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Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient.

Publication ,  Journal Article
Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Johnson, GA
Published in: Magn Reson Med
October 1999

In imaging of hyperpolarized noble gases, a knowledge of the diffusion coefficient (D) is important both as a contrast mechanism and in the design of pulse sequences. We have made diffusion coefficient maps of both hyperpolarized (3)He and (129)Xe in guinea pig lungs. Along the length of the trachea, (3)He D values were on average 2.4 cm(2)/sec, closely reproducing calculated values for free gas (2.05 cm(2)/sec). The (3)He D values measured perpendicular to the length of the trachea were approximately a factor of two less, indicating restriction to diffusion. Further evidence of restricted diffusion was seen in the distal pulmonary airspaces as the average (3)He D was 0.16 cm(2)/sec. An additional cause for the smaller (3)He D in the lung was due to the presence of air, which is composed of heavier and larger gases. The (129)Xe results show similar trends, with the trachea D averaging 0.068 cm(2)/sec and the lung D averaging 0.021 cm(2)/sec. Magn Reson Med 42:721-728, 1999.

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Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

October 1999

Volume

42

Issue

4

Start / End Page

721 / 728

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Pulmonary Diffusing Capacity
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Helium
  • Guinea Pigs
  • Animals
  • 4003 Biomedical engineering
 

Citation

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Chen, X. J., Möller, H. E., Chawla, M. S., Cofer, G. P., Driehuys, B., Hedlund, L. W., & Johnson, G. A. (1999). Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient. Magn Reson Med, 42(4), 721–728. https://doi.org/10.1002/(sici)1522-2594(199910)42:4<721::aid-mrm14>3.0.co;2-d
Chen, X. J., H. E. Möller, M. S. Chawla, G. P. Cofer, B. Driehuys, L. W. Hedlund, and G. A. Johnson. “Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient.Magn Reson Med 42, no. 4 (October 1999): 721–28. https://doi.org/10.1002/(sici)1522-2594(199910)42:4<721::aid-mrm14>3.0.co;2-d.
Chen XJ, Möller HE, Chawla MS, Cofer GP, Driehuys B, Hedlund LW, et al. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient. Magn Reson Med. 1999 Oct;42(4):721–8.
Chen, X. J., et al. “Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient.Magn Reson Med, vol. 42, no. 4, Oct. 1999, pp. 721–28. Pubmed, doi:10.1002/(sici)1522-2594(199910)42:4<721::aid-mrm14>3.0.co;2-d.
Chen XJ, Möller HE, Chawla MS, Cofer GP, Driehuys B, Hedlund LW, Johnson GA. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient. Magn Reson Med. 1999 Oct;42(4):721–728.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

October 1999

Volume

42

Issue

4

Start / End Page

721 / 728

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Pulmonary Diffusing Capacity
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Helium
  • Guinea Pigs
  • Animals
  • 4003 Biomedical engineering