Skip to main content
Journal cover image

Stem cell source and outcome after hematopoietic stem cell transplantation (HSCT) in children and adolescents with acute leukemia.

Publication ,  Journal Article
Peters, C; Cornish, JM; Parikh, SH; Kurtzberg, J
Published in: Pediatr Clin North Am
February 2010

Allogeneic hematopoietic stem cell transplantation from siblings, unrelated donors or HLA mismatched family members has become an important procedure to offer a chance of cure to children and adolescents with acute leukemia at high risk of relapse and those with certain genetic diseases. Bone marrow (BM) was the only stem cell source for many years. During the past 15 years, peripheral blood stem cells from granulocyte colony-stimulating factor (G-CSF) mobilized healthy donors, or umbilical cord blood from related or unrelated donors, have become available. Each stem cell source has different risks/benefits for patients and donors, the choice depending not only on availability, but also on HLA compatibility and urgency of the HSCT. This review will analyze the advantages and limitations of each of these options, and the main criteria which can be applied when choosing the appropriate stem cell source for pediatric transplant recipients with acute leukemia.

Duke Scholars

Published In

Pediatr Clin North Am

DOI

EISSN

1557-8240

Publication Date

February 2010

Volume

57

Issue

1

Start / End Page

27 / 46

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tissue and Organ Harvesting
  • Tissue Donors
  • Stem Cells
  • Pediatrics
  • Leukemia
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Child
  • Adolescent
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Peters, C., Cornish, J. M., Parikh, S. H., & Kurtzberg, J. (2010). Stem cell source and outcome after hematopoietic stem cell transplantation (HSCT) in children and adolescents with acute leukemia. Pediatr Clin North Am, 57(1), 27–46. https://doi.org/10.1016/j.pcl.2010.01.004
Peters, Christina, Jacqueline M. Cornish, Suhag H. Parikh, and Joanne Kurtzberg. “Stem cell source and outcome after hematopoietic stem cell transplantation (HSCT) in children and adolescents with acute leukemia.Pediatr Clin North Am 57, no. 1 (February 2010): 27–46. https://doi.org/10.1016/j.pcl.2010.01.004.
Peters C, Cornish JM, Parikh SH, Kurtzberg J. Stem cell source and outcome after hematopoietic stem cell transplantation (HSCT) in children and adolescents with acute leukemia. Pediatr Clin North Am. 2010 Feb;57(1):27–46.
Peters, Christina, et al. “Stem cell source and outcome after hematopoietic stem cell transplantation (HSCT) in children and adolescents with acute leukemia.Pediatr Clin North Am, vol. 57, no. 1, Feb. 2010, pp. 27–46. Pubmed, doi:10.1016/j.pcl.2010.01.004.
Peters C, Cornish JM, Parikh SH, Kurtzberg J. Stem cell source and outcome after hematopoietic stem cell transplantation (HSCT) in children and adolescents with acute leukemia. Pediatr Clin North Am. 2010 Feb;57(1):27–46.
Journal cover image

Published In

Pediatr Clin North Am

DOI

EISSN

1557-8240

Publication Date

February 2010

Volume

57

Issue

1

Start / End Page

27 / 46

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tissue and Organ Harvesting
  • Tissue Donors
  • Stem Cells
  • Pediatrics
  • Leukemia
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Child
  • Adolescent