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Cogan's syndrome.

Publication ,  Journal Article
St Clair, EW; McCallum, RM
Published in: Curr Opin Rheumatol
January 1999

Work originating in the 1940s led to the characterization of a rare, chronic inflammatory disorder with a unique predilection for the cornea and vestibuloauditory apparatus, now called Cogan's syndrome (CS) after the ophthalmologist who first described it. CS occurs primarily in young adults and typically presents with interstitial keratitis (IK) and Ménière's-like episodes developing within several months of each other. The inflammatory process may target other ocular sites, and the disease itself may be accompanied by aortitis or a Takayasu's-like or medium-sized vessel vasculitis. Morbidity in CS results from deafness and complications from cardiovascular disease. Most evidence suggests that the ocular and vestibuloauditory manifestations are not a consequence of vasculitis but rather mediated by other immunologic mechanisms, possibly organ-specific autoimmunity. The cornerstone of treatment in CS is corticosteroids, topically for IK and systemically for inner ear dysfunction. Early corticosteroid therapy appears to be critical for reversing hearing loss. Cochlear implants can partially restore auditory function and have been a salvation for patients who suffer from deafness as a result of permanent cochlear damage.

Duke Scholars

Published In

Curr Opin Rheumatol

DOI

ISSN

1040-8711

Publication Date

January 1999

Volume

11

Issue

1

Start / End Page

47 / 52

Location

United States

Related Subject Headings

  • Syndrome
  • Keratitis
  • Humans
  • Hearing Loss, Sudden
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
St Clair, E. W., & McCallum, R. M. (1999). Cogan's syndrome. Curr Opin Rheumatol, 11(1), 47–52. https://doi.org/10.1097/00002281-199901000-00008
St Clair, E. W., and R. M. McCallum. “Cogan's syndrome.Curr Opin Rheumatol 11, no. 1 (January 1999): 47–52. https://doi.org/10.1097/00002281-199901000-00008.
St Clair EW, McCallum RM. Cogan's syndrome. Curr Opin Rheumatol. 1999 Jan;11(1):47–52.
St Clair, E. W., and R. M. McCallum. “Cogan's syndrome.Curr Opin Rheumatol, vol. 11, no. 1, Jan. 1999, pp. 47–52. Pubmed, doi:10.1097/00002281-199901000-00008.
St Clair EW, McCallum RM. Cogan's syndrome. Curr Opin Rheumatol. 1999 Jan;11(1):47–52.

Published In

Curr Opin Rheumatol

DOI

ISSN

1040-8711

Publication Date

January 1999

Volume

11

Issue

1

Start / End Page

47 / 52

Location

United States

Related Subject Headings

  • Syndrome
  • Keratitis
  • Humans
  • Hearing Loss, Sudden
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences