Scholars@Duke
Brian Joseph Soher

Brian Joseph Soher

Associate Professor in Radiology
Radiology
brian.soher@duke.edu
Box 3808 Med Ctr, Camrd, Durham, NC 27710
North 1821A, Durham, NC 27710

Selected Publications

Influence of running on femoroacetabular joint bone-to-bone distances.

Journal Article J Orthop Res · April 2024 There is limited data quantifying the influence of running on hip cartilage mechanics. The goal of this investigation was to quantify changes in hip joint bone-to-bone distance in response to a 3-mile treadmill run. We acquired magnetic resonance (MR) imag ... Full text Link to item Cite

Vespa: Integrated applications for RF pulse design, spectral simulation and MRS data analysis.

Journal Article Magn Reson Med · September 2023 PURPOSE: The Vespa package (Versatile Simulation, Pulses, and Analysis) is described and demonstrated. It provides workflows for developing and optimizing linear combination modeling (LCM) fitting for 1 H MRS data using intuitive graphical user interface i ... Full text Link to item Cite

NIfTI-MRS: A standard data format for magnetic resonance spectroscopy.

Journal Article Magn Reson Med · December 2022 PURPOSE: Multiple data formats in the MRS community currently hinder data sharing and integration. NIfTI-MRS is proposed as a standard spectroscopy data format, implemented as an extension to the Neuroimaging informatics technology initiative (NIfTI) forma ... Full text Link to item Cite

Design and validation of a semi-automatic bone segmentation algorithm from MRI to improve research efficiency.

Journal Article Sci Rep · May 12, 2022 Segmentation of medical images into different tissue types is essential for many advancements in orthopaedic research; however, manual segmentation techniques can be time- and cost-prohibitive. The purpose of this work was to develop a semi-automatic segme ... Full text Link to item Cite

Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region.

Journal Article Eur Spine J · March 2022 PURPOSE: Magnetic resonance imaging (MRI) is routinely used to evaluate spine pathology; however, standard imaging findings weakly correlate to low back pain. Abnormal disc mechanical function is implicated as a cause of back pain but is not assessed using ... Full text Open Access Link to item Cite

Influence of editing pulse flip angle on J-difference MR spectroscopy.

Journal Article Magn Reson Med · February 2022 PURPOSE: To investigate the editing-pulse flip angle (FA) dependence of editing efficiency and ultimately to maximize the edited signal of commonly edited MR spectroscopy (MRS) signals, such as gamma-aminobutyric acid (GABA) and lactate. METHODS: Density-m ... Full text Link to item Cite

Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM.

Journal Article Magn Reson Med · January 2022 PURPOSE: Fitting of MRS data plays an important role in the quantification of metabolite concentrations. Many different spectral fitting packages are used by the MRS community. A fitting challenge was set up to allow comparison of fitting methods on the ba ... Full text Link to item Cite

The association between language-based task-functional magnetic resonance imaging hemodynamics and baseline GABA+ and glutamate-glutamine measured in pre-supplementary motor area: A pilot study in an aging model.

Journal Article Front Psychiatry · 2022 Aging is a natural phenomenon that elicits slow and progressive cerebrovascular and neurophysiological changes that eventually lead to cognitive decline. The objective of this pilot study is to examine the association of GABA+ and glutamate-glutamine (Glx) ... Full text Link to item Cite

Across-vendor standardization of semi-LASER for single-voxel MRS at 3T.

Journal Article NMR Biomed · May 2021 The semi-adiabatic localization by adiabatic selective refocusing (sLASER) sequence provides single-shot full intensity signal with clean localization and minimal chemical shift displacement error and was recommended by the international MRS Consensus Grou ... Full text Link to item Cite

Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations.

Journal Article NMR Biomed · May 2021 Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to date, these methods have not had a significant impact on clinical care, and their use remains la ... Full text Link to item Cite

Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations.

Journal Article NMR Biomed · May 2021 Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower ... Full text Link to item Cite

Global brain volume and N-acetyl-aspartate decline over seven decades of normal aging.

Journal Article Neurobiol Aging · February 2021 We characterize the whole-brain N-acetyl-aspartate (WBNAA) and brain tissue fractions across the adult lifespan and test the hypothesis that, despite age-related atrophy, neuronal integrity (reflected by WBNAA) is preserved in normal aging. Two-hundred-and ... Full text Link to item Cite

T2 relaxation times of macromolecules and metabolites in the human brain at 9.4 T.

Journal Article Magn Reson Med · August 2020 PURPOSE: Relaxation times can contribute to spectral assignment. In this study, effective T2 relaxation times ( T2eff ) of macromolecules are reported for gray and white matter-rich voxels in the human brain at 9.4 T. The T2eff of macromolecules are helpfu ... Full text Link to item Cite

Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.

Journal Article JCI Insight · January 30, 2020 We hypothesized that dynamic perfluorinated gas MRI would sensitively detect mild cystic fibrosis (CF) lung disease. This cross-sectional study enrolled 20 healthy volunteers and 24 stable subjects with CF, including a subgroup of subjects with normal forc ... Full text Link to item Cite

Advanced single voxel 1 H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations.

Journal Article NMR Biomed · January 10, 2020 Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions which result in subtle metabolite c ... Full text Link to item Cite

Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

Journal Article Magn Reson Med · August 2019 Proton MRS (1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine use is largely re ... Full text Link to item Cite

A convolutional neural network to filter artifacts in spectroscopic MRI.

Journal Article Magn Reson Med · November 2018 PURPOSE: Proton MRSI is a noninvasive modality capable of generating volumetric maps of in vivo tissue metabolism without the need for ionizing radiation or injected contrast agent. Magnetic resonance spectroscopic imaging has been shown to be a viable ima ... Full text Link to item Cite

AutoVOI: real-time automatic prescription of volume-of-interest for single voxel spectroscopy.

Journal Article Magn Reson Med · November 2018 PURPOSE: To develop a fast and automated volume-of-interest (VOI) prescription pipeline (AutoVOI) for single-voxel MRS that removes the need for manual VOI placement, allows flexible VOI planning in any brain region, and enables high inter- and intra-subje ... Full text Link to item Cite

A magnetic resonance imaging framework for quantifying intervertebral disc deformation in vivo: Reliability and application to diurnal variations in lumbar disc shape.

Journal Article J Biomech · April 11, 2018 Low back pain is a significant socioeconomic burden in the United States and lumbar intervertebral disc degeneration is frequently implicated as a cause. The discs play an important mechanical role in the spine, yet the relationship between disc function a ... Full text Open Access Link to item Cite

Whole brain neuronal abnormalities in focal epilepsy quantified with proton MR spectroscopy.

Journal Article Epilepsy Res · January 2018 OBJECTIVE: To test the hypothesis that localization-related epilepsy is associated with widespread neuronal dysfunction beyond the ictal focus, reflected by a decrease in patients' global concentration of their proton MR spectroscopy (1H-MRS) observed mark ... Full text Link to item Cite

Global brain metabolic quantification with whole-head proton MRS at 3 T.

Journal Article NMR Biomed · October 2017 Total N-acetyl-aspartate + N-acetyl-aspartate-glutamate (NAA), total creatine (Cr) and total choline (Cho) proton MRS (1 H-MRS) signals are often used as surrogate markers in diffuse neurological pathologies, but spatial coverage of this methodology is lim ... Full text Link to item Cite

Quantifying global-brain metabolite level changes with whole-head proton MR spectroscopy at 3T.

Journal Article Magn Reson Imaging · January 2017 BACKGROUND AND PURPOSE: To assess the sensitivity of non-localized, whole-head 1H-MRS to an individual's serial changes in total-brain NAA, Glx, Cr and Cho concentrations - metabolite metrics often used as surrogate markers in neurological pathologies. MAT ... Full text Link to item Cite

Quantifying spectra in the frequency domain

Journal Article eMagRes · January 1, 2016 This article provides an overview of frequency-domain spectral fitting methods for one-dimensional magnetic resonance spectra (MRS) in vivo. Methods presented range from simple peak integration, curve-fitting based on different line-shape models, through t ... Full text Cite

Whole-Brain N-Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge.

Journal Article AJNR Am J Neuroradiol · November 2015 BACKGROUND AND PURPOSE: Although NAA is often used as a marker of neuronal health and integrity in neurologic disorders, its normal response to physiologic challenge is not well-established and its changes are almost always attributed exclusively to brain ... Full text Link to item Cite

Correlation between quantitative whole-body muscle magnetic resonance imaging and clinical muscle weakness in Pompe disease.

