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In vivo MRI using real-time production of hyperpolarized 129Xe.

Publication ,  Journal Article
Driehuys, B; Pollaro, J; Cofer, GP
Published in: Magn Reson Med
July 2008

MR imaging of hyperpolarized (HP) nuclei is challenging because they are typically delivered in a single dose of nonrenewable magnetization, from which the entire image must be derived. This problem can be overcome with HP (129)Xe, which can be produced sufficiently rapidly to deliver in dilute form (1%) continuously and on-demand. We demonstrate a real-time in vivo delivery of HP (129)Xe mixture to rats, a capability we now routinely use for setting frequency, transmitter gain, shimming, testing pulse sequences, scout imaging, and spectroscopy. Compared to images acquired using conventional fully concentrated (129)Xe, real-time (129)Xe images have 26-fold less signal, but clearly depict ventilation abnormalities. Real-time (129)Xe MRI could be useful for time-course studies involving acute injury or response to treatment. Ultimately, real-time (129)Xe MRI could be done with more highly concentrated (129)Xe, which could increase the signal-to-noise ratio by 100 relative to these results to enable a new class of gas imaging applications.

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Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

July 2008

Volume

60

Issue

1

Start / End Page

14 / 20

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Spectrum Analysis
  • Rats, Inbred F344
  • Rats
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Computer Systems
  • Animals
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

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Driehuys, B., Pollaro, J., & Cofer, G. P. (2008). In vivo MRI using real-time production of hyperpolarized 129Xe. Magn Reson Med, 60(1), 14–20. https://doi.org/10.1002/mrm.21651
Driehuys, Bastiaan, Jim Pollaro, and Gary P. Cofer. “In vivo MRI using real-time production of hyperpolarized 129Xe.Magn Reson Med 60, no. 1 (July 2008): 14–20. https://doi.org/10.1002/mrm.21651.
Driehuys B, Pollaro J, Cofer GP. In vivo MRI using real-time production of hyperpolarized 129Xe. Magn Reson Med. 2008 Jul;60(1):14–20.
Driehuys, Bastiaan, et al. “In vivo MRI using real-time production of hyperpolarized 129Xe.Magn Reson Med, vol. 60, no. 1, July 2008, pp. 14–20. Pubmed, doi:10.1002/mrm.21651.
Driehuys B, Pollaro J, Cofer GP. In vivo MRI using real-time production of hyperpolarized 129Xe. Magn Reson Med. 2008 Jul;60(1):14–20.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

July 2008

Volume

60

Issue

1

Start / End Page

14 / 20

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Spectrum Analysis
  • Rats, Inbred F344
  • Rats
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Computer Systems
  • Animals
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering