Quantification of contrast in clinical MR brain imaging at high magnetic field.
The relative contrast between two tissues in a magnetic resonance (MR) image is shown to be quantifiable for any combination of pulse timing parameters, provided the intrinsic parameters are known. Based on multiple inversion-recovery and spin echo images, a region-of-interest T1, T2 and density analysis was conducted at 1.4T in selected patients with diagnosed neuropathology for various brain tissues. The resulting tissue parameters subsequently served to calculate the contrast-to-noise (C/N) ratio for typical tissue interfaces as a function of the operator-variable pulse timing parameters and the data were compared with the images. Although such calculations may be useful as a protocol selection aid, it is obvious that an optimized pulse protocol can only be established for a single tissue interface. The data also reveal that a T2-discriminating pulse sequence like Carr-Purcell-Meiboom-Gill with long repetition time, generally advocated as clinically most effective, may not always be ideal.
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- Nuclear Medicine & Medical Imaging
- Neuroma, Acoustic
- Multiple Sclerosis
- Magnetic Resonance Spectroscopy
- Humans
- Brain Diseases
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Nuclear Medicine & Medical Imaging
- Neuroma, Acoustic
- Multiple Sclerosis
- Magnetic Resonance Spectroscopy
- Humans
- Brain Diseases
- 3202 Clinical sciences
- 1103 Clinical Sciences