Journal Article Muscle Nerve · May 2015 INTRODUCTION: Previous examination of whole-body muscle involvement in Pompe disease has been limited to physical examination and/or qualitative magnetic resonance imaging (MRI). In this study we assess the feasibility of quantitative proton-density fat-fr ... Full text Open Access Link to item Cite

Automated whole-brain N-acetylaspartate proton MRS quantification.

Journal Article NMR Biomed · November 2014 Concentration of the neuronal marker, N-acetylaspartate (NAA), a quantitative metric for the health and density of neurons, is currently obtained by integration of the manually defined peak in whole-head proton ((1) H)-MRS. Our goal was to develop a full s ... Full text Link to item Cite

Clinical proton MR spectroscopy in central nervous system disorders.

Journal Article Radiology · March 2014 A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectrosc ... Full text Link to item Cite

Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans.

Journal Article Chest · October 2013 BACKGROUND: Fluorine-enhanced MRI is a relatively inexpensive and straightforward technique that facilitates regional assessments of pulmonary ventilation. In this report, we assess its suitability through the use of perfluoropropane (PFP) in a cohort of h ... Full text Link to item Cite

Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses.

Journal Article Magn Reson Med · May 2013 Two approaches to high-resolution SENSE-encoded magnetic resonance spectroscopic imaging (MRSI) of the human brain at 7 Tesla (T) with whole-slice coverage are described. Both sequences use high-bandwidth radiofrequency pulses to reduce chemical shift disp ... Full text Link to item Cite

Bulbar muscle weakness and fatty lingual infiltration in glycogen storage disorder type IIIa.

Journal Article Mol Genet Metab · November 2012 Glycogen storage disorder type III (GSD III) is a rare autosomal recessive disorder resulting from a deficiency of glycogen debranching enzyme, critical in cytosolic glycogen degradation. GSD IIIa, the most common form of GSD III, primarily affects the liv ... Full text Open Access Link to item Cite

Improved initial value estimation for short echo time magnetic resonance spectroscopy spectral analysis using short T2 signal attenuation.

Journal Article Magn Reson Med · May 2012 Featured Publication Robust spectral analysis of magnetic resonance spectroscopy data frequently uses a spectral model with prior metabolite signal information within a nonlinear least squares optimization algorithm. Starting values for the spectral model greatly influence the ... Full text Link to item Cite

Comprehensive analysis of the Cramer-Rao bounds for magnetic resonance temperature change measurement in fat-water voxels using multi-echo imaging.

Journal Article MAGMA · February 2012 Featured Publication OBJECT: The aim of this paper is to characterize the noise propagation for MRI temperature change measurement with emphasis on finding the best echo time combinations that yield the lowest temperature noise. MATERIALS AND METHODS: A Cramer-Rao lower-bound ... Full text Link to item Cite

Titanium vs carbon coated ceramic breast tissue marker clips: 3T MR susceptibility artifact and local signal disturbance.

Journal Article Acad Radiol · June 2011 RATIONALE AND OBJECTIVES: Spectroscopy signal of a breast lesion may be disrupted by the presence of metal from a biopsy marking clip. This study compares the size of magnetic resonance (MR) susceptibility artifacts and degree of local spectroscopy signal ... Full text Link to item Cite

Improved hyperthermia treatment control using SAR/temperature simulation and PRFS magnetic resonance thermal imaging.

Journal Article Int J Hyperthermia · 2011 PURPOSE: This article explores the feasibility of using coupled electromagnetic and thermodynamic simulations to improve planning and control of hyperthermia treatments for cancer. The study investigates the usefulness of preplanning to improve heat locali ... Full text Link to item Cite

Correction of breathing-induced errors in magnetic resonance thermometry of hyperthermia using multiecho field fitting techniques.

Journal Article Med Phys · December 2010 Featured Publication PURPOSE: Breathing motion can create large errors when performing magnetic resonance (MR) thermometry of the breast. Breath holds can be used to minimize these errors, but not eliminate them. Between breath holds, the referenceless method can be used to fu ... Full text Link to item Cite

Virtual MRS. Spectral Simulation and its Applications.

