Skip to main content
Journal cover image

Dynamics of magnetization in hyperpolarized gas MRI of the lung.

Publication ,  Journal Article
Johnson, GA; Cates, G; Chen, XJ; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Saam, B; Shattuck, MD; Swartz, J
Published in: Magn Reson Med
July 1997

The magnetization in hyperpolarized gas (HP) MRI is generated by laser polarization that is independent of the magnet and imaging process. As a consequence, there is no equilibrium magnetization during the image acquisition. The competing processes of gas inflow and depolarization of the spins lead to large changes in signal as one samples k-space. A model is developed of dynamic changes in polarization of hyperpolarized 3He during infusion and in vivo imaging of the lung and verified experimentally in a live guinea pig. Projection encoding is used to measure the view-to-view variation with temporal resolution < 4 ms. Large excitation angles effectively sample the magnetization in the early stages of inflow, highlighting larger airways, while smaller excitation angles produce images of the more distal spaces. The work provides a basis for pulse sequences designed to effectively exploit HP MRI in the lung.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

July 1997

Volume

38

Issue

1

Start / End Page

66 / 71

Location

United States

Related Subject Headings

  • Respiration
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Helium
  • Guinea Pigs
  • Animals
  • 4003 Biomedical engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Johnson, G. A., Cates, G., Chen, X. J., Cofer, G. P., Driehuys, B., Happer, W., … Swartz, J. (1997). Dynamics of magnetization in hyperpolarized gas MRI of the lung. Magn Reson Med, 38(1), 66–71. https://doi.org/10.1002/mrm.1910380111
Johnson, G. A., G. Cates, X. J. Chen, G. P. Cofer, B. Driehuys, W. Happer, L. W. Hedlund, B. Saam, M. D. Shattuck, and J. Swartz. “Dynamics of magnetization in hyperpolarized gas MRI of the lung.Magn Reson Med 38, no. 1 (July 1997): 66–71. https://doi.org/10.1002/mrm.1910380111.
Johnson GA, Cates G, Chen XJ, Cofer GP, Driehuys B, Happer W, et al. Dynamics of magnetization in hyperpolarized gas MRI of the lung. Magn Reson Med. 1997 Jul;38(1):66–71.
Johnson, G. A., et al. “Dynamics of magnetization in hyperpolarized gas MRI of the lung.Magn Reson Med, vol. 38, no. 1, July 1997, pp. 66–71. Pubmed, doi:10.1002/mrm.1910380111.
Johnson GA, Cates G, Chen XJ, Cofer GP, Driehuys B, Happer W, Hedlund LW, Saam B, Shattuck MD, Swartz J. Dynamics of magnetization in hyperpolarized gas MRI of the lung. Magn Reson Med. 1997 Jul;38(1):66–71.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

July 1997

Volume

38

Issue

1

Start / End Page

66 / 71

Location

United States

Related Subject Headings

  • Respiration
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Helium
  • Guinea Pigs
  • Animals
  • 4003 Biomedical engineering