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Incorporation of a left ventricle finite element model defining infarction into the XCAT imaging phantom.

Publication ,  Journal Article
Veress, AI; Segars, WP; Tsui, BMW; Gullberg, GT
Published in: IEEE Trans Med Imaging
April 2011

The 4D extended cardiac-torso (XCAT) phantom was developed to provide a realistic and flexible model of the human anatomy and cardiac and respiratory motions for use in medical imaging research. A prior limitation to the phantom was that it did not accurately simulate altered functions of the heart that result from cardiac pathologies such as coronary artery disease (CAD). We overcame this limitation in a previous study by combining the phantom with a finite-element (FE) mechanical model of the left ventricle (LV) capable of more realistically simulating regional defects caused by ischemia. In the present work, we extend this model giving it the ability to accurately simulate motion abnormalities caused by myocardial infarction (MI), a far more complex situation in terms of altered mechanics compared with the modeling of acute ischemia. The FE model geometry is based on high resolution CT images of a normal male subject. An anterior region was defined as infarcted and the material properties and fiber distribution were altered, according to the bio-physiological properties of two types of infarction, i.e., fibrous and remodeled infarction (30% thinner wall than fibrous case). Compared with the original, surface-based 4D beating heart model of the XCAT, where regional abnormalities are modeled by simply scaling down the motion in those regions, the FE model was found to provide a more accurate representation of the abnormal motion of the LV due to the effects of fibrous infarction as well as depicting the motion of remodeled infarction. In particular, the FE models allow for the accurate depiction of dyskinetic motion. The average circumferential strain results were found to be consistent with measured dyskinetic experimental results. Combined with the 4D XCAT phantom, the FE model can be used to produce realistic multimodality sets of imaging data from a variety of patients in which the normal or abnormal cardiac function is accurately represented.

Duke Scholars

Published In

IEEE Trans Med Imaging

DOI

EISSN

1558-254X

Publication Date

April 2011

Volume

30

Issue

4

Start / End Page

915 / 927

Location

United States

Related Subject Headings

  • Ventricular Function
  • Tomography, Emission-Computed
  • Thorax
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Myocardial Infarction
  • Models, Cardiovascular
  • Models, Anatomic
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Veress, A. I., Segars, W. P., Tsui, B. M. W., & Gullberg, G. T. (2011). Incorporation of a left ventricle finite element model defining infarction into the XCAT imaging phantom. IEEE Trans Med Imaging, 30(4), 915–927. https://doi.org/10.1109/TMI.2010.2089801
Veress, Alexander I., W Paul Segars, Benjamin M. W. Tsui, and Grant T. Gullberg. “Incorporation of a left ventricle finite element model defining infarction into the XCAT imaging phantom.IEEE Trans Med Imaging 30, no. 4 (April 2011): 915–27. https://doi.org/10.1109/TMI.2010.2089801.
Veress AI, Segars WP, Tsui BMW, Gullberg GT. Incorporation of a left ventricle finite element model defining infarction into the XCAT imaging phantom. IEEE Trans Med Imaging. 2011 Apr;30(4):915–27.
Veress, Alexander I., et al. “Incorporation of a left ventricle finite element model defining infarction into the XCAT imaging phantom.IEEE Trans Med Imaging, vol. 30, no. 4, Apr. 2011, pp. 915–27. Pubmed, doi:10.1109/TMI.2010.2089801.
Veress AI, Segars WP, Tsui BMW, Gullberg GT. Incorporation of a left ventricle finite element model defining infarction into the XCAT imaging phantom. IEEE Trans Med Imaging. 2011 Apr;30(4):915–927.

Published In

IEEE Trans Med Imaging

DOI

EISSN

1558-254X

Publication Date

April 2011

Volume

30

Issue

4

Start / End Page

915 / 927

Location

United States

Related Subject Headings

  • Ventricular Function
  • Tomography, Emission-Computed
  • Thorax
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Myocardial Infarction
  • Models, Cardiovascular
  • Models, Anatomic
  • Male
  • Humans