Journal Article Annual Reports on NMR Spectroscopy · October 15, 2010 There has been a significant increase in the use of spectral simulation in many areas of clinical research in the past decade, due greatly to improved access to more powerful mainstream computers and open source simulation software packages. Spectral simul ... Full text Cite

Bayesian k -space-time reconstruction of MR spectroscopic imaging for enhanced resolution.

Journal Article IEEE Trans Med Imaging · July 2010 Featured Publication A k-space-time Bayesian statistical reconstruction method (K-Bayes) is proposed for the reconstruction of metabolite images of the brain from proton (1H) magnetic resonance (MR) spectroscopic imaging (MRSI) data. K-Bayes performs full spectral fitting of t ... Full text Link to item Cite

Noninvasive temperature mapping with MRI using chemical shift water-fat separation.

Journal Article Magn Reson Med · May 2010 Featured Publication Tissues containing both water and lipids, e.g., breast, confound standard MR proton reference frequency-shift methods for mapping temperatures due to the lack of temperature-induced frequency shift in lipid protons. Generalized Dixon chemical shift-based w ... Full text Link to item Cite

(1)H MRS detection of glycine residue of reduced glutathione in vivo.

Journal Article J Magn Reson · February 2010 Featured Publication Glutathione (GSH) is a powerful antioxidant found inside different kinds of cells, including those of the central nervous system. Detection of GSH in the human brain using (1)H MR spectroscopy is hindered by low concentration and spectral overlap with othe ... Full text Link to item Cite

Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy.

Journal Article Neuro Oncol · February 2010 The aim of the study was to determine if biochemical changes indicative of injury, assessed using magnetic resonance spectroscopic imaging (SI), are observed after stereotactic radiosurgery (SRS). The study included patients who underwent SI immediately be ... Full text Link to item Cite

Characterization of adrenal lesions: comparison of 2D and 3D dual gradient-echo MR imaging at 3 T--preliminary results.

Journal Article Radiology · January 2010 Featured Publication PURPOSE: To retrospectively compare a two-dimensional (2D) and a three-dimensional (3D) technique for in-phase (IP) and opposed-phase (OP) single-breath-hold 3-T magnetic resonance (MR) imaging in the characterization of adrenal lesions, with histopatholog ... Full text Link to item Cite

Virtual MRS: Spectral Simulation and its Applications

Journal Article ANNUAL REPORTS ON NMR SPECTROSCOPY, VOL 71 · January 1, 2010 Full text Link to item Cite

Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T.

Journal Article Magn Reson Med · November 2009 The structure and metabolism of the rhesus macaque brain, an advanced model for neurologic diseases and their treatment response, is often studied noninvasively with MRI and (1)H-MR spectroscopy. Due to the shorter transverse relaxation time (T(2)) at the ... Full text Link to item Cite

Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas.

Journal Article Med Phys · November 2009 PURPOSE: To establish accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. METHODS: Protocol patients with advanced extremity sarcomas were tr ... Full text Link to item Cite

Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.

Journal Article Proc SPIE Int Soc Opt Eng · February 25, 2009 A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance therma ... Full text Link to item Cite

WE‐C‐BRC‐02: Combined Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE‐MRI) and Magnetic Resonance Thermal Imaging (MRTI) for Optimal Hyperthermia Treatment of Advanced Extremity Sarcomas: Fifteen Patients Update

Conference Medical Physics · January 1, 2009 Purpose: To deliver optimal hyperthermia (HT) treatments for patients with advanced extremity sarcomas using DCE‐MRI and MRTI Method and Materials: Patients were treated on a protocol using radiotherapy consisting of 45 Gy and once a week HT for 5 weeks in ... Full text Cite

Hyperthermia MRI temperature measurement: evaluation of measurement stabilisation strategies for extremity and breast tumours.

Journal Article Int J Hyperthermia · 2009 Featured Publication PURPOSE: MR thermometry using the proton resonance frequency shift (PRFS) method has been used to measure temperature changes during clinical hyperthermia treatment. However, frequency drift of the MRI system can add large errors to the measured temperatur ... Full text Link to item Cite

Effect of echo time pair selection on quantitative analysis for adrenal tumor characterization with in-phase and opposed-phase MR imaging: initial experience.

