Overview
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.
Current Appointments & Affiliations
Associate Professor Emeritus in Surgery
·
2022 - Present
Surgery, Plastic, Maxillofacial, and Oral Surgery,
Surgery
Associate Research Professor of Biomedical Engineering
·
2010 - Present
Biomedical Engineering,
Pratt School of Engineering
Core Faculty in Innovation & Entrepreneurship
·
2018 - Present
Duke Innovation & Entrepreneurship,
University Initiatives & Academic Support Units
Recent Publications
Optimization of the IntraVascular Oxygenator Catheter Using Angular Oscillation.
Journal Article Ann Biomed Eng · March 2024 We demonstrate a methodology which both improves oxygen transport and reduces or eliminates bubble formation in a novel hyperbaric membrane oxygenator catheter model system. Angular oscillations were introduced to a bundle of hollow fiber membranes (HFMs) ... Full text Link to item CiteIntravascular Gas Exchange: Physiology, Literature Review, and Current Efforts.
Journal Article Respir Care · April 2022 Acute respiratory failure with inadequate oxygenation and/or ventilation is a common reason for ICU admission in children and adults. Despite the morbidity and mortality associated with acute respiratory failure, few proven treatment options exist beyond i ... Full text Link to item CiteThe Influence of Topical Vasodilator-Induced Pharmacologic Delay on Cutaneous Flap Viability and Vascular Remodeling.
Journal Article Plast Reconstr Surg · March 1, 2022 BACKGROUND: Surgical delay is a well-described technique to improve survival of random and pedicled cutaneous flaps. The aim of this study was to test the topical agents minoxidil and iloprost as agents of pharmacologic delay to induce vascular remodeling ... Full text Link to item CiteRecent Grants
University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027A Novel Scaffold to Promote Skin Regeneration
ResearchPrincipal Investigator · Awarded by FirstString Research, Inc. · 2017 - 2019Bruce Klitzman Sponsored Professorship
ResearchPrincipal Investigator · Awarded by Profusa, Inc. · 2017 - 2018View All Grants
Recent Artistic Works
Spring concert 2024: An American in Paris by Gershwin
Musical Performance May 5, 2024 https://youtu.be/e9-KIStZtXsCity Trees by Michael Markowski
Musical Performance December 1, 2017 https://www.youtube.com/watch?v=9pRcDJoddPMDuke Medicine Orchestra Concert
Musical Performance May 8, 2016 Duke Medicine Orchestra plays The Sorcerer's ApprenticeView All Artistic Works
Education, Training & Certifications
University of Virginia ·
1979
Ph.D.