Scholars@Duke publication: PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.

PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.

Publication , Journal Article

Malek, G; Hu, P; Wielgus, A; Dwyer, M; Cousins, S

Published in: Adv Exp Med Biol

2010

The pathophysiology of 'early' dry age-related macular degeneration (ARMD), characterized by the accumulation of lipid and protein-rich sub-retinal deposits remains largely unknown. Accumulation and dysregulated turnover of lipids as well as extracellular matrix (ECM) molecules in sub-retinal pigment epithelial (RPE) deposits and Bruch's membrane, itself an ECM, play a role in ARMD. Epidemiological studies have shown an increased risk for the disease associated with higher dietary intake of long chain poly-unsaturated fatty acids (LCPUFA) and specifically more so for n-6 versus n-3 fatty acids. PUFAs are membrane targets of lipid peroxidation and natural ligands for the nuclear receptors, peroxisome proliferator activated receptors (PPAR). Here we investigated the expression of genes involved in lipid metabolism and expression of the three isoforms of PPARs in an immortalized cell line of human RPE cells (ARPE19) in the presence or absence of fatty acids.

Duke Scholars

Author Goldis Malek Ophthalmology, Vitreoretinal Diseases & Surgery

Author Scott William Cousins Ophthalmology, Vitreoretinal Diseases & Surgery

Published In

Adv Exp Med Biol

DOI

10.1007/978-1-4419-1399-9_49

ISSN

0065-2598

Publication Date

2010

Volume

664

Start / End Page

429 / 436

Location

United States

Related Subject Headings

RNA, Messenger
Protein Isoforms
Pigment Epithelium of Eye
Peroxisome Proliferator-Activated Receptors
Macular Degeneration
Lipid Metabolism
Humans
General & Internal Medicine
Gene Expression Regulation
Fatty Acids, Unsaturated

Citation

APA

Chicago

ICMJE

MLA

NLM

Malek, G., Hu, P., Wielgus, A., Dwyer, M., & Cousins, S. (2010). PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration. Adv Exp Med Biol, 664, 429–436. https://doi.org/10.1007/978-1-4419-1399-9_49

Malek, Goldis, Peng Hu, Albert Wielgus, Mary Dwyer, and Scott Cousins. “PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.” Adv Exp Med Biol 664 (2010): 429–36. https://doi.org/10.1007/978-1-4419-1399-9_49.

Malek G, Hu P, Wielgus A, Dwyer M, Cousins S. PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration. Adv Exp Med Biol. 2010;664:429–36.

Malek, Goldis, et al. “PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.” Adv Exp Med Biol, vol. 664, 2010, pp. 429–36. Pubmed, doi:10.1007/978-1-4419-1399-9_49.

Malek G, Hu P, Wielgus A, Dwyer M, Cousins S. PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration. Adv Exp Med Biol. 2010;664:429–436.