Journal Article Radiology · July 2008 Featured Publication PURPOSE: To determine the effect of two pairs of echo times (TEs) for in-phase (IP) and opposed-phase (OP) 3.0-T magnetic resonance (MR) imaging on (a) quantitative analysis prospectively in a phantom study and (b) diagnostic accuracy retrospectively in a ... Full text Link to item Cite

Regional metabolite T2 in the healthy rhesus macaque brain at 7T.

Journal Article Magn Reson Med · May 2008 Although the rhesus macaque brain is an excellent model system for the study of neurological diseases and their responses to treatment, its small size requires much higher spatial resolution, motivating use of ultra-high-field (B(0)) imagers. Their weaker ... Full text Link to item Cite

Haemodialysis patients with sleep apnoea syndrome experience increased central adiposity and altered muscular composition and functionality.

Journal Article Nephrol Dial Transplant · January 2008 BACKGROUND: Sleep apnoea frequently affects patients with end-stage renal disease. However, it is still unclear whether or to what extent sleep disorders may affect functional capacity and quality of life in haemodialysis patients. We tested the hypothesis ... Full text Link to item Cite

A review of MR physics: 3T versus 1.5T.

Journal Article Magn Reson Imaging Clin N Am · August 2007 This article illustrates changes in the underlying physics concepts related to increasing the main magnetic field from 1.5T to 3T. The effects of these changes on tissue constants and practical hardware limitations is discussed as they affect scan time, qu ... Full text Link to item Cite

Human brain-structure resolved T(2) relaxation times of proton metabolites at 3 Tesla.

Journal Article Magn Reson Med · June 2007 The transverse relaxation times, T(2), of N-acetylaspartate (NAA), total choline (Cho), and creatine (Cr) obtained at 3T in several human brain regions of eight healthy volunteers are reported. They were obtained simultaneously in 320 voxels with three-dim ... Full text Link to item Cite

GAVA: spectral simulation for in vivo MRS applications.

Journal Article J Magn Reson · April 2007 Featured Publication An application that provides a flexible and easy to use interface to the GAMMA spectral simulation package is described that is targeted at investigations using in vivo MR spectroscopic methods. The program makes available a number of widely used spatially ... Full text Link to item Cite

From the RSNA refresher courses: MR imaging in hyperthermia.

Journal Article Radiographics · 2007 There is growing clinical evidence that the combination of radiation therapy and hyperthermia, when delivered at moderate temperatures (40 degrees-45 degrees C) for sustained times (30-90 minutes), is of benefit with regard to palliative relief of cancer, ... Full text Link to item Cite

Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging.

Journal Article NMR Biomed · June 2006 Featured Publication Image reconstruction for magnetic resonance spectroscopic imaging (MRSI) requires specialized spatial and spectral data processing methods and benefits from the use of several sources of prior information that are not commonly available, including MRI-deri ... Full text Link to item Cite

Robust analysis of short echo time (1)H MRSI of human brain.

Journal Article Magn Reson Med · March 2006 Featured Publication Short echo time proton MR Spectroscopic Imaging (MRSI) suffers from low signal-to-noise ratio (SNR), limiting accuracy to estimate metabolite intensities. A method to coherently sum spectra in a region of interest of the human brain by appropriate peak ali ... Full text Link to item Cite

Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging.

Journal Article Alzheimer Dis Assoc Disord · 2006 Previous magnetic resonance (MR) spectroscopy studies of Alzheimer disease (AD) reporting reduced N-acetyl aspartate (NAA) and increased myo-Inositol (mI) used single voxel techniques, which have limited ability to assess the regional distribution of the m ... Full text Link to item Cite

A review of 1H MR spectroscopy findings in Alzheimer's disease.

Journal Article Neuroimaging Clin N Am · November 2005 Hydrogen-1 MR spectroscopy (MRS) studies demonstrate metabolic differences between patients who have Alzheimer's disease (AD) and cognitive normal age-matched controls. Clinical MRS also shows regional variations in metabolites between patients who have AD ... Full text Link to item Cite

Observation of coupled 1H metabolite resonances at long TE.

Journal Article Magn Reson Med · June 2005 Featured Publication A PRESS localization (1)H MRS acquisition sequence with a Carr-Purcell train of refocusing pulses (CP-PRESS) has been implemented using global refocusing "sandwich" pulses. The CP pulse train minimized the effects of J-coupled dephasing in metabolites with ... Full text Link to item Cite

Numerical simulation of PRESS localized MR spectroscopy.

