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Distinct expression patterns of CD123 and CD34 on normal bone marrow B-cell precursors ("hematogones") and B lymphoblastic leukemia blasts.

Publication ,  Journal Article
Hassanein, NM; Alcancia, F; Perkinson, KR; Buckley, PJ; Lagoo, AS
Published in: Am J Clin Pathol
October 2009

We compared the expression of CD123, the alpha chain of the interleukin-3 receptor, on normal B-cell precursors in bone marrow ("hematogones") from 75 specimens and on leukemic blasts in 45 newly diagnosed B-acute lymphoblastic leukemias (B-ALL) cases. We found that the less mature hematogones (dim CD45+) that express CD34 lack CD123 expression, whereas the more mature hematogones (moderate CD45+) lack CD34 but always express CD123. In contrast with this discordant pattern of CD34 and CD123 expression in hematogones, blasts in 41 (91%) of 45 cases of B-ALL showed concordant expression of the 2 antigens: 80% (36 of 45) cases expressed both antigens, whereas 11% (5 of 45) expressed neither. We found that these distinct patterns of CD34/CD123 expression on hematogones (discordant) and B-ALL blasts (concordant) remain stable after chemotherapy and are useful in differentiating small populations of residual blasts from hematogones that may be simultaneously present.

Duke Scholars

Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

October 2009

Volume

132

Issue

4

Start / End Page

573 / 580

Location

England

Related Subject Headings

  • Precursor Cells, B-Lymphoid
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
  • Pathology
  • Leukocytes
  • Interleukin-3 Receptor alpha Subunit
  • Humans
  • Bone Marrow
  • Antigens, CD34
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hassanein, N. M., Alcancia, F., Perkinson, K. R., Buckley, P. J., & Lagoo, A. S. (2009). Distinct expression patterns of CD123 and CD34 on normal bone marrow B-cell precursors ("hematogones") and B lymphoblastic leukemia blasts. Am J Clin Pathol, 132(4), 573–580. https://doi.org/10.1309/AJCPO4DS0GTLSOEI
Hassanein, Nagwa M., Felisa Alcancia, Kathryn R. Perkinson, Patrick J. Buckley, and Anand S. Lagoo. “Distinct expression patterns of CD123 and CD34 on normal bone marrow B-cell precursors ("hematogones") and B lymphoblastic leukemia blasts.Am J Clin Pathol 132, no. 4 (October 2009): 573–80. https://doi.org/10.1309/AJCPO4DS0GTLSOEI.
Hassanein NM, Alcancia F, Perkinson KR, Buckley PJ, Lagoo AS. Distinct expression patterns of CD123 and CD34 on normal bone marrow B-cell precursors ("hematogones") and B lymphoblastic leukemia blasts. Am J Clin Pathol. 2009 Oct;132(4):573–80.
Hassanein, Nagwa M., et al. “Distinct expression patterns of CD123 and CD34 on normal bone marrow B-cell precursors ("hematogones") and B lymphoblastic leukemia blasts.Am J Clin Pathol, vol. 132, no. 4, Oct. 2009, pp. 573–80. Pubmed, doi:10.1309/AJCPO4DS0GTLSOEI.
Hassanein NM, Alcancia F, Perkinson KR, Buckley PJ, Lagoo AS. Distinct expression patterns of CD123 and CD34 on normal bone marrow B-cell precursors ("hematogones") and B lymphoblastic leukemia blasts. Am J Clin Pathol. 2009 Oct;132(4):573–580.
Journal cover image

Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

October 2009

Volume

132

Issue

4

Start / End Page

573 / 580

Location

England

Related Subject Headings

  • Precursor Cells, B-Lymphoid
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
  • Pathology
  • Leukocytes
  • Interleukin-3 Receptor alpha Subunit
  • Humans
  • Bone Marrow
  • Antigens, CD34
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences