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Control of gene expression and assembly of chromosomal subdomains by chromatin regulators with antagonistic functions.

Publication ,  Journal Article
Lam, AL; Pazin, DE; Sullivan, BA
Published in: Chromosoma
September 2005

Epigenetic regulation of higher-order chromatin structure controls gene expression and the assembly of chromosomal domains during cell division, differentiation, and development. The proposed "histone code" integrates a complex system of histone modifications and chromosomal proteins that establish and maintain distinctive types of chromatin, such as euchromatin, heterochromatin, and centromeric (CEN) chromatin. The reversible nature of histone acetylation, phosphorylation, and (most recently discovered) methylation are mechanisms for controlling gene expression and partitioning the genome into functional domains. Many different regions of the genome contain similar epigenetic marks (histone modifications), raising the question as to how they are independently specified and regulated. In this review, we will focus on several recent discoveries in chromatin and chromosome biology: (1) identification of long-elusive histone "de-methylating" enzymes that affect chromatin structure, and (2) assembly and maintenance of chromatin domains, specifically heterochromatin and euchromatin, through a dynamic equilibrium of modifying enzymes, histone modifications, and histone variants identified biochemically and genetically.

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Published In

Chromosoma

DOI

ISSN

0009-5915

Publication Date

September 2005

Volume

114

Issue

4

Start / End Page

242 / 251

Location

Austria

Related Subject Headings

  • Transcription, Genetic
  • Saccharomyces cerevisiae
  • Humans
  • Gene Expression Regulation
  • Developmental Biology
  • Chromosomes
  • Chromatin
  • Animals
  • 3105 Genetics
  • 0604 Genetics
 

Citation

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Lam, A. L., Pazin, D. E., & Sullivan, B. A. (2005). Control of gene expression and assembly of chromosomal subdomains by chromatin regulators with antagonistic functions. Chromosoma, 114(4), 242–251. https://doi.org/10.1007/s00412-005-0001-0
Lam, Ai Leen, Dorothy E. Pazin, and Beth A. Sullivan. “Control of gene expression and assembly of chromosomal subdomains by chromatin regulators with antagonistic functions.Chromosoma 114, no. 4 (September 2005): 242–51. https://doi.org/10.1007/s00412-005-0001-0.
Lam, Ai Leen, et al. “Control of gene expression and assembly of chromosomal subdomains by chromatin regulators with antagonistic functions.Chromosoma, vol. 114, no. 4, Sept. 2005, pp. 242–51. Pubmed, doi:10.1007/s00412-005-0001-0.
Journal cover image

Published In

Chromosoma

DOI

ISSN

0009-5915

Publication Date

September 2005

Volume

114

Issue

4

Start / End Page

242 / 251

Location

Austria

Related Subject Headings

  • Transcription, Genetic
  • Saccharomyces cerevisiae
  • Humans
  • Gene Expression Regulation
  • Developmental Biology
  • Chromosomes
  • Chromatin
  • Animals
  • 3105 Genetics
  • 0604 Genetics