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Numerical simulation of PRESS localized MR spectroscopy.

Publication ,  Journal Article
Maudsley, AA; Govindaraju, V; Young, K; Aygula, ZK; Pattany, PM; Soher, BJ; Matson, GB
Published in: J Magn Reson
March 2005

Numerical simulations of NMR spectra can provide a rapid and convenient method for optimizing acquisition sequence parameters and generating prior spectral information required for parametric spectral analysis. For spatially resolved spectroscopy, spatially dependent variables affect the resultant spectral amplitudes and phases, which must therefore be taken into account in any spectral simulation model. In this study, methods for numerical simulation of spectra obtained using the PRESS localization pulse sequence are examined. A comparison is made between three different simulation models that include different levels of detail regarding the spatial distributions of the excitation functions, and spin evolution during application of the pulses. These methods were evaluated for measurement of spectra from J-coupled spin systems that are of interest for in vivo proton spectroscopy and results compared with experimental data. It is demonstrated that for optimized refocusing pulses it is sufficient to account for chemical shift effects only, although there is some advantage to implementing a more general numerical simulation approach that includes information on RF pulse excitation profiles, which provides sufficient accuracy while maintaining moderate computational requirements and flexibility to handle different spin systems.

Duke Scholars

Published In

J Magn Reson

DOI

ISSN

1090-7807

Publication Date

March 2005

Volume

173

Issue

1

Start / End Page

54 / 63

Location

United States

Related Subject Headings

  • Magnetic Resonance Spectroscopy
  • Lactic Acid
  • Computer Simulation
  • Biophysics
  • Aspartic Acid
  • 51 Physical sciences
  • 40 Engineering
  • 09 Engineering
  • 02 Physical Sciences
 

Citation

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Maudsley, A. A., Govindaraju, V., Young, K., Aygula, Z. K., Pattany, P. M., Soher, B. J., & Matson, G. B. (2005). Numerical simulation of PRESS localized MR spectroscopy. J Magn Reson, 173(1), 54–63. https://doi.org/10.1016/j.jmr.2004.11.018
Maudsley, Andrew A., Varanavasi Govindaraju, Karl Young, Zakaria K. Aygula, Pradip M. Pattany, Brian J. Soher, and Gerald B. Matson. “Numerical simulation of PRESS localized MR spectroscopy.J Magn Reson 173, no. 1 (March 2005): 54–63. https://doi.org/10.1016/j.jmr.2004.11.018.
Maudsley AA, Govindaraju V, Young K, Aygula ZK, Pattany PM, Soher BJ, et al. Numerical simulation of PRESS localized MR spectroscopy. J Magn Reson. 2005 Mar;173(1):54–63.
Maudsley, Andrew A., et al. “Numerical simulation of PRESS localized MR spectroscopy.J Magn Reson, vol. 173, no. 1, Mar. 2005, pp. 54–63. Pubmed, doi:10.1016/j.jmr.2004.11.018.
Maudsley AA, Govindaraju V, Young K, Aygula ZK, Pattany PM, Soher BJ, Matson GB. Numerical simulation of PRESS localized MR spectroscopy. J Magn Reson. 2005 Mar;173(1):54–63.
Journal cover image

Published In

J Magn Reson

DOI

ISSN

1090-7807

Publication Date

March 2005

Volume

173

Issue

1

Start / End Page

54 / 63

Location

United States

Related Subject Headings

  • Magnetic Resonance Spectroscopy
  • Lactic Acid
  • Computer Simulation
  • Biophysics
  • Aspartic Acid
  • 51 Physical sciences
  • 40 Engineering
  • 09 Engineering
  • 02 Physical Sciences