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Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols.

Publication ,  Journal Article
Hyman, LM; Franz, KJ
Published in: Coordination chemistry reviews
October 2012

Oxidative stress is a common feature shared by many diseases, including neurodegenerative diseases. Factors that contribute to cellular oxidative stress include elevated levels of reactive oxygen species, diminished availability of detoxifying thiols, and the misregulation of metal ions (both redox-active iron and copper as well as non-redox active calcium and zinc). Deciphering how each of these components interacts to contribute to oxidative stress presents an interesting challenge. Fluorescent sensors can be powerful tools for detecting specific analytes within a complicated cellular environment. Reviewed here are several classes of small molecule fluorescent sensors designed to detect several molecular participants of oxidative stress. We focus our review on describing the design, function and application of probes to detect metal cations, reactive oxygen species, and intracellular thiol-containing compounds. In addition, we highlight the intricacies and complications that are often faced in sensor design and implementation.

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Published In

Coordination chemistry reviews

DOI

ISSN

0010-8545

Publication Date

October 2012

Volume

256

Issue

19-20

Start / End Page

2333 / 2356

Related Subject Headings

  • General Chemistry
  • 4003 Biomedical engineering
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences
  • 0306 Physical Chemistry (incl. Structural)
  • 0302 Inorganic Chemistry
 

Citation

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Hyman, L. M., & Franz, K. J. (2012). Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols. Coordination Chemistry Reviews, 256(19–20), 2333–2356. https://doi.org/10.1016/j.ccr.2012.03.009
Hyman, Lynne M., and Katherine J. Franz. “Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols.Coordination Chemistry Reviews 256, no. 19–20 (October 2012): 2333–56. https://doi.org/10.1016/j.ccr.2012.03.009.
Hyman LM, Franz KJ. Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols. Coordination chemistry reviews. 2012 Oct;256(19–20):2333–56.
Hyman, Lynne M., and Katherine J. Franz. “Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols.Coordination Chemistry Reviews, vol. 256, no. 19–20, Oct. 2012, pp. 2333–56. Epmc, doi:10.1016/j.ccr.2012.03.009.
Hyman LM, Franz KJ. Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols. Coordination chemistry reviews. 2012 Oct;256(19–20):2333–2356.
Journal cover image

Published In

Coordination chemistry reviews

DOI

ISSN

0010-8545

Publication Date

October 2012

Volume

256

Issue

19-20

Start / End Page

2333 / 2356

Related Subject Headings

  • General Chemistry
  • 4003 Biomedical engineering
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences
  • 0306 Physical Chemistry (incl. Structural)
  • 0302 Inorganic Chemistry