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Ventilatory and metabolic effects of hypercapnia in conscious rats: AVP V1 receptor block.

Publication ,  Journal Article
Walker, JK; Jennings, DB
Published in: Canadian journal of physiology and pharmacology
April 1998

In conscious dogs, arginine vasopressin (AVP) inhibits an angiotensin II drive to ventilation during air breathing and during acute hypercapnia. To determine whether AVP inhibits respiration in rats, as in dogs, respiration and metabolism were measured in six male Sprague-Dawley rats using a plethysmograph. Rats breathed air, followed by 5% and 6.5% CO2 with or without AVP V1 receptor block. In unblocked experiments, minute ventilation (V) increased to a comparable level during inhalation of both CO2 gas mixtures, resulting in a flattening of the ventilatory response to increased Paco2. However, oxygen consumption decreased during 6.5% CO2, compared with 5% CO2, so that the ventilatory equivalent for O2 increased in a more linear manner with respect to Paco2. The main effect of AVP V1 receptor block was to increase mean arterial blood pressure; there was no significant effect of AVP V1 receptor block on respiratory responses. AVP does not inhibit respiration in conscious rats as it does in conscious dogs.

Duke Scholars

Published In

Canadian journal of physiology and pharmacology

DOI

EISSN

1205-7541

ISSN

0008-4212

Publication Date

April 1998

Volume

76

Issue

4

Start / End Page

361 / 366

Related Subject Headings

  • Respiratory Physiological Phenomena
  • Receptors, Vasopressin
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Male
  • Hypercapnia
  • Hormone Antagonists
  • Heart Rate
  • Blood Pressure
 

Citation

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Walker, J. K., & Jennings, D. B. (1998). Ventilatory and metabolic effects of hypercapnia in conscious rats: AVP V1 receptor block. Canadian Journal of Physiology and Pharmacology, 76(4), 361–366. https://doi.org/10.1139/cjpp-76-4-361
Walker, J. K., and D. B. Jennings. “Ventilatory and metabolic effects of hypercapnia in conscious rats: AVP V1 receptor block.Canadian Journal of Physiology and Pharmacology 76, no. 4 (April 1998): 361–66. https://doi.org/10.1139/cjpp-76-4-361.
Walker JK, Jennings DB. Ventilatory and metabolic effects of hypercapnia in conscious rats: AVP V1 receptor block. Canadian journal of physiology and pharmacology. 1998 Apr;76(4):361–6.
Walker, J. K., and D. B. Jennings. “Ventilatory and metabolic effects of hypercapnia in conscious rats: AVP V1 receptor block.Canadian Journal of Physiology and Pharmacology, vol. 76, no. 4, Apr. 1998, pp. 361–66. Epmc, doi:10.1139/cjpp-76-4-361.
Walker JK, Jennings DB. Ventilatory and metabolic effects of hypercapnia in conscious rats: AVP V1 receptor block. Canadian journal of physiology and pharmacology. 1998 Apr;76(4):361–366.

Published In

Canadian journal of physiology and pharmacology

DOI

EISSN

1205-7541

ISSN

0008-4212

Publication Date

April 1998

Volume

76

Issue

4

Start / End Page

361 / 366

Related Subject Headings

  • Respiratory Physiological Phenomena
  • Receptors, Vasopressin
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Male
  • Hypercapnia
  • Hormone Antagonists
  • Heart Rate
  • Blood Pressure