Journal Article J Magn Reson · March 2005 Featured Publication Numerical simulations of NMR spectra can provide a rapid and convenient method for optimizing acquisition sequence parameters and generating prior spectral information required for parametric spectral analysis. For spatially resolved spectroscopy, spatiall ... Full text Link to item Cite

Evaluation of variable line-shape models and prior information in automated 1H spectroscopic imaging analysis.

Journal Article Magn Reson Med · December 2004 Analysis of in vivo short TE 1H spectra is complicated by broad baseline signal contributions and resonance line-shape distortions. Although the assumptions of ideal metabolite resonance line-shapes and slowly varying baseline signals can be used to separa ... Full text Link to item Cite

Magnetic resonance spectroscopic imaging reconstruction with deformable shape-intensity models.

Journal Article Magn Reson Med · September 2003 Featured Publication A new method, based on a deformable shape-intensity model (DSM), was developed to improve the signal-to-noise ratio (SNR) of multidimensional magnetic resonance spectroscopic imaging (MRSI) data sets without affecting spectral lineshapes and linewidths. Im ... Full text Link to item Cite

Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder.

Journal Article Am J Psychiatry · May 2003 OBJECTIVE: Previous studies attempting to identify neuropathological alterations in the hippocampus in bipolar disorder have been inconclusive. The objective of this study was to determine if the concentration of N-acetylaspartate, a neuronal and axonal ma ... Full text Link to item Cite

Brain metabolite profiles of T1-hypointense lesions in relapsing-remitting multiple sclerosis.

Journal Article AJNR Am J Neuroradiol · January 2003 BACKGROUND AND PURPOSE: Persistent T1-hypointense lesions ("black holes") are thought to represent permanent damage of brain parenchyma. We attempted to ascertain whether the metabolic profiles of these hypointense areas support this hypothesis and whether ... Link to item Cite

Muscle atrophy in patients receiving hemodialysis: effects on muscle strength, muscle quality, and physical function.

Journal Article Kidney Int · January 2003 BACKGROUND: Dialysis patients are less active and have reduced functional capacity compared to individuals with normal renal function. Muscle atrophy and weakness may contribute to these problems. This investigation was undertaken to quantify the extent of ... Full text Link to item Cite

Multisection proton MR spectroscopy for mesial temporal lobe epilepsy.

Journal Article AJNR Am J Neuroradiol · September 2002 BACKGROUND AND PURPOSE: Extensive metabolic impairments have been reported in association with mesial temporal lobe epilepsy (mTLE). We investigated whether proton MR spectroscopy ((1)H-MRS) depicts metabolic changes beyond the hippocampus in cases of mTLE ... Link to item Cite

A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia.

Journal Article Neuroimage · May 2002 In this report, we describe the implementation and application of a fully automated segmentation routine using SPM99 algorithms and MATLAB for clinical Magnetic Resonance Spectroscopic Imaging (MRSI) studies. By segmenting high-resolution 3-D image data an ... Full text Link to item Cite

Reproducibility of 3D proton spectroscopy in the human brain.

Journal Article Magn Reson Med · March 2002 The inter- and intrasubject reproducibility of the metabolite levels of N-acetylaspartate (NAA), creatine (Cr), and choline (Cho), obtained with three-dimensional (3D) multivoxel proton spectroscopy (1H-MRS), was analyzed in eight healthy volunteers. Seria ... Full text Link to item Cite

Assessment of 3D proton MR echo-planar spectroscopic imaging using automated spectral analysis.

Journal Article Magn Reson Med · December 2001 For many clinical applications of proton MR spectroscopic imaging (MRSI) of the brain, diagnostic assessment is limited by insufficient coverage provided by single- or multislice acquisition methods as well as by the use of volume preselection methods. Add ... Full text Link to item Cite

Evidence for altered cerebellar vermis neuronal integrity in schizophrenia.

Journal Article Psychiatry Res · October 1, 2001 To determine if there was evidence for altered neuronal integrity in the cerebellar vermis of patients with schizophrenia, the authors measured N-acetyl-aspartate (NAA, a putative neuronal/axonal marker) using in vivo proton magnetic resonance spectroscopi ... Full text Link to item Cite

Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability.

Journal Article Magn Reson Imaging · October 2001 Multislice proton magnetic resonance spectroscopic imaging (1H MRSI) at 25 ms echo time was used to measure concentrations of myo-inositol (mI), N-acetylaspartate (NAA), and creatine (Cr) and choline (Cho) in ten normal subjects between 22 and 84 years of ... Full text Link to item Cite

Representation of strong baseline contributions in 1H MR spectra.

Journal Article Magn Reson Med · June 2001 A comparison is made between two optimization procedures and two data models for automated analysis of in vivo proton MR spectra of brain, typical of that obtained using MR spectroscopic imaging at 1.5 Tesla. First, a shift invariant wavelet filter is pres ... Full text Link to item Cite

Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity.

Journal Article Magn Reson Med · June 2001 This work describes the use of magnetic resonance (MR) microscopy to examine changes in tibial trabecular bone structure in mice following 28 days of hindlimb suspension, a model simulating the effects of microgravity in rodents. In this first MR study inv ... Full text Link to item Cite

Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis.

Journal Article Magn Reson Imaging · November 2000 Featured Publication Spectral analysis of short TE in vivo proton magnetic resonance spectroscopic imaging (MRSI) data are complicated by the presence of spectral overlap, low signal to noise and uncharacterized signal contributions. In this study, it is shown that an automate ... Full text Link to item Cite

Confidence images for MR spectroscopic imaging.

Journal Article Magn Reson Med · October 2000 Automated spectral analysis and estimation of signal amplitudes from magnetic resonance data generally constitutes a difficult nonlinear optimization problem. Obtaining a measure of the degree of confidence that one has in the estimated parameters is as im ... Full text Link to item Cite

1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.

Journal Article Mult Scler · June 2000 OBJECTIVE: To compare brain metabolite levels in patients with primary progressive (PP) and relapsing remitting (RR) MS and controls. HYPOTHESES: (1) creatine (Cr), a putative marker of gliosis, is elevated and N-acetylaspartate (NAA), a putative marker of ... Full text Link to item Cite

Effects of age, medication, and illness duration on the N-acetyl aspartate signal of the anterior cingulate region in schizophrenia.

Journal Article Schizophr Res · February 14, 2000 The authors performed a MRSI study of the anterior cingulate gyrus in 19 schizophrenic patients under stable medication and 16 controls in order to corroborate previous findings of reduced NAA in the anterior cingulate region in schizophrenia. Furthermore, ... Full text Link to item Cite

Neural substrates of orthographic lexical access as demonstrated by functional brain imaging.

Journal Article Neuropsychiatry Neuropsychol Behav Neurol · January 2000 OBJECTIVE: To delineate regions involved in visual word recognition. BACKGROUND: The processes and regions involved in visual word recognition have been somewhat controversial for over 100 years. METHODS: This study used regional cerebral blood flow as ass ... Link to item Cite

1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS

Journal Article Multiple Sclerosis · 2000 Objective: To compare brain metabolite levels in patients with primary progressive (PP) and relapsing remitting (RR) MS and controls. Hypotheses: (1) creatine (Cr), a putative marker of gliosis, is elevated and N-acetylaspartate (NAA), a putative marker of ... Cite

Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging.

Journal Article Magn Reson Med · December 1998 Featured Publication An automated method for analysis of in vivo proton magnetic resonance (MR) spectra and reconstruction of metabolite distributions from MR spectroscopic imaging (MRSI) data is described. A parametric spectral model using acquisition specific, a priori infor ... Full text Link to item Cite

Automated spectral analysis II: application of wavelet shrinkage for characterization of non-parameterized signals.

Journal Article Magn Reson Med · December 1998 Featured Publication An iterative method for differentiating between known resonances and uncharacterized baseline contributions in MR spectra is described. The method alternates parametric modeling, using a priori knowledge of spectral parameters, with non-parametric characte ... Full text Link to item Cite

Automated spectral analysis I: formation of a priori information by spectral simulation.

Journal Article Magn Reson Med · December 1998 Featured Publication A spectral simulation method is described for generating a priori information for use in parametric spectral analysis. The method makes use of GAMMA (S. A. Smith, T. O. Levante, B. H. Meier, R. R. Ernst, J. Magn. Reson., 106A, 75-105, 1994), a programming ... Full text Link to item Cite

Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1998 Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of ... Full text Cite

Magnetic resonance perfusion imaging in acute middle cerebral artery stroke: comparison of blood volume and bolus peak arrival time.

Journal Article J Stroke Cerebrovasc Dis · 1998 Ten patients with a diagnosis of acute middle cerebral artery stroke were evaluated using perfusion magnetic resonance imaging (MRI) during bolus injection of gadolinium diethylenetriaminepentaacetic acid (GdDTPA), MR angiography, and conventional MRI. Sca ... Full text Link to item Cite

Object shape processing in the visual system evaluated using functional MRI.

Journal Article Neurology · May 1997 We used functional MRI (fMRI) to determine the cortical regions activated during processing of visual object shape in humans in six men and three women, using a paradigm with a baseline condition of simple shape detection and an activated condition of obje ... Full text Link to item Cite

Visual activation in alpha-chloralose-anaesthetized cats does not cause lactate accumulation in the visual cortex as detected by [1H]NMR difference spectroscopy.

Journal Article Eur J Neurosci · April 1997 The hypothesis that neuronal activation results in lactate accumulation due to mismatch between glucose and oxygen consumption was tested in the cat model of visual activation by monitoring cerebral metabolism with localized 1H nuclear magnetic resonance s ... Full text Link to item Cite

Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference.

Journal Article Magn Reson Med · September 1996 Featured Publication Data from a previously published, multi-site trial (P.G. Webb, N. Sailasuta, S.J. Kohler, T. Raidy, R.A. Moats, R.E. Hurd. Automated single-voxel proton MRS: technical development and multisite verification. Magn. Reson. Med. 31, 365-373 (1994)) of a fully ... Full text Link to item Cite

Quantitative proton MR spectroscopic imaging of the human brain.

Journal Article Magn Reson Med · March 1996 Featured Publication Multislice proton MR spectroscopic images (SI) of the brain were quantitated, using the phantom replacement technique. In 16 normal volunteers, ranging in age from 5 to 74 years, average "whole brain" concentrations of choline (Cho), creatine (Cr), and N-a ... Full text Link to item Cite

Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions.

Journal Article Magn Reson Med · January 1995 In the elderly, asymptomatic white matter hyperintensities are common on T2-weighted magnetic resonance imaging (MRI). In symptomatic patients, such MRI appearances correlate with varied postmortem findings including demyelination or stroke. What structura ... Full text Link to item Cite

Comparison of functional MR and H2 15O positron emission tomography in stimulation of the primary visual cortex.

Journal Article AJNR Am J Neuroradiol · 1995 PURPOSE: To locate spoiled gradient-echo functional MR signal changes in relation to brain parenchyma. METHODS: The region of the primary visual cortex was evaluated using functional MR and H2 15O positron emission tomography in each of six male subjects w ... Link to item Cite

Acute stroke: evaluation with serial proton MR spectroscopic imaging.

Journal Article Radiology · September 1994 PURPOSE: To investigate the evolution of metabolic changes detectable with proton magnetic resonance (MR) spectroscopic imaging in acute stroke and to compare these findings with those of conventional MR imaging. MATERIALS AND METHODS: A patient with middl ... Full text Link to item Cite

Quantitative proton spectroscopy of canine brain: in vivo and in vitro correlations.

Journal Article Magn Reson Med · August 1994 Quantitative, single-voxel proton NMR spectroscopy of normal brain was performed in five adult beagle dogs using the cerebral water signal as an internal intensity reference. The same brain regions were then rapidly isolated and frozen using a pneumatic bi ... Full text Link to item Cite

Quantitative proton spectroscopy and histology of a canine brain tumor model.

Journal Article Magn Reson Med · October 1993 Quantitative, single voxel proton nuclear magnetic resonance (NMR) spectroscopy and histological analysis was performed in eight dogs implanted with the transplantable canine glioma model of Wodinsky (Proc. Am. Assoc. Cancer Res. 10, 99 (1969)). Signals fr ... Full text Link to item Cite

Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference.

Journal Article NMR Biomed · 1993 The use of cerebral water as an internal intensity standard for the quantitation of spatially localized proton spectra of the human brain is investigated. The method is validated on standard samples of N-acetyl aspartate (NAA) and lactate, and possible sou ... Full text Link to item Cite

In vivo proton NMR spectroscopy of the human liver

Journal Article Proceedings of the Society of Magnetic Resonance in Medicine · 1993 Cite