In vivo cytokine-associated responses to biomaterials.
Cytokines, chemokines, and growth factors were analyzed periodically over eight weeks from the wound exudate fluid surrounding biomaterials implanted subcutaneously within stainless steel mesh cages. TNF-alpha, MCP-1, MIP-1alpha, IL-2, IL-6, IL-1beta, VEGF, IL-4, and IL-10 were measured from exudate samples collected from cages containing specimens of polyethylene (PE), polyurethane (PU), or organotin polyvinyl chloride (ot-PVC). Empty cages served as negative controls, and lipopolysaccharide (LPS) served as a positive control. Cytokine, chemokine, and growth factor concentrations decreased from the time of implantation to eight weeks post-implantation, and there was an overall increase in cytokine, chemokine, and growth factor production for material-containing cages compared to empty cages. However, cytokine production was only modestly affected by the different surface chemistries of the three implanted polymeric materials.
Duke Scholars
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Related Subject Headings
- Tumor Necrosis Factor-alpha
- Rats, Sprague-Dawley
- Rats
- Prostheses and Implants
- Polyvinyl Chloride
- Polyurethanes
- Polyethylene
- Organotin Compounds
- Materials Testing
- Male
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Rats, Sprague-Dawley
- Rats
- Prostheses and Implants
- Polyvinyl Chloride
- Polyurethanes
- Polyethylene
- Organotin Compounds
- Materials Testing
- Male