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Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: thirty-six-month results.

Publication ,  Journal Article
Jain, N; Stinnett, SS; Jaffe, GJ
Published in: Ophthalmology
January 2012

PURPOSE: To assess long-term visual outcomes and adverse events from a fluocinolone acetonide (FA) sustained drug delivery implant in eyes with chronic macular edema from central retinal vein occlusion (CRVO). DESIGN: Prospective interventional case series. PARTICIPANTS: A total of 24 eyes of 23 subjects with vision loss associated with chronic macular edema from CRVO. INTERVENTION: Implantation of an intravitreal FA sustained drug delivery system. MAIN OUTCOME MEASURES: The primary outcome measure was mean Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity letter score at 36 months after implantation. Secondary outcome measures included number of subjects with ≥ 10-letter improvement in ETDRS letter score, central foveal thickness (CFT), total macular volume, and intraocular pressure (IOP). RESULTS: At 1, 2, and 3 years after implantation, mean visual acuity showed gains of 4.5 (P = 0.52), 8.2 (P = 0.07), and 3.4 (P = 0.64) letters, respectively, and 32%, 56%, and 50% of study eyes, respectively, showed at least a 10-letter gain in ETDRS score. At these same time points, mean CFT improved by 247 (44%; P = 0.002), 212 (38%; P < 0.001), and 250 μm (45%; P<0.001), respectively. During the study period, all phakic eyes ultimately underwent cataract extraction, and 5 eyes underwent glaucoma surgery. CONCLUSIONS: The FA drug delivery system provided sustained visual acuity and anatomic benefit in patients with macular edema from CRVO, and it has promise as a therapeutic option for selected patients with this condition. The main complications were cataract and elevated IOP. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

January 2012

Volume

119

Issue

1

Start / End Page

132 / 137

Location

United States

Related Subject Headings

  • Vitreous Body
  • Visual Acuity
  • Trabeculectomy
  • Retinal Vein Occlusion
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema
  • Intraocular Pressure
 

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Jain, N., Stinnett, S. S., & Jaffe, G. J. (2012). Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: thirty-six-month results. Ophthalmology, 119(1), 132–137. https://doi.org/10.1016/j.ophtha.2011.06.019
Jain, Nieraj, Sandra S. Stinnett, and Glenn J. Jaffe. “Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: thirty-six-month results.Ophthalmology 119, no. 1 (January 2012): 132–37. https://doi.org/10.1016/j.ophtha.2011.06.019.
Jain, Nieraj, et al. “Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: thirty-six-month results.Ophthalmology, vol. 119, no. 1, Jan. 2012, pp. 132–37. Pubmed, doi:10.1016/j.ophtha.2011.06.019.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

January 2012

Volume

119

Issue

1

Start / End Page

132 / 137

Location

United States

Related Subject Headings

  • Vitreous Body
  • Visual Acuity
  • Trabeculectomy
  • Retinal Vein Occlusion
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema
  • Intraocular Pressure