Brian Joseph Soher
Associate Professor in Radiology
My research focuses on the development and clinical translation of quantitative, multi-parametric MRI and MR spectroscopy (MRS) data acquisition and analysis techniques. These methods are applicable to the characterization of both chronic and focal pathologies, originally in the brain, but more recently in other organs such as liver and muscle. The overarching goals of these investigations are 1) to improve acquired data quality, 2) to obtain the maximum amount of useful information and/or to exclude confounding signals, and 3) to acquire additional a priori information that can make a given analysis more robust. My practical goals are to develop flexible, reusable and user-friendly tools and techniques, primarily through open source software packages, that can be applied in a robust manner for clinical investigative and diagnostic use.
My early research aimed at developing robust quantitation methods for spectroscopic imaging (SI) data analysis in the brain. As part of a multi-disciplinary team I helped develop a cross-platform GUI-driven suite of spectral processing/analysis tools to simplify the use of SI in clinical research. Throughout my career, I have continued work to expand spatial coverage, to create simulations of metabolic data acquisition to extend the accuracy of the models used to fit the SI data, and to develop acquisition and post-processing algorithms to remove unwanted water and lipid signals. This work led up to the idea for which I received my first R01. It has also resulted in two open-source software packages, MIDAS and Vespa (http://mrir.med.miami.edu:8000/midas and https://vespa-mrs.github.io/vespa.io/) that have received wide acceptance by many researchers and groups.
The latest versions of these tools are in active use in CAMRD studies investigating 1) volumetric changes in physiologic biomarkers of cellular breakdown in the brain due to high grade glioma progression, 2) changes in liver energy homeostasis due to a challenge using injected fructose, 3) spectral analysis and quantitation of edited single-voxel MRS method such as MEGA-PRESS and MEGA-sLASER to isolate small metabolite signals like GABA and 2HG. I also work actively to educate my colleagues as to the existence and applicability of these and other tools that I have access to due to my contacts in the MR research community.
More recently, I have developed a number of research projects in the rapidly changing area of body MR. Initial projects were to characterize the use of high-speed 3D MR imaging sequences to characterize the presence of water and fat in various organs. Standard in- and opposed-phase techniques were compared with newer fat-water separated imaging techniques. Fat-water separation imaging methods create individual water and fat images that maintain useful anatomic references while allowing both fat and water signals to be viewed separately. In parallel with our technique development for water-far imaging techniques, I developed and patented a novel technique for utilizing the heat insensitive nature of fat to non-invasively map temperature changes during the application of hyperthermia treatments for sarcomas.
Currently, I am investigating the use of tissue modelling to estimate absolute tissue fat fractions to provide a normalization technique for comparing in- and opposed-phase measures across platforms, sequences and field strengths. I am also working on an R01 that measures dynamic liver energy metabolism to help detect and stage NASH patients.
My early research aimed at developing robust quantitation methods for spectroscopic imaging (SI) data analysis in the brain. As part of a multi-disciplinary team I helped develop a cross-platform GUI-driven suite of spectral processing/analysis tools to simplify the use of SI in clinical research. Throughout my career, I have continued work to expand spatial coverage, to create simulations of metabolic data acquisition to extend the accuracy of the models used to fit the SI data, and to develop acquisition and post-processing algorithms to remove unwanted water and lipid signals. This work led up to the idea for which I received my first R01. It has also resulted in two open-source software packages, MIDAS and Vespa (http://mrir.med.miami.edu:8000/midas and https://vespa-mrs.github.io/vespa.io/) that have received wide acceptance by many researchers and groups.
The latest versions of these tools are in active use in CAMRD studies investigating 1) volumetric changes in physiologic biomarkers of cellular breakdown in the brain due to high grade glioma progression, 2) changes in liver energy homeostasis due to a challenge using injected fructose, 3) spectral analysis and quantitation of edited single-voxel MRS method such as MEGA-PRESS and MEGA-sLASER to isolate small metabolite signals like GABA and 2HG. I also work actively to educate my colleagues as to the existence and applicability of these and other tools that I have access to due to my contacts in the MR research community.
More recently, I have developed a number of research projects in the rapidly changing area of body MR. Initial projects were to characterize the use of high-speed 3D MR imaging sequences to characterize the presence of water and fat in various organs. Standard in- and opposed-phase techniques were compared with newer fat-water separated imaging techniques. Fat-water separation imaging methods create individual water and fat images that maintain useful anatomic references while allowing both fat and water signals to be viewed separately. In parallel with our technique development for water-far imaging techniques, I developed and patented a novel technique for utilizing the heat insensitive nature of fat to non-invasively map temperature changes during the application of hyperthermia treatments for sarcomas.
Currently, I am investigating the use of tissue modelling to estimate absolute tissue fat fractions to provide a normalization technique for comparing in- and opposed-phase measures across platforms, sequences and field strengths. I am also working on an R01 that measures dynamic liver energy metabolism to help detect and stage NASH patients.
