Acetate metabolism and aging: An emerging connection.
Publication
, Journal Article
Shimazu, T; Hirschey, MD; Huang, J-Y; Ho, LTY; Verdin, E
Published in: Mech Ageing Dev
2010
Sirtuins are NAD(+)-dependent protein deacetylases that regulate gene silencing, energy metabolism and aging from bacteria to mammals. SIRT3, a mammalian mitochondrial sirtuin, deacetylates acetyl-CoA synthetase (AceCS2) in the mitochondria. AceCS2 is conserved from bacteria to humans, catalyzes the conversion of acetate to acetyl-CoA and enables peripheral tissues to utilize acetate during fasting conditions. Here, we review the regulation of acetate metabolism by sirtuins, the remarkable conservation of this metabolic regulatory pathway and its emerging role in the regulation of aging and longevity.
Duke Scholars
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Published In
Mech Ageing Dev
DOI
EISSN
1872-6216
Publication Date
2010
Volume
131
Issue
7-8
Start / End Page
511 / 516
Location
Ireland
Related Subject Headings
- Sirtuins
- Mitochondria
- Longevity
- Humans
- Gerontology
- Energy Metabolism
- Cellular Senescence
- Animals
- Aging
- Age Factors
Citation
APA
Chicago
ICMJE
MLA
NLM
Shimazu, T., Hirschey, M. D., Huang, J.-Y., Ho, L. T. Y., & Verdin, E. (2010). Acetate metabolism and aging: An emerging connection. Mech Ageing Dev, 131(7–8), 511–516. https://doi.org/10.1016/j.mad.2010.05.001
Shimazu, Tadahiro, Matthew D. Hirschey, Jing-Yi Huang, Linh T. Y. Ho, and Eric Verdin. “Acetate metabolism and aging: An emerging connection.” Mech Ageing Dev 131, no. 7–8 (2010): 511–16. https://doi.org/10.1016/j.mad.2010.05.001.
Shimazu T, Hirschey MD, Huang J-Y, Ho LTY, Verdin E. Acetate metabolism and aging: An emerging connection. Mech Ageing Dev. 2010;131(7–8):511–6.
Shimazu, Tadahiro, et al. “Acetate metabolism and aging: An emerging connection.” Mech Ageing Dev, vol. 131, no. 7–8, 2010, pp. 511–16. Pubmed, doi:10.1016/j.mad.2010.05.001.
Shimazu T, Hirschey MD, Huang J-Y, Ho LTY, Verdin E. Acetate metabolism and aging: An emerging connection. Mech Ageing Dev. 2010;131(7–8):511–516.
Published In
Mech Ageing Dev
DOI
EISSN
1872-6216
Publication Date
2010
Volume
131
Issue
7-8
Start / End Page
511 / 516
Location
Ireland
Related Subject Headings
- Sirtuins
- Mitochondria
- Longevity
- Humans
- Gerontology
- Energy Metabolism
- Cellular Senescence
- Animals
- Aging
- Age Factors