In vivo MRI using real-time production of hyperpolarized 129Xe.
MR imaging of hyperpolarized (HP) nuclei is challenging because they are typically delivered in a single dose of nonrenewable magnetization, from which the entire image must be derived. This problem can be overcome with HP (129)Xe, which can be produced sufficiently rapidly to deliver in dilute form (1%) continuously and on-demand. We demonstrate a real-time in vivo delivery of HP (129)Xe mixture to rats, a capability we now routinely use for setting frequency, transmitter gain, shimming, testing pulse sequences, scout imaging, and spectroscopy. Compared to images acquired using conventional fully concentrated (129)Xe, real-time (129)Xe images have 26-fold less signal, but clearly depict ventilation abnormalities. Real-time (129)Xe MRI could be useful for time-course studies involving acute injury or response to treatment. Ultimately, real-time (129)Xe MRI could be done with more highly concentrated (129)Xe, which could increase the signal-to-noise ratio by 100 relative to these results to enable a new class of gas imaging applications.
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- Xenon Isotopes
- Spectrum Analysis
- Rats, Inbred F344
- Rats
- Nuclear Medicine & Medical Imaging
- Magnetic Resonance Imaging
- Computer Systems
- Animals
- 4003 Biomedical engineering
- 0903 Biomedical Engineering
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Xenon Isotopes
- Spectrum Analysis
- Rats, Inbred F344
- Rats
- Nuclear Medicine & Medical Imaging
- Magnetic Resonance Imaging
- Computer Systems
- Animals
- 4003 Biomedical engineering
- 0903 Biomedical Engineering