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Elastin-like polypeptides as thermally targeted drug carriers

Publication ,  Journal Article
Meyer, D; Chilkoti, A
Published in: Annals of Biomedical Engineering
December 1, 2000

Here, we present the tissue distribution of radiolabeled ELP carriers that were injected into athymic mice with implanted tumors (human glioma D54MG). We observed a two-fold increase in ELP accumulation when the tumor was heated versus unheated animals. Stringent controls show that the observed enhancement is largely caused by the phase transition of the ELP carrier. Ongoing optimization studies seek to determine the effect of ELP MW, concentration, and administration protocol on targeting efficiency.

Duke Scholars

Published In

Annals of Biomedical Engineering

ISSN

0090-6964

Publication Date

December 1, 2000

Volume

28

Issue

SUPPL. 1

Related Subject Headings

  • Biomedical Engineering
  • 11 Medical and Health Sciences
  • 09 Engineering
 

Citation

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MLA
NLM
Meyer, D., & Chilkoti, A. (2000). Elastin-like polypeptides as thermally targeted drug carriers. Annals of Biomedical Engineering, 28(SUPPL. 1).
Meyer, D., and A. Chilkoti. “Elastin-like polypeptides as thermally targeted drug carriers.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
Meyer D, Chilkoti A. Elastin-like polypeptides as thermally targeted drug carriers. Annals of Biomedical Engineering. 2000 Dec 1;28(SUPPL. 1).
Meyer, D., and A. Chilkoti. “Elastin-like polypeptides as thermally targeted drug carriers.” Annals of Biomedical Engineering, vol. 28, no. SUPPL. 1, Dec. 2000.
Meyer D, Chilkoti A. Elastin-like polypeptides as thermally targeted drug carriers. Annals of Biomedical Engineering. 2000 Dec 1;28(SUPPL. 1).
Journal cover image

Published In

Annals of Biomedical Engineering

ISSN

0090-6964

Publication Date

December 1, 2000

Volume

28

Issue

SUPPL. 1

Related Subject Headings

  • Biomedical Engineering
  • 11 Medical and Health Sciences
  • 09 Engineering