Current Appointments & Affiliations
- Associate Professor in Radiology, Radiology, Clinical Science Departments 2021
- Affiliate of the Center for Brain Imaging and Analysis, Duke-UNC Center for Brain Imaging and Analysis, Institutes and Centers 2009
Contact Information
- Box 3808 Med Ctr, Camrd, Durham, NC 27710
- North 1821A, Durham, NC 27710
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brian.soher@duke.edu
(919) 684-7350
- Background
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Education, Training, & Certifications
- Ph.D., Johns Hopkins University 1996
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Previous Appointments & Affiliations
- Associate Professor of Radiology, Radiology, Clinical Science Departments 2018 - 2020
- Associate Professor of Radiology, Radiology, Clinical Science Departments 2012 - 2018
- Assistant Professor in Radiology, Radiology, Clinical Science Departments 2007 - 2012
- Assistant Professor in Radiology, Radiology, Clinical Science Departments 2006 - 2007
- Assistant Research Professor in Radiology, Radiology, Clinical Science Departments 2004 - 2006
- Instructor, Temporary in the Department of Radiology, Radiology, Clinical Science Departments 2004
- Research
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Selected Grants
- Improved monitoring of 2-Hydroxyglutarate to stage response of combined Vorasidenib and Tumor Specific Peptide Vaccine therapies in recurrent IDH1 mutant lower grade glioma awarded by National Institutes of Health 2022 - 2026
- Modeling the effects of chronic marijuana use on neuroinflammation and HIV-related neuronal injury awarded by National Institutes of Health 2020 - 2025
- Partnership for Magnetic Resonance Spectroscopy Biomarker Development awarded by University of Minnesota 2015 - 2021
- Quantitative Staging and Therapeutic Response in IDH-1 Mutated Glioblastomas awarded by National Institutes of Health 2017 - 2021
- The Role of Obstructive Sleep Apnea in Neuroinflammation and Postoperative Cognitive Dysfunction awarded by Foundation for Anesthesia Education and Research 2019 - 2021
- Non-invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe MRI awarded by National Institutes of Health 2016 - 2020
- Human Lung Regional Ventilation Defect Severity Measured by Fluorine-19 Gas MRI awarded by National Institutes of Health 2012 - 2018
- Impact of Fructose on Metabolism, Energy Homeostasis and MR biomarkers in NAFLD awarded by National Institutes of Health 2012 - 2016
- Intermolecular Multiple-Quantum Coherence Effects in MRI awarded by National Institutes of Health 2005 - 2015
- ACRIN MR Physics Center of Excellence awarded by American College of Radiology Imaging Network 2014 - 2015
- ACRIN MR Physics Center of Excellence awarded by American College of Radiology Imaging Network 2013 - 2014
- MrSPA: Integrated tools and development platform for magnetic resonance research awarded by National Institutes of Health 2008 - 2012
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External Relationships
- BrainSpec
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Clarke, William T., Tiffany K. Bell, Uzay E. Emir, Mark Mikkelsen, Georg Oeltzschner, Amirmohammad Shamaei, Brian J. Soher, and Martin Wilson. “NIfTI-MRS: A standard data format for magnetic resonance spectroscopy.” Magn Reson Med 88, no. 6 (December 2022): 2358–70. https://doi.org/10.1002/mrm.29418.Full Text Link to Item
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Soher, Brian J., William T. Clarke, Martin Wilson, Jamie Near, and Georg Oeltzschner. “Community-Organized Resources for Reproducible MRS Data Analysis.” Magnetic Resonance in Medicine 88, no. 5 (November 2022): 1959–61. https://doi.org/10.1002/mrm.29387.Full Text
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Heckelman, Lauren N., Brian J. Soher, Charles E. Spritzer, Brian D. Lewis, and Louis E. DeFrate. “Design and validation of a semi-automatic bone segmentation algorithm from MRI to improve research efficiency.” Sci Rep 12, no. 1 (May 12, 2022): 7825. https://doi.org/10.1038/s41598-022-11785-6.Full Text Link to Item
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Martin, John T., Alexander B. Oldweiler, Andrzej S. Kosinski, Charles E. Spritzer, Brian J. Soher, Melissa M. Erickson, Adam P. Goode, and Louis E. DeFrate. “Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region.” Eur Spine J 31, no. 3 (March 2022): 746–54. https://doi.org/10.1007/s00586-021-07097-4.Full Text Link to Item
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Tapper, Sofie, Steve C. N. Hui, Muhammad G. Saleh, Helge J. Zöllner, Georg Oeltzschner, Jamie Near, Brian J. Soher, and Richard A. E. Edden. “Influence of editing pulse flip angle on J-difference MR spectroscopy.” Magn Reson Med 87, no. 2 (February 2022): 589–96. https://doi.org/10.1002/mrm.29008.Full Text Link to Item
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Krishnamurthy, Lisa C., Isabella Paredes Spir, Natalie O. Rocha, Brian J. Soher, Edward J. Auerbach, Bruce A. Crosson, and Venkatagiri Krishnamurthy. “The association between language-based task-functional magnetic resonance imaging hemodynamics and baseline GABA+ and glutamate-glutamine measured in pre-supplementary motor area: A pilot study in an aging model.” Front Psychiatry 13 (2022): 904845. https://doi.org/10.3389/fpsyt.2022.904845.Full Text Link to Item
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Marjańska, Małgorzata, Dinesh K. Deelchand, Roland Kreis, and Roland 2016 ISMRM MRS Study Group Fitting Challenge Team. “Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM.” Magn Reson Med 87, no. 1 (January 2022): 11–32. https://doi.org/10.1002/mrm.28942.Full Text Link to Item
