulmonary research.

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Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

December 2021

Volume

86

Issue

6

Start / End Page

2966 / 2986

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Respiration
  • Pulmonary Ventilation
  • Nuclear Medicine & Medical Imaging
  • Multicenter Studies as Topic
  • Magnetic Resonance Imaging
  • Lung
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

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Niedbalski, P. J., Hall, C. S., Castro, M., Eddy, R. L., Rayment, J. H., Svenningsen, S., … Woods, J. C. (2021). Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium. Magn Reson Med, 86(6), 2966–2986. https://doi.org/10.1002/mrm.28985
Niedbalski, Peter J., Chase S. Hall, Mario Castro, Rachel L. Eddy, Jonathan H. Rayment, Sarah Svenningsen, Grace Parraga, et al. “Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium.Magn Reson Med 86, no. 6 (December 2021): 2966–86. https://doi.org/10.1002/mrm.28985.
Niedbalski PJ, Hall CS, Castro M, Eddy RL, Rayment JH, Svenningsen S, Parraga G, Zanette B, Santyr GE, Thomen RP, Stewart NJ, Collier GJ, Chan H-F, Wild JM, Fain SB, Miller GW, Mata JF, Mugler JP, Driehuys B, Willmering MM, Cleveland ZI, Woods JC. Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium. Magn Reson Med. 2021 Dec;86(6):2966–2986.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

December 2021

Volume

86

Issue

6

Start / End Page

2966 / 2986

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Respiration
  • Pulmonary Ventilation
  • Nuclear Medicine & Medical Imaging
  • Multicenter Studies as Topic
  • Magnetic Resonance Imaging
  • Lung
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering