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Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases.

Publication ,  Journal Article
Möller, HE; Chen, XJ; Chawla, MS; Driehuys, B; Hedlund, LW; Johnson, GA
Published in: J Magn Reson
November 1998

The nonequilibrium bulk magnetic moment of hyperpolarized (HP) noble gases generated by optical pumping has unique characteristics. Based on the Bloch equations, a model was developed describing the signal dynamics of HP gases used in magnetic resonance imaging (MRI) of the lung with special consideration to the breathing cycle. Experimental verification included extensive investigations with HP 3He and 129Xe during both inspiration and held breath in live guinea pigs. Radial acquisition was used to investigate the view variations with a temporal resolution of 5 ms. Agreement between theoretical predictions and in vivo results was excellent. Additionally, information about effects from noble gas diffusion and spin-lattice relaxation was obtained. In vivo results for T1 were 28.8 +/- 1.8 s for 3He and 31.3 +/- 1.8 s for 129Xe. Comparison with in vitro data indicated that relaxation in the pulmonary gas space is dominated by dipolar coupling with molecular oxygen. The results provide a quantitative basis for optimizing pulse sequence design in HP gas MRI of the lung.

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Published In

J Magn Reson

DOI

ISSN

1090-7807

Publication Date

November 1998

Volume

135

Issue

1

Start / End Page

133 / 143

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Noble Gases
  • Models, Theoretical
  • Magnetics
  • Magnetic Resonance Imaging
  • Lung
  • Image Enhancement
  • Guinea Pigs
  • Biophysics
  • Animals
 

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Möller, H. E., Chen, X. J., Chawla, M. S., Driehuys, B., Hedlund, L. W., & Johnson, G. A. (1998). Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases. J Magn Reson, 135(1), 133–143. https://doi.org/10.1006/jmre.1998.1563
Möller, H. E., X. J. Chen, M. S. Chawla, B. Driehuys, L. W. Hedlund, and G. A. Johnson. “Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases.J Magn Reson 135, no. 1 (November 1998): 133–43. https://doi.org/10.1006/jmre.1998.1563.
Möller HE, Chen XJ, Chawla MS, Driehuys B, Hedlund LW, Johnson GA. Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases. J Magn Reson. 1998 Nov;135(1):133–43.
Möller, H. E., et al. “Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases.J Magn Reson, vol. 135, no. 1, Nov. 1998, pp. 133–43. Pubmed, doi:10.1006/jmre.1998.1563.
Möller HE, Chen XJ, Chawla MS, Driehuys B, Hedlund LW, Johnson GA. Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases. J Magn Reson. 1998 Nov;135(1):133–143.
Journal cover image

Published In

J Magn Reson

DOI

ISSN

1090-7807

Publication Date

November 1998

Volume

135

Issue

1

Start / End Page

133 / 143

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Noble Gases
  • Models, Theoretical
  • Magnetics
  • Magnetic Resonance Imaging
  • Lung
  • Image Enhancement
  • Guinea Pigs
  • Biophysics
  • Animals