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Cudalbu, Cristina, Kevin L. Behar, Pallab K. Bhattacharyya, Wolfgang Bogner, Tamas Borbath, Robin A. de Graaf, Rolf Gruetter, et al. “Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations.” Nmr Biomed 34, no. 5 (May 2021): e4393. https://doi.org/10.1002/nbm.4393.Full Text Link to Item
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Deelchand, Dinesh K., Adam Berrington, Ralph Noeske, James M. Joers, Arvin Arani, Joseph Gillen, Michael Schär, et al. “Across-vendor standardization of semi-LASER for single-voxel MRS at 3T.” Nmr Biomed 34, no. 5 (May 2021): e4218. https://doi.org/10.1002/nbm.4218.Full Text Link to Item
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Maudsley, Andrew A., Ovidiu C. Andronesi, Peter B. Barker, Alberto Bizzi, Wolfgang Bogner, Anke Henning, Sarah J. Nelson, Stefan Posse, Dikoma C. Shungu, and Brian J. Soher. “Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations.” Nmr Biomed 34, no. 5 (May 2021): e4309. https://doi.org/10.1002/nbm.4309.Full Text Link to Item
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Kirov, Ivan I., Marc Sollberger, Matthew S. Davitz, Lidia Glodzik, Brian J. Soher, James S. Babb, Andreas U. Monsch, Achim Gass, and Oded Gonen. “Global brain volume and N-acetyl-aspartate decline over seven decades of normal aging.” Neurobiol Aging 98 (February 2021): 42–51. https://doi.org/10.1016/j.neurobiolaging.2020.10.024.Full Text Link to Item
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Murali-Manohar, Saipavitra, Tamas Borbath, Andrew Martin Wright, Brian Soher, Ralf Mekle, and Anke Henning. “T2 relaxation times of macromolecules and metabolites in the human brain at 9.4 T.” Magn Reson Med 84, no. 2 (August 2020): 542–58. https://doi.org/10.1002/mrm.28174.Full Text Link to Item
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Goralski, Jennifer L., Sang Hun Chung, Tyler M. Glass, Agathe S. Ceppe, Esther O. Akinnagbe-Zusterzeel, Aaron T. Trimble, Richard C. Boucher, et al. “Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.” Jci Insight 5, no. 2 (January 30, 2020). https://doi.org/10.1172/jci.insight.133400.Full Text Link to Item
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Öz, Gülin, Dinesh K. Deelchand, Jannie P. Wijnen, Vladimír Mlynárik, Lijing Xin, Ralf Mekle, Ralph Noeske, Tom W. J. Scheenen, Ivan Tkáč, and Ivan Experts’ Working Group on Advanced Single Voxel 1H MRS. “Advanced single voxel 1 H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations.” Nmr Biomed, January 10, 2020, e4236. https://doi.org/10.1002/nbm.4236.Full Text Link to Item
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Wilson, Martin, Ovidiu Andronesi, Peter B. Barker, Robert Bartha, Alberto Bizzi, Patrick J. Bolan, Kevin M. Brindle, et al. “Methodological consensus on clinical proton MRS of the brain: Review and recommendations.” Magn Reson Med 82, no. 2 (August 2019): 527–50. https://doi.org/10.1002/mrm.27742.Full Text Link to Item
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Gurbani, Saumya S., Eduard Schreibmann, Andrew A. Maudsley, James Scott Cordova, Brian J. Soher, Harish Poptani, Gaurav Verma, Peter B. Barker, Hyunsuk Shim, and Lee A. D. Cooper. “A convolutional neural network to filter artifacts in spectroscopic MRI.” Magn Reson Med 80, no. 5 (November 2018): 1765–75. https://doi.org/10.1002/mrm.27166.Full Text Link to Item
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Park, Young Woo, Dinesh K. Deelchand, James M. Joers, Brian Hanna, Adam Berrington, Joseph S. Gillen, Kejal Kantarci, et al. “AutoVOI: real-time automatic prescription of volume-of-interest for single voxel spectroscopy.” Magn Reson Med 80, no. 5 (November 2018): 1787–98. https://doi.org/10.1002/mrm.27203.Full Text Link to Item
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Kirov, Ivan I., Ruben Kuzniecky, Hoby P. Hetherington, Brian J. Soher, Matthew S. Davitz, James S. Babb, Heath R. Pardoe, Jullie W. Pan, and Oded Gonen. “Erratum to "Whole brain neuronal abnormalities in focal epilepsy quantified with proton MR spectroscopy" [Epilepsy Res. 139 (2018) 85-91].” Epilepsy Res 143 (July 2018): 130. https://doi.org/10.1016/j.eplepsyres.2018.04.002.Full Text Link to Item
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Martin, John T., Alexander B. Oldweiler, Charles E. Spritzer, Brian J. Soher, Melissa M. Erickson, Adam P. Goode, and Louis E. DeFrate. “A magnetic resonance imaging framework for quantifying intervertebral disc deformation in vivo: Reliability and application to diurnal variations in lumbar disc shape.” J Biomech 71 (April 11, 2018): 291–95. https://doi.org/10.1016/j.jbiomech.2018.01.045.Full Text Link to Item
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Kirov, Ivan I., Ruben Kuzniecky, Hoby P. Hetherington, Brian J. Soher, Matthew S. Davitz, James S. Babb, Heath R. Pardoe, Jullie W. Pan, and Oded Gonen. “Whole brain neuronal abnormalities in focal epilepsy quantified with proton MR spectroscopy.” Epilepsy Res 139 (January 2018): 85–91. https://doi.org/10.1016/j.eplepsyres.2017.11.017.Full Text Link to Item
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Zhang, Jun, Ashirbani Saha, Brian J. Soher, and Maciej A. Mazurowski. “Automatic deep learning-based normalization of breast dynamic contrast-enhanced magnetic resonance images.” Corr abs/1807.02152 (2018).
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Kirov, Ivan I., William E. Wu, Brian J. Soher, Matthew S. Davitz, Jeffrey H. Huang, James S. Babb, Mariana Lazar, Girish Fatterpekar, and Oded Gonen. “Global brain metabolic quantification with whole-head proton MRS at 3 T.” Nmr Biomed 30, no. 10 (October 2017). https://doi.org/10.1002/nbm.3754.Full Text Link to Item
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Davitz, Matthew S., William E. Wu, Brian J. Soher, James S. Babb, Ivan I. Kirov, Jeffrey Huang, Girish Fatterpekar, and Oded Gonen. “Quantifying global-brain metabolite level changes with whole-head proton MR spectroscopy at 3T.” Magn Reson Imaging 35 (January 2017): 15–19. https://doi.org/10.1016/j.mri.2016.08.012.Full Text Link to Item
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Pradhan, S., B. J. Soher, and P. B. Barker. “Quantifying spectra in the frequency domain.” Emagres 5, no. 2 (January 1, 2016): 1247–56. https://doi.org/10.1002/9780470034590.emrstm1444.Full Text
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Chawla, S., Y. Ge, H. Lu, O. Marshall, M. S. Davitz, G. Fatterpekar, B. J. Soher, and O. Gonen. “Whole-Brain N-Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge.” Ajnr Am J Neuroradiol 36, no. 11 (November 2015): 2055–61. https://doi.org/10.3174/ajnr.A4424.Full Text Link to Item
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Horvath, Jeffrey J., Stephanie L. Austin, Laura E. Case, Karla B. Greene, Harrison N. Jones, Brian J. Soher, Priya S. Kishnani, and Mustafa R. Bashir. “Correlation between quantitative whole-body muscle magnetic resonance imaging and clinical muscle weakness in Pompe disease.” Muscle Nerve 51, no. 5 (May 2015): 722–30. https://doi.org/10.1002/mus.24437.Full Text Link to Item
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Soher, Brian J., William E. Wu, Assaf Tal, Pippa Storey, Ke Zhang, James S. Babb, Ivan I. Kirov, Yvonne W. Lui, and Oded Gonen. “Automated whole-brain N-acetylaspartate proton MRS quantification.” Nmr Biomed 27, no. 11 (November 2014): 1275–84. https://doi.org/10.1002/nbm.3185.Full Text Link to Item
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Oz, Gülin, Jeffry R. Alger, Peter B. Barker, Robert Bartha, Alberto Bizzi, Chris Boesch, Patrick J. Bolan, et al. “Clinical proton MR spectroscopy in central nervous system disorders.” Radiology 270, no. 3 (March 2014): 658–79. https://doi.org/10.1148/radiol.13130531.Full Text Link to Item
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Halaweish, Ahmed F., Richard E. Moon, W Michael Foster, Brian J. Soher, H Page McAdams, James R. MacFall, Maureen D. Ainslie, Neil R. MacIntyre, and H Cecil Charles. “Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans.” Chest 144, no. 4 (October 2013): 1300–1310. https://doi.org/10.1378/chest.12-2597.Full Text Link to Item
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Zhu, He, Brian J. Soher, Ronald Ouwerkerk, Michael Schär, and Peter B. Barker. “Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses.” Magn Reson Med 69, no. 5 (May 2013): 1217–25. https://doi.org/10.1002/mrm.24357.Full Text Link to Item
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Horvath, Jeffrey J., Stephanie L. Austin, Harrison N. Jones, Elizabeth J. Drake, Laura E. Case, Brian J. Soher, Mustafa R. Bashir, and Priya S. Kishnani. “Bulbar muscle weakness and fatty lingual infiltration in glycogen storage disorder type IIIa.” Mol Genet Metab 107, no. 3 (November 2012): 496–500. https://doi.org/10.1016/j.ymgme.2012.09.025.Full Text Link to Item
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Steinberg, Jeffrey, and Brian J. Soher. “Improved initial value estimation for short echo time magnetic resonance spectroscopy spectral analysis using short T2 signal attenuation.” Magn Reson Med 67, no. 5 (May 2012): 1195–1202. https://doi.org/10.1002/mrm.23102.Full Text Link to Item
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Wyatt, Cory, Brian J. Soher, Kavitha Arunachalam, and James MacFall. “Comprehensive analysis of the Cramer-Rao bounds for magnetic resonance temperature change measurement in fat-water voxels using multi-echo imaging.” Magma 25, no. 1 (February 2012): 49–61. https://doi.org/10.1007/s10334-011-0247-x.Full Text Link to Item
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Ghate, Sujata V., Jay A. Baker, Ashley D. Hawkins, and Brian J. Soher. “Titanium vs carbon coated ceramic breast tissue marker clips: 3T MR susceptibility artifact and local signal disturbance.” Acad Radiol 18, no. 6 (June 2011): 770–73. https://doi.org/10.1016/j.acra.2011.01.008.Full Text Link to Item
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Li, Zhen, Martin Vogel, Paolo F. Maccarini, Vadim Stakhursky, Brian J. Soher, Oana I. Craciunescu, Shiva Das, Omar A. Arabe, Williams T. Joines, and Paul R. Stauffer. “Improved hyperthermia treatment control using SAR/temperature simulation and PRFS magnetic resonance thermal imaging.” Int J Hyperthermia 27, no. 1 (2011): 86–99. https://doi.org/10.3109/02656736.2010.501509.Full Text Link to Item
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Wyatt, Cory R., Brian J. Soher, and James R. MacFall. “Correction of breathing-induced errors in magnetic resonance thermometry of hyperthermia using multiecho field fitting techniques.” Med Phys 37, no. 12 (December 2010): 6300–6309. https://doi.org/10.1118/1.3515462.Full Text Link to Item
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Soher, B. J., K. Young, and L. Kaiser. “Virtual MRS. Spectral Simulation and its Applications.” Annual Reports on Nmr Spectroscopy 71, no. C (October 15, 2010): 77–102. https://doi.org/10.1016/B978-0-08-089054-8.00003-4.Full Text
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Kornak, J., K. Young, B. J. Soher, and A. A. Maudsley. “Erratum: Bayesian kappa;-space-time reconstruction of MR spectroscopic imaging for enhanced resolution (IEEE Transactions on Medical Imaging (2010) 29:7 (1333-1350)).” Ieee Transactions on Medical Imaging 29, no. 9 (September 1, 2010): 1697. https://doi.org/10.1109/TMI.2010.2068670.Full Text
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Kornak, John, Karl Young, Brian J. Soher, and Andrew A. Maudsley. “Bayesian k -space-time reconstruction of MR spectroscopic imaging for enhanced resolution.” Ieee Trans Med Imaging 29, no. 7 (July 2010): 1333–50. https://doi.org/10.1109/TMI.2009.2037956.Full Text Link to Item
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Soher, Brian J., Cory Wyatt, Scott B. Reeder, and James R. MacFall. “Noninvasive temperature mapping with MRI using chemical shift water-fat separation.” Magn Reson Med 63, no. 5 (May 2010): 1238–46. https://doi.org/10.1002/mrm.22310.Full Text Link to Item
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Kaiser, Lana G., Małgorzata Marjańska, Gerald B. Matson, Isabelle Iltis, Seth D. Bush, Brian J. Soher, Susanne Mueller, and Karl Young. “(1)H MRS detection of glycine residue of reduced glutathione in vivo.” J Magn Reson 202, no. 2 (February 2010): 259–66. https://doi.org/10.1016/j.jmr.2009.11.013.Full Text Link to Item
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Kelsey, Chris R., Srinivasan Mukundan, Zhiheng Wang, Carol A. Hahn, Brian J. Soher, and John P. Kirkpatrick. “Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy.” Neuro Oncol 12, no. 2 (February 2010): 145–52. https://doi.org/10.1093/neuonc/nop040.Full Text Link to Item
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Marin, Daniele, Brian J. Soher, Brian M. Dale, Daniel T. Boll, Richard S. Youngblood, and Elmar M. Merkle. “Characterization of adrenal lesions: comparison of 2D and 3D dual gradient-echo MR imaging at 3 T--preliminary results.” Radiology 254, no. 1 (January 2010): 179–87. https://doi.org/10.1148/radiol.09090486.Full Text Link to Item
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Soher, Brian J., Karl Young, and Lana Kaiser. “Virtual MRS: Spectral Simulation and its Applications.” Edited by G. A. Webb. Annual Reports on Nmr Spectroscopy, Vol 71 71 (January 1, 2010): 77–102. https://doi.org/10.1016/S0066-4103(10)71003-6.Full Text Link to Item
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Craciunescu, Oana I., Paul R. Stauffer, Brian J. Soher, Cory R. Wyatt, Omar Arabe, Paolo Maccarini, Shiva K. Das, et al. “Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas.” Med Phys 36, no. 11 (November 2009): 4848–58. https://doi.org/10.1118/1.3227506.Full Text Link to Item
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Liu, Songtao, Oded Gonen, Roman Fleysher, Lazar Fleysher, James S. Babb, Brian J. Soher, Chan-Gyu Joo, Eva-Maria Ratai, and R Gilberto González. “Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T.” Magn Reson Med 62, no. 5 (November 2009): 1292–99. https://doi.org/10.1002/mrm.22117.Full Text Link to Item
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Stauffer, Pr, Oi Craciunescu, P. Maccarini, C. Wyatt, K. Arunachalam, O. Arabe, V. Stakhursky, et al. “Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.” Proc Spie Int Soc Opt Eng 7181 (February 25, 2009). https://doi.org/10.1117/12.812188.Full Text Link to Item
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Wyatt, Cory, Brian Soher, Paolo Maccarini, H Cecil Charles, Paul Stauffer, and James Macfall. “Hyperthermia MRI temperature measurement: evaluation of measurement stabilisation strategies for extremity and breast tumours.” Int J Hyperthermia 25, no. 6 (2009): 422–33. https://doi.org/10.1080/02656730903133762.Full Text Link to Item
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Schindera, Sebastian T., Brian J. Soher, David M. Delong, Brian M. Dale, and Elmar M. Merkle. “Effect of echo time pair selection on quantitative analysis for adrenal tumor characterization with in-phase and opposed-phase MR imaging: initial experience.” Radiology 248, no. 1 (July 2008): 140–47. https://doi.org/10.1148/radiol.2481071069.Full Text Link to Item
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Liu, Songtao, Oded Gonen, Lazar Fleysher, Roman Fleysher, Brian J. Soher, Sarah Pilkenton, Margaret R. Lentz, Eva-Maria Ratai, and R Gilberto González. “Regional metabolite T2 in the healthy rhesus macaque brain at 7T.” Magn Reson Med 59, no. 5 (May 2008): 1165–69. https://doi.org/10.1002/mrm.21574.Full Text Link to Item
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Sakkas, Giorgos K., Konstantinos I. Gourgoulianis, Christina Karatzaferi, Vassilios Liakopoulos, Maria D. Maridaki, Chaido Pastaka, Eleftherios Lavdas, et al. “Haemodialysis patients with sleep apnoea syndrome experience increased central adiposity and altered muscular composition and functionality.” Nephrol Dial Transplant 23, no. 1 (January 2008): 336–44. https://doi.org/10.1093/ndt/gfm559.Full Text Link to Item
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Soher, Brian J., Brian M. Dale, and Elmar M. Merkle. “A review of MR physics: 3T versus 1.5T.” Magn Reson Imaging Clin N Am 15, no. 3 (August 2007): 277–v. https://doi.org/10.1016/j.mric.2007.06.002.Full Text Link to Item
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Zaaraoui, Wafaa, Lazar Fleysher, Roman Fleysher, Songtao Liu, Brian J. Soher, and Oded Gonen. “Human brain-structure resolved T(2) relaxation times of proton metabolites at 3 Tesla.” Magn Reson Med 57, no. 6 (June 2007): 983–89. https://doi.org/10.1002/mrm.21250.Full Text Link to Item
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Soher, Brian J., Karl Young, Aaron Bernstein, Zakaria Aygula, and Andrew A. Maudsley. “GAVA: spectral simulation for in vivo MRS applications.” J Magn Reson 185, no. 2 (April 2007): 291–99. https://doi.org/10.1016/j.jmr.2007.01.005.Full Text Link to Item
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MacFall, James R., and Brian J. Soher. “From the RSNA refresher courses: MR imaging in hyperthermia.” Radiographics 27, no. 6 (2007): 1809–18. https://doi.org/10.1148/rg.276075097.Full Text Link to Item
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Maudsley, A. A., A. Darkazanli, J. R. Alger, L. O. Hall, N. Schuff, C. Studholme, Y. Yu, et al. “Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging.” Nmr Biomed 19, no. 4 (June 2006): 492–503. https://doi.org/10.1002/nbm.1025.Full Text Link to Item
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Zhu, X. P., K. Young, A. Ebel, B. J. Soher, L. Kaiser, G. Matson, W. M. Weiner, and N. Schuff. “Robust analysis of short echo time (1)H MRSI of human brain.” Magn Reson Med 55, no. 3 (March 2006): 706–11. https://doi.org/10.1002/mrm.20805.Full Text Link to Item
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Zhu, Xiaoping, Norbert Schuff, John Kornak, Brian Soher, Kristine Yaffe, Joel H. Kramer, Frank Ezekiel, Bruce L. Miller, William J. Jagust, and Michael W. Weiner. “Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging.” Alzheimer Dis Assoc Disord 20, no. 2 (2006): 77–85. https://doi.org/10.1097/01.wad.0000213809.12553.fc.Full Text Link to Item
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Soher, Brian J., P Murali Doraiswamy, and H Cecil Charles. “A review of 1H MR spectroscopy findings in Alzheimer's disease.” Neuroimaging Clin N Am 15, no. 4 (November 2005): 847–xi. https://doi.org/10.1016/j.nic.2005.09.013.Full Text Link to Item
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Soher, Brian J., Pradip M. Pattany, Gerald B. Matson, and Andrew A. Maudsley. “Observation of coupled 1H metabolite resonances at long TE.” Magn Reson Med 53, no. 6 (June 2005): 1283–87. https://doi.org/10.1002/mrm.20491.Full Text Link to Item
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Maudsley, Andrew A., Varanavasi Govindaraju, Karl Young, Zakaria K. Aygula, Pradip M. Pattany, Brian J. Soher, and Gerald B. Matson. “Numerical simulation of PRESS localized MR spectroscopy.” J Magn Reson 173, no. 1 (March 2005): 54–63. https://doi.org/10.1016/j.jmr.2004.11.018.Full Text Link to Item
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Soher, Brian J., and Andrew A. Maudsley. “Evaluation of variable line-shape models and prior information in automated 1H spectroscopic imaging analysis.” Magn Reson Med 52, no. 6 (December 2004): 1246–54. https://doi.org/10.1002/mrm.20295.Full Text Link to Item
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Zhu, Xiao-Ping, An-Tao Du, Geon-Ho Jahng, Brian J. Soher, Andrew A. Maudsley, Michael W. Weiner, and Norbert Schuff. “Magnetic resonance spectroscopic imaging reconstruction with deformable shape-intensity models.” Magn Reson Med 50, no. 3 (September 2003): 474–82. https://doi.org/10.1002/mrm.10572.Full Text Link to Item
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Deicken, Raymond F., Mary P. Pegues, Susan Anzalone, Robert Feiwell, and Brian Soher. “Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder.” Am J Psychiatry 160, no. 5 (May 2003): 873–82. https://doi.org/10.1176/appi.ajp.160.5.873.Full Text Link to Item
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Johansen, Kirsten L., Tiffany Shubert, Julie Doyle, Brian Soher, Giorgos K. Sakkas, and Jane A. Kent-Braun. “Muscle atrophy in patients receiving hemodialysis: effects on muscle strength, muscle quality, and physical function.” Kidney Int 63, no. 1 (January 2003): 291–97. https://doi.org/10.1046/j.1523-1755.2003.00704.x.Full Text Link to Item
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Li, Belinda S. Y., Juleiga Regal, Brian J. Soher, Lois J. Mannon, Robert I. Grossman, and Oded Gonen. “Brain metabolite profiles of T1-hypointense lesions in relapsing-remitting multiple sclerosis.” Ajnr Am J Neuroradiol 24, no. 1 (January 2003): 68–74.Link to Item
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Capizzano, Arístides A., Peter Vermathen, Kenneth D. Laxer, Gerald B. Matson, Andrew A. Maudsley, Brian J. Soher, Norbert W. Schuff, and Michael W. Weiner. “Multisection proton MR spectroscopy for mesial temporal lobe epilepsy.” Ajnr Am J Neuroradiol 23, no. 8 (September 2002): 1359–68.Link to Item
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Weber-Fahr, W., G. Ende, D. F. Braus, P. Bachert, B. J. Soher, F. A. Henn, and C. Büchel. “A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia.” Neuroimage 16, no. 1 (May 2002): 49–60. https://doi.org/10.1006/nimg.2002.1057.Full Text Link to Item
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Li, Belinda S. Y., James S. Babb, Brian J. Soher, Andrew A. Maudsley, and Oded Gonen. “Reproducibility of 3D proton spectroscopy in the human brain.” Magn Reson Med 47, no. 3 (March 2002): 439–46. https://doi.org/10.1002/mrm.10081.Full Text Link to Item
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Ebel, A., B. J. Soher, and A. A. Maudsley. “Assessment of 3D proton MR echo-planar spectroscopic imaging using automated spectral analysis.” Magn Reson Med 46, no. 6 (December 2001): 1072–78. https://doi.org/10.1002/mrm.1301.Full Text Link to Item
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Deicken, R. F., R. Feiwell, N. Schuff, and B. Soher. “Evidence for altered cerebellar vermis neuronal integrity in schizophrenia.” Psychiatry Res 107, no. 3 (October 1, 2001): 125–34. https://doi.org/10.1016/s0925-4927(01)00103-2.Full Text Link to Item
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Wiedermann, D., N. Schuff, G. B. Matson, B. J. Soher, A. T. Du, A. A. Maudsley, and M. W. Weiner. “Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability.” Magn Reson Imaging 19, no. 8 (October 2001): 1073–80. https://doi.org/10.1016/s0730-725x(01)00441-6.Full Text Link to Item
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Gardner, J. R., C. P. Hess, A. G. Webb, R. W. Tsika, M. J. Dawson, and V. Gulani. “Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity.” Magn Reson Med 45, no. 6 (June 2001): 1122–25. https://doi.org/10.1002/mrm.1148.Full Text Link to Item
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Soher, B. J., K. Young, and A. A. Maudsley. “Representation of strong baseline contributions in 1H MR spectra.” Magn Reson Med 45, no. 6 (June 2001): 966–72. https://doi.org/10.1002/mrm.1129.Full Text Link to Item
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Gruber, S., B. S. Li, B. J. Soher, V. Mlynarik, E. V. Moser, and O. Gonen. “Head-to-head performance comparison of 3D multivoxel proton MR spectroscopy: 1.5 vs 3 Tesla in the human brain.” Radiology 217 (November 1, 2000): 251–251.Link to Item
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Li, B. S., J. S. Babb, B. J. Soher, A. A. Maudsley, and O. Gonen. “Quantification of the variability of 3D proton magnetic resonance spectroscopy (1H-MRS) in healthy human brains.” Radiology 217 (November 1, 2000): 250–51.Link to Item
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Soher, B. J., P. Vermathen, N. Schuff, D. Wiedermann, D. J. Meyerhoff, M. W. Weiner, and A. A. Maudsley. “Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis.” Magn Reson Imaging 18, no. 9 (November 2000): 1159–65. https://doi.org/10.1016/s0730-725x(00)00212-5.Full Text Link to Item
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Young, K., D. Khetselius, B. J. Soher, and A. A. Maudsley. “Confidence images for MR spectroscopic imaging.” Magn Reson Med 44, no. 4 (October 2000): 537–45. https://doi.org/10.1002/1522-2594(200010)44:4<537::aid-mrm7>3.0.co;2-8.Full Text Link to Item
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Suhy, J., W. D. Rooney, D. E. Goodkin, A. A. Capizzano, B. J. Soher, A. A. Maudsley, E. Waubant, P. B. Andersson, and M. W. Weiner. “1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.” Mult Scler 6, no. 3 (June 2000): 148–55. https://doi.org/10.1177/135245850000600303.Full Text Link to Item
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Suhy, J., W. D. Rooney, D. E. Goodkin, A. A. Capizzano, B. J. Soher, A. A. Maudsley, E. Waubant, P. B. Andersson, and M. W. Weiner. “H-1 MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.” Multiple Sclerosis Journal 6, no. 3 (June 1, 2000): 148–55.Link to Item
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Ende, G., D. F. Braus, S. Walter, W. Weber-Fahr, B. Soher, A. A. Maudsley, and F. A. Henn. “Effects of age, medication, and illness duration on the N-acetyl aspartate signal of the anterior cingulate region in schizophrenia.” Schizophr Res 41, no. 3 (February 14, 2000): 389–95. https://doi.org/10.1016/s0920-9964(99)00089-4.Full Text Link to Item
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Hart, J., M. A. Kraut, S. Kremen, B. Soher, and B. Gordon. “Neural substrates of orthographic lexical access as demonstrated by functional brain imaging.” Neuropsychiatry Neuropsychol Behav Neurol 13, no. 1 (January 2000): 1–7.Link to Item
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Suhy, J., W. D. Rooney, D. E. Goodkin, A. A. Capizzano, B. J. Soher, A. A. Maudsley, E. Waubant, P. B. Andersson, and M. W. Weiner. “1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.” Multiple Sclerosis 6, no. 3 (2000): 148–55.
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Weiner, M. W., A. Maudsley, N. Schuff, B. J. Soher, P. Vermathen, G. Fein, and K. Laxer. “Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis.” Proceedings of Spie the International Society for Optical Engineering 3337 (December 1, 1998): 203–9. https://doi.org/10.1117/12.312565.Full Text
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Soher, B. J., K. Young, V. Govindaraju, and A. A. Maudsley. “Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging.” Magn Reson Med 40, no. 6 (December 1998): 822–31. https://doi.org/10.1002/mrm.1910400607.Full Text Link to Item
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Young, K., B. J. Soher, and A. A. Maudsley. “Automated spectral analysis II: application of wavelet shrinkage for characterization of non-parameterized signals.” Magn Reson Med 40, no. 6 (December 1998): 816–21. https://doi.org/10.1002/mrm.1910400606.Full Text Link to Item
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Young, K., V. Govindaraju, B. J. Soher, and A. A. Maudsley. “Automated spectral analysis I: formation of a priori information by spectral simulation.” Magn Reson Med 40, no. 6 (December 1998): 812–15. https://doi.org/10.1002/mrm.1910400605.Full Text Link to Item
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Soher, B. J., J. H. Gillard, R. N. Bryan, S. M. Oppenheimer, and P. B. Barker. “Magnetic resonance perfusion imaging in acute middle cerebral artery stroke: comparison of blood volume and bolus peak arrival time.” J Stroke Cerebrovasc Dis 7, no. 1 (1998): 17–23. https://doi.org/10.1016/s1052-3057(98)80017-7.Full Text Link to Item
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Kraut, M., J. Hart, B. J. Soher, and B. Gordon. “Object shape processing in the visual system evaluated using functional MRI.” Neurology 48, no. 5 (May 1997): 1416–20. https://doi.org/10.1212/wnl.48.5.1416.Full Text Link to Item
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Kauppinen, R. A., S. M. Eleff, J. A. Ulatowski, M. Kraut, B. Soher, and P. C. van Zijl. “Visual activation in alpha-chloralose-anaesthetized cats does not cause lactate accumulation in the visual cortex as detected by [1H]NMR difference spectroscopy.” Eur J Neurosci 9, no. 4 (April 1997): 654–61. https://doi.org/10.1111/j.1460-9568.1997.tb01414.x.Full Text Link to Item
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Soher, B. J., R. E. Hurd, N. Sailasuta, and P. B. Barker. “Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference.” Magn Reson Med 36, no. 3 (September 1996): 335–39. https://doi.org/10.1002/mrm.1910360302.Full Text Link to Item
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Soher, B. J., P. C. van Zijl, J. H. Duyn, and P. B. Barker. “Quantitative proton MR spectroscopic imaging of the human brain.” Magn Reson Med 35, no. 3 (March 1996): 356–63. https://doi.org/10.1002/mrm.1910350313.Full Text Link to Item
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GILLARD, J. H., A. Y. RAZUMOVSKY, B. J. SOHER, P. B. BARKER, D. F. HANLEY, R. N. BRYAN, and S. M. OPPENHEIMER. “MACROVASCULAR AND MICROVASCULAR ASSESSMENT OF ACUTE STROKE USING TCD AND GADOLINIUM-DTPA MR PERFUSION IMAGING - A COMPARATIVE-STUDY.” Stroke 26, no. 4 (April 1, 1995): 729–729.Link to Item
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SOHER, B. J., J. H. GILLARD, P. B. BARKER, R. N. BRYAN, and S. M. OPPENHEIMER. “IDENTIFICATION OF PERFUSION PENUMBRA IN ACUTE MIDDLE CEREBRAL ARTERIAL STROKE BY GADOLINIUM-DTPA MRI.” Stroke 26, no. 1 (January 1, 1995): 180–180.Link to Item
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Kraut, M. A., S. Marenco, B. J. Soher, D. F. Wong, and R. N. Bryan. “Comparison of functional MR and H2 15O positron emission tomography in stimulation of the primary visual cortex.” Ajnr Am J Neuroradiol 16, no. 10 (1995): 2101–7.Link to Item
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Oppenheimer, S. M., R. N. Bryan, T. E. Conturo, B. J. Soher, T. J. Preziosi, and P. B. Barker. “Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions.” Magn Reson Med 33, no. 1 (January 1995): 61–68. https://doi.org/10.1002/mrm.1910330109.Full Text Link to Item
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Barker, P. B., J. H. Gillard, P. C. van Zijl, B. J. Soher, D. F. Hanley, A. M. Agildere, S. M. Oppenheimer, and R. N. Bryan. “Acute stroke: evaluation with serial proton MR spectroscopic imaging.” Radiology 192, no. 3 (September 1994): 723–32. https://doi.org/10.1148/radiology.192.3.8058940.Full Text Link to Item
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Barker, P. B., S. N. Breiter, B. J. Soher, J. C. Chatham, J. R. Forder, M. A. Samphilipo, C. A. Magee, and J. H. Anderson. “Quantitative proton spectroscopy of canine brain: in vivo and in vitro correlations.” Magn Reson Med 32, no. 2 (August 1994): 157–63. https://doi.org/10.1002/mrm.1910320202.Full Text Link to Item
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MARENCO, S., M. A. KRAUT, B. J. SOHER, M. ACEVEDO, S. E. KIM, C. C. MELTZER, R. N. BRYAN, and D. F. WONG. “A COMPARISON OF FUNCTIONAL MRI AND H2O-15 PET CHANGES DURING VISUAL-STIMULATION.” Journal of Nuclear Medicine 35, no. 5 (May 1, 1994): P32–P32.Link to Item
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Barker, P. B., S. J. Blackband, J. C. Chatham, B. J. Soher, M. A. Samphilipo, C. A. Magee, J. D. Hilton, J. D. Strandberg, and J. H. Anderson. “Quantitative proton spectroscopy and histology of a canine brain tumor model.” Magn Reson Med 30, no. 4 (October 1993): 458–64. https://doi.org/10.1002/mrm.1910300408.Full Text Link to Item
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SOHER, B. J. “In vivo proton NMR spectroscopy of the human liver.” Proceedings of the Society of Magnetic Resonance in Medicine 1 (1993).
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Barker, P. B., B. J. Soher, S. J. Blackband, J. C. Chatham, V. P. Mathews, and R. N. Bryan. “Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference.” Nmr Biomed 6, no. 1 (1993): 89–94. https://doi.org/10.1002/nbm.1940060114.Full Text Link to Item
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Conference Papers
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Austin, Stephanie, Jeffrey Horvath, Ramin Javin, Laura Case, Karla Greene, Brian J. Soher, Priya Kishnani, and Mustafa Bashir. “Quantitative whole-body muscle MRI, clinical muscle group weakness, and muscle-map correlation in adult patients with Pompe disease.” In Molecular Genetics and Metabolism, 111:S21–22. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2014. https://doi.org/10.1016/j.ymgme.201312.030.Full Text Link to Item
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Craciunescu, O., J. Macfall, B. Soher, P. Stauffer, P. Maccarini, E. Jones, N. Larrier, et al. “WE‐C‐BRC‐02: Combined Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE‐MRI) and Magnetic Resonance Thermal Imaging (MRTI) for Optimal Hyperthermia Treatment of Advanced Extremity Sarcomas: Fifteen Patients Update.” In Medical Physics, 36:2760, 2009. https://doi.org/10.1118/1.3182470.Full Text
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