Analysis of regulatory CD8 T cells in Qa-1-deficient mice.
The mouse protein Qa-1 (HLA-E in humans) is essential for immunological protection and immune regulation. Although Qa-1 has been linked to CD8 T cell-dependent suppression, the physiological relevance of this observation is unclear. We generated mice deficient in Qa-1 to develop an understanding of this process. Qa-1-deficient mice develop exaggerated secondary CD4 responses to foreign and self peptides. Enhanced responses to proteolipid protein self peptide were associated with resistance of Qa-1-deficient CD4 T cells to Qa-1-restricted CD8 T suppressor activity and increased susceptibility to experimental autoimmune encephalomyelitis. These findings delineate a Qa-1-dependent T cell-T cell inhibitory interaction that prevents the pathogenic expansion of autoreactive CD4 T cell populations and consequent autoimmune disease.
Duke Scholars
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- Mice
- Immunology
- Histocompatibility Antigens Class I
- Herpesvirus 1, Human
- HLA-E Antigens
- HLA Antigens
- Chromosomes, Artificial, Bacterial
- CD8-Positive T-Lymphocytes
- Blotting, Western
- Animals
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Mice
- Immunology
- Histocompatibility Antigens Class I
- Herpesvirus 1, Human
- HLA-E Antigens
- HLA Antigens
- Chromosomes, Artificial, Bacterial
- CD8-Positive T-Lymphocytes
- Blotting, Western
- Animals