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Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations.

Publication ,  Journal Article
Cudalbu, C; Behar, KL; Bhattacharyya, PK; Bogner, W; Borbath, T; de Graaf, RA; Gruetter, R; Henning, A; Juchem, C; Kreis, R; Lee, P; Lei, H ...
Published in: NMR Biomed
May 2021

Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower peaks of metabolites and often complicate their quantification but they also may have potential importance as biomarkers in specific diseases. Thus, separation of broad MM signals from low molecular weight metabolites enables accurate determination of metabolite concentrations and is of primary interest in many studies. Other studies attempt to understand the origin of the MM spectrum, to decompose it into individual spectral regions or peaks and to use the components of the MM spectrum as markers of various physiological or pathological conditions in biomedical research or clinical practice. The aim of this consensus paper is to provide an overview and some recommendations on how to handle the MM signals in different types of studies together with a list of open issues in the field, which are all summarized at the end of the paper.

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Published In

NMR Biomed

DOI

EISSN

1099-1492

Publication Date

May 2021

Volume

34

Issue

5

Start / End Page

e4393

Location

England

Related Subject Headings

  • Young Adult
  • Signal Processing, Computer-Assisted
  • Proton Magnetic Resonance Spectroscopy
  • Nuclear Medicine & Medical Imaging
  • Models, Theoretical
  • Middle Aged
  • Metabolome
  • Magnetic Resonance Imaging
  • Macromolecular Substances
  • Lipids
 

Citation

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Cudalbu, C., Behar, K. L., Bhattacharyya, P. K., Bogner, W., Borbath, T., de Graaf, R. A., … Mlynárik, V. (2021). Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations. NMR Biomed, 34(5), e4393. https://doi.org/10.1002/nbm.4393
Cudalbu, Cristina, Kevin L. Behar, Pallab K. Bhattacharyya, Wolfgang Bogner, Tamas Borbath, Robin A. de Graaf, Rolf Gruetter, et al. “Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations.NMR Biomed 34, no. 5 (May 2021): e4393. https://doi.org/10.1002/nbm.4393.
Cudalbu C, Behar KL, Bhattacharyya PK, Bogner W, Borbath T, de Graaf RA, et al. Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations. NMR Biomed. 2021 May;34(5):e4393.
Cudalbu, Cristina, et al. “Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations.NMR Biomed, vol. 34, no. 5, May 2021, p. e4393. Pubmed, doi:10.1002/nbm.4393.
Cudalbu C, Behar KL, Bhattacharyya PK, Bogner W, Borbath T, de Graaf RA, Gruetter R, Henning A, Juchem C, Kreis R, Lee P, Lei H, Marjańska M, Mekle R, Murali-Manohar S, Považan M, Rackayová V, Simicic D, Slotboom J, Soher BJ, Starčuk Z, Starčuková J, Tkáč I, Williams S, Wilson M, Wright AM, Xin L, Mlynárik V. Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations. NMR Biomed. 2021 May;34(5):e4393.
Journal cover image

Published In

NMR Biomed

DOI

EISSN

1099-1492

Publication Date

May 2021

Volume

34

Issue

5

Start / End Page

e4393

Location

England

Related Subject Headings

  • Young Adult
  • Signal Processing, Computer-Assisted
  • Proton Magnetic Resonance Spectroscopy
  • Nuclear Medicine & Medical Imaging
  • Models, Theoretical
  • Middle Aged
  • Metabolome
  • Magnetic Resonance Imaging
  • Macromolecular Substances
